Abstract:
:Associations between drug consumption during pregnancy and the birth of children with oral clefts were studied in material from the Finnish Register of Congenital Malformations, consisting of 599 children with clefts and their matched controls. Information concerning maternal drug consumption was partly prospective. During the first trimester, analgesic, chemotherapeutic and antineurotic drugs had all been significantly more frequently used by the mothers of children with clefts, than by the control mothers. The consumption of drugs was in general more frequent among mothers of children with cleft lip, with or without cleft palate, than among those of children with cleft palate alone.
journal_name
Int J Epidemioljournal_title
International journal of epidemiologyauthors
Saxén Idoi
10.1093/ije/4.1.37keywords:
subject
Has Abstractpub_date
1975-03-01 00:00:00pages
37-44issue
1eissn
0300-5771issn
1464-3685journal_volume
4pub_type
杂志文章abstract::We undertook a case-control study to investigate the association between chemicals in maternal drinking water consumed during pregnancy and congenital heart disease in the offspring. Two hundred and seventy affected children and 665 healthy children were enrolled in the study. Information on contaminant levels in mate...
journal_title:International journal of epidemiology
pub_type: 杂志文章
doi:10.1093/ije/17.3.589
更新日期:1988-09-01 00:00:00
abstract::Despite the extreme differences in the incidence of lung cancer between black and white Americans of each sex, little information is available on the sex-race-specific lung cancer risk due to tobacco use. In the current study, case-control data were examined for sex-race differences in the lung cancer risk associated ...
journal_title:International journal of epidemiology
pub_type: 杂志文章
doi:10.1093/ije/22.4.592
更新日期:1993-08-01 00:00:00
abstract:OBJECTIVES:To examine whether educational attainment and intelligence have causal effects on risk of Alzheimer's disease (AD), independently of each other. DESIGN:Two-sample univariable and multivariable Mendelian randomization (MR) to estimate the causal effects of education on intelligence and vice versa, and the to...
journal_title:International journal of epidemiology
pub_type: 杂志文章
doi:10.1093/ije/dyz280
更新日期:2020-08-01 00:00:00
abstract:BACKGROUND AND OBJECTIVE:Live vaccines may have beneficial non-specific effects. We tested whether the live measles, mumps and rubella (MMR) vaccine compared with the non-live diphtheria-tetanus-acellular-pertussis-inactivated-polio-Haemophilus influenzae type b (DTaP-IPV-Hib) vaccine as the most recent vaccine was ass...
journal_title:International journal of epidemiology
pub_type: 杂志文章
doi:10.1093/ije/dyz062
更新日期:2019-12-01 00:00:00
abstract::In an extensive health survey 115 male viscose rayon workers exposed to carbon disulphide (CS2) and 76 referents not exposed to this chemical were interviewed using the WHO cardiovascular questionnaire and responded to a self-administered questionnaire. A 12-lead ECG was taken and coded using the Minnesota code. Blood...
journal_title:International journal of epidemiology
pub_type: 杂志文章
doi:10.1093/ije/21.4.745
更新日期:1992-08-01 00:00:00
abstract:BACKGROUND:Extended breastfeeding is known to benefit the health of children in developing countries and despite widespread expectations of a decline in breastfeeding in these countries, it has been demonstrated that the incidence and duration of breastfeeding are in fact increasing many countries. METHODS:In this pap...
journal_title:International journal of epidemiology
pub_type: 杂志文章
doi:10.1093/ije/25.1.94
更新日期:1996-02-01 00:00:00
abstract:BACKGROUND:The health benefits of physical activity are well established, but the overall amount of physical activity associated with cardiovascular and other health outcomes, and whether the relationships are similar in men and women and at different ages is still debated. This may be partly related to different metho...
journal_title:International journal of epidemiology
pub_type: 杂志文章
doi:10.1093/ije/dyl079
更新日期:2006-08-01 00:00:00
abstract::Prospective data from the Matlab surveillance area in rural Bangladesh, 1974-1982, were used in this study to show that divorced and never-married adults (aged 15-44 years) had significantly higher mortality than their currently married peers with differences in disability status accounting for some of this excess ris...
journal_title:International journal of epidemiology
pub_type: 杂志文章
doi:10.1093/ije/22.3.445
更新日期:1993-06-01 00:00:00
abstract:BACKGROUND:We explored methods to develop uncorrelated variables for epidemiological analysis models. They were used to examine associations between respiratory health outcomes and multiple household risk factors. METHODS:We analysed data collected in the Four Chinese Cities Study (FCCS) to examine health effects on p...
journal_title:International journal of epidemiology
pub_type: 杂志文章
doi:10.1093/ije/dyg278
更新日期:2004-06-01 00:00:00
abstract:BACKGROUND:A growing body of literature suggests that physical activity may be a protective factor against hip fracture. METHODS:To study the association between hip fracture risk and recreational physical activity at various ages, changes in activity during adult life, occupational physical activity and how risks var...
journal_title:International journal of epidemiology
pub_type: 杂志文章
doi:10.1093/ije/29.2.308
更新日期:2000-04-01 00:00:00
abstract::To develop a procedure for maximizing the discrimination of smoking status, the authors analysed parallel samples of thiocyanate and cotinine in serum, and carbon monoxide (CO) in expired air in a cohort of 145 male subjects aged 45-65 years. The sensitivity and specificity were 93% and 82%, 97% and 83%, and 98% and 1...
journal_title:International journal of epidemiology
pub_type: 杂志文章
doi:10.1093/ije/21.3.488
更新日期:1992-06-01 00:00:00
abstract:Background:There is limited knowledge about the optimal timing of antiretroviral treatment initiation in older children and adolescents. Methods:A total of 20 576 antiretroviral treatment (ART)-naïve patients, aged 1-16 years at enrolment, from 19 cohorts in Europe, Southern Africa and West Africa, were included. We c...
journal_title:International journal of epidemiology
pub_type: 杂志文章,多中心研究
doi:10.1093/ije/dyw097
更新日期:2017-04-01 00:00:00
abstract::A comparative study of the effects of combined oral contraceptives (OC) on coagulation and fibrinolytic variables using standardized laboratory technique and methodology has been performed in Dublin (Ireland), Salvador (Brazil), Santiago (Chile) and Singapore. Of 777 entrants to the study, 622 were randomly allocated ...
journal_title:International journal of epidemiology
pub_type: 临床试验,杂志文章,多中心研究,随机对照试验
doi:10.1093/ije/20.4.913
更新日期:1991-12-01 00:00:00
abstract:BACKGROUND:A central pattern of body fat is recognized as a risk indicator of cardiovascular diseases in adulthood. The development of this body fat pattern from childhood into adulthood however, remains to be explored. METHODS:The development of two trunk skinfolds (subscapular; supra-iliac), two extremity skinfolds ...
journal_title:International journal of epidemiology
pub_type: 杂志文章
doi:10.1093/ije/25.6.1162
更新日期:1996-12-01 00:00:00
abstract:BACKGROUND:It is well established now that the incidence of schizophrenia is extremely high for several ethnic minority groups in western Europe, but there is considerable variation among groups. We investigated whether the increased risk among these groups depends upon the degree to which they perceive discrimination ...
journal_title:International journal of epidemiology
pub_type: 杂志文章
doi:10.1093/ije/dym085
更新日期:2007-08-01 00:00:00
abstract::Serial blood specimens from Rh-negative pregnant women sent to laboratory for Rh antibody testing were stored and used for influenza investigations. The study period covered three epidemics, each caused by a different variant of influenza A (H3N2) virus. The relationship between pre-epidemic haemagglutination inhibiti...
journal_title:International journal of epidemiology
pub_type: 杂志文章
doi:10.1093/ije/4.2.127
更新日期:1975-06-01 00:00:00
abstract:BACKGROUND:Previous studies do not provide a clear picture of the relationship between nitrogen dioxide (NO(2)) exposure and asthma. METHODS:Eighteen schools using unflued gas heating in winter were randomly allocated to either retain their heaters (10 control schools) or to have replacement flued gas or electric heat...
journal_title:International journal of epidemiology
pub_type: 临床试验,杂志文章,随机对照试验
doi:10.1093/ije/dyh018
更新日期:2004-02-01 00:00:00
abstract::In an effort to search for causes of malnutrition in the urban environment to guide intervention efforts, a study of more than 2000 mother/child pairs was conducted in Kinshasa, Zaire. Under the auspices of the Zairian National Nutrition Planning Center a representative sample of a large lower class urban population w...
journal_title:International journal of epidemiology
pub_type: 杂志文章
doi:10.1093/ije/17.3.556
更新日期:1988-09-01 00:00:00
abstract::The European Atherosclerosis Research Study--EARS--is a multicentre collaborative project sponsored by the European Community. Its main objective is to study, in young people, the biological expression of a paternal history of premature acute myocardial infarction (AMI) and the relative share of heredity and environme...
journal_title:International journal of epidemiology
pub_type: 杂志文章,多中心研究
doi:10.1093/ije/23.3.465
更新日期:1994-06-01 00:00:00
abstract:BACKGROUND:Endometriosis has been associated with a higher risk of cutaneous melanoma, but the mechanisms underlying this association are unknown.Some constitutional factors known to influence melanoma risk have been associated with endometriosis in some retrospective studies. However, prospective data are scarce, and ...
journal_title:International journal of epidemiology
pub_type: 杂志文章
doi:10.1093/ije/dyt235
更新日期:2014-02-01 00:00:00
abstract:BACKGROUND:The incidence of hepatitis C (HCV) infection among injecting drug users (IDUs) in Dublin is particularly high by international standards. The most robust predictor of an IDU's HCV status is his or her total number of lifetime injecting episodes. It has been proposed that participation in specific unsafe inje...
journal_title:International journal of epidemiology
pub_type: 杂志文章
doi:10.1093/ije/dyh347
更新日期:2005-02-01 00:00:00
abstract:BACKGROUND:There are several existing systematic reviews of prevalence of dementia for mainland China, Hong Kong and Taiwan, but several studies have been newly reported. The aim of this study is to update prevalence data in this region and test for variation across geographical areas and time periods using the new dat...
journal_title:International journal of epidemiology
pub_type: 杂志文章
doi:10.1093/ije/dyy007
更新日期:2018-06-01 00:00:00
abstract::Microscopic examination of multiple faeces samples of 2 825 persons was carried out in the Metropolitan Lagos. Overall prevalence of Entamoeba histolytica was 11.2%. Prevalence increased rapidly in younger age groups and there were no real differences between males and females. Prevalence was high among families who a...
journal_title:International journal of epidemiology
pub_type: 杂志文章
doi:10.1093/ije/8.1.55
更新日期:1979-03-01 00:00:00
abstract:OBJECTIVES:The aim of the present historical cohort study was to enhance the understanding of the unusual mortality pattern seen among seafarers. The main object was to describe the mortality pattern of Danish seafarers in recent years with special reference to the influence of accidents in the maritime workplace and a...
journal_title:International journal of epidemiology
pub_type: 杂志文章
doi:10.1093/ije/25.6.1237
更新日期:1996-12-01 00:00:00
abstract:BACKGROUND:It is unclear when in the life course do social inequalities in inflammation emerge. We examined whether the association between socioeconomic position (SEP) and C-reactive protein (CRP) is determined at conception, in childhood, adolescence or adulthood in 1484 participants from the population-based Cardiov...
journal_title:International journal of epidemiology
pub_type: 杂志文章
doi:10.1093/ije/dym244
更新日期:2008-04-01 00:00:00
abstract:Background:Many interventions delivered to improve health may benefit not only direct recipients but also people in close physical or social proximity. Our objective was to review all published literature about the spillover effects of interventions on health outcomes in low-middle income countries and to identify meth...
journal_title:International journal of epidemiology
pub_type: 杂志文章,评审
doi:10.1093/ije/dyx039
更新日期:2017-08-01 00:00:00
abstract:BACKGROUND:Ciprofloxacin, ceftriaxone and pivmecillinam are the antibiotics currently recommended by the World Health Organization (WHO) for the treatment of dysentery in children; yet there have been no reviews of the clinical effectiveness of these antibiotics in recent years. METHODS:We reviewed all literature repo...
journal_title:International journal of epidemiology
pub_type: 杂志文章,meta分析,评审
doi:10.1093/ije/dyq024
更新日期:2010-04-01 00:00:00
abstract:BACKGROUND:Several studies have shown that inactivated, whole-cell oral cholera vaccines (OCVs) confer both direct protection on vaccinees and herd protection on populations. Because our earlier cluster-randomized effectiveness trial (CRT) in urban Bangladesh failed to detect OCV herd protection, we reanalysed the tria...
journal_title:International journal of epidemiology
pub_type: 杂志文章,随机对照试验
doi:10.1093/ije/dyz060
更新日期:2019-08-01 00:00:00
abstract:BACKGROUND:Recent studies have found that cotinine is a better predictor of birthweight than the number of cigarettes smoked in pregnancy. In this paper we test this hypothesis and use cotinine to explore the effect of environmental tobacco smoke (ETS) on birthweight. METHODS:In all, 1254 white women were interviewed ...
journal_title:International journal of epidemiology
pub_type: 杂志文章
doi:10.1093/ije/27.4.647
更新日期:1998-08-01 00:00:00
abstract::In view of the many changes in the approach to the detection and management of hypertension that have occurred, the paucity of current data on this subject in Israel limits the possibilities of making international comparisons or evaluating trends. This study contributes recent information on the occupationally-active...
journal_title:International journal of epidemiology
pub_type: 杂志文章
doi:10.1093/ije/21.4.676
更新日期:1992-08-01 00:00:00