Abstract:
:We reviewed the literature of medication trials in ADHD to evaluate the scope of the available non-stimulant treatments. A variety of compounds with a common noradrenergic/ dopaminergic activity have shown documented anti-ADHD activity. There is a substantial body of literature documenting the efficacy of tricyclic antidepressants on ADHD in over 1,000 subjects. In addition, the atypical antidepressant bupropion and the novel noradrenergic specific antidepressant tomoxetine have also been documented to be effective in the treatment of ADHD in controlled clinical trials. Despite wide use, the scientific base supporting the efficacy of alpha-2, noradrenergic agonists continues to be limited. Several lines of evidence provide preliminary support for the potential benefits of cholinergic cognitive enhancing drugs in such as anticholinesterase inhibitors (tacrine, donepezil) as well as novel nicotinic analogues (ABT-418). Despite these promising results, more research is needed on alternative pharmacologic treatments for the treatment of ADHD.
journal_name
Eur Child Adolesc Psychiatryjournal_title
European child & adolescent psychiatryauthors
Biederman J,Spencer Tdoi
10.1007/s007870070019keywords:
subject
Has Abstractpub_date
2000-01-01 00:00:00pages
I51-9eissn
1018-8827issn
1435-165Xjournal_volume
9 Suppl 1pub_type
杂志文章,评审abstract::The greater burden of illness in youth with co-occurring attention-deficit/hyperactivity disorder (ADHD) and major depressive disorder (MDD) deserves further investigation, specifically regarding the influence of other psychiatric or medical conditions and the pharmacotherapies prescribed. A retrospective cohort desig...
journal_title:European child & adolescent psychiatry
pub_type: 杂志文章
doi:10.1007/s00787-014-0541-z
更新日期:2015-01-01 00:00:00
abstract::Maternal depression symptoms (MDS) are a robust risk factor for internalising problems (IP) in the offspring. However, the relative importance of MDS and other factors associated with it (i.e. other types of maternal psychopathology, maternal parenting practices, family characteristics) is not well understood. To (a) ...
journal_title:European child & adolescent psychiatry
pub_type: 杂志文章
doi:10.1007/s00787-017-1096-6
更新日期:2018-07-01 00:00:00
abstract::One third of children with autistic spectrum disorders (or pervasive developmental disorders) enter that state by regression from a more normal prior development at the onset of epilepsy or epileptiform abnormality in the electroencephalogram. In a very small proportion structural lesions of the temporal lobes are dis...
journal_title:European child & adolescent psychiatry
pub_type: 杂志文章
doi:10.1007/s007870050128
更新日期:1999-09-01 00:00:00
abstract:OBJECTIVES:Based on the investigation of 144 families (144 patients affected by Multiple Sclerosis (MS), 109 partners, and 192 children) examined in three different European child and adolescent psychiatric University centres by means of questionnaires, we evaluated the prevalence of psychological symptoms in the offsp...
journal_title:European child & adolescent psychiatry
pub_type: 杂志文章
doi:10.1007/s00787-006-0589-5
更新日期:2007-04-01 00:00:00
abstract::Given the known behavior effects of oxytocin,and in particular its putative effect on trust, affiliation and anxiety, we hypothesized that oxytocin may be involved in the development and expression of callous-unemotional traits in children with aggressive antisocial behavior. We recruited 162 children between the ages...
journal_title:European child & adolescent psychiatry
pub_type: 杂志文章
doi:10.1007/s00787-012-0240-6
更新日期:2012-03-01 00:00:00
abstract::Within the International Collaborative Outcome Study of Eating Disorders in Adolescence (ICOSEDA) we studied the clinical features, treatment, and outcome in consecutive cohorts of adolescent patients at five sites in former West Berlin and East Berlin, Zurich, Sofia and Bucharest. A total of N = 242 patients were fol...
journal_title:European child & adolescent psychiatry
pub_type: 杂志文章,多中心研究
doi:10.1007/s00787-003-1112-x
更新日期:2003-01-01 00:00:00
abstract::This study investigated depressive psychopathology and psychosocial functioning in adolescent anorexia nervosa patients at a three year follow-up in comparison to healthy age-matched controls. Three standardized rating instruments (HRSD, SDS, BDI) were used for assessing depression and the Morgan-Russell scales for de...
journal_title:European child & adolescent psychiatry
pub_type: 杂志文章
doi:10.1007/BF02125569
更新日期:1993-07-01 00:00:00
abstract::The importance of paying attention to scale levels is emphasized and it is pointed out that Steven's hierarchy of ratio, interval, ordinal, and nominal scales is too narrow; other important scale properties have to be considered. For instance, sometimes a carefully constructed variable on a nominal scale contains more...
journal_title:European child & adolescent psychiatry
pub_type: 杂志文章
doi:10.1007/BF00538540
更新日期:1996-01-01 00:00:00
abstract:OBJECTIVE:This study evaluated the differences in suicidal behaviour between adolescent anorexia nervosa (AN) and bulimia nervosa (BN), and the association of age, menarche timing, duration of eating disorder (ED), depression and general psychopathological symptoms (GSI) with suicidal behaviour in adolescent ED. METHO...
journal_title:European child & adolescent psychiatry
pub_type: 杂志文章
doi:10.1007/s00787-005-0473-8
更新日期:2005-08-01 00:00:00
abstract::Previous studies have demonstrated that many children with conduct problems (CP) also show internalising psychopathology (IP). However, it remains unclear whether the presence of IP serves as a protective or risk factor for the severity and development of CP. The aim of the present study was to assess the prevalence a...
journal_title:European child & adolescent psychiatry
pub_type: 杂志文章
doi:10.1007/s00787-011-0229-6
更新日期:2012-01-01 00:00:00
abstract::Pediatric bipolar disorder (BD) and unipolar disorder (UD) share common symptomatic and functional impairments. Various brain imaging techniques have been used to investigate the integrity of brain white matter (WM) and gray matter (GM) in these disorders. Despite promising preliminary findings, it is still unclear wh...
journal_title:European child & adolescent psychiatry
pub_type: 杂志文章,评审
doi:10.1007/s00787-014-0614-z
更新日期:2014-11-01 00:00:00
abstract::This study compared the neuropsychological test profiles of non-mentally retarded girls and boys consecutively referred to a neuropsychiatric clinic and those of contrast cases of girls from mainstream classrooms of one Göteborg school district. To avoid overreliance on the male prototype with regard to diagnostic cri...
journal_title:European child & adolescent psychiatry
pub_type: 杂志文章
doi:10.1007/s007870070041
更新日期:2000-09-01 00:00:00
abstract::Evidence points to an independent relationship among childhood maltreatment, impairments in executive functions (EF) and disruptive behavior disorders (DBD). However, it is still not fully understood how these three factors are interrelated. This study evaluated the association between childhood maltreatment and DBD t...
journal_title:European child & adolescent psychiatry
pub_type: 杂志文章
doi:10.1007/s00787-019-01408-3
更新日期:2020-07-01 00:00:00
abstract::This paper describes the effect of pre-migration and post-migration experiences on the mental health of a sample of 40 refugee children aged 8-16 who lived in London with at least one parent or a refugee relative. Children's post-traumatic stress disorder (PTSD) and depression symptoms were assessed with standardised ...
journal_title:European child & adolescent psychiatry
pub_type: 杂志文章
doi:10.1007/s00787-004-0422-y
更新日期:2004-12-01 00:00:00
abstract::A number of public health interventions aimed at increasing the uptake of breastfeeding are in place in the United States and other Western countries. While the physical health and nutritional benefits of breastfeeding for the mother and child are relatively well established, the evidence for psychological effects is ...
journal_title:European child & adolescent psychiatry
pub_type: 杂志文章,多中心研究
doi:10.1007/s00787-011-0224-y
更新日期:2011-12-01 00:00:00
abstract::The aim of the investigation was to detect neuropsychological markers, such as sustained and selective attention and executive functions, which contribute to the vulnerability to schizophrenia especially in young persons. Performance was assessed in 32 siblings and children of schizophrenic patients and 32 matched con...
journal_title:European child & adolescent psychiatry
pub_type: 杂志文章
doi:10.1007/s00787-006-0547-2
更新日期:2006-10-01 00:00:00
abstract::Twenty-two Hungarian families with Rett syndrome girls were genealogically examined. None of our 23 probands was born to first-cousin couples, but we established increased number of consanguineous marriages among the ancestors of the patients. Observing the places where the Rett families originate from, we found a pre...
journal_title:European child & adolescent psychiatry
pub_type: 杂志文章
doi:
更新日期:1997-01-01 00:00:00
abstract::Allergic rhinitis (AR) is common in children. Characteristic symptoms of AR may result in daytime inattention, irritability, and hyperactivity, which are also components of ADHD. Conflicting data in previous studies exist regarding the relationship between ADHD and AR. The aim of this study was to examine the prevalen...
journal_title:European child & adolescent psychiatry
pub_type: 杂志文章
doi:10.1007/s00787-012-0369-3
更新日期:2013-05-01 00:00:00
abstract::Attention Deficit and Hyperactive Disorder (ADHD) and Autism Spectrum Disorders (ASD) are frequent comorbid neurodevelopmental conditions and the overlap between both disorders remains to be delineated. A more complete understanding of the shared genetic and environmental factors is needed. Using a family-based method...
journal_title:European child & adolescent psychiatry
pub_type: 杂志文章
doi:10.1007/s00787-018-1206-0
更新日期:2019-02-01 00:00:00
abstract::The developmental course of hyperactivity-impulsivity and inattention symptoms from infancy to adolescence has not been documented in a population sample. The aim of this study was to describe the developmental course of hyperactivity-impulsivity and inattention symptoms from 1.5 to 17 years using multiple informants,...
journal_title:European child & adolescent psychiatry
pub_type: 杂志文章
doi:10.1007/s00787-018-1258-1
更新日期:2019-07-01 00:00:00
abstract::The main aim of this study was to examine the moderating effects of attention deficit hyperactivity disorder (ADHD) on anxiety disorders in children. Data were analyzed from a large referred sample of children with anxiety disorder without comorbid ADHD (anxiety disorder, N = 253), anxiety disorder plus comorbid ADHD ...
journal_title:European child & adolescent psychiatry
pub_type: 杂志文章
doi:10.1007/s00787-009-0041-8
更新日期:2010-02-01 00:00:00
abstract:OBJECTIVE:To investigate the current situation of Child and Adolescent Psychiatry (CAP) training in European countries. In addition, current agenda of different organizations in order to harmonize the training across Europe are reported. METHOD:In order to collect data for this descriptive documentation on CAP trainin...
journal_title:European child & adolescent psychiatry
pub_type: 杂志文章
doi:10.1007/s00787-006-0599-3
更新日期:2006-12-01 00:00:00
abstract::The Revised Behaviour Summarized Evaluation Scale (BSE-R) was developed for the objective evaluation of autistic behaviours in order to facilitate the recording of the evolution of developmentally disabled children. Among its 29 items, 13 items that precisely describe the degree of autistic behaviours were extracted b...
journal_title:European child & adolescent psychiatry
pub_type: 杂志文章
doi:10.1007/BF01980489
更新日期:1995-10-01 00:00:00
abstract::Anorexia nervosa (AN) and bulimia nervosa (BN) are complex disorders characterized by disordered eating behavior where the patient's attitude towards weight and shape, as well as their perception of body shape, are disturbed. Formal genetic studies on twins and families suggested a substantial genetic influence for AN...
journal_title:European child & adolescent psychiatry
pub_type: 杂志文章,评审
doi:10.1007/s00787-009-0085-9
更新日期:2010-03-01 00:00:00
abstract:INTRODUCTION:We present the results of a 42 year long-term follow-up of 44 patients (19 males, 25 females) with childhood-onset schizophrenia (COS, age at onset: 7-14 years) who could be traced for a second follow-up examination 27 years after the first follow-up. METHOD:Data from interviews, clinical records, premorb...
journal_title:European child & adolescent psychiatry
pub_type: 杂志文章,评审
doi:10.1007/pl00010687
更新日期:1999-01-01 00:00:00
abstract::Parental psychopathology is associated with increased psychosocial maladjustment in adolescents. We examined, from a psychosocial perspective, the association between parental psychological distress and psychosocial maladjustment in adolescents and assessed the mediating role of psychosocial covariates. This is a cros...
journal_title:European child & adolescent psychiatry
pub_type: 杂志文章
doi:10.1007/s00787-010-0094-8
更新日期:2010-07-01 00:00:00
abstract::Few studies have examined the effectiveness of outpatient cognitive-behavioral therapy (CBT) delivered in routine care settings for children and adolescents with mental disorders. This observational study examined changes in behavioral and emotional problems of adolescents with mental disorders during routine outpatie...
journal_title:European child & adolescent psychiatry
pub_type: 杂志文章
doi:10.1007/s00787-017-1021-z
更新日期:2018-01-01 00:00:00
abstract::A two week course in Child and Adolescent Psychiatry was given in St. Petersburg as part of the partnership between the City's Child and Adolescent Psychiatry Service and Division of Child and Adolescent Psychiatry at Leicester University Medical School. In such a short course, it was necessary to focus on areas of pa...
journal_title:European child & adolescent psychiatry
pub_type: 杂志文章
doi:10.1007/BF00538848
更新日期:1996-12-01 00:00:00
abstract::Comparatively little information is available from population-based studies on subgroup trajectories of attention-deficit/hyperactivity disorder (ADHD) core symptoms of inattention and hyperactivity-impulsivity (particularly as defined by DSM-IV and ICD-10). Recent report of a subgroup with high and increasing inatten...
journal_title:European child & adolescent psychiatry
pub_type: 杂志文章
doi:10.1007/s00787-014-0634-8
更新日期:2015-06-01 00:00:00
abstract::Neurofeedback (NF) could help to improve attentional and self-management capabilities in children with attention-deficit/hyperactivity disorder (ADHD). In a randomised controlled trial, NF training was found to be superior to a computerised attention skills training (AST) (Gevensleben et al. in J Child Psychol Psychia...
journal_title:European child & adolescent psychiatry
pub_type: 杂志文章,随机对照试验
doi:10.1007/s00787-010-0109-5
更新日期:2010-09-01 00:00:00