Intraocular pressure of rhesus monkey (Macaca mulatta). I. An initial survey of two free-breeding colonies.

Abstract:

:As part of an ophthalmic and anthropometric survey of two free-breeding rhesus monkey (Macaca mulatta) populations, intraocular pressure (IOP) of 114 animals was measured under ketamine catalepsia with the use of a floating-tip pneumatonometer. The mean IOP of the 102 animals included in the main analyses was 14.9 +/- 2.1 (S.D.) mm Hg. The age distribution of animals in this sample ranged from 7 months to 21 years and reflected reasonably well the estimated age distribution in the total population (approximately 1600 macaques). Since ketamine does not have a barbiturate-like effect on IOP, this value can be regarded as a good estimate of the normal IOP of rhesus monkeys. No significant differences were found between left and right eyes nor between males and females. However, the mean IOP of infants and juveniles (7 months to 3 years) was significantly higher (15.7 +/- 2.0 mm Hg; n = 33) than that of young adult and adult rhesus monkeys (14.5 +/- 2.0; n = 69). The IOP of young animals (less than or equal to 6 years) showed a decline between 9 A.M. and 2 P.M., whereas the IOPs of older animals showed only small fluctuations between 8 A.M. and 5 P.M. This study shows that the normal IOP of macaques is remarkably similar to that of humans and demonstrates the fesibility of surveying IOP in free-ranging primates.

authors

Bito LZ,Merritt SQ,DeRousseau CJ

keywords:

subject

Has Abstract

pub_date

1979-08-01 00:00:00

pages

785-93

issue

8

eissn

0146-0404

issn

1552-5783

journal_volume

18

pub_type

杂志文章
  • Macular choroidal thickness in unilateral amblyopic children.

    abstract:PURPOSE:To investigate the choroidal thickness (CT) in children with amblyopia through spectral-domain optical coherence tomography (SD-OCT). METHODS:Thirty-seven children with unilateral amblyopia and 22 children with normal vision participated in the study. Cross-sectional images of the choroid of evaluated eyes wer...

    journal_title:Investigative ophthalmology & visual science

    pub_type: 杂志文章

    doi:10.1167/iovs.14-14439

    authors: Xu J,Zheng J,Yu S,Sun Z,Zheng W,Qu P,Chen Y,Chen W,Yu X

    更新日期:2014-10-14 00:00:00

  • Response of the vestibulo-ocular reflex to differing programs of acceleration.

    abstract::The vestibulo-ocular reflex of normal monkeys was tested by a modified Bárány spinning test (B-test) and by sinosoidal rotation. The two tests gave concordant estimates of the time constant and corner frequency. Deviation from concordance was caused largely by modification of the reflex during the testing procedures. ...

    journal_title:Investigative ophthalmology & visual science

    pub_type: 杂志文章

    doi:

    authors: Blair S,Gavin M

    更新日期:1979-10-01 00:00:00

  • Ocular inflammation in autoimmune MRL/Mp mice.

    abstract::Congenic mice of the MRL/Mp strain spontaneously develop an autoimmune connective tissue disease that shares immunologic and histopathologic features with the human disorders systemic lupus erythematosus, rheumatoid arthritis, and systemic vasculitis. The autoimmune disorder in these mice is markedly accelerated by th...

    journal_title:Investigative ophthalmology & visual science

    pub_type: 杂志文章

    doi:

    authors: Jabs DA,Alexander EL,Green WR

    更新日期:1985-09-01 00:00:00

  • Corneal endothelial cell survival in organ cultures under acute oxidative stress: effect of VIP.

    abstract:PURPOSE:Human corneal endothelium, a neural crest-derived tissue, has a very limited regenerative capacity and may depend on trophic factors for its survival throughout life, as well as after injury and during storage before transplantation. The purpose of this study was to determine whether vasoactive intestinal pepti...

    journal_title:Investigative ophthalmology & visual science

    pub_type: 杂志文章

    doi:

    authors: Koh SW,Waschek JA

    更新日期:2000-12-01 00:00:00

  • Optical Coherence Tomography Angiography in the Evaluation of Geographic Atrophy Area Extension.

    abstract:Purpose:To investigate the application of optical coherence tomography angiography (OCT-A) in evaluation of geographic atrophy (GA) secondary to age-related macular degeneration (AMD). Methods:Patients with GA were prospectively enrolled and studied with blue fundus autofluorescence (FAF), en face structural OCT, and ...

    journal_title:Investigative ophthalmology & visual science

    pub_type: 杂志文章

    doi:10.1167/iovs.17-22508

    authors: Corbelli E,Sacconi R,Rabiolo A,Mercuri S,Carnevali A,Querques L,Bandello F,Querques G

    更新日期:2017-10-01 00:00:00

  • Cell attachment to, and contraction of, the retina in vitro.

    abstract:PURPOSE:To examine the behavior of fibroblasts and retinal pigment epithelial cells after attachment to the retinal surface in vitro to elucidate the pathobiology of the early stages of epiretinal membrane formation. METHODS:Human retinal pigment epithelial (HRPE) cells and bovine Tenon's capsule fibroblasts (BTFs) we...

    journal_title:Investigative ophthalmology & visual science

    pub_type: 杂志文章

    doi:

    authors: Allamby D,Foreman D,Carrington L,McLeod D,Boulton M

    更新日期:1997-09-01 00:00:00

  • Measurement of evoked potentials after electrical stimulation of the human optic nerve.

    abstract:PURPOSE:To examine the visual evoked potentials (VEP) and electroretinograms (ERG) generated during electrical stimulation of the human optic nerve using the optic nerve visual prosthesis. METHODS:Two volunteers blind from retinitis pigmentosa (RP) and with no light perception each received a chronically implanted opt...

    journal_title:Investigative ophthalmology & visual science

    pub_type: 杂志文章

    doi:10.1167/iovs.09-4346

    authors: Brelén ME,Vince V,Gérard B,Veraart C,Delbeke J

    更新日期:2010-10-01 00:00:00

  • Adipogenesis in thyroid eye disease.

    abstract:PURPOSE:Adipogenesis contributes to the pathogenesis of thyroid eye disease (TED). Thyrotropin receptor (TSHR) transcripts are present in orbital fat. This study was conducted to determine whether they are expressed as functional protein, and if so, whether this is restricted to TED orbits or to a particular stage in a...

    journal_title:Investigative ophthalmology & visual science

    pub_type: 杂志文章

    doi:

    authors: Crisp M,Starkey KJ,Lane C,Ham J,Ludgate M

    更新日期:2000-10-01 00:00:00

  • Homocysteine levels in the vitreous of proliferative diabetic retinopathy and rhegmatogenous retinal detachment: its modulating role on lysyl oxidase.

    abstract:PURPOSE:Homocysteine (Hcys), a well-known inducer of vascular endothelial cell damage has been associated with extracellular matrix changes. Lysyl oxidase (LOX) is a copper-dependent amine oxidase that initiates the covalent cross-linking of collagen and elastin in the extracellular matrix (ECM). LOX contributes to the...

    journal_title:Investigative ophthalmology & visual science

    pub_type: 杂志文章

    doi:10.1167/iovs.08-2667

    authors: Coral K,Angayarkanni N,Gomathy N,Bharathselvi M,Pukhraj R,Rupak R

    更新日期:2009-08-01 00:00:00

  • Structural brain abnormalities in patients with primary open-angle glaucoma: a study with 3T MR imaging.

    abstract:PURPOSE:We examined changes of the central nervous system in patients with advanced primary open-angle glaucoma (POAG). METHODS:The clinical observational study included 15 patients with bilateral advanced POAG and 15 healthy normal control subjects, matched for age and sex with the study group. Retinal nerve fiber l...

    journal_title:Investigative ophthalmology & visual science

    pub_type: 杂志文章

    doi:10.1167/iovs.12-9893

    authors: Chen WW,Wang N,Cai S,Fang Z,Yu M,Wu Q,Tang L,Guo B,Feng Y,Jonas JB,Chen X,Liu X,Gong Q

    更新日期:2013-01-17 00:00:00

  • Photodynamic therapy using Lu-Tex induces apoptosis in vitro, and its effect is potentiated by angiostatin in retinal capillary endothelial cells.

    abstract:PURPOSE:To examine the effect of combining angiostatin with photodynamic therapy (PDT) using Lutetium Texaphyrin (Lu-Tex; Alcon, Fort Worth, TX) as a photosensitizer in bovine retinal capillary endothelial (BRCE) and retinal pigment epithelial (RPE) cells and to determine the mode of PDT-induced cell death in these cel...

    journal_title:Investigative ophthalmology & visual science

    pub_type: 杂志文章

    doi:

    authors: Renno RZ,Delori FC,Holzer RA,Gragoudas ES,Miller JW

    更新日期:2000-11-01 00:00:00

  • Placental CpG Methylation of Inflammation, Angiogenic, and Neurotrophic Genes and Retinopathy of Prematurity.

    abstract:Purpose:Extremely preterm infants are at increased risk for retinopathy of prematurity (ROP). We previously identified several inflammatory proteins that were expressed early in life and are associated with an increased risk of ROP and several angiogenic and neurotrophic growth factors in the neonatal systemic circulat...

    journal_title:Investigative ophthalmology & visual science

    pub_type: 杂志文章,多中心研究

    doi:10.1167/iovs.18-26466

    authors: Bulka CM,Dammann O,Santos HP Jr,VanderVeen DK,Smeester L,Fichorova R,O'Shea TM,Fry RC

    更新日期:2019-07-01 00:00:00

  • Effect of 1,25-dihydroxyvitamin D3 on Th17 and Th1 response in patients with Behçet's disease.

    abstract:PURPOSE:1,25-Dihydroxyvitamin D3 (VitD3) has been shown to have immunoregulatory properties in animal models. In this study, we investigated its inhibitory effect on the immune response in Behçet's disease (BD) patients and the possible mechanisms involved. METHODS:Naive CD4(+) T cells from active BD patients and norm...

    journal_title:Investigative ophthalmology & visual science

    pub_type: 杂志文章

    doi:10.1167/iovs.12-10398

    authors: Tian Y,Wang C,Ye Z,Xiao X,Kijlstra A,Yang P

    更新日期:2012-09-21 00:00:00

  • Roles played by toll-like receptor-9 in corneal endothelial cells after herpes simplex virus type 1 infection.

    abstract:PURPOSE:To determine the roles played by toll-like receptor 9 (TLR9) in cultured human corneal endothelial (HCEn) cells after herpes simplex virus type 1 (HSV-1) infection and to characterize the TLR9-mediated antiviral responses. METHOD:Immortalized HCEn cells were examined for TLR expression. The upregulation of inf...

    journal_title:Investigative ophthalmology & visual science

    pub_type: 杂志文章

    doi:10.1167/iovs.11-7805

    authors: Takeda S,Miyazaki D,Sasaki S,Yamamoto Y,Terasaka Y,Yakura K,Yamagami S,Ebihara N,Inoue Y

    更新日期:2011-08-24 00:00:00

  • Memantine blocks mitochondrial OPA1 and cytochrome c release and subsequent apoptotic cell death in glaucomatous retina.

    abstract:PURPOSE:To determine whether intraocular pressure (IOP) elevation alters OPA1 expression and triggers OPA1 release, as well as whether the uncompetitive N-methyl-d-aspartate (NMDA) glutamate receptor antagonist memantine blocks OPA1 release and subsequent apoptotic cell death in glaucomatous DBA/2J mouse retina. METHO...

    journal_title:Investigative ophthalmology & visual science

    pub_type: 杂志文章

    doi:10.1167/iovs.08-2499

    authors: Ju WK,Kim KY,Angert M,Duong-Polk KX,Lindsey JD,Ellisman MH,Weinreb RN

    更新日期:2009-02-01 00:00:00

  • Effects of bone marrow mesenchymal stem cell transplantation on light-damaged retina.

    abstract::PURPOSE. To investigate the effects and possible mechanisms of rat bone marrow mesenchymal stem cell (BMSC) transplantation on the light-damaged retinal structure and the apoptosis of photoreceptors. METHODS. DAPI-labeled BMSCs were transplanted into the subretinal space of light-damaged Sprague-Dawley rats 10 days af...

    journal_title:Investigative ophthalmology & visual science

    pub_type: 杂志文章

    doi:10.1167/iovs.08-3314

    authors: Zhang Y,Wang W

    更新日期:2010-07-01 00:00:00

  • Sialoglycoproteins of the frog rod outer segment plasma membrane.

    abstract::Photoreceptors can segregate inner segment proteins from outer segment proteins. It is uncertain whether such a sorting process occurs during disc morphogenesis in rods, thereby resulting in an outer segment plasma membrane which differs compositionally from the discs. In this study, the plasma membranes of intact, pu...

    journal_title:Investigative ophthalmology & visual science

    pub_type: 杂志文章

    doi:

    authors: Polans AS,Burton MD

    更新日期:1988-10-01 00:00:00

  • Higher Contrast Requirement for Letter Recognition and Macular RGC+ Layer Thinning in Glaucoma Patients and Older Adults.

    abstract:Purpose:Growing evidence suggests the involvement of the macula even in early stages of glaucoma. However, little is known about the impact of glaucomatous macular damage on central pattern vision. Here we examine the contrast requirement for letter recognition and its relationship with retinal thickness in the macular...

    journal_title:Investigative ophthalmology & visual science

    pub_type: 杂志文章

    doi:10.1167/iovs.17-22621

    authors: Chien L,Liu R,Girkin C,Kwon M

    更新日期:2017-12-01 00:00:00

  • In Vivo Three-Dimensional Lamina Cribrosa Strains in Healthy, Ocular Hypertensive, and Glaucoma Eyes Following Acute Intraocular Pressure Elevation.

    abstract:Purpose:To compare in vivo lamina cribrosa (LC) strains (deformations) following acute IOP elevation in healthy, glaucoma, and ocular hypertensive subjects. Methods:There were 20 healthy, 20 high-tension primary open-angle glaucoma (POAG), 16 primary angle-closure glaucoma (PACG), and 20 ocular hypertensive (OHT; with...

    journal_title:Investigative ophthalmology & visual science

    pub_type: 杂志文章

    doi:10.1167/iovs.17-21982

    authors: Beotra MR,Wang X,Tun TA,Zhang L,Baskaran M,Aung T,Strouthidis NG,Girard MJA

    更新日期:2018-01-01 00:00:00

  • Refractive errors in an urban population in Southern India: the Andhra Pradesh Eye Disease Study.

    abstract:PURPOSE:To assess the prevalence, distribution, and demographic associations of refractive error in an urban population in southern India. METHODS:Two thousand five hundred twenty-two subjects of all ages, representative of the Hyderabad population, were examined in the population-based Andhra Pradesh Eye Disease Stud...

    journal_title:Investigative ophthalmology & visual science

    pub_type: 杂志文章

    doi:

    authors: Dandona R,Dandona L,Naduvilath TJ,Srinivas M,McCarty CA,Rao GN

    更新日期:1999-11-01 00:00:00

  • Ocular Delivery of PACAP1-27 Protects the Retina From Ischemic Damage in Rodents.

    abstract:Purpose:Pituitary adenylate cyclase activating polypeptide (PACAP) is neuroprotective in neuronal injuries. Bilateral common carotid artery occlusion (BCCAO) causes chronic hypoperfusion-induced degeneration in the rat retina, where we proved the retinoprotective effect of intravitreal PACAP. Although this route of adm...

    journal_title:Investigative ophthalmology & visual science

    pub_type: 杂志文章

    doi:10.1167/iovs.16-20630

    authors: Werling D,Reglodi D,Banks WA,Salameh TS,Kovacs K,Kvarik T,Vaczy A,Kovacs L,Mayer F,Danyadi B,Lokos E,Tamas A,Toth G,Biro Z,Atlasz T

    更新日期:2016-12-01 00:00:00

  • Latanoprost's effects on TIMP-1 and TIMP-2 expression in human ciliary muscle cells.

    abstract:PURPOSE:To determine the effect of treatment with latanoprost on the tissue inhibitors of metalloproteinase (TIMP)-1 and -2 in cultured human ciliary muscle (HCM) cells. METHODS:Confluent serum-starved HCM cells were exposed to increasing concentrations of latanoprost acid (LA, 1 nM to 10 micro M) for 6, 18, and 24 ho...

    journal_title:Investigative ophthalmology & visual science

    pub_type: 杂志文章

    doi:

    authors: Anthony TL,Lindsey JD,Weinreb RN

    更新日期:2002-12-01 00:00:00

  • Isolation of non-pigmented epithelial cells from rabbit ciliary body.

    abstract::We describe a new technique for the separation and isolation of nonpigmented ciliary body epithelial cells from rabbit. Excised ciliary body is incubated in a medium buffered with EGTA to a free-Ca2+ concentration of 10(-8) M, and the nonpigmented cell layer is separated from the pigmented layer by microdissection und...

    journal_title:Investigative ophthalmology & visual science

    pub_type: 杂志文章

    doi:

    authors: Fain GL,Cilluffo MC,Fain MJ,Lee DA

    更新日期:1988-05-01 00:00:00

  • Long-term corneal morphology after PRK by in vivo confocal microscopy.

    abstract:PURPOSE:To examine human corneal morphology and nerve recovery 5 years after photorefractive keratectomy (PRK). METHODS:Fourteen eyes of 14 patients (ages, 27-53 years) who underwent 6-mm diameter PRK for low to moderate myopia (spherical equivalent [SE] -2.5 to -8.0 D) were examined once 5 years after surgery. Nine h...

    journal_title:Investigative ophthalmology & visual science

    pub_type: 杂志文章

    doi:10.1167/iovs.02-0247

    authors: Moilanen JA,Vesaluoma MH,Müller LJ,Tervo TM

    更新日期:2003-03-01 00:00:00

  • Senescent Changes and Topography of the Dark-Adapted Multifocal Electroretinogram.

    abstract:Purpose:To investigate the topographic changes of the dark-adapted multifocal electroretinogram (mfERG) across adulthood in the central retina and compare the topography between macular versus extramacular, nasal versus temporal, and inferior versus superior retinal areas. Methods:Sixty-five subjects (18-88 years) rec...

    journal_title:Investigative ophthalmology & visual science

    pub_type: 杂志文章

    doi:10.1167/iovs.16-20953

    authors: Panorgias A,Tillman M,Sutter EE,Moshiri A,Gerth-Kahlert C,Werner JS

    更新日期:2017-02-01 00:00:00

  • Changes in fibroblast mechanostat set point and mechanosensitivity: an adaptive response to mechanical stress in floppy eyelid syndrome.

    abstract:PURPOSE:Floppy eyelid syndrome (FES) is an acquired hyperelasticity disorder affecting the upper eyelid. The tarsal plate becomes hyperelastic with a loss of intrinsic rigidity. As a result, the eyelid is subjected to cyclic mechanical stress. This condition was used as a model to investigate changes in dynamic fibrobl...

    journal_title:Investigative ophthalmology & visual science

    pub_type: 杂志文章

    doi:10.1167/iovs.09-4724

    authors: Ezra DG,Ellis JS,Beaconsfield M,Collin R,Bailly M

    更新日期:2010-08-01 00:00:00

  • Visual acuity is related to parafoveal retinal thickness in patients with retinitis pigmentosa and macular cysts.

    abstract:PURPOSE:To quantify the prevalence and effect on visual acuity of macular cysts in a large cohort of patients with retinitis pigmentosa. METHODS:In 316 patients with typical forms of retinitis pigmentosa, visual acuity was measured with Early Treatment Diabetic Retinopathy Study (ETDRS) charts, macular cysts were dete...

    journal_title:Investigative ophthalmology & visual science

    pub_type: 杂志文章

    doi:10.1167/iovs.08-1992

    authors: Sandberg MA,Brockhurst RJ,Gaudio AR,Berson EL

    更新日期:2008-10-01 00:00:00

  • Alpha2-Adrenergic-Agonist Brimonidine Stimulates Negative Feedback and Attenuates Injury-Induced Phospho-ERK and Dedifferentiation of Chicken Müller Cells.

    abstract:PURPOSE:Retinal injury induces Müller cell dedifferentiation by activating extracellular signal-regulated kinase (ERK) signaling. Stimulation of α2-adrenergic receptors protects against injury but also activates ERK in Müller cells. The purpose of this work was to study the effect of α2-adrenergic signaling on injury-i...

    journal_title:Investigative ophthalmology & visual science

    pub_type: 杂志文章

    doi:10.1167/iovs.15-16816

    authors: Harun-Or-Rashid M,Díaz-DelCastillo M,Galindo-Romero C,Hallböök F

    更新日期:2015-09-01 00:00:00

  • A homozygous frameshift mutation in BEST1 causes the classical form of Best disease in an autosomal recessive mode.

    abstract:PURPOSE:Best disease is a monogenic macular degeneration caused mainly by heterozygous mutations in the BEST1 gene. The objective was to characterize the molecular and clinical features of patients with the classical form of Best disease that is inherited in an autosomal recessive mode. METHODS:Clinical evaluation inc...

    journal_title:Investigative ophthalmology & visual science

    pub_type: 杂志文章

    doi:10.1167/iovs.11-7174

    authors: Bitner H,Mizrahi-Meissonnier L,Griefner G,Erdinest I,Sharon D,Banin E

    更新日期:2011-07-18 00:00:00

  • Assessment of Transepidermal Water Loss From the Ocular Area in Dry Eye Disease.

    abstract:Purpose:To investigate transepidermal water loss (TEWL) from the ocular area in dry eye disease (DED) and evaluate the correlation between ocular TEWL and other DED parameters. Methods:Transepidermal water loss from the ocular area in 56 eyes with DED and 38 healthy eyes was measured using a Tewameter TM300 that was e...

    journal_title:Investigative ophthalmology & visual science

    pub_type: 杂志文章

    doi:10.1167/iovs.16-20109

    authors: Jeon HS,Youn SW,Jeon HE,Kim JH,Hyon JY

    更新日期:2016-09-01 00:00:00