Mesp2 initiates somite segmentation through the Notch signalling pathway.

Abstract:

:The Notch-signalling pathway is important in establishing metameric pattern during somitogenesis. In mice, the lack of either of two molecules involved in the Notch-signalling pathway, Mesp2 or presenilin-1 (Ps1), results in contrasting phenotypes: caudalized versus rostralized vertebra. Here we adopt a genetic approach to analyse the molecular mechanism underlying the establishment of rostro-caudal polarity in somites. By focusing on the fact that expression of a Notch ligand, Dll1, is important for prefiguring somite identity, we found that Mesp2 initiates establishment of rostro-caudal polarity by controlling two Notch-signalling pathways. Initially, Mesp2 activates a Ps1-independent Notch-signalling cascade to suppress Dll1 expression and specify the rostral half of the somite. Ps1-mediated Notch-signalling is required to induce Dll1 expression in the caudal half of the somite. Therefore, Mesp2- and Ps1-dependent activation of Notch-signalling pathways might differentially regulate Dll1 expression, resulting in the establishment of the rostro-caudal polarity of somites.

journal_name

Nat Genet

journal_title

Nature genetics

authors

Takahashi Y,Koizumi K,Takagi A,Kitajima S,Inoue T,Koseki H,Saga Y

doi

10.1038/78062

keywords:

subject

Has Abstract

pub_date

2000-08-01 00:00:00

pages

390-6

issue

4

eissn

1061-4036

issn

1546-1718

journal_volume

25

pub_type

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