Mycobacterial proteins--immune targets for antituberculous subunit vaccine.

Abstract:

:Cellular and humoral immunity induced by Mycobacterium tuberculosis has led to identification of newer vaccine candidates, but despite this, many questions concerning the protection against tuberculosis remain unanswered. Recent progress in this field has centered on T cell subset responses and cytokines that these cells secrete. There has been a steady progress in identification and characterization of several classes of major mycobacterial proteins which includes secretory/export proteins, cell wall associated proteins, heat shock proteins and cytoplasmic proteins. The protein antigens are now believed to represent the key protective immunity inducing antigens in the bacillus. In this review, various mycobacterial protein antigens of vaccination potential are compared for their efficacy in light of current immunological knowledge.

journal_name

Indian J Exp Biol

authors

Dhiman N,Khuller GK

keywords:

subject

Has Abstract

pub_date

1999-12-01 00:00:00

pages

1157-66

issue

12

eissn

0019-5189

issn

0975-1009

journal_volume

37

pub_type

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