Abstract:
:Cellular and humoral immunity induced by Mycobacterium tuberculosis has led to identification of newer vaccine candidates, but despite this, many questions concerning the protection against tuberculosis remain unanswered. Recent progress in this field has centered on T cell subset responses and cytokines that these cells secrete. There has been a steady progress in identification and characterization of several classes of major mycobacterial proteins which includes secretory/export proteins, cell wall associated proteins, heat shock proteins and cytoplasmic proteins. The protein antigens are now believed to represent the key protective immunity inducing antigens in the bacillus. In this review, various mycobacterial protein antigens of vaccination potential are compared for their efficacy in light of current immunological knowledge.
journal_name
Indian J Exp Bioljournal_title
Indian journal of experimental biologyauthors
Dhiman N,Khuller GKkeywords:
subject
Has Abstractpub_date
1999-12-01 00:00:00pages
1157-66issue
12eissn
0019-5189issn
0975-1009journal_volume
37pub_type
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journal_title:Indian journal of experimental biology
pub_type: 杂志文章
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journal_title:Indian journal of experimental biology
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journal_title:Indian journal of experimental biology
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abstract::Aeromonas sp. from Lamellidens marginalis produced L-asparaginase when grown at 37 degrees C. The optimum enzyme activity was at pH 9 when temperature was 45 degrees C. Half-life of partially purified enzyme at 50 degrees C and 55 degrees C was 35 and 20 min, respectively. Activation and deactivation energies of parti...
journal_title:Indian journal of experimental biology
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更新日期:2000-11-01 00:00:00
abstract::Oral administration of 70% methanolic extract of T. cordifolia stem to male rats at the dose level of 100 mg/rat/day for 60 days did not cause body weight loss but decreased the weight of testes, epididymis, seminal vesicle and ventral prostate in a significant manner. Sperm motility as well as sperm density were redu...
journal_title:Indian journal of experimental biology
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journal_title:Indian journal of experimental biology
pub_type: 杂志文章
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abstract::Repeated weekly infections with S aureus, of bovine mammary origin, for three times evoked an immediate and a delayed type hypersensitivity in rabbits. The skin responses at 6 hr were characterized by oedema, haemorrhages and infiltration of polymorphonuclear cells. While at 24 hr it was dominated by mononuclear cells...
journal_title:Indian journal of experimental biology
pub_type: 杂志文章
doi:
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abstract::Growth of C. tetragonoloba suffered with increase in concentration of Pb in soil. Plant biomass declined significantly at concentrations above 60 ppm of Pb. Roots showed more pronounced impact as compared to shoots. At highest applied concentration of lead (100 ppm), fresh weight of fruits decreased by 33% and dry wei...
journal_title:Indian journal of experimental biology
pub_type: 杂志文章
doi:
更新日期:2001-05-01 00:00:00
abstract::A simple dot-immunobinding assay (Dot-Iba) in nitrocellulose paper was developed for the detection of specific IgG antibody to Mycobacterium tuberculosis antigen 5 and mycobacterial antigen in cerebrospinal fluid of patients with tuberculous meningitis (TBM). The assay gave 77.1% sensitivity for the detection of IgG a...
journal_title:Indian journal of experimental biology
pub_type: 杂志文章
doi:
更新日期:1991-05-01 00:00:00
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journal_title:Indian journal of experimental biology
pub_type: 杂志文章
doi:
更新日期:1999-07-01 00:00:00
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journal_title:Indian journal of experimental biology
pub_type: 杂志文章
doi:
更新日期:1992-03-01 00:00:00
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journal_title:Indian journal of experimental biology
pub_type: 杂志文章
doi:
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abstract::Mannich bases and styryl derivatives of imidazolones were evaluated for their antiparkinsonian activity. Two compounds showed potent antiparkinsonian activity. These active compounds also showed binding with dopamine receptors in striatal membrane preparation of rat brain. ...
journal_title:Indian journal of experimental biology
pub_type: 杂志文章
doi:
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abstract::Role of dietary energy and local ovarian hormones in conceptus development in the rat was evaluated by giving ip injections of estrogen and progesterone under diet restricted and/or dextrose supplemented conditions, using the experimental model of ovarian compensatory hypertrophy. Replacement of estrogen on day 2 and ...
journal_title:Indian journal of experimental biology
pub_type: 杂志文章
doi:
更新日期:1993-10-01 00:00:00
abstract::Stevia rebaudiana (Bert.) Bertoni is an important medicinal plant used as noncaloric commercial sweetener. Plants regenerated with higher levels of copper sulphate in the medium exhibited enhanced activity of peroxidase and polyphenoloxidase (PPO) enzymes. Transmission electron microscopy (TEM) revealed increase in si...
journal_title:Indian journal of experimental biology
pub_type: 杂志文章
doi:
更新日期:2014-09-01 00:00:00
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journal_title:Indian journal of experimental biology
pub_type: 杂志文章
doi:
更新日期:2008-01-01 00:00:00
abstract::When compared with the standard free muscle grafts, predenervated and nerve crushed chick gastrocnemius muscle grafts followed an identical and ordered sequence of tissue degeneration-regeneration. Atrophy of the fibres during ischaemic degeneration was accompanied by loss of weight, noncollagenous proteins and increm...
journal_title:Indian journal of experimental biology
pub_type: 杂志文章
doi:
更新日期:1994-06-01 00:00:00
abstract::Alcaligenes faecalis kw-A selected for possessing good denitrification efficiency was used for biofilm development. The biofilm could be developed on a glass surface within 12 hr when 5%, Ix 10(8) cells/ml was used as inoculum. The microcolonies were seen in 6 hr and glycocalyx in 9 hr stage. At 24 hr the biofilm was ...
journal_title:Indian journal of experimental biology
pub_type: 杂志文章
doi:
更新日期:2005-06-01 00:00:00
abstract::Mechanism of radioprotective action of caffeine by studying the gamma radiation -induced killing of yeast, S. cerevisae is reported. The results reveal that caffeine specifically protects aerobically (oxic) grown cells from gamma - radiation and sensitizes anaerobically (hypoxic) grown cells to some extent. Using radi...
journal_title:Indian journal of experimental biology
pub_type: 杂志文章
doi:
更新日期:2001-12-01 00:00:00
abstract::Leydig cells are the primary source of androgens in the mammalian testis. It is established that the luteinizing hormone (LH) produced by the anterior pituitary is required to maintain the structure and function of the Leydig cells in the postnatal testis. Until recent years, a role by the thyroid hormones on Leydig c...
journal_title:Indian journal of experimental biology
pub_type: 杂志文章,评审
doi:
更新日期:2005-11-01 00:00:00
abstract::Nicotine administration (2.5 mg/kg of body weight, sc, 5 days a week for 22 weeks) enhanced lipid peroxidative indices (thiobarbituric acid reactive substances and hydroperoxides) accompanied by a significant increase in the marker enzymes alanine transaminase, aspartate transaminase, alkaline phosphatase and lactate ...
journal_title:Indian journal of experimental biology
pub_type: 杂志文章
doi:
更新日期:2007-02-01 00:00:00
abstract::Putative anxiolytic activity of ethanolic extract of Indian A. pindrow Royle leaf was investigated in rats using various experimental paradigms of anxiety viz. open field exploratory behaviour, elevated plus maze (EPM) and elevated zero maze (EZM) tests. Pilot studies indicated that single dose administration of extra...
journal_title:Indian journal of experimental biology
pub_type: 杂志文章
doi:
更新日期:2000-04-01 00:00:00
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journal_title:Indian journal of experimental biology
pub_type: 杂志文章
doi:
更新日期:2007-04-01 00:00:00
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journal_title:Indian journal of experimental biology
pub_type: 杂志文章
doi:
更新日期:2014-11-01 00:00:00
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journal_title:Indian journal of experimental biology
pub_type: 杂志文章,评审
doi:
更新日期:2000-09-01 00:00:00
abstract::The effect of long term administration of thyroid hormones and its deprivation on delayed type hypersensitivity (DTH) reaction to 2-4 dinitrochlorobenzene (DNCB) was studied. Animals were either pre-treated with thyroid hormones (T3 or T4) for 15 days and then subjected to DNCB skin test or the animals received thyroi...
journal_title:Indian journal of experimental biology
pub_type: 杂志文章
doi:
更新日期:1989-05-01 00:00:00
abstract::Administration of bromocriptine (Bc), an ergot derivative having dopamine receptor agonist activity, to rats on day 1-5 of pregnancy prevented implantation of blastocysts and significantly suppressed uterine glucosamine 6-phosphate synthase activity. There was no effect on implantation or the enzyme activity when Bc w...
journal_title:Indian journal of experimental biology
pub_type: 杂志文章
doi:
更新日期:1993-04-01 00:00:00
abstract::Parathyroid hormone (PTH), calcitonin (CT)and calciferol (Vit. D3) operate synchronously to maintain a balance between calcium and phosphate levels in serum. An aberration of specific steps in the homeostatic process results in hypo/hyper phosphatemia. These aberrations may eventually lead to several diseased states. ...
journal_title:Indian journal of experimental biology
pub_type: 杂志文章
doi:
更新日期:1990-04-01 00:00:00
abstract::Biotin deficiency produced by feeding raw egg white caused decrease in the concentration of many glycosaminoglycans (GAG) in the aorta in rats fed standard laboratory diet and atherogenic diet. This decrease has been observed to be due to the increased activity of enzymes involved in the degradation of GAG and glycohy...
journal_title:Indian journal of experimental biology
pub_type: 杂志文章
doi:
更新日期:1993-02-01 00:00:00
abstract::Aerobic and microaerobic diazotrophs possess numerous oxygen restriction strategies to protect nitrogenase from inactivation by oxygen without interfering with energy generation through oxidative phosphorylation. Protection by conformational change in nitrogenase was first detected and described in Azotobacter. This s...
journal_title:Indian journal of experimental biology
pub_type: 杂志文章
doi:
更新日期:2002-02-01 00:00:00