Neonatal lead exposure impairs development of rodent barrel field cortex.

abstract：:The charge-stabilization effect associated with alpha-helices in proteins has been reexamined by microscopic calculations without any a priori assumptions about the dielectric constant of the protein. The calculations reproduce the observed charge stabilization effect of a helix in two well-defined test cases: a histi...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Aqvist J,Luecke H,Quiocho FA,Warshel A

更新日期：1991-03-01 00:00:00

abstract：:A near-full-length casbene synthase cDNA clone, pCS7, was isolated by using a partial cDNA clone, pCS4, to probe a lambda gt10 library constructed from poly(A)+ RNA from elicited castor bean seedlings. The cDNA insert had a length of 1983 bases with a polyadenylate tail of 19 bases. Translation of the cDNA sequence re...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Mau CJ,West CA

更新日期：1994-08-30 00:00:00

abstract：:A nonselective ex vivo assay was used to directly detect and quantify zidovudine (AZT)-resistant human immunodeficiency virus type 1 (HIV-1) in the blood of treated and untreated patients. In contrast to previous reports, drug-resistant virus was detected in peripheral blood mononuclear cells of a few of the patients ...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Mohri H,Singh MK,Ching WT,Ho DD

更新日期：1993-01-01 00:00:00

abstract：:The role of global climate change in the decline of biodiversity and the emergence of infectious diseases remains controversial, and the effect of climatic variability, in particular, has largely been ignored. For instance, it was recently revealed that the proposed link between climate change and widespread amphibian...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Rohr JR,Raffel TR

更新日期：2010-05-04 00:00:00

abstract：:The tendency for genetic architectures to exhibit epistasis among mutations plays a central role in the modern synthesis of evolutionary biology and in theoretical descriptions of many evolutionary processes. Nevertheless, few studies unquestionably show whether, and how, mutations typically interact. Beneficial mutat...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Sanjuán R,Moya A,Elena SF

更新日期：2004-10-26 00:00:00

abstract：:The signal recognition particle (SRP) is a ribonucleoprotein composed of an Alu domain and an S domain. The S domain contains unique sequence SRP RNA and four SRP proteins: SRP19, SRP54, SRP68, and SRP72. SRP interacts with ribosomes to bring translating membrane and secreted proteins to the endoplasmic reticulum (ER)...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Politz JC,Yarovoi S,Kilroy SM,Gowda K,Zwieb C,Pederson T

更新日期：2000-01-04 00:00:00

abstract：:Total nuclear proteins extracted from cell lines representing various stages of differentiation of mouse B lymphocytes were studied by computer analysis of two-dimensional gels. Of the 1438 spots present on the gels, 55 varied significantly in intensity during differentiation. The variations occurred most often in ste...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Rabilloud T,Pennetier JL,Hibner U,Vincens P,Tarroux P,Rougeon F

更新日期：1991-03-01 00:00:00

abstract：:Ghrelin is a newly discovered peptide and an endogenous ligand for growth hormone (GH) secretagogue (GHS) receptor. It has been shown to possess various central and peripheral effects, including GH secretion, food intake, and gastric and cardiac effects. Ghrelin and the GHS receptor are expressed also in pancreatic is...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Doi A,Shono T,Nishi M,Furuta H,Sasaki H,Nanjo K

更新日期：2006-01-24 00:00:00

abstract：:Observing the structure and regeneration of the myelin sheath in peripheral nerves following injury and during repair would help in understanding the pathogenesis and treatment of neurological diseases caused by an abnormal myelin sheath. In the present study, transmission electron microscopy, immunofluorescence stain...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Liu B,Xin W,Tan JR,Zhu RP,Li T,Wang D,Kan SS,Xiong DK,Li HH,Zhang MM,Sun HH,Wagstaff W,Zhou C,Wang ZJ,Zhang YG,He TC

更新日期：2019-10-29 00:00:00

abstract：:The heterodimeric Elongin BC complex has been shown to interact in vitro and in cells with a conserved BC-box motif found in an increasing number of proteins including RNA polymerase II elongation factor Elongin A, suppressor of cytokine signaling (SOCS)-box proteins, and the von Hippel-Lindau tumor suppressor protein...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Brower CS,Sato S,Tomomori-Sato C,Kamura T,Pause A,Stearman R,Klausner RD,Malik S,Lane WS,Sorokina I,Roeder RG,Conaway JW,Conaway RC

更新日期：2002-08-06 00:00:00

abstract：:The epothilones represent a promising class of natural product-based antitumor drug candidates. Although these compounds operate through a microtubule stabilization mechanism similar to that of taxol, the epothilones offer a major potential therapeutic advantage in that they retain their activity against multidrug-res...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Chou TC,Zhang X,Zhong ZY,Li Y,Feng L,Eng S,Myles DR,Johnson R Jr,Wu N,Yin YI,Wilson RM,Danishefsky SJ

更新日期：2008-09-02 00:00:00

abstract：:From a genomic library constructed from sperm DNA of the inbred BALB/c mouse, we previously isolated 54 cosmid clones that contain 36 class I genes and can be divided by restriction map analyses into 13 gene clusters. We have isolated single- and low-copy DNA probes from each of these clusters to visualize restriction...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Winoto A,Steinmetz M,Hood L

更新日期：1983-06-01 00:00:00

abstract：:Spider-like forms of purified reovirus RNA have been characterized by electron microscopy. These structures contained 11.3 +/- 0.8 mum of double-stranded RNA and up to 20 arms, each of distinct length. Length measurements of 64 "spiders" suggest that in these structures the viral genome is folded fairly specifically. ...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Kavenoff R,Talcove D,Mudd JA

更新日期：1975-11-01 00:00:00

abstract：:The mapping of eye-specific, geniculocortical inputs to primary visual cortex (V1) is highly sensitive to the balance of correlated activity between the two eyes during a restricted postnatal critical period for ocular dominance plasticity. This critical period is likely to have amplified expression of genes and prote...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Lyckman AW,Horng S,Leamey CA,Tropea D,Watakabe A,Van Wart A,McCurry C,Yamamori T,Sur M

更新日期：2008-07-08 00:00:00

abstract：:Misfolding and aggregation of Cu, Zn superoxide dismutase (SOD1) is implicated in neuronal death in amyotrophic lateral sclerosis. Each SOD1 monomer binds to 1 copper and 1 zinc ion and maintains its disulfide bond (Cys-57-Cys-146) in the reducing cytoplasm of cell. Mounting experimental evidence suggests that metal l...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Ding F,Dokholyan NV

更新日期：2008-12-16 00:00:00

abstract：:We recently have introduced the term vasculogenic mimicry to describe the unique ability of aggressive melanoma tumor cells to form tubular structures and patterned networks in three-dimensional culture, which "mimics" embryonic vasculogenic networks formed by differentiating endothelial cells. In the current study, w...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Hendrix MJ,Seftor EA,Meltzer PS,Gardner LM,Hess AR,Kirschmann DA,Schatteman GC,Seftor RE

更新日期：2001-07-03 00:00:00

abstract：:The mechanisms that regulate insulin secretion were investigated using capacitance measurements of exocytosis in single beta cells maintained in tissue culture. Exocytosis was stimulated by voltage-clamp depolarizations to activate the voltage-dependent Ca2+ channels that mediate Ca2+ influx into the beta cell. Under ...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Ammälä C,Eliasson L,Bokvist K,Berggren PO,Honkanen RE,Sjöholm A,Rorsman P

更新日期：1994-05-10 00:00:00

abstract：:A central question in stem cell biology is whether organ homeostasis is maintained in adult organs through undifferentiated stem cells or self-duplication of specialized cell populations. To address this issue in the exocrine pancreas we analyzed the Bmi1-labeled cell lineage of pancreatic acinar cells. Previously, we...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Sangiorgi E,Capecchi MR

更新日期：2009-04-28 00:00:00

abstract：:The sodium/iodide symporter (NIS) mediates active I(-) transport in the thyroid-the first step in thyroid hormone biosynthesis-with a 2 Na(+): 1 I(-) stoichiometry. The two Na(+) binding sites (Na1 and Na2) and the I(-) binding site interact allosterically: when Na(+) binds to a Na(+) site, the affinity of NIS for the...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Ferrandino G,Nicola JP,Sánchez YE,Echeverria I,Liu Y,Amzel LM,Carrasco N

更新日期：2016-09-13 00:00:00

abstract：:The neuraminidase inhibitors oseltamivir and zanamivi are used to treat H5N1 influenza. However, oseltamivir-resistant H5N1 viruses have been isolated from oseltamivir-treated patients. Moreover, reassortment between H5N1 viruses and oseltamvir-resistant human H1N1 viruses currently circulating could create oseltamivi...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Kiso M,Takahashi K,Sakai-Tagawa Y,Shinya K,Sakabe S,Le QM,Ozawa M,Furuta Y,Kawaoka Y

更新日期：2010-01-12 00:00:00

abstract：:MicroRNA-34a (miR-34a) is the most highly elevated hepatic miR in obese mice and is also substantially elevated in patients who have steatosis, but its role in obesity and metabolic dysfunction remains unclear. After a meal, FGF19 is secreted from the ileum; binds to a hepatic membrane receptor complex, FGF19 receptor...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Fu T,Choi SE,Kim DH,Seok S,Suino-Powell KM,Xu HE,Kemper JK

更新日期：2012-10-02 00:00:00

abstract：:We advance a theory of resilience as it applies to the challenges of international development. The conceptualization we advance for development resilience focuses on the stochastic dynamics of individual and collective human well-being, especially on the avoidance of and escape from chronic poverty over time in the f...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Barrett CB,Constas MA

更新日期：2014-10-07 00:00:00

abstract：:Thiostrepton (TSR), an archetypal bimacrocyclic thiopeptide antibiotic that arises from complex posttranslational modifications of a genetically encoded precursor peptide, possesses a quinaldic acid (QA) moiety within the side-ring system of a thiopeptide-characteristic framework. Focusing on selective engineering of ...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Zheng Q,Wang S,Duan P,Liao R,Chen D,Liu W

更新日期：2016-12-13 00:00:00

abstract：:We have tried to find out why Ascaris hemoglobin has such an exceptionally high oxygen affinity (P50 approximately 0.004 mmHg; 1 mmHg = 133 Pa). Following Kloek et al., we have synthesized the N-terminal globin domain of Ascaris hemoglobin in Escherichia coli [Kloek, A. P., Yang, J., Mathews, F. S. & Goldberg, D. (199...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： De Baere I,Perutz MF,Kiger L,Marden MC,Poyart C

更新日期：1994-02-15 00:00:00

abstract：:Both naturally occurring and synthetic phosphatidic acid (PtdOH) molecules show the phenomenon of spontaneous vesiculation on jump in pH value. This method involves a transient increase in pH of smectic PtdOH dispersions to values between 10 and 12. Such a pH increase induces spontaneous vesiculation with the formatio...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Hauser H

更新日期：1989-07-01 00:00:00

abstract：:We describe two Drosophila melanogaster transcription units that are highly homologous to a rat Na+-channel cDNA. They appear to encode the major subunits of two distinct Na+-channel proteins. One of these maps to the second chromosome and is identical to a Na+-channel gene whose partial sequence has been previously r...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Ramaswami M,Tanouye MA

更新日期：1989-03-01 00:00:00

abstract：:TIM-4, a member of the TIM family expressed on antigen-presenting cells, binds to phosphatidylserine exposed on the surface of apoptotic bodies. However, the significance of this interaction in vivo remains unknown because other receptors have been implicated in the clearance of apoptotic bodies and could compensate f...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Rodriguez-Manzanet R,Sanjuan MA,Wu HY,Quintana FJ,Xiao S,Anderson AC,Weiner HL,Green DR,Kuchroo VK

更新日期：2010-05-11 00:00:00

abstract：:Selection is widely accepted as the principal force shaping phenotypic variation within populations. Its importance in speciation and macroevolution has been questioned, however, because phenotypic differences between species or higher taxa sometimes appear to be nonadaptive. Here, we use the quantitative trait locus ...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Rieseberg LH,Widmer A,Arntz AM,Burke JM

更新日期：2002-09-17 00:00:00

abstract：:Current understanding of the integration of cell division and expansion in the development of plant lateral organs such as leaves is limited. Cell number is established during a mitotic phase, and subsequent growth into a mature organ relies primarily on cell expansion accompanied by endocycles. Here we show that the ...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Dewitte W,Scofield S,Alcasabas AA,Maughan SC,Menges M,Braun N,Collins C,Nieuwland J,Prinsen E,Sundaresan V,Murray JA

更新日期：2007-09-04 00:00:00

abstract：:Detection and avoidance of impending obstacles is crucial to preventing head and body injuries in daily life. To safely avoid obstacles, locations of objects approaching the body surface are usually detected via the visual system and then used by the motor system to guide defensive movements. Mediating between visual ...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Huang RS,Chen CF,Tran AT,Holstein KL,Sereno MI

更新日期：2012-10-30 00:00:00