Influence of macrophage infiltration of herniated lumbar disc tissue on outcome after lumbar disc surgery.

Abstract:

STUDY DESIGN:An immunohistochemical examination of the presence of inflammatory cells in routinely processed resection specimens of the lumbar disc, and a comparison of the histologic results with clinical data collected prospectively before and after surgery. OBJECTIVES:To assess the influence of inflammatory reactions in herniated lumbar disc specimens on the outcome after lumbar disc surgery. SUMMARY OF BACKGROUND DATA:Histologic and biochemical studies on herniated lumbar disc tissue led to the notion of inflammation-induced sciatic pain. At this writing, no investigations have sought to discover how outcome after lumbar disc surgery is influenced by histologically described inflammation. METHODS:Disc specimens from 79 patients who underwent surgery for lumbar disc herniation were studied immunohistologically with regard to the presence of inflammatory reactions. Of these, 92% were followed up approximately 7 months after surgery. The histologic results were compared with the outcome at follow-up evaluation. RESULTS:A statistically significant correlation was found between the histologically proven inflammation and the outcome, as shown by the pain grading scale. CONCLUSIONS:The results from this study seem to support the theory of a foreign body reaction to the herniated material. This reaction may result in inflammation-induced sciatic pain.

journal_name

Spine (Phila Pa 1976)

journal_title

Spine

authors

Woertgen C,Rothoerl RD,Brawanski A

doi

10.1097/00007632-200004010-00017

keywords:

subject

Has Abstract

pub_date

2000-04-01 00:00:00

pages

871-5

issue

7

eissn

0362-2436

issn

1528-1159

journal_volume

25

pub_type

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