Nitric oxide synthase gene therapy in vascular pathology.

Abstract:

:Nitric oxide (NO) is intimately involved in vascular homeostasis through its antiplatelet, antiproliferative, and vasodilating actions. Because of these beneficial properties, methods of harnessing NO for the prevention of vascular injury responses, such as intimal hyperplasia, are being explored. One such method involves gene transfer of an NO synthase (NOS) to sites of vascular injury to provide for local NO synthesis. Gene delivery of the inducible NOS (iNOS) cDNA to sites of vascular injury in animal models dramatically reduced smooth muscle proliferation and intimal hyperplasia. The cellular mechanisms by which NO inhibits smooth muscle cell proliferation appear to be independent of cyclic guanosine monophosphate production but are linked to the upregulation of the cell cycle inhibitor p21. p21 upregulation occurs independent of p53 expression. Instead, p42/44 mitogen activated protein kinase activation by NO results in reduced cellular proliferation and increased p21 expression, suggesting NO inhibits intimal hyperplasia through cell cycle arrest as mediated by p21 and the signaling pathway involved in p21 upregulation may be regulated by p42/44 mitogen activated protein kinase.

journal_name

Semin Perinatol

journal_title

Seminars in perinatology

authors

Kibbe MR,Tzeng E

doi

10.1016/s0146-0005(00)80056-7

keywords:

subject

Has Abstract

pub_date

2000-02-01 00:00:00

pages

51-4

issue

1

eissn

0146-0005

issn

1558-075X

pii

S0146-0005(00)80056-7

journal_volume

24

pub_type

杂志文章,评审
  • Endocrinology of lactation.

    abstract::Hormones are necessary for the growth of mammary glands, for initiation of the secretory process, and for the maintenance of an established lactation in all mammals. Hormonal changes which occur in late pregnancy and the early postpartum period are described and graphed. This data was derived from research with anim...

    journal_title:Seminars in perinatology

    pub_type: 杂志文章,评审

    doi:

    authors: Tucker HA

    更新日期:1979-07-01 00:00:00

  • Ethical issues in periviable birth.

    abstract::Ethics is an essential dimension of the management of periviable birth in both clinical practice and research. The goal of clinical care in periviable birth is to improve outcomes for current pregnant and fetal patients. The goal of research in periviable birth is to improve outcomes for future pregnant patients and f...

    journal_title:Seminars in perinatology

    pub_type: 杂志文章

    doi:10.1053/j.semperi.2013.06.027

    authors: Chervenak FA,McCullough LB

    更新日期:2013-12-01 00:00:00

  • Prenatal diagnosis and multiple pregnancy.

    abstract::The incidence of twins, triplets, and high-order multiples has increased dramatically in the last two decades secondary to greater reliance on fertility treatments and to delayed childbearing. Offspring of a multiple gestation are at increased risk for both chromosomal and structural abnormalities. Prenatal diagnosis ...

    journal_title:Seminars in perinatology

    pub_type: 杂志文章,评审

    doi:10.1053/j.semperi.2005.08.005

    authors: Cleary-Goldman J,D'Alton ME,Berkowitz RL

    更新日期:2005-10-01 00:00:00

  • First trimester screening for aneuploidy: nuchal translucency sonography.

    abstract::Prenatal diagnosis of fetal aneuploidy is a continuously and rapidly evolving area of research. Currently in the United States, the standard of care for screening pregnancies for aneuploidy involves assessment of maternal age together with the use of multiple second trimester maternal serum markers. This screening app...

    journal_title:Seminars in perinatology

    pub_type: 杂志文章,评审

    doi:10.1016/s0146-0005(99)80003-2

    authors: Stewart TL,Malone FD

    更新日期:1999-10-01 00:00:00

  • The medical and legal aspects of maternal mortality.

    abstract::Sudden unexpected changes in the life of a family create many different emotions in various family members. The death of a young woman during or after her pregnancy is especially difficult because of the strain it places on family dynamics. One of the consequences is that there is, commonly, a newborn, and perhaps oth...

    journal_title:Seminars in perinatology

    pub_type: 杂志文章

    doi:10.1053/j.semperi.2011.09.014

    authors: Elliott JP

    更新日期:2012-02-01 00:00:00

  • Acute gastric aspiration: prevention and treatment.

    abstract::Pulmonary aspiration of gastric contents is a leading cause of maternal morbidity and mortality for patients during labor. The risk is increased in those women who require obstetric surgery and general anesthesia. Furthermore, gastric aspiration is believed to be largely preventable. Care providers can reduce the risk...

    journal_title:Seminars in perinatology

    pub_type: 杂志文章,评审

    doi:10.1016/s0146-0005(97)80074-2

    authors: Rowe TF

    更新日期:1997-08-01 00:00:00

  • Congenital diaphragmatic hernia-associated cardiac dysfunction.

    abstract::There is increasing evidence that cardiac dysfunction is a key contributor to CDH pathophysiology. Dysfunction in both right and left ventricles is common in the early neonatal period, contributes to clinical disease severity, and is associated with adverse outcomes including death and ECMO use. Early and routine asse...

    journal_title:Seminars in perinatology

    pub_type: 杂志文章,评审

    doi:10.1053/j.semperi.2019.07.007

    authors: Patel N,Massolo AC,Kipfmueller F

    更新日期:2020-02-01 00:00:00

  • Auditory impairment in infants at risk for bilirubin-induced neurologic dysfunction.

    abstract::Classical and subtypes of kernicterus associated with bilirubin toxicity can be differentiated in part with physiological auditory measures that include auditory-evoked potentials and measures of cochlear integrity. The combination of these auditory measures suggests that bilirubin exposure results in auditory system ...

    journal_title:Seminars in perinatology

    pub_type: 杂志文章,评审

    doi:10.1053/j.semperi.2011.02.011

    authors: Shapiro SM,Popelka GR

    更新日期:2011-06-01 00:00:00

  • Genetics of patent ductus arteriosus susceptibility and treatment.

    abstract::The ductus arteriosus is a vital fetal structure designed to close shortly after birth. Although many physiologic and pharmacologic investigations have characterized the closure of this structure, genetic studies of persistent patency of the ductus arteriosus (patent ductus arteriosus, PDA) are relatively recent. Prog...

    journal_title:Seminars in perinatology

    pub_type: 杂志文章,评审

    doi:10.1053/j.semperi.2011.09.019

    authors: Hajj H,Dagle JM

    更新日期:2012-04-01 00:00:00

  • Cranial ultrasonography in neonates: role and limitations.

    abstract::In experienced hands, cranial ultrasonography (cUS) is an excellent tool to detect the most frequently occurring brain abnormalities in preterm and full-term neonates, to study the evolution of lesions, and to follow brain maturation. It enables screening of the brain and serial imaging in high-risk neonates. However,...

    journal_title:Seminars in perinatology

    pub_type: 杂志文章,评审

    doi:10.1053/j.semperi.2009.10.002

    authors: van Wezel-Meijler G,Steggerda SJ,Leijser LM

    更新日期:2010-02-01 00:00:00

  • Amniotic fluid antibacterial mechanisms: newer concepts.

    abstract::In this review the factors present in human amniotic fluid that may function to inhibit bacterial growth have been examined. It appears that several potential antibacterial systems are present. Lysozyme and B-lysin may significantly contribute to the killing of gram-positive bacteria. Whether or not the remaining anti...

    journal_title:Seminars in perinatology

    pub_type: 杂志文章,评审

    doi:

    authors: Schlievert P,Johnson W,Galask RP

    更新日期:1977-01-01 00:00:00

  • Complications of parenteral nutrition.

    abstract::There have been no controlled studies that clearly document a beneficial effect of TPN on neonatal mortality and morbidity. Beneficial effects such as reducing the time required to achieve some targeted weight and enhancing positive nitrogen balance are used in support of TPN. The positive opinion about TPN is strongl...

    journal_title:Seminars in perinatology

    pub_type: 杂志文章,评审

    doi:

    authors: Gutcher G,Cutz E

    更新日期:1986-07-01 00:00:00

  • Industry perspectives on prenatal genetic testing.

    abstract::Until recent years, prenatal genetic tests have been almost exclusively developed and implemented by academic physicians and laboratories. In the last several years, industry has led the development of novel prenatal genetic tests, funded clinical trials and implemented these tests into clinical practice. That these e...

    journal_title:Seminars in perinatology

    pub_type: 杂志文章,评审

    doi:10.1053/j.semperi.2018.07.021

    authors: Swanson A,Goldberg JD

    更新日期:2018-08-01 00:00:00

  • Ichthyosis in the newborn.

    abstract::The ichthyoses encompass a variety of genetic disorders marked by abnormal epidermal differentiation. The neonatal period is critical for patients with ichthyosis because of the risk for significant associated morbidity and mortality, with the majority of complications arising as a result of impaired barrier function....

    journal_title:Seminars in perinatology

    pub_type: 杂志文章,评审

    doi:10.1053/j.semperi.2012.11.001

    authors: Craiglow BG

    更新日期:2013-02-01 00:00:00

  • Infections in VLBW infants: studies from the NICHD Neonatal Research Network.

    abstract::Infection is a serious complication among very low birth weight (VLBW) preterm infants hospitalized in neonatal intensive care units. This article reviews studies from the National Institute of Child Health and Human Development (NICHD) Neonatal Research Network including infection data from observational studies and ...

    journal_title:Seminars in perinatology

    pub_type: 杂志文章,评审

    doi:10.1016/s0146-0005(03)00046-6

    authors: Stoll BJ,Hansen N

    更新日期:2003-08-01 00:00:00

  • Cirrhosis and portal hypertension in pregnancy.

    abstract::Cirrhosis and portal hypertension infrequently coincide with pregnancy but increase maternal and fetal morbidity and mortality when present. Chronic liver disease and portal hypertension are not contraindications to pregnancy but necessitate intensive monitoring throughout pregnancy. The complications of liver disease...

    journal_title:Seminars in perinatology

    pub_type: 杂志文章,评审

    doi:10.1016/s0146-0005(98)80048-7

    authors: Russell MA,Craigo SD

    更新日期:1998-04-01 00:00:00

  • Examination of the twin placenta.

    abstract::Twin birth rates have increased dramatically over the past three decades, and twins currently account for 3% of all pregnancies. Twin pregnancies of any type are at risk for prematurity. In addition, monochorionic twin pregnancies (25-30% of all twin pregnancies) are predisposed to a specific set of complications, inc...

    journal_title:Seminars in perinatology

    pub_type: 杂志文章,评审

    doi:10.1053/j.semperi.2014.10.005

    authors: Paepe ME

    更新日期:2015-02-01 00:00:00

  • Aortopathy in pregnancy.

    abstract::Up to half of all aortic dissections and ruptures in women younger than 40 years are associated with pregnancy. In pregnancy, women with aortic disease such as arteritis and aortitis are at significant risk of aneurysmal formation and dissection with potential for catastrophic outcomes. Pregnancy places predisposed wo...

    journal_title:Seminars in perinatology

    pub_type: 杂志文章,评审

    doi:10.1053/j.semperi.2014.04.019

    authors: Smok DA

    更新日期:2014-08-01 00:00:00

  • Antifungal pharmacotherapy for neonatal candidiasis.

    abstract::Candida is a leading cause of late onset infection (> 3 days of age) in the premature infant. Therefore, decisions about the diagnosis and management of infections caused by Candida are commonplace in the neonatal intensive care unit. Despite this fact, there are few comparative trials about treatment of neonatal Cand...

    journal_title:Seminars in perinatology

    pub_type: 杂志文章,评审

    doi:10.1016/s0146-0005(03)00060-0

    authors: Bliss JM,Wellington M,Gigliotti F

    更新日期:2003-10-01 00:00:00

  • Angiotensin converting enzyme: history and relevance.

    abstract::The renin angiotensin system (RAS) is now recognized as the body's most powerful hormone system for controlling renal hemodynamics and sodium excretion and, therefore, body fluid volumes and arterial pressure. The discovery of angiotensin converting enzyme inhibitors (ACEi) was a keystone for the understanding of the ...

    journal_title:Seminars in perinatology

    pub_type: 历史文章,杂志文章

    doi:10.1016/s0146-0005(00)80046-4

    authors: Ferreira SH

    更新日期:2000-02-01 00:00:00

  • The newborn with ambiguous genitalia.

    abstract::The unexpectedness of genital ambiguity in an infant creates an urgent and stressful situation. A logical approach, using a team of specialists together with nursery staff and physicians, allows each member to contribute expertise and unnecessary overlap of investigations. The psychological needs of the parents should...

    journal_title:Seminars in perinatology

    pub_type: 杂志文章,评审

    doi:

    authors: McGillivray BC

    更新日期:1992-12-01 00:00:00

  • Prostaglandins and the developing kidney.

    abstract::Prostaglandins PGE2, PGD2, PGI2, and PGF2 alpha, as well as thromboxanes and leukotrienes, are synthesized by the fetal and neonatal kidney. The major prostaglandin, PGE2, PGD2, and PGI2, increase RBF, free water clearance, urine flow, and natriuresis. Alterations in the synthetic and catabolic activity of renal prost...

    journal_title:Seminars in perinatology

    pub_type: 杂志文章,评审

    doi:

    authors: Gleason CA

    更新日期:1987-01-01 00:00:00

  • Theoretical foundations of learning through simulation.

    abstract::Health care simulation is a powerful educational tool to help facilitate learning for clinicians and change their practice to improve patient outcomes and safety. To promote effective life-long learning through simulation, the educator needs to consider individuals, their experiences, and their environments. Effective...

    journal_title:Seminars in perinatology

    pub_type: 杂志文章,评审

    doi:10.1053/j.semperi.2011.01.002

    authors: Zigmont JJ,Kappus LJ,Sudikoff SN

    更新日期:2011-04-01 00:00:00

  • Ethical dilemmas in medical innovation and research: distinguishing experimentation from practice.

    abstract::The words research and experimentation continue to have the power to evoke fear in potential subjects. But much of standard practice, particularly in critical care settings, involves interventions of unknown efficacy and safety. Innovation also abounds in practice settings, typically unchecked by prospective or retros...

    journal_title:Seminars in perinatology

    pub_type: 杂志文章,评审

    doi:10.1016/s0146-0005(98)80038-4

    authors: Fost N

    更新日期:1998-06-01 00:00:00

  • Prediction and prevention of spontaneous preterm birth in twin gestations.

    abstract::The incidence of twin gestation has increased significantly over the past 30 years. One of the most significant public health implications of this trend is the increased incidence of preterm birth (PTB). Efforts to improve neonatal outcomes must address the rate of PTB, particularly among multiple gestations, which co...

    journal_title:Seminars in perinatology

    pub_type: 杂志文章,评审

    doi:10.1053/j.semperi.2012.02.003

    authors: Brubaker SG,Gyamfi C

    更新日期:2012-06-01 00:00:00

  • The adverse renal effects of prostaglandin-synthesis inhibitors in the newborn rabbit.

    abstract::Nonsteroidal anti-inflammatory drugs are frequently used during pregnancy (premature labor, polyhydramnios) and the immediate postnatal period (closure of patent ductus arteriosus). This article evaluates the renal effect of 3 nonspecific COX inhibitors (aspirin, indomethacin, and ibuprofen) in newborn rabbits. Five g...

    journal_title:Seminars in perinatology

    pub_type: 杂志文章

    doi:10.1053/sper.2002.37310

    authors: Guignard JP

    更新日期:2002-12-01 00:00:00

  • The role of hyperoxia in the pathogenesis of experimental BPD.

    abstract::Supplemental oxygen is often used as a life-saving therapy in the treatment of preterm infants. However, its protracted use can lead to the development of bronchopulmonary dysplasia (BPD), and more recently, has been associated with adversely affecting the general health of children and adolescents who were born prete...

    journal_title:Seminars in perinatology

    pub_type: 杂志文章,评审

    doi:10.1053/j.semperi.2013.01.002

    authors: Buczynski BW,Maduekwe ET,O'Reilly MA

    更新日期:2013-04-01 00:00:00

  • Prediction of preeclampsia.

    abstract::The onset of preeclampsia at or near to term is associated with low maternal and neonatal morbidity and mortality. In contrast, those patients (1%) who suffer early onset preeclampsia engender significant maternal and perinatal morbidity and mortality. Therefore, because of the lack of proven prophylaxis for preeclamp...

    journal_title:Seminars in perinatology

    pub_type: 杂志文章,评审

    doi:10.1016/s0146-0005(99)80059-7

    authors: Myatt L,Miodovnik M

    更新日期:1999-02-01 00:00:00

  • Pharmacologic interventions for the prevention and treatment of retinopathy of prematurity.

    abstract::Retinopathy of Prematurity (ROP) is a preventable neovascular retinal disease with a lifetime impact on vision and ocular morbidities. Retinal vessel immaturity and oxygen therapy, influenced or modulated by several risk factors including oxidative stress, intermittent hypoxia and desaturations, inflammation, infectio...

    journal_title:Seminars in perinatology

    pub_type: 杂志文章,评审

    doi:10.1053/j.semperi.2019.05.009

    authors: Aranda JV,Qu J,Valencia GB,Beharry KD

    更新日期:2019-10-01 00:00:00

  • Placental transfer of selected substances of abuse.

    abstract::The placenta was classically considered a barrier, but in 1957 this notion was shattered. This organ is only a selective filter and metabolic site. In this review, the placental transfer of the top 17 substances of abuse are analyzed. In the National Library of Medicine only 41 papers that documented placental transfe...

    journal_title:Seminars in perinatology

    pub_type: 杂志文章,评审

    doi:10.1016/s0146-0005(96)80082-6

    authors: Little BB,VanBeveren TT

    更新日期:1996-04-01 00:00:00