TNK-tPA for acute myocardial infarction: the clinical experience.

abstract：:Recombinant factor VIIa (rFVIIa; Novoseven) is used for treatment of hemophilia patients with inhibitors. There are poorly defined differences in clinical responsiveness between individuals. Prior to licensure in the United States, rFVIIa was available through the compassionate use program, during which two patients d...

journal_title：Thrombosis and haemostasis

authors： Key NS,Christie B,Henderson N,Nelsestuen GL

更新日期：2002-07-01 00:00:00

abstract：:Malondialdehyde (MDA) is a stable produce of arachidonic acid metabolism, catalyzed by the enzyme cyclo-oxygenase. The experimental conditions for measuring the kinetics of MDA formation in rat citrated platelet-rich plasma were defined. Platelets were stimulated with either arachidonic acid, the substrate of MDA, or ...

journal_title：Thrombosis and haemostasis

authors： Rajtar G,Livio M,Merino J,de Gaetano G

更新日期：1980-10-31 00:00:00

abstract：:To study the predictive value of coagulation markers concerning clinical outcome, prothrombin fragment F1.2 (F1.2), fibrin monomer antigen (FM), D-Dimer (DD), and fibrinogen were measured in plasma samples drawn 2 and 7 days after acute myocardial infarction (AMI) in 314 consecutive patients randomized in a clinical t...

journal_title：Thrombosis and haemostasis

authors： Dempfle CE,Kontny F,Abildgaard U

更新日期：1999-05-01 00:00:00

abstract：:Use of oral contraceptives (OC) that combine a progestogen with synthetic ethinyl estradiol (EE) is associated with increased risk of venous thromboembolism. NOMAC/E2 is a new monophasic OC that combines nomegestrol acetate (NOMAC), a highly selective progestogen, with 17β-estradiol (E2). The study objective was to co...

journal_title：Thrombosis and haemostasis

authors： Gaussem P,Alhenc-Gelas M,Thomas JL,Bachelot-Loza C,Remones V,Ali FD,Aiach M,Scarabin PY

更新日期：2011-03-01 00:00:00

abstract：:This study aims to establish the relative effectiveness and safety of low molecular weight heparin in elderly patients with venous thrombosis in order to find an alternative to oral anticoagulant therapy with less bleeding complications in the long-term treatment of deep venous thrombosis (DVT). One hundred consecutiv...

journal_title：Thrombosis and haemostasis

authors： Veiga F,Escribá A,Maluenda MP,López Rubio M,Margalet I,Lezana A,Gallego J,Ribera JM

更新日期：2000-10-01 00:00:00

abstract：:We tested different types of clot for their ability to provoke procoagulant activity in platelets: normal clots from platelet poor plasma (des AABB- or fibrin II clots), similar clots in which the adsorbed thrombin has been inhibited by hirudin, and clots obtained by the action of two snake venom enzymes that release ...

journal_title：Thrombosis and haemostasis

authors： Kumar R,Béguin S,Hemker HC

更新日期：1995-09-01 00:00:00

abstract：:Ridogrel (6.3 x 10(-6) to 10(-4) M) inhibited contractions of isolated rat caudal arteries and rabbit femoral arteries caused by U-46619. The slope of an Arunlakshana-Schild plot (pA2-value: 3.4 x 10(-6) M) on the caudal artery was slightly higher than one (1.14). This effect was maximal within 20 min of incubation of...

journal_title：Thrombosis and haemostasis

authors： Janssens WJ,Cools FJ,Hoskens LA,Van Nueten JM

更新日期：1990-08-13 00:00:00

abstract：:Deep vein thrombosis (DVT) in children occurs primarily in the upper body venous system. This prospective diagnostic study compared bilateral venography and ultrasound for detection of DVT in the upper venous system in 66 children with acute lymphoblastic leukemia. Results were interpreted by central blinded adjudicat...

journal_title：Thrombosis and haemostasis

authors： Male C,Chait P,Ginsberg JS,Hanna K,Andrew M,Halton J,Anderson R,McCusker P,Wu J,Abshire T,Cherrick I,Mahoney D,Mitchell L

更新日期：2002-04-01 00:00:00

abstract：:It was our aim to assess whether factor V Leiden (FVL) and G20210A prothrombin (FII) mutation are associated with the presence of residual vein obstruction (RVO) after a standard course of anticoagulation for a first episode of idiopathic proximal deep-vein thrombosis (DVT) of the lower limbs, with or without symptoma...

journal_title：Thrombosis and haemostasis

authors： Cosmi B,Legnani C,Pengo V,Ghirarduzzi A,Testa S,Poli D,Prisco D,Tripodi A,Palareti G,PROLONG Investigators (on behalf of FCSA, Italian Federation of Anticoagulation Clinics).

更新日期：2013-03-01 00:00:00

abstract：:A series of aromatic amidino compounds were investigated for their inhibitory effect on platelet agglutination and platelet aggregation. Agglutination of fresh or fixed platelets was produced by bovine plasma or by human plasma in combination with ristocetin, while aggregation of fresh platelets was induced by ADP, th...

journal_title：Thrombosis and haemostasis

authors： Geratz JD,Tidwell RR,Brinkhous KM,Mohammad SF,Dann O,Loewe H

更新日期：1978-04-30 00:00:00

abstract：:Accumulating evidence indicates that accelerated formation of fibrin clots composed of compact, highly-branched networks with thin fibres which are relatively resistant to plasmin-mediated lysis can be commonly observed in patients with venous or arterial thrombosis. This review discusses characteristics of fibrin clo...

journal_title：Thrombosis and haemostasis

authors： Undas A

更新日期：2014-07-03 00:00:00

abstract：:Computer-assisted oral anticoagulant dosage is being increasingly used to meet growing demands for oral anticoagulation. The DAWN AC is one of the most widely used computer-dosage programs. Evidence of its value and that of other computer programs has been based previously only on laboratory evidence of "time in targe...

journal_title：Thrombosis and haemostasis

authors： Poller L,Keown M,Ibrahim S,Lowe G,Moia M,Turpie AG,Roberts C,van den Besselaar AM,van der Meer FJ,Tripodi A,Palareti G,Shiach C,Bryan S,Samama M,Burgess-Wilson M,Heagerty A,Maccallum P,Wright D,Jespersen J,European

更新日期：2009-03-01 00:00:00

abstract：:Thrombocytopenia and platelet dysfunction induced by extracorporeal blood circulation are thought to contribute to postsurgical bleeding complications in neonates undergoing cardiac surgery with cardiopulmonary bypass (CPB). In this study, we examined how changes in platelet function relate to changes in platelet coun...

journal_title：Thrombosis and haemostasis

authors： Zwifelhofer NMJ,Bercovitz RS,Cole R,Yan K,Simpson PM,Moroi A,Newman PJ,Niebler RA,Scott JP,Stuth EAD,Woods RK,Benson DW,Newman DK

更新日期：2020-01-01 00:00:00

abstract：:Platelets from cattle with the Chediak-Higashi syndrome (CHS) have a platelet dense granule deficiency. One hypothesis for the platelet dense granule deficiency is that the granule is simply not formed in CHS megakaryocytes (MK). Alternative hypotheses include that the granule is assembled in CHS MK but a functional a...

journal_title：Thrombosis and haemostasis

authors： Meyers K,Seachord C

更新日期：1990-10-22 00:00:00

abstract：:The technique of crossed immunoelectrophoresis has been used to study the binding to purified antithrombin III (At III) of heparin and other mucopolysaccharides. The technique was unable to detect differences among samples of whole heparin from various manufacturers, but proved useful in studying the binding of hepari...

journal_title：Thrombosis and haemostasis

authors： Barrowcliffe TW

更新日期：1980-02-29 00:00:00

abstract：:Lysosomal Associated Membrane Protein-2 (LAMP-2) is an inherent component of lysosomal granule membranes in diverse cell types, including platelets. We examined platelets for evidence of LAMP-2 in dense granule membranes as CD63 has previously been shown to be present in both lysosomal and dense granule membranes. Imm...

journal_title：Thrombosis and haemostasis

authors： Israels SJ,McMillan EM,Robertson C,Singhory S,McNicol A

更新日期：1996-04-01 00:00:00

abstract：:It is widely anticipated that large platelets are more reactive than small platelets. This was mainly shown in Ca2+-poor media albeit extracellular Ca2+ is utilized by platelets for activation. We determined the impact of extracellular Ca2+ on functional differences between large and small platelets in response to thr...

journal_title：Thrombosis and haemostasis

authors： Handtke S,Wesche J,Palankar R,Greinacher A,Thiele T

更新日期：2020-07-01 00:00:00

abstract：:This study compares the ability of unmodified and carbohydrate-modified forms of factor VIII/von Willebrand factor (FVIII/vWF) protein to bind to platelets in the presence of ristocetin or thrombin. Treatment of intact FVIII/vWF with alpha-D-neuraminidase results in more than 95% desialylation. Asialo FVIII/vWF retain...

journal_title：Thrombosis and haemostasis

authors： Goudemand J,Mazurier C,Samor B,Bouquelet S,Montreuil J,Goudemand M

更新日期：1985-06-24 00:00:00

abstract：:Early treatment of disseminated intravascular coagulation (DIC) is recommended but global coagulation tests used in authorized DIC criteria are not sensitive for diagnosis of early-phase DIC. We examined the plasma levels of thrombin-antithrombin complex (TAT), plasmin-plasmin inhibitor complex (PPIC) and D-dimer in p...

journal_title：Thrombosis and haemostasis

authors： Asakura H,Wada H,Okamoto K,Iba T,Uchiyama T,Eguchi Y,Kawasugi K,Koga S,Mayumi T,Koike K,Gando S

更新日期：2006-02-01 00:00:00

abstract：BACKGROUND: Accurate diagnosis of symptomatic low von Willebrand factor (VWF) remains a major challenge in von Willebrand disease (VWD). However, present tests do not adequately take into account flow forces that, at very high shear rates, reveal a weakness in the VWF-platelet glycoprotein glycoprotein Ib bond in norma...

journal_title：Thrombosis and haemostasis

authors： Grabowski EF,Van Cott EM,Bornikova L,Boyle DC,Silva RL

更新日期：2020-05-01 00:00:00

abstract：:Unfractionated heparin is the most commonly used anticoagulant in ST-elevation myocardial infarction (STEMI) and its effect can be monitored with activated partial thromboplastin time (aPTT). However, the optimal aPTT range during heparin therapy after primary percutaneous coronary intervention (PCI) is yet to be defi...

journal_title：Thrombosis and haemostasis

authors： Kikkert WJ,van Nes SH,Lieve KV,Dangas GD,van Straalen J,Vis M,Baan J Jr,Koch KT,de Winter RJ,Piek JJ,Tijssen JG,Henriques JP

更新日期：2013-05-01 00:00:00

abstract：:Inhibition of adenylate cyclase in intact platelets by addition of compounds such as 2', 5' - dideoxyadenosine prevented the inhibition of platelet aggregation by PGE1 but did not affect the responses of platelets to aggregating agents in the absence of PGE1. This confirms that cyclic AMP mediates the effects of PGE1 ...

journal_title：Thrombosis and haemostasis

authors： Haslam RJ,Davidson MM,Fox JE,Lynham JA

更新日期：1978-10-31 00:00:00

abstract：:Causative mutations in the factor VIII gene of seven unrelated patients with severe haemophilia A were identified using the mutation screening procedure conformation sensitive gel electrophoresis (1) and characterised by direct sequencing. Female family members of all patients had requested either carrier status deter...

journal_title：Thrombosis and haemostasis

authors： Williams IJ,Abuzenadah A,Winship PR,Preston FE,Dolan G,Wright J,Peake IR,Goodeve AC

更新日期：1998-04-01 00:00:00

abstract：:Abnormal antithrombin III (AT III) was found in the plasma of a 31-year-old female who suffered from recurrent thrombotic episodes. Heparin cofactor activity was 28% of normal and undetectable when measured by inhibition of thrombin and factor Xa (F.Xa), while both progressive antithrombin and antifactor Xa activities...

journal_title：Thrombosis and haemostasis

authors： Okajima K,Ueyama H,Hashimoto Y,Sasaki Y,Matsumoto K,Okabe H,Inoue M,Araki S,Takatsuki K

更新日期：1989-02-28 00:00:00

abstract：:Human platelets have unique and reproducible mRNA profiles, with evidence for distinct profiles in haematopoietic stem cell disorders associated with thrombocytosis. Platelet transcript profiling is traditionally studied by microarray analysis, quantitative reverse transcription-PCR or serial analysis of gene expressi...

journal_title：Thrombosis and haemostasis

authors： Gnatenko DV,Zhu W,Bahou WF

更新日期：2008-11-01 00:00:00

abstract：:Intraluminal thrombus formation in aortic abdominal aneurysms (AAA) is associated with adverse clinical prognosis. Interplay between coagulation and inflammation, characterised by leukocyte infiltration and cytokine production, has been implicated in AAA thrombus formation. We studied leukocyte (CD45+) content by flow...

journal_title：Thrombosis and haemostasis

authors： Sagan A,Mrowiecki W,Mikolajczyk TP,Urbanski K,Siedlinski M,Nosalski R,Korbut R,Guzik TJ

更新日期：2012-11-01 00:00:00

abstract：:Mature circulating endothelial cells (CECs) are novel cellular markers of endothelial damage/dysfunction. The two main techniques of CEC enumeration are flow cytometry (FC) and immunomagnetic bead (IB) isolation. Both quantify CECs accurately, but a direct comparison of both methods has not been reported. We sought to...

journal_title：Thrombosis and haemostasis

authors： Goon PK,Boos CJ,Stonelake PS,Blann AD,Lip GY

更新日期：2006-07-01 00:00:00

abstract：:We have recently demonstrated that the proinflammatory cytokine, interleukin-6 (IL-6), could upregulate the production of protein S in the human hepatoma cell line, HepG-2, but not in endothelial cells. In this study, we have demonstrated that the combination of exogenous IL-6 and soluble IL-6 receptor (sIL-6R) could ...

journal_title：Thrombosis and haemostasis

authors： Hooper WC,Phillips DJ,Evatt BL

更新日期：1997-05-01 00:00:00

abstract：:Clot retraction is an essential step during primary haemostasis, thereby promoting thrombus stability and wound healing. Integrin αIIbβ3 plays a critical role in clot retraction, by inducing acto-myosin interactions that allow platelet cytoskeleton reorganisation. However, the signalling pathways that lead to clot ret...

journal_title：Thrombosis and haemostasis

authors： Egot M,Kauskot A,Lasne D,Gaussem P,Bachelot-Loza C

更新日期：2013-12-01 00:00:00

abstract：:Thrombus formation at an artificial surface in contact with blood is a complex process that encompasses accretion of platelets from flowing blood and fibrin deposition. Platelet adhesion and fibrin formation are intimately intertwined reactions that are triggered by different sets of surface adsorbed plasma proteins. ...

journal_title：Thrombosis and haemostasis

authors： Keuren JF,Wielders SJ,Willems GM,Morra M,Lindhout T

更新日期：2002-04-01 00:00:00