Changes in membrane trafficking and actin dynamics during axon formation in cultured hippocampal neurons.

Abstract:

:Neurons begin to polarize when one of the neurites becomes the axon. Hippocampal neurons in cell culture have a sharp transition between their unpolarized and polarized stage revealed by the rapid growth of the future axon. Recent progress shows that both a cytoplasmic membrane flow and actin dynamics govern axon formation, and thereby initial neuronal polarization. We here review these mechanisms, evaluate their physiological role, and show similarities to the transient polarization of migrating fibroblasts. Finally, we present a model how actin dynamics and vectorial membrane flow may interact to achieve axon formation.

journal_name

Microsc Res Tech

authors

Bradke F,Dotti CG

doi

10.1002/(SICI)1097-0029(20000101)48:1<3::AID-JEMT2

keywords:

subject

Has Abstract

pub_date

2000-01-01 00:00:00

pages

3-11

issue

1

eissn

1059-910X

issn

1097-0029

pii

10.1002/(SICI)1097-0029(20000101)48:1<3::AID-JEMT2

journal_volume

48

pub_type

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