Agonist-stimulated pathways of calcium signaling in pancreatic acinar cells.

Abstract:

:In pancreatic acinar cells stimulation of different intracellular pathways leads to different patterns of Ca2+ signaling. Bombesin induces activation of both phosphatidylinositol 4,5-bisphosphate (PIP2)-specific phospholipase C (PLC) and phospholipase D (PLD). The latter leads to generation of diacylglycerol (DAG) in addition to that produced by activation of PIP2-PLC. Strong activation of protein kinase C (PKC) results in inhibition of Ca(2+)-induced Ca2+ release from Ca2+ pools arranged in sequence to the luminally located IP3-sensitive Ca2+ pools. Consequently the Ca2+ wave which starts in the luminal cell pole is slower in the presence of bombesin (5 microm/s) as compared to that in the presence of acetylcholine (17 microm/s) which activates PIP2-PLC but not PLD. Activation of high-affinity CCK-receptors triggers a Ca2+ wave with slow propagation (5 microm/s) due to stimulation of phospholipase A2 (PLA2) and generation of arachidonic acid, which in turn leads to inhibition of Ca(2+)-induced Ca2+ release. Low-affinity CCK-receptors are coupled to both PIP2-PLC and PLD.

journal_name

Biol Chem

journal_title

Biological chemistry

authors

Schulz I,Krause E,González A,Göbel A,Sternfeld L,Schmid A

doi

10.1515/BC.1999.111

keywords:

subject

Has Abstract

pub_date

1999-07-01 00:00:00

pages

903-8

issue

7-8

eissn

1431-6730

issn

1437-4315

journal_volume

380

pub_type

杂志文章,评审
  • A fluorescence correlation spectroscopy study of ligand interaction with cytokinin-specific binding protein from mung bean.

    abstract::Cytokinins are essential plant hormones that regulate numerous physiological processes. Recently, a protein was identified in mung bean (Vigna radiata) and characterized as a cytokinin-specific binding protein (VrCSBP). Fluorescence correlation spectroscopy was used to investigate the interaction between VrCSBP and it...

    journal_title:Biological chemistry

    pub_type: 杂志文章

    doi:10.1515/BC.2010.005

    authors: Zawadzki P,Slósarek G,Boryski J,Wojtaszek P

    更新日期:2010-01-01 00:00:00

  • Cloning and characterization of a dominant-negative vps1 allele of the yeast Saccharomyces cerevisiae.

    abstract::The gene product of the yeast VPS1 gene is a member of a family of high-molecular-weight GTP-binding proteins that are involved in diverse cellular processes. The Vps1 protein (Vps1p) was shown to perform an essential function in the yeast secretory pathway. Here, we report the isolation and characterization of a muta...

    journal_title:Biological chemistry

    pub_type: 杂志文章

    doi:

    authors: Finken-Eigen M,Müller S,Köhrer K

    更新日期:1997-10-01 00:00:00

  • Role of sigma 1 receptor in high fat diet-induced peripheral neuropathy.

    abstract::The neurobiological mechanisms of obesity-induced peripheral neuropathy are poorly understood. We evaluated the role of Sigma-1 receptor (Sig-1R) and NMDA receptor (NMDARs) in the spinal cord in peripheral neuropathy using an animal model of high fat diet-induced diabetes. We examined the expression of Sig-1R and NMDA...

    journal_title:Biological chemistry

    pub_type: 杂志文章

    doi:10.1515/hsz-2017-0117

    authors: Song T,Zhao J,Ma X,Zhang Z,Jiang B,Yang Y

    更新日期:2017-09-26 00:00:00

  • Monitoring human parvovirus B19 virus-like particles and antibody complexes in solution by fluorescence correlation spectroscopy.

    abstract::Fluorescence correlation spectroscopy (FCS) was used in monitoring human parvovirus B19 virus-like particle (VLP) antibody complexes from acute phase and past-immunity serum samples. The Oregon Green 488-labeled VLPs gave an average diffusion coefficient of 1.7 x 10(-7) cm2 s(-1) with an apparent hydrodynamic radius o...

    journal_title:Biological chemistry

    pub_type: 杂志文章

    doi:10.1515/BC.2004.011

    authors: Toivola J,Michel PO,Gilbert L,Lahtinen T,Marjomäki V,Hedman K,Vuento M,Oker-Blom C

    更新日期:2004-01-01 00:00:00

  • Specific inhibition of interleukin-13 activity by a recombinant human single-chain immunoglobulin domain directed against the IL-13 receptor alpha1 chain.

    abstract::Interleukin-13 (IL-13) is a T-cell-derived pleiotropic cytokine of particular medical importance because of its critical role in the development of allergic asthma. The effects of IL-13 on its target cells are mediated through a dimeric transmembrane receptor (IL-13R), which shares the IL-4Ralpha subunit with the IL-4...

    journal_title:Biological chemistry

    pub_type: 杂志文章

    doi:10.1515/BC.2007.036

    authors: Knackmuss S,Krause S,Engel K,Reusch U,Virchow JC,Mueller T,Kraich M,Little M,Luttmann W,Friedrich K

    更新日期:2007-03-01 00:00:00

  • six-banded, a novel Drosophila gene, is expressed in 6 segmental stripes during embryonic development and in the eye imaginal disc.

    abstract::We have characterised a Drosophila P-element enhancer detector insertion F125, which is expressed in the embryonic head and CNS as well as in various third instar imaginal discs. In an attempt to identify the gene with the equivalent expression pattern, we have characterised an adjacent gene. It encodes two novel conc...

    journal_title:Biological chemistry

    pub_type: 杂志文章

    doi:10.1515/bchm.1997.378.10.1119

    authors: Zeidler MP,Mlodzik M

    更新日期:1997-10-01 00:00:00

  • Central nervous system: cholesterol turnover, brain development and neurodegeneration.

    abstract::The average amount of cholesterol in the whole animal equals approximately 2100 mg/kg body weight, and 15% and 23% of this sterol in the mouse and human, respectively, is found in the central nervous system. There is no detectable uptake across the blood-brain barrier of cholesterol carried in lipoproteins in the plas...

    journal_title:Biological chemistry

    pub_type: 杂志文章,评审

    doi:10.1515/BC.2009.035

    authors: Dietschy JM

    更新日期:2009-04-01 00:00:00

  • Role of hypoxia inducible factor-1α for interferon synthesis in mouse dendritic cells.

    abstract::Dendritic cells (DCs) are an important link between innate and adaptive immunity. DCs get activated in inflamed tissues where oxygen tension is usually low, which requires the transcription factor hypoxia inducible factor (HIF)-1 for cellular adaptation. To investigate whether the HIF-1 transcriptional complex plays a...

    journal_title:Biological chemistry

    pub_type: 杂志文章,评审

    doi:10.1515/hsz-2012-0320

    authors: Wobben R,Hüsecken Y,Lodewick C,Gibbert K,Fandrey J,Winning S

    更新日期:2013-04-01 00:00:00

  • The YidC/Oxa1/Alb3 protein family: common principles and distinct features.

    abstract::The members of the YidC/Oxa1/Alb3 protein family are evolutionary conserved in all three domains of life. They facilitate the insertion of membrane proteins into bacterial, mitochondrial, and thylakoid membranes and have been implicated in membrane protein folding and complex formation. The major classes of substrates...

    journal_title:Biological chemistry

    pub_type: 杂志文章,评审

    doi:10.1515/hsz-2012-0199

    authors: Saller MJ,Wu ZC,de Keyzer J,Driessen AJ

    更新日期:2012-11-01 00:00:00

  • Inhibition of inducible tumor necrosis factor-alpha expression by the fungal epipolythiodiketopiperazine gliovirin.

    abstract::TNF-alpha is a major pro-inflammatory cytokine that regulates further cytokine induction, especially of IL-1 and IL-6, in many human diseases including cancer, inflammation and immune disorders. In a search for new inhibitors of inducible TNF-alpha promoter activity and expression, cultures of the imperfect fungus Tri...

    journal_title:Biological chemistry

    pub_type: 杂志文章

    doi:10.1515/BC.2007.066

    authors: Rether J,Serwe A,Anke T,Erkel G

    更新日期:2007-06-01 00:00:00

  • Kallikrein 6 is a mediator of K-RAS-dependent migration of colon carcinoma cells.

    abstract::Kallikrein 6 (KLK6) is a trypsin-like serine peptidase whose relevance in various types of cancers is currently being explored. Previous studies have shown that KLK6 mRNA is upregulated in colon and gastric cancers; however, the regulatory mechanisms and phenotypic consequences of this upregulation are largely unknown...

    journal_title:Biological chemistry

    pub_type: 杂志文章

    doi:10.1515/BC.2008.087

    authors: Henkhaus RS,Gerner EW,Ignatenko NA

    更新日期:2008-06-01 00:00:00

  • Topotecan and methotrexate alter expression of the apoptosis-related genes BCL2, FAS and BCL2L12 in leukemic HL-60 cells.

    abstract::The BCL2 family of genes (B-cell CLL/lymphoma 2; Bcl-2) plays a pivotal role in the highly regulated process of apoptosis. We have recently cloned a newly identified member of this family, BCL2L12, which was found to be differentially expressed in many tumors. It is known that topotecan and methotrexate act through in...

    journal_title:Biological chemistry

    pub_type: 杂志文章

    doi:10.1515/BC.2006.203

    authors: Floros KV,Talieri M,Scorilas A

    更新日期:2006-12-01 00:00:00

  • When, how and why? Regulated proteolysis by the essential FtsH protease in Escherichia coli.

    abstract::Cellular proteomes are dynamic and adjusted to permanently changing conditions by ATP-fueled proteolytic machineries. Among the five AAA+ proteases in Escherichia coli FtsH is the only essential and membrane-anchored metalloprotease. FtsH is a homohexamer that uses its ATPase domain to unfold and translocate substrate...

    journal_title:Biological chemistry

    pub_type: 杂志文章,评审

    doi:10.1515/hsz-2016-0302

    authors: Bittner LM,Arends J,Narberhaus F

    更新日期:2017-05-01 00:00:00

  • Effects of magnesium ions on recombinant human furin: selective activation of hydrolytic activity upon substrates derived from virus envelope glycoprotein.

    abstract::Here we report a detailed analysis of magnesium (Mg²+) ion effects on furin hydrolysis of fluorescent resonance energy transfer decapeptide substrates derived from canonical R-X-K/R-R furin cleavage motifs within certain viral envelope glycoproteins and eukaryotic proproteins. Using virus-derived sequences a selective...

    journal_title:Biological chemistry

    pub_type: 杂志文章

    doi:10.1515/BC.2010.114

    authors: Izidoro MA,Assis DM,Oliveira V,Santos JA,Juliano MA,Lindberg I,Juliano L

    更新日期:2010-09-01 00:00:00

  • DNA-plasmids of HIV-1 induce systemic and mucosal immune responses.

    abstract::DNA-based immunization has been shown to induce protective immunity against several microbial pathogens including HIV-1. Several routes of DNA vaccination have been exploited. However, the properties of the immune responses seem to differ with the different routes used for DNA delivery, ultimately affecting the outcom...

    journal_title:Biological chemistry

    pub_type: 杂志文章

    doi:10.1515/BC.1999.049

    authors: Asakura Y,Lundholm P,Kjerrström A,Benthin R,Lucht E,Fukushima J,Schwartz S,Okuda K,Wahren B,Hinkula J

    更新日期:1999-03-01 00:00:00

  • Full length cDNA of rat RT1.DMa and RT1.DMb and expression of RT1.DM genes in dendritic and Langerhans cells.

    abstract::MHC encoded DM heterodimers and classical MHC class II complexes meet in an endosomal/lysosomal compartment where DM heterodimers support peptide loading of MHC class II. Studies on peptide loading of rat class II and on peptide persistence in cells of the dendritic lineage prompted us to establish full length cDNA cl...

    journal_title:Biological chemistry

    pub_type: 杂志文章

    doi:10.1515/bchm.1997.378.9.1005

    authors: Kurth D,Neumann J,Demleitner K,Hildmann J,Mehlig M,Scheicher C,Wendling U,Sun D,Reske K

    更新日期:1997-09-01 00:00:00

  • Contribution of astrocytes to metabolic dysfunction in the Alzheimer's disease brain.

    abstract::Historically considered as accessory cells to neurons, there is an increasing interest in the role of astrocytes in normal and pathological conditions. Astrocytes are involved in neurotransmitter recycling, antioxidant supply, ion buffering and neuroinflammation, i.e. a lot of the same pathways that go astray in Alzhe...

    journal_title:Biological chemistry

    pub_type: 杂志文章,评审

    doi:10.1515/hsz-2019-0140

    authors: Zulfiqar S,Garg P,Nieweg K

    更新日期:2019-08-27 00:00:00

  • Defects of corneocyte structural proteins and epidermal barrier in atopic dermatitis.

    abstract::The main function of the epidermis is to establish a vital multifunctional barrier between the body and its external environment. A defective epidermal barrier is one of the key features of atopic dermatitis (AD), a chronic and relapsing inflammatory skin disorder that affects up to 20% of children and 2-3% of adults ...

    journal_title:Biological chemistry

    pub_type: 杂志文章,评审

    doi:10.1515/hsz-2015-0141

    authors: Le Lamer M,Pellerin L,Reynier M,Cau L,Pendaries V,Leprince C,Méchin MC,Serre G,Paul C,Simon M

    更新日期:2015-11-01 00:00:00

  • Annexins - insights from knockout mice.

    abstract::Annexins are a highly conserved protein family that bind to phospholipids in a calcium (Ca2+) - dependent manner. Studies with purified annexins, as well as overexpression and knockdown approaches identified multiple functions predominantly linked to their dynamic and reversible membrane binding behavior. However, mos...

    journal_title:Biological chemistry

    pub_type: 杂志文章,评审

    doi:10.1515/hsz-2016-0168

    authors: Grewal T,Wason SJ,Enrich C,Rentero C

    更新日期:2016-10-01 00:00:00

  • Molecular interactions within the plant TOC complex.

    abstract::Protein transport, especially into different cellular compartments, is a highly coordinated and regulated process. The molecular machineries which carry out these transport processes are highly complex in structure, function, and regulation. In the case of chloroplasts, thousands of protein molecules have been estimat...

    journal_title:Biological chemistry

    pub_type: 杂志文章,评审

    doi:10.1515/BC.2009.051

    authors: Sommer MS,Schleiff E

    更新日期:2009-08-01 00:00:00

  • Diversity of GPI-anchored fungal adhesins.

    abstract::Selective adhesion of fungal cells to one another and to foreign surfaces is fundamental for the development of multicellular growth forms and the successful colonization of substrates and host organisms. Accordingly, fungi possess diverse cell wall-associated adhesins, mostly large glycoproteins, which present N-term...

    journal_title:Biological chemistry

    pub_type: 杂志文章,评审

    doi:10.1515/hsz-2020-0199

    authors: Essen LO,Vogt MS,Mösch HU

    更新日期:2020-11-26 00:00:00

  • The ugly side of amphetamines: short- and long-term toxicity of 3,4-methylenedioxymethamphetamine (MDMA, 'Ecstasy'), methamphetamine and D-amphetamine.

    abstract::Amphetamine ('Speed'), methamphetamine ('Ice') and its congener 3,4-methylenedioxymethamphetamine (MDMA; 'Ecstasy') are illicit drugs abused worldwide for their euphoric and stimulant effects. Despite compelling evidence for chronic MDMA neurotoxicity in animal models, the physiological consequences of such toxicity i...

    journal_title:Biological chemistry

    pub_type: 杂志文章,评审

    doi:10.1515/BC.2011.016

    authors: Steinkellner T,Freissmuth M,Sitte HH,Montgomery T

    更新日期:2011-01-01 00:00:00

  • Epigallocatechin gallate inhibits endothelial exocytosis.

    abstract::Consumption of green tea is associated with a decrease in cardiovascular mortality. The beneficial health effects of green tea are attributed in part to polyphenols, organic compounds found in tea that lower blood pressure, reduce body fat, decrease LDL cholesterol, and inhibit inflammation. We hypothesized that epiga...

    journal_title:Biological chemistry

    pub_type: 杂志文章

    doi:10.1515/BC.2008.095

    authors: Yamakuchi M,Bao C,Ferlito M,Lowenstein CJ

    更新日期:2008-07-01 00:00:00

  • Purification and MALDI-MS characterization of stressin, a stress-associated glycoprotein.

    abstract::Glycoconjugates have a whole spectrum of biological roles, from those that appear trivial to those that are crucial. Results accumulated in the past years indicate they might also play an important role in the response to stress, a complex physiological response of the human organism to various threats. We have recent...

    journal_title:Biological chemistry

    pub_type: 杂志文章

    doi:10.1515/BC.1999.058

    authors: Lauc G,Peter-Katalinić J,Dabelić S,Flögel M

    更新日期:1999-04-01 00:00:00

  • Functional mapping of the EcoRV DNA methyltransferase by random mutagenesis and screening for catalytically inactive mutants.

    abstract::M.EcoRV is an alpha-adenine DNA methyltransferase. According to structure predictions, the enzyme consists of a catalytic domain, which has a structure similar to all other DNA-methyltransferases, and a smaller DNA-recognition domain. We have investigated this enzyme by random mutagenesis, using error-prone PCR, follo...

    journal_title:Biological chemistry

    pub_type: 杂志文章

    doi:10.1515/bchm.1998.379.4-5.475

    authors: Friedrich T,Roth M,Helm-Kruse S,Jeltsch A

    更新日期:1998-04-01 00:00:00

  • Molecular determinants of Drosophila immunophilin FKBP39 nuclear localization.

    abstract::FK506-binding proteins (FKBPs) belong to a distinct class of immunophilins that interact with immunosuppressants. They use their peptidyl-prolyl isomerase (PPIase) activity to catalyze the cis-trans conversion of prolyl bonds in proteins during protein-folding events. FKBPs also act as a unique group of chaperones. Th...

    journal_title:Biological chemistry

    pub_type: 杂志文章

    doi:10.1515/hsz-2017-0251

    authors: Orłowski M,Popławska K,Pieprzyk J,Szczygieł-Sommer A,Więch A,Zarębski M,Tarczewska A,Dobrucki J,Ożyhar A

    更新日期:2018-04-25 00:00:00

  • Accumulation of mini-plasmin in the cerebral capillaries causes vascular invasion of the murine brain by a pneumotropic influenza A virus: implications for influenza-associated encephalopathy.

    abstract::The infectivity and pathogenicity of influenza virus are primarily determined by host cellular trypsin-type processing proteases which cleave the viral membrane fusion glycoprotein hemagglutinin (HA). Therefore the distribution of the processing protease is a major determinant of the infectious organ tropism. The comm...

    journal_title:Biological chemistry

    pub_type: 杂志文章,评审

    doi:10.1515/BC.2004.057

    authors: Yao D,Chen Y,Kuwajima M,Shiota M,Kido H

    更新日期:2004-06-01 00:00:00

  • Visualisation of transforming growth factor-beta 1, tissue kallikrein, and kinin and transforming growth factor-beta receptors on human clear-cell renal carcinoma cells.

    abstract::Transforming growth factor-beta1 (TGF-beta1) has a biphasic effect on the growth of renal epithelial cells. In transformed cells, TGF-beta1 appears to accelerate the proliferation of malignant cells. The diverse cellular functions of TGF-beta1 are regulated by three high-affinity serine/threonine kinase receptors, nam...

    journal_title:Biological chemistry

    pub_type: 杂志文章

    doi:10.1515/BC.2005.045

    authors: Moodley R,Snyman C,Odhav B,Bhoola KD

    更新日期:2005-04-01 00:00:00

  • DNA-binding specificity of PAR and C/EBP leucine zipper proteins: a single amino acid substitution in the C/EBP DNA-binding domain confers PAR-like specificity to C/EBP.

    abstract::PAR and C/EBP family proteins are liver-enriched basic leucine zipper (bZip) transcription factors that bind similar sites on the promoters of albumin and cholesterol 7 alpha hydroxylase genes. However, C/EBP proteins have a more relaxed binding specificity than PAR proteins, in that they recognize many sites within p...

    journal_title:Biological chemistry

    pub_type: 杂志文章

    doi:

    authors: Falvey E,Marcacci L,Schibler U

    更新日期:1996-12-01 00:00:00

  • Importance of tRNA interactions with 23S rRNA for peptide bond formation on the ribosome: studies with substrate analogs.

    abstract::The major enzymatic activity of the ribosome is the catalysis of peptide bond formation. The active site -- the peptidyl transferase center -- is composed of ribosomal RNA (rRNA), and interactions between rRNA and the reactants, peptidyl-tRNA and aminoacyl-tRNA, are crucial for the reaction to proceed rapidly and effi...

    journal_title:Biological chemistry

    pub_type: 杂志文章,评审

    doi:10.1515/BC.2007.077

    authors: Beringer M,Rodnina MV

    更新日期:2007-07-01 00:00:00