Vitamin C and superoxide dismutase (SOD) for diabetic retinopathy.

Abstract:

BACKGROUND:There is increasing evidence that diabetic retinopathy is caused by the action of free radicals. Radical scavengers like vitamin C and superoxide dismutase (SOD) may influence the outcome and progression of diabetic retinopathy, but no systematic review of the literature has been published to examine this hypothesis. OBJECTIVES:The aim of the current research was to review the literature in a standard systematic way in order to assess the effects of vitamin C and superoxide dismutase on diabetic retinopathy in methodologically robust trials. SEARCH STRATEGY:We tried to obtain studies from computerised searches of MEDLINE, EMBASE, CINAHL, Web of Science and The Cochrane Library. SELECTION CRITERIA:Only randomized clinical trials (RCTs) that evaluated the effect of vitamin C, superoxide dismutase or both in the treatment of diabetic retinopathy were considered. DATA COLLECTION AND ANALYSIS:Two authors independently read all abstracts, titles or both and wanted to assess risk of bias and to perform data extraction. Discrepancies were planned to be resolved by consensus or by the judgement of a third author. MAIN RESULTS:A total of 241 publications were identified by the electronic searches. Of these, 28 were identified as potentially containing information about the treatment of patients with diabetic retinopathy using vitamin C or SOD and were read in full. No trial evaluated the treatment of diabetic retinopathy with vitamin C or SOD. AUTHORS' CONCLUSIONS:No research to date has adequately examined the treatment of diabetic retinopathy with vitamin C or SOD in such a way as to indicate whether this form of intervention has a significant impact on the progress of this clinical condition. The potential role of these substances in the treatment of diabetic retinopathy remains open to debate, and it is suggested that future research focusing on patient-oriented outcomes should address this important issue.

authors

Lopes de Jesus CC,Atallah AN,Valente O,Moça Trevisani VF

doi

10.1002/14651858.CD006695.pub2

subject

Has Abstract

pub_date

2008-01-23 00:00:00

pages

CD006695

issue

1

issn

1469-493X

pub_type

杂志文章,评审
  • Financial benefits for child health and well-being in low income or socially disadvantaged families in developed world countries.

    abstract:BACKGROUND:A strong and consistent relationship has been observed between relative poverty and poor child health and wellbeing even among rich nations. This review set out to examine evidence that additional monies provided to poor or disadvantaged families may benefit children by reducing relative poverty and thereby ...

    journal_title:The Cochrane database of systematic reviews

    pub_type: 杂志文章,meta分析,评审

    doi:10.1002/14651858.CD006358.pub2

    authors: Lucas PJ,McIntosh K,Petticrew M,Roberts Hm,Shiell A

    更新日期:2008-04-16 00:00:00

  • Non-pharmacological interventions for epilepsy in people with intellectual disabilities.

    abstract:BACKGROUND:Approximately 30% of epilepsy patients remain refractory to drug treatment and continue to experience seizures whilst taking one or more antiepileptic drugs. There are a number of non-pharmacological interventions available to refractory patients which may be used in conjunction with or as an alternative to ...

    journal_title:The Cochrane database of systematic reviews

    pub_type: 杂志文章,评审

    doi:10.1002/14651858.CD005502.pub2

    authors: Beavis J,Kerr M,Marson AG

    更新日期:2007-10-17 00:00:00

  • Care delivery and self-management strategies for children with epilepsy.

    abstract:BACKGROUND:In response to criticism that epilepsy care for children has little impact, healthcare professionals and administrators have developed various service models and strategies to address perceived inadequacies. OBJECTIVES:To assess the effects of any specialised or dedicated intervention for epilepsy versus us...

    journal_title:The Cochrane database of systematic reviews

    pub_type: 杂志文章,评审

    doi:10.1002/14651858.CD006245.pub4

    authors: Fleeman N,Bradley PM

    更新日期:2018-03-01 00:00:00

  • Infection control strategies for preventing the transmission of meticillin-resistant Staphylococcus aureus (MRSA) in nursing homes for older people.

    abstract:BACKGROUND:Nursing homes for older people provide an environment likely to promote the acquisition and spread of meticillin-resistant Staphylococcus aureus (MRSA), putting residents at increased risk of colonisation and infection. It is recognised that infection prevention and control strategies are important in preven...

    journal_title:The Cochrane database of systematic reviews

    pub_type: 杂志文章,评审

    doi:10.1002/14651858.CD006354.pub4

    authors: Hughes C,Tunney M,Bradley MC

    更新日期:2013-11-19 00:00:00

  • Intravenous oxytocin alone for cervical ripening and induction of labour.

    abstract:BACKGROUND:Oxytocin is the commonest induction agent used worldwide. It has been used alone, in combination with amniotomy or following cervical ripening with other pharmacological or non-pharmacological methods. Prior to the introduction of prostaglandin agents oxytocin was used as a cervical ripening agent as well. I...

    journal_title:The Cochrane database of systematic reviews

    pub_type: 杂志文章,评审

    doi:10.1002/14651858.CD003246

    authors: Kelly AJ,Tan B

    更新日期:2001-01-01 00:00:00

  • Corticosteroid therapy for nephrotic syndrome in children.

    abstract:BACKGROUND:In nephrotic syndrome protein leaks from the blood to the urine through the glomeruli resulting in hypoproteinaemia and generalised oedema. While most children with nephrotic syndrome respond to corticosteroids, 80% experience a relapsing course. Corticosteroids have reduced the mortality rate to around 3%. ...

    journal_title:The Cochrane database of systematic reviews

    pub_type: 杂志文章,meta分析,评审

    doi:10.1002/14651858.CD001533.pub5

    authors: Hahn D,Hodson EM,Willis NS,Craig JC

    更新日期:2015-03-18 00:00:00

  • Uterine artery embolization for symptomatic uterine fibroids.

    abstract:BACKGROUND:Uterine fibroids cause heavy prolonged bleeding, pain, pressure symptoms and subfertility. The traditional method of treatment has been surgery as medical therapies have not proven effective. Uterine artery embolization has been reported to be an effective and safe alternative to treat fibroids in women not ...

    journal_title:The Cochrane database of systematic reviews

    pub_type: 杂志文章,meta分析,评审

    doi:10.1002/14651858.CD005073.pub4

    authors: Gupta JK,Sinha A,Lumsden MA,Hickey M

    更新日期:2014-12-26 00:00:00

  • Penicillin for secondary prevention of rheumatic fever.

    abstract:BACKGROUND:People with a history of rheumatic fever are at high risk of recurrent attacks of rheumatic fever and developing rheumatic heart disease following a streptococcal throat infection. Giving penicillin to these people can prevent recurrent attacks of rheumatic fever and subsequent rheumatic heart disease. Howev...

    journal_title:The Cochrane database of systematic reviews

    pub_type: 杂志文章,评审

    doi:10.1002/14651858.CD002227

    authors: Manyemba J,Mayosi BM

    更新日期:2002-01-01 00:00:00

  • Effects of glucocorticoids on radiological progression in rheumatoid arthritis.

    abstract:BACKGROUND:Glucocorticoid use in rheumatoid arthritis (RA) is widespread. Two Cochrane Reviews have been published examining the short term clinical benefit of low dose glucocorticoids compared to non-steroidal anti-inflammatory drugs and demonstrate good short term and medium term clinical benefits. The possibility th...

    journal_title:The Cochrane database of systematic reviews

    pub_type: 杂志文章,meta分析,评审

    doi:10.1002/14651858.CD006356

    authors: Kirwan JR,Bijlsma JW,Boers M,Shea BJ

    更新日期:2007-01-24 00:00:00

  • Direct-acting antivirals for chronic hepatitis C.

    abstract:BACKGROUND:Millions of people worldwide suffer from hepatitis C, which can lead to severe liver disease, liver cancer, and death. Direct-acting antivirals (DAAs) are relatively new and expensive interventions for chronic hepatitis C, and preliminary results suggest that DAAs may eradicate hepatitis C virus (HCV) from t...

    journal_title:The Cochrane database of systematic reviews

    pub_type: 杂志文章,meta分析,评审

    doi:10.1002/14651858.CD012143.pub2

    authors: Jakobsen JC,Nielsen EE,Feinberg J,Katakam KK,Fobian K,Hauser G,Poropat G,Djurisic S,Weiss KH,Bjelakovic M,Bjelakovic G,Klingenberg SL,Liu JP,Nikolova D,Koretz RL,Gluud C

    更新日期:2017-06-06 00:00:00

  • Perioperative nutrition for the treatment of bladder cancer by radical cystectomy.

    abstract:BACKGROUND:Radical cystectomy (RC) is the primary surgical treatment for muscle-invasive urothelial carcinoma of the bladder. This major operation is typically associated with an extended hospital stay, a prolonged recovery period and potentially major complications. Nutritional interventions are beneficial in some peo...

    journal_title:The Cochrane database of systematic reviews

    pub_type: 杂志文章

    doi:10.1002/14651858.CD010127.pub2

    authors: Burden S,Billson HA,Lal S,Owen KA,Muneer A

    更新日期:2019-05-20 00:00:00

  • Antenatal lower genital tract infection screening and treatment programs for preventing preterm delivery.

    abstract:BACKGROUND:Preterm birth is birth before 37 weeks' gestation. Genital tract infection is one of the causes of preterm birth. Infection screening during pregnancy has been used to reduce preterm birth. However, infection screening may have some adverse effects, e.g. increased antibiotic drug resistance, increased costs ...

    journal_title:The Cochrane database of systematic reviews

    pub_type: 杂志文章,评审

    doi:10.1002/14651858.CD006178.pub2

    authors: Swadpanich U,Lumbiganon P,Prasertcharoensook W,Laopaiboon M

    更新日期:2008-04-16 00:00:00

  • Inhaled sodium cromoglycate for asthma in children.

    abstract:BACKGROUND:Sodium cromoglycate has been recommended as maintenance treatment for childhood asthma for many years. Its use has decreased since 1990, when inhaled corticosteroids became popular, but it is still used in many countries. OBJECTIVES:To determine the efficacy of sodium cromoglycate compared to placebo in the...

    journal_title:The Cochrane database of systematic reviews

    pub_type: 杂志文章,meta分析,评审

    doi:10.1002/14651858.CD002173.pub2

    authors: van der Wouden JC,Uijen JH,Bernsen RM,Tasche MJ,de Jongste JC,Ducharme F

    更新日期:2008-10-08 00:00:00

  • Transfusion of fresher versus older red blood cells for all conditions.

    abstract:BACKGROUND:Red blood cell transfusion is a common treatment for anaemia in many clinical conditions. One current concern is uncertainty as to the clinical consequences (notably efficacy and safety) of transfusing red blood cell units that have been stored for different durations of time before a transfusion. If evidenc...

    journal_title:The Cochrane database of systematic reviews

    pub_type: 杂志文章,评审

    doi:10.1002/14651858.CD010801.pub2

    authors: Brunskill SJ,Wilkinson KL,Doree C,Trivella M,Stanworth S

    更新日期:2015-05-12 00:00:00

  • Local cooling for relieving pain from perineal trauma sustained during childbirth.

    abstract:BACKGROUND:Perineal trauma is common during childbirth and may be painful. Contemporary maternity practice includes offering women numerous forms of pain relief, including the local application of cooling treatments. This Cochrane Review is an update of a review last updated in 2012. OBJECTIVES:To evaluate the effecti...

    journal_title:The Cochrane database of systematic reviews

    pub_type: 杂志文章,meta分析

    doi:10.1002/14651858.CD006304.pub4

    authors: East CE,Dorward ED,Whale RE,Liu J

    更新日期:2020-10-09 00:00:00

  • Interventions for non-oliguric hyperkalaemia in preterm neonates.

    abstract:BACKGROUND:Non-oliguric hyperkalaemia of the newborn is defined as a plasma potassium level > 6.5 mmol/L in the absence of acute renal failure. Hyperkalaemia is a common complication in the first 48 hours of life in very low birth weight (birth weight < 1500 g) and/or very preterm newborns (< 32 weeks gestational age)....

    journal_title:The Cochrane database of systematic reviews

    pub_type: 杂志文章,meta分析,评审

    doi:10.1002/14651858.CD005257.pub2

    authors: Vemgal P,Ohlsson A

    更新日期:2007-01-24 00:00:00

  • Endoscopic retrograde cholangiopancreatography in gallstone-associated acute pancreatitis.

    abstract:BACKGROUND:Early endoscopic retrograde cholangio-pancreatography with or without endoscopic sphincterotomy (ERCP+/-ES) has been advocated to reduce complications in patients presenting with a severe attack of gallstone-associated acute pancreatitis (GAP). However, a recent trial has reported contradictory results. Impo...

    journal_title:The Cochrane database of systematic reviews

    pub_type: 杂志文章,meta分析,评审

    doi:10.1002/14651858.CD003630.pub2

    authors: Ayub K,Imada R,Slavin J

    更新日期:2004-10-18 00:00:00

  • Electronic mosquito repellents for preventing mosquito bites and malaria infection.

    abstract:BACKGROUND:Electronic mosquito repellents (EMRs) are marketed to prevent mosquitoes biting and to prevent malaria. OBJECTIVES:To assess whether EMRs prevent mosquito bites, and to assess any evidence of an effect on malaria infection. SEARCH STRATEGY:In August 2006, we searched the Cochrane Infectious Diseases Group ...

    journal_title:The Cochrane database of systematic reviews

    pub_type: 杂志文章,评审

    doi:10.1002/14651858.CD005434.pub2

    authors: Enayati AA,Hemingway J,Garner P

    更新日期:2007-04-18 00:00:00

  • Vaginal chlorhexidine during labour to prevent early-onset neonatal group B streptococcal infection.

    abstract:BACKGROUND:Early-onset group B beta-hemolytic streptococcus (GBS) infection accounts for approximately 30% of neonatal infections, has a high mortality rate and is acquired through vertical transmission from colonized mothers. Several trials have demonstrated the efficacy of intrapartum chemoprophylaxis (IPC) for preve...

    journal_title:The Cochrane database of systematic reviews

    pub_type: 杂志文章,评审

    doi:10.1002/14651858.CD003520.pub2

    authors: Stade B,Shah V,Ohlsson A

    更新日期:2004-01-01 00:00:00

  • Antioxidants for chronic kidney disease.

    abstract:BACKGROUND:Chronic kidney disease (CKD) is a significant risk factor for premature cardiovascular disease and death. Increased oxidative stress in people with CKD has been implicated as a potential causative factor for some cardiovascular diseases. Antioxidant therapy may reduce cardiovascular mortality and morbidity i...

    journal_title:The Cochrane database of systematic reviews

    pub_type: 杂志文章,meta分析,评审

    doi:10.1002/14651858.CD008176.pub2

    authors: Jun M,Venkataraman V,Razavian M,Cooper B,Zoungas S,Ninomiya T,Webster AC,Perkovic V

    更新日期:2012-10-17 00:00:00

  • Lithium for schizophrenia.

    abstract:BACKGROUND:Many people with schizophrenia do not achieve a satisfactory treatment response with ordinary antipsychotic drug treatment. In these cases, various add-on medications are used, among them lithium. OBJECTIVES:To review the effects of lithium for the treatment of schizophrenia and schizophrenia-like psychoses...

    journal_title:The Cochrane database of systematic reviews

    pub_type: 杂志文章,评审

    doi:10.1002/14651858.CD003834

    authors: Leucht S,McGrath J,Kissling W

    更新日期:2003-01-01 00:00:00

  • Long-acting inhaled bronchodilators for cystic fibrosis.

    abstract:BACKGROUND:Cystic fibrosis is a life-limiting inherited condition which affects one in 2500 newborns in the UK and 70,000 children and adults worldwide. The condition is multifaceted and affects many systems in the body. The respiratory system is particularly affected due to a build up of thickened secretions and a pre...

    journal_title:The Cochrane database of systematic reviews

    pub_type: 杂志文章,meta分析,评审

    doi:10.1002/14651858.CD012102.pub2

    authors: Smith S,Edwards CT

    更新日期:2017-12-19 00:00:00

  • Spinal cord stimulation for cancer-related pain in adults.

    abstract:BACKGROUND:This is an update of a review first published in The Cochrane Library in Issue 3, 2013. Cancer-related pain places a heavy burden on public health with related high expenditure. Severe pain is associated with a decreased quality of life in patients with cancer. A significant proportion of patients with cance...

    journal_title:The Cochrane database of systematic reviews

    pub_type: 杂志文章,评审

    doi:10.1002/14651858.CD009389.pub3

    authors: Peng L,Min S,Zejun Z,Wei K,Bennett MI

    更新日期:2015-06-29 00:00:00

  • Antioxidant supplements for prevention of mortality in healthy participants and patients with various diseases.

    abstract:BACKGROUND:Our systematic review has demonstrated that antioxidant supplements may increase mortality. We have now updated this review. OBJECTIVES:To assess the beneficial and harmful effects of antioxidant supplements for prevention of mortality in adults. SEARCH METHODS:We searched The Cochrane Library, MEDLINE, EM...

    journal_title:The Cochrane database of systematic reviews

    pub_type: 杂志文章,meta分析,评审

    doi:10.1002/14651858.CD007176.pub2

    authors: Bjelakovic G,Nikolova D,Gluud LL,Simonetti RG,Gluud C

    更新日期:2012-03-14 00:00:00

  • Local corticosteroid injection for carpal tunnel syndrome.

    abstract:BACKGROUND:Carpal tunnel syndrome is a clinical syndrome manifested by signs and symptoms of irritation of the median nerve at the level of the carpal tunnel in the wrist. Local corticosteroid injection for carpal tunnel syndrome has been studied but its effectiveness and duration of benefit of local corticosteroid inj...

    journal_title:The Cochrane database of systematic reviews

    pub_type: 杂志文章,meta分析,评审

    doi:10.1002/14651858.CD001554

    authors: Marshall S,Tardif G,Ashworth N

    更新日期:2002-01-01 00:00:00

  • Omega 3 fatty acid for the prevention of cognitive decline and dementia.

    abstract:BACKGROUND:Evidence from observational studies suggests that diets high in omega-3 long-chain polyunsaturated fatty acids (PUFA) may protect people from cognitive decline and dementia. The strength of this potential protective effect has recently been tested in randomised controlled trials. OBJECTIVES:To assess the ef...

    journal_title:The Cochrane database of systematic reviews

    pub_type: 杂志文章,meta分析,评审

    doi:10.1002/14651858.CD005379.pub3

    authors: Sydenham E,Dangour AD,Lim WS

    更新日期:2012-06-13 00:00:00

  • Post-operative radiotherapy for ductal carcinoma in situ of the breast.

    abstract:BACKGROUND:The addition of radiotherapy (RT) following breast conserving surgery (BCS) was first shown to reduce the risk of ipsilateral recurrence in the treatment of invasive breast cancer. Ductal carcinoma in situ (DCIS) is a pre-invasive lesion. Recurrence of ipsilateral disease following BCS can be either DCIS or ...

    journal_title:The Cochrane database of systematic reviews

    pub_type: 杂志文章,meta分析,评审

    doi:10.1002/14651858.CD000563.pub5

    authors: Goodwin A,Parker S,Ghersi D,Wilcken N

    更新日期:2009-07-08 00:00:00

  • Surgical versus conservative interventions for displaced intra-articular calcaneal fractures.

    abstract:BACKGROUND:Fractures of the calcaneus (heel bone) comprise up to 2% of all fractures. These fractures are mostly caused by a fall from a height, and are common in younger adults. Treatment can be surgical or non-surgical; however, there is clinical uncertainty over optimal management. OBJECTIVES:To assess the effects ...

    journal_title:The Cochrane database of systematic reviews

    pub_type: 杂志文章,meta分析,评审

    doi:10.1002/14651858.CD008628.pub2

    authors: Bruce J,Sutherland A

    更新日期:2013-01-31 00:00:00

  • Edaravone for acute intracerebral haemorrhage.

    abstract:BACKGROUND:Intracerebral haemorrhage (ICH) causes significant morbidity and mortality. Prognosis for ICH patients is poor. Edaravone may be safe and effective in reducing the risk of early death and improving long-term functional outcomes in survivors. OBJECTIVES:To assess the safety and efficacy of edaravone for acut...

    journal_title:The Cochrane database of systematic reviews

    pub_type: 杂志文章,meta分析,评审

    doi:10.1002/14651858.CD007755.pub2

    authors: Yang J,Liu M,Zhou J,Zhang S,Lin S,Zhao H

    更新日期:2011-02-16 00:00:00

  • Extracorporeal photopheresis versus standard treatment for acute graft-versus-host disease after haematopoietic stem cell transplantation in paediatric patients.

    abstract:BACKGROUND:Acute graft-versus-host disease (aGvHD) is a major cause of morbidity and mortality after haematopoietic stem cell transplantation (HSCT) occurring in 8% to 59% of the recipients. Currently, the therapeutic mainstay for aGvHD is corticosteroids. However, there is no established standard treatment for steroid...

    journal_title:The Cochrane database of systematic reviews

    pub_type: 杂志文章,评审

    doi:10.1002/14651858.CD009759.pub3

    authors: Weitz M,Strahm B,Meerpohl JJ,Schmidt M,Bassler D

    更新日期:2015-12-15 00:00:00