Homeotic genes and the arthropod head: expression patterns of the labial, proboscipedia, and Deformed genes in crustaceans and insects.

Abstract:

:cDNA fragments of the homologues of the Drosophila head homeotic genes labial (lab), proboscipedia (pb), and Deformed (Dfd) have been isolated from the crustacean Porcellio scaber. Because the accumulation domains of the head homeotic complex (Hox) genes had not been previously reported for crustaceans, we studied the expression patterns of these genes in P. scaber embryos by using in situ hybridization. The P. scaber lab homologue is expressed in the developing second antennal segment and its appendages. This expression domain in crustaceans and in the homologous intercalary segment of insects suggests that the lab gene specified this metamere in the last common ancestor of these two groups. The expression domain of the P. scaber pb gene is in the posterior part of the second antennal segment. This domain, in contrast to that in insects, is colinear with the domains of other head genes in P. scaber, and it differs from the insect pb gene expression domain in the posterior mouthparts, suggesting that the insect and crustacean patterns evolved independently from a broader ancestral domain similar to that found in modern chelicerates. P. scaber Dfd is expressed in the mandibular segment and paragnaths (a pair of ventral mouthpart structures associated with the stomodeum) and differs from insects, where expression is in the mandibular and maxillary segments. Thus, like pb, Dfd shows a divergent Hox gene deployment. We conclude that homologous structures of the mandibulate head display striking differences in their underlying developmental programs related to Hox gene expression.

authors

Abzhanov A,Kaufman TC

doi

10.1073/pnas.96.18.10224

keywords:

subject

Has Abstract

pub_date

1999-08-31 00:00:00

pages

10224-9

issue

18

eissn

0027-8424

issn

1091-6490

journal_volume

96

pub_type

杂志文章
  • Tumor-promoting phorbol esters stimulate myelopoiesis and suppress erythropoiesis in cultures of mouse bone marrow cells.

    abstract::Tumor-promoting phorbol esters affect the ability of mouse hematopoietic progenitor cells to form morphologically recognizable colonies in culture. They induce myeloid progenitor cells to form colonies of the monocyte/macrophage type in the absence of exogenous granulocyte/macrophage colony-stimulating factor. Convers...

    journal_title:Proceedings of the National Academy of Sciences of the United States of America

    pub_type: 杂志文章

    doi:10.1073/pnas.78.7.4402

    authors: Sieber F,Stuart RK,Spivak JL

    更新日期:1981-07-01 00:00:00

  • Mechanism of IgM polymerization.

    abstract::The stoichiometry of J chain in pentamer IgM has been determined by measuring the radiolabeled thiols in the constituent chains after complete reduction and alkylation of the polymer. One mole of J was found to be disulfide bonded to 1 mol of pentamer. The linkage of J chain in IgM has been determined by correlating t...

    journal_title:Proceedings of the National Academy of Sciences of the United States of America

    pub_type: 杂志文章

    doi:10.1073/pnas.71.3.657

    authors: Chapuis RM,Koshland ME

    更新日期:1974-03-01 00:00:00

  • Stimuli-responsive clustered nanoparticles for improved tumor penetration and therapeutic efficacy.

    abstract::A principal goal of cancer nanomedicine is to deliver therapeutics effectively to cancer cells within solid tumors. However, there are a series of biological barriers that impede nanomedicine from reaching target cells. Here, we report a stimuli-responsive clustered nanoparticle to systematically overcome these multip...

    journal_title:Proceedings of the National Academy of Sciences of the United States of America

    pub_type: 杂志文章

    doi:10.1073/pnas.1522080113

    authors: Li HJ,Du JZ,Du XJ,Xu CF,Sun CY,Wang HX,Cao ZT,Yang XZ,Zhu YH,Nie S,Wang J

    更新日期:2016-04-12 00:00:00

  • Carboxyfullerenes as neuroprotective agents.

    abstract::Two regioisomers with C3 or D3 symmetry of water-soluble carboxylic acid C60 derivatives, containing three malonic acid groups per molecule, were synthesized and found to be equipotent free radical scavengers in solution as assessed by EPR analysis. Both compounds also inhibited the excitotoxic death of cultured corti...

    journal_title:Proceedings of the National Academy of Sciences of the United States of America

    pub_type: 杂志文章

    doi:10.1073/pnas.94.17.9434

    authors: Dugan LL,Turetsky DM,Du C,Lobner D,Wheeler M,Almli CR,Shen CK,Luh TY,Choi DW,Lin TS

    更新日期:1997-08-19 00:00:00

  • Importance of growth hormone for the induction of hepatic low density lipoprotein receptors.

    abstract::This investigation was undertaken to determine the possible role of growth hormone (GH) in the hormonal regulation of hepatic low density lipoprotein (LDL) receptor expression. Treatment of normal rats with estrogen (ethynylestradiol, 5 mg/kg per day) increased the number of hepatic LDL receptors, and the LDL receptor...

    journal_title:Proceedings of the National Academy of Sciences of the United States of America

    pub_type: 杂志文章

    doi:10.1073/pnas.89.15.6983

    authors: Rudling M,Norstedt G,Olivecrona H,Reihnér E,Gustafsson JA,Angelin B

    更新日期:1992-08-01 00:00:00

  • Design and analysis of synthetic carbon fixation pathways.

    abstract::Carbon fixation is the process by which CO(2) is incorporated into organic compounds. In modern agriculture in which water, light, and nutrients can be abundant, carbon fixation could become a significant growth-limiting factor. Hence, increasing the fixation rate is of major importance in the road toward sustainabili...

    journal_title:Proceedings of the National Academy of Sciences of the United States of America

    pub_type: 杂志文章

    doi:10.1073/pnas.0907176107

    authors: Bar-Even A,Noor E,Lewis NE,Milo R

    更新日期:2010-05-11 00:00:00

  • High throughput 3D super-resolution microscopy reveals Caulobacter crescentus in vivo Z-ring organization.

    abstract::We created a high-throughput modality of photoactivated localization microscopy (PALM) that enables automated 3D PALM imaging of hundreds of synchronized bacteria during all stages of the cell cycle. We used high-throughput PALM to investigate the nanoscale organization of the bacterial cell division protein FtsZ in l...

    journal_title:Proceedings of the National Academy of Sciences of the United States of America

    pub_type: 杂志文章

    doi:10.1073/pnas.1313368111

    authors: Holden SJ,Pengo T,Meibom KL,Fernandez Fernandez C,Collier J,Manley S

    更新日期:2014-03-25 00:00:00

  • Transcriptional regulation of the tyrosine hydroxylase gene by glucocorticoid and cyclic AMP.

    abstract::Glucocorticoid and cyclic AMP increase tyrosine hydroxylase (TH) activity and mRNA levels in pheochromocytoma cultures. The transcriptional activity of the TH gene, as measured by nuclear run-on assay, is also increased when cultures are treated with the synthetic glucocorticoid dexamethasone or agents that increase i...

    journal_title:Proceedings of the National Academy of Sciences of the United States of America

    pub_type: 杂志文章

    doi:10.1073/pnas.84.11.3550

    authors: Lewis EJ,Harrington CA,Chikaraishi DM

    更新日期:1987-06-01 00:00:00

  • Detection and isolation of a new DNA polymerase from human breast tumor cell line HBT-3 by (dT)12-18-cellulose chromatography.

    abstract::Column chromatography on (dT)(12-18)-cellulose was used to detect and isolate a novel DNA polymerase activity from human breast tumor cell line HBT-3. The new enzyme is similar to those of mammalian RNA tumor viruses in its molecular size, preference for poly(A).(dT)(12-18) as compared to either poly(dA).(dT)(12-18) o...

    journal_title:Proceedings of the National Academy of Sciences of the United States of America

    pub_type: 杂志文章

    doi:10.1073/pnas.70.8.2453

    authors: Gerwin BI,Bassin RH

    更新日期:1973-08-01 00:00:00

  • CD22 ligand-binding and signaling domains reciprocally regulate B-cell Ca2+ signaling.

    abstract::A high proportion of human B cells carry B-cell receptors (BCRs) that are autoreactive. Inhibitory receptors such as CD22 can downmodulate autoreactive BCR responses. With its extracellular domain, CD22 binds to sialic acids in α2,6 linkages in cis, on the surface of the same B cell or in trans, on other cells. Sialic...

    journal_title:Proceedings of the National Academy of Sciences of the United States of America

    pub_type: 杂志文章

    doi:10.1073/pnas.1304888110

    authors: Müller J,Obermeier I,Wöhner M,Brandl C,Mrotzek S,Angermüller S,Maity PC,Reth M,Nitschke L

    更新日期:2013-07-23 00:00:00

  • Exploring the energy landscape in proteins.

    abstract::We present two methods to probe the energy landscape and motions of proteins in the context of molecular dynamics simulations of the helix-forming S-peptide of RNase A and the RNase A-3'-UMP enzyme-product complex. The first method uses the generalized ergodic measure to compute the rate of conformational space sampli...

    journal_title:Proceedings of the National Academy of Sciences of the United States of America

    pub_type: 杂志文章

    doi:10.1073/pnas.90.3.809

    authors: Straub JE,Thirumalai D

    更新日期:1993-02-01 00:00:00

  • von Willebrand disease type B: a missense mutation selectively abolishes ristocetin-induced von Willebrand factor binding to platelet glycoprotein Ib.

    abstract::von Willebrand factor (vWF) is a multimeric glycoprotein that mediates the adhesion of platelets to the subendothelium by binding to platelet glycoprotein Ib. For human vWF, this interaction can be induced in vitro by the antibiotic ristocetin or the snake venom protein botrocetin. A missense mutation, Gly-561-->Ser, ...

    journal_title:Proceedings of the National Academy of Sciences of the United States of America

    pub_type: 杂志文章

    doi:10.1073/pnas.89.20.9846

    authors: Rabinowitz I,Tuley EA,Mancuso DJ,Randi AM,Firkin BG,Howard MA,Sadler JE

    更新日期:1992-10-15 00:00:00

  • cGAS-mediated stabilization of IFI16 promotes innate signaling during herpes simplex virus infection.

    abstract::Interferon γ-inducible protein 16 (IFI16) and cGMP-AMP synthase (cGAS) have both been proposed to detect herpesviral DNA directly in herpes simplex virus (HSV)-infected cells and initiate interferon regulatory factor-3 signaling, but it has been unclear how two DNA sensors could both be required for this response. We ...

    journal_title:Proceedings of the National Academy of Sciences of the United States of America

    pub_type: 杂志文章

    doi:10.1073/pnas.1424637112

    authors: Orzalli MH,Broekema NM,Diner BA,Hancks DC,Elde NC,Cristea IM,Knipe DM

    更新日期:2015-04-07 00:00:00

  • Comparative genomics of the restriction-modification systems in Helicobacter pylori.

    abstract::Helicobacter pylori is a Gram-negative bacterial pathogen with a small genome of 1.64-1.67 Mb. More than 20 putative DNA restriction-modification (R-M) systems, comprising more than 4% of the total genome, have been identified in the two completely sequenced H. pylori strains, 26695 and J99, based on sequence similari...

    journal_title:Proceedings of the National Academy of Sciences of the United States of America

    pub_type: 杂志文章

    doi:10.1073/pnas.051612298

    authors: Lin LF,Posfai J,Roberts RJ,Kong H

    更新日期:2001-02-27 00:00:00

  • Structure-assisted redesign of a protein-zinc-binding site with femtomolar affinity.

    abstract::We have inserted a fourth protein ligand into the zinc coordination polyhedron of carbonic anhydrase II (CAII) that increases metal affinity 200-fold (Kd = 20 fM). The three-dimensional structures of threonine-199-->aspartate (T199D) and threonine-199-->glutamate (T199E) CAIIs, determined by x-ray crystallographic met...

    journal_title:Proceedings of the National Academy of Sciences of the United States of America

    pub_type: 杂志文章

    doi:10.1073/pnas.92.11.5017

    authors: Ippolito JA,Baird TT Jr,McGee SA,Christianson DW,Fierke CA

    更新日期:1995-05-23 00:00:00

  • Cytotoxic T cells: Lyt phenotype and blocking of killing activity by Lyt antisera.

    abstract::WE REEXAMINED TWO QUESTIONS CONCERNING LYT ANTIGENS OF CYTOTOXIC T CELLS OF THE MOUSE: is Lyt-1 antigen expressed on cytotoxic effector cells and can cytotoxicity be blocked by antibody to Lyt antigens in the absence of added complement? A 3-hr (51)Cr-release assay with splenic effector cells and leukemia or myeloma t...

    journal_title:Proceedings of the National Academy of Sciences of the United States of America

    pub_type: 杂志文章

    doi:10.1073/pnas.76.4.1977

    authors: Nakayama E,Shiku H,Stockert E,Oettgen HF,Old LJ

    更新日期:1979-04-01 00:00:00

  • Involvement of {beta}-catenin and unusual behavior of CBP and p300 in glucocorticosteroid signaling in Schwann cells.

    abstract::In the nervous system, glucocorticosteroid hormones play a major role during development and adult life. Myelin-forming cells are among the targets of glucocorticosteroids, which have been shown to promote myelination both in the central and peripheral nervous system. Glucocorticosteroid-stimulated gene transcription ...

    journal_title:Proceedings of the National Academy of Sciences of the United States of America

    pub_type: 杂志文章

    doi:10.1073/pnas.0506930102

    authors: Fonte C,Grenier J,Trousson A,Chauchereau A,Lahuna O,Baulieu EE,Schumacher M,Massaad C

    更新日期:2005-10-04 00:00:00

  • Antibodies to a peptide from the maize auxin-binding protein have auxin agonist activity.

    abstract::The major auxin-binding protein in maize membranes is thought to function as a physiological receptor. From earlier information, including the use of site-directed irreversible inhibitors, several of the amino acids likely to form part of the active auxin-binding site were provisionally assigned. Inspection of the ami...

    journal_title:Proceedings of the National Academy of Sciences of the United States of America

    pub_type: 杂志文章

    doi:10.1073/pnas.89.15.7208

    authors: Venis MA,Napier RM,Barbier-Brygoo H,Maurel C,Perrot-Rechenmann C,Guern J

    更新日期:1992-08-01 00:00:00

  • Converting Escherichia coli into an archaebacterium with a hybrid heterochiral membrane.

    abstract::One of the main differences between bacteria and archaea concerns their membrane composition. Whereas bacterial membranes are made up of glycerol-3-phosphate ester lipids, archaeal membranes are composed of glycerol-1-phosphate ether lipids. Here, we report the construction of a stable hybrid heterochiral membrane thr...

    journal_title:Proceedings of the National Academy of Sciences of the United States of America

    pub_type: 杂志文章

    doi:10.1073/pnas.1721604115

    authors: Caforio A,Siliakus MF,Exterkate M,Jain S,Jumde VR,Andringa RLH,Kengen SWM,Minnaard AJ,Driessen AJM,van der Oost J

    更新日期:2018-04-03 00:00:00

  • Relational representation in the olfactory system.

    abstract::The perceptual quality of odors usually is robust to variability in concentration. However, maps of neural activation across the olfactory bulb glomerular layer are not stable in this respect; rather, glomerular odor representations both broaden and intensify as odorant concentrations are increased. The relative level...

    journal_title:Proceedings of the National Academy of Sciences of the United States of America

    pub_type: 杂志文章

    doi:10.1073/pnas.0608564104

    authors: Cleland TA,Johnson BA,Leon M,Linster C

    更新日期:2007-02-06 00:00:00

  • Diagnostic power of diffuse reflectance spectroscopy for targeted detection of breast lesions with microcalcifications.

    abstract::Microcalcifications geographically target the location of abnormalities within the breast and are of critical importance in breast cancer diagnosis. However, despite stereotactic guidance, core needle biopsy fails to retrieve microcalcifications in up to 15% of patients. Here, we introduce an approach based on diffuse...

    journal_title:Proceedings of the National Academy of Sciences of the United States of America

    pub_type: 临床试验,杂志文章

    doi:10.1073/pnas.1215473110

    authors: Soares JS,Barman I,Dingari NC,Volynskaya Z,Liu W,Klein N,Plecha D,Dasari RR,Fitzmaurice M

    更新日期:2013-01-08 00:00:00

  • Cytosolic rat brain synapsin I is a diacylglycerol kinase.

    abstract::The phosphorylation of diacylglycerol (DG), a reaction catalyzed by DG kinase, may be critical in the termination of effector-induced signals mediated by protein kinase C. Synapsin I is a principal target of intracellular protein kinases and is thought to be involved in the release of neurotransmitter from axon termin...

    journal_title:Proceedings of the National Academy of Sciences of the United States of America

    pub_type: 杂志文章

    doi:10.1073/pnas.88.14.6137

    authors: Kahn DW,Besterman JM

    更新日期:1991-07-15 00:00:00

  • Circular single-stranded RNA replicon in Saccharomyces cerevisiae.

    abstract::Circular RNA replicons have been reported in plants and, in one case, in animal cells. We describe such an element in yeast. In certain yeast strains, a 20S RNA species appears on transfer of cells to acetate medium. This phenotype shows cytoplasmic (non-Mendelian) inheritance and the 20S RNA is associated with 23-kDa...

    journal_title:Proceedings of the National Academy of Sciences of the United States of America

    pub_type: 杂志文章

    doi:10.1073/pnas.87.19.7628

    authors: Matsumoto Y,Fishel R,Wickner RB

    更新日期:1990-10-01 00:00:00

  • Rlip depletion prevents spontaneous neoplasia in TP53 null mice.

    abstract::TP53 (p53) is a tumor suppressor whose functions are lost or altered in most malignancies. p53 homozygous knockout (p53-/-) mice uniformly die of spontaneous malignancy, typically T-cell lymphoma. RALBP1 (RLIP76, Rlip) is a stress-protective, mercapturic acid pathway transporter protein that also functions as a Ral ef...

    journal_title:Proceedings of the National Academy of Sciences of the United States of America

    pub_type: 杂志文章

    doi:10.1073/pnas.1719586115

    authors: Awasthi S,Tompkins J,Singhal J,Riggs AD,Yadav S,Wu X,Singh S,Warden C,Liu Z,Wang J,Slavin TP,Weitzel JN,Yuan YC,Awasthi M,Srivastava SK,Awasthi YC,Singhal SS

    更新日期:2018-04-10 00:00:00

  • Disparate actions of hydroxyurea in potentiation of purine and pyrimidine 2',3'-dideoxynucleoside activities against replication of human immunodeficiency virus.

    abstract::We and other groups have recently reported the potentiation by ribonucleotide reductase inhibitors such as hydroxyurea of the anti-human immunodeficiency virus type 1 (HIV-1) activity of purine and pyrimidine 2',3'-dideoxynucleosides in both resting and phytohemagglutinin-stimulated peripheral blood mononuclear cells....

    journal_title:Proceedings of the National Academy of Sciences of the United States of America

    pub_type: 杂志文章

    doi:10.1073/pnas.92.18.8333

    authors: Gao WY,Johns DG,Chokekuchai S,Mitsuya H

    更新日期:1995-08-29 00:00:00

  • Identification and characterization of the neurofibromatosis type 1 protein product.

    abstract::The neurofibromatosis type 1 (NF1) gene responsible for von Recklinghausen neurofibromatosis is related to regulators of ras proteins, and a portion of NF1 that is homologous to the ras GTPase-activating protein (GAP) encodes a similar GTPase-stimulating activity. We have raised rabbit antisera to a bacterially synthe...

    journal_title:Proceedings of the National Academy of Sciences of the United States of America

    pub_type: 杂志文章

    doi:10.1073/pnas.88.22.9914

    authors: DeClue JE,Cohen BD,Lowy DR

    更新日期:1991-11-15 00:00:00

  • Painting of fourth, a chromosome-specific protein in Drosophila.

    abstract::Chromosome-specific gene regulation is known thus far only as a mechanism to equalize the transcriptional activity of the single male X chromosome with that of the two female X chromosomes. In Drosophila melanogaster, a complex including the five Male-Specific Lethal (MSL) proteins, "paints" the male X chromosome, med...

    journal_title:Proceedings of the National Academy of Sciences of the United States of America

    pub_type: 杂志文章

    doi:10.1073/pnas.111581298

    authors: Larsson J,Chen JD,Rasheva V,Rasmuson-Lestander A,Pirrotta V

    更新日期:2001-05-22 00:00:00

  • Optical signatures of multifold fermions in the chiral topological semimetal CoSi.

    abstract::We report the optical conductivity in high-quality crystals of the chiral topological semimetal CoSi, which hosts exotic quasiparticles known as multifold fermions. We find that the optical response is separated into several distinct regions as a function of frequency, each dominated by different types of quasiparticl...

    journal_title:Proceedings of the National Academy of Sciences of the United States of America

    pub_type: 杂志文章

    doi:10.1073/pnas.2010752117

    authors: Xu B,Fang Z,Sánchez-Martínez MÁ,Venderbos JWF,Ni Z,Qiu T,Manna K,Wang K,Paglione J,Bernhard C,Felser C,Mele EJ,Grushin AG,Rappe AM,Wu L

    更新日期:2020-11-03 00:00:00

  • Exogenous expression of mouse interferon gamma cDNA in mouse neuroblastoma C1300 cells results in reduced tumorigenicity by augmented anti-tumor immunity.

    abstract::To examine the influence of interferon gamma (IFN-gamma) on tumorigenicity, we established constitutively IFN-gamma-producing cell lines from a malignant mouse neuroblastoma, C1300, by retroviral transfer of a mouse IFN-gamma cDNA. The gene-transferred cells generally showed an enhanced high-level expression of the ma...

    journal_title:Proceedings of the National Academy of Sciences of the United States of America

    pub_type: 杂志文章

    doi:10.1073/pnas.86.23.9456

    authors: Watanabe Y,Kuribayashi K,Miyatake S,Nishihara K,Nakayama E,Taniyama T,Sakata T

    更新日期:1989-12-01 00:00:00

  • An α/β-hydrolase fold protein in the biosynthesis of thiostrepton exhibits a dual activity for endopeptidyl hydrolysis and epoxide ring opening/macrocyclization.

    abstract::Thiostrepton (TSR), an archetypal bimacrocyclic thiopeptide antibiotic that arises from complex posttranslational modifications of a genetically encoded precursor peptide, possesses a quinaldic acid (QA) moiety within the side-ring system of a thiopeptide-characteristic framework. Focusing on selective engineering of ...

    journal_title:Proceedings of the National Academy of Sciences of the United States of America

    pub_type: 杂志文章

    doi:10.1073/pnas.1612607113

    authors: Zheng Q,Wang S,Duan P,Liao R,Chen D,Liu W

    更新日期:2016-12-13 00:00:00