Multiple neonatal endocrinopathies in McCune-Albright syndrome.

Abstract:

:Two cases of McCune-Albright syndrome (MAS) are reported who presented in the neonatal period with profound failure to thrive, cardio-respiratory distress, precocious puberty and Cushing's syndrome for which both underwent bilateral adrenalectomy. Both girls had also bilateral nephrocalcinosis; in one case that may have been attributed to Cushing's syndrome, but in the second case the cause remained obscure with no obvious abnormality of calcium metabolism. The first girl had hydrocephalus which is uncommon in this condition and the second girl still failed to thrive at the age of 6 years, despite adequate caloric intake and hormonal manipulation. A constellation of other abnormal features are described. These cases illustrate the complexity of MAS which can become a life-threatening or a debilitating disorder.

authors

Bareille P,Azcona C,Stanhope R

doi

10.1046/j.1440-1754.1999.00337.x

keywords:

subject

Has Abstract

pub_date

1999-06-01 00:00:00

pages

315-8

issue

3

eissn

1034-4810

issn

1440-1754

journal_volume

35

pub_type

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