Differential increase in Fos immunoreactivity in hypothalamic and septal nuclei by arginine8-vasopressin and desglycinamide9-arginine8-vasopressin.

Abstract:

:Subcutaneous or intracerebroventricular injection of either arginine8-vasopressin or desglycinamide9-arginine8-vasopressin has been shown to facilitate memory, reduce or reverse the effects of amnesic drugs, and maintain tolerance to some effects of ethanol. These actions of vasopressin (and, by inference, of desglycinamide9-arginine8-vasopressin) are mediated by vasopressin V1 receptors in brain, via a c-fos-dependent mechanism, but the receptors at which the desglycinamide analog acts have not been identified. The precise central sites are also not known, but evidence of several types suggested the anterior hypothalamus and septum as probable loci of vasopressin action. In the present work, this question was studied by immunocytochemistry, using antibodies against Fos and Fos-like proteins. The numbers of Fos-immunoreactive nuclei were counted in several related brain regions and structures, after administration of arginine8-vasopressin, des-Gly9-[Arg8]-vasopressin or saline. A subcutaneous injection of vasopressin, but not of saline, enhanced Fos expression in the paraventricular, supraoptic and suprachiasmatic nuclei of the hypothalamus, but the desglycinamide analog stimulated Fos expression only in the suprachiasmatic nucleus. Vasopressin injection significantly increased the number of Fos-immunoreactive cells in the intermediate lateral septum, medial septum, and dorsal and ventral divisions of the lateral septum. In contrast, the desglycinamide analog increased the numbers of Fos-immunoreactive cells in the dorsal and intermediate portions of the lateral septum, but caused no change in the medial septum, and a decrease in the ventral portion of the lateral septum. Increased Fos expression was also found in the subfornical organ after subcutaneous injection of either vasopressin or the desglycinamide analog. Double labeling with antibodies against Fos protein and against vasopressin revealed that most of the vasopressin-induced Fos-immunoreactive cells in the supraoptic, paraventricular and suprachiasmatic hypothalamic nuclei are also vasopressin immunoreactive, i.e. they are vasopressin-producing neurons. These findings suggest that a circuit involving V1 receptors in the subfornical organ, connecting fibres to the suprachiasmatic nucleus, and vasopressinergic projections from the suprachiasmatic nucleus to the lateral septum, may play a central role in mediating the actions of both vasopressin and its desglycinamide analog in the maintenance of ethanol tolerance.

journal_name

Neuroscience

journal_title

Neuroscience

authors

Lança AJ,Wu PH,Jung B,Liu JF,Ng V,Kalant H

doi

10.1016/s0306-4522(98)00709-x

keywords:

subject

Has Abstract

pub_date

1999-01-01 00:00:00

pages

1331-41

issue

4

eissn

0306-4522

issn

1873-7544

pii

S0306-4522(98)00709-X

journal_volume

91

pub_type

杂志文章
  • Excitatory actions of GABA in developing brain are mediated by l-type Ca2+ channels and dependent on age, sex, and brain region.

    abstract::Although GABA is the major inhibitory neurotransmitter in adult brain, it exerts depolarizing actions in developing neurons that include activation of voltage-gated calcium channels. The depolarizing actions of GABA serve an obvious trophic function, but the specific physiological significance of excitatory versus inh...

    journal_title:Neuroscience

    pub_type: 杂志文章

    doi:10.1016/s0306-4522(02)00794-7

    authors: Perrot-Sinal TS,Auger AP,McCarthy MM

    更新日期:2003-01-01 00:00:00

  • Ipsilateral versus contralateral spontaneous post-stroke neuroplastic changes: involvement of BDNF?

    abstract::Stroke is a leading cause of death and disability in industrialized countries. Although surviving patients exhibit a certain degree of restoration of function attributable to brain plasticity, the majority of stroke survivors has to struggle with persisting deficits. In order to potentiate post-stroke recovery, severa...

    journal_title:Neuroscience

    pub_type: 杂志文章

    doi:10.1016/j.neuroscience.2012.11.054

    authors: Madinier A,Bertrand N,Rodier M,Quirié A,Mossiat C,Prigent-Tessier A,Marie C,Garnier P

    更新日期:2013-02-12 00:00:00

  • Effects of preconditioning with normobaric hyperoxia on Na⁺/Ca²⁺ exchanger in the rat brain.

    abstract:BACKGROUND:Recent studies suggest that normobaric hyperoxia (HO) reduces hypoxia-reoxygenation injury in the rat brain. We have attempted to determine the effect of HO on Na(+)-Ca(2+) exchangers (NCX) in the rat stroke model. METHODS:Rats were divided into two experimental groups. The first group was exposed to 95% in...

    journal_title:Neuroscience

    pub_type: 杂志文章

    doi:10.1016/j.neuroscience.2013.01.064

    authors: Mohammadi E,Bigdeli MR

    更新日期:2013-05-01 00:00:00

  • Growth factor regulation of neurogenesis in adult olfactory epithelium.

    abstract::Neurogenesis continues throughout adult life in the mammalian olfactory epithelium. This process is a dynamic state of proliferation, differentiation and cell death, probably regulated by autocrine and paracrine signals such as peptide growth factors. Previous investigations have demonstrated roles for some growth fac...

    journal_title:Neuroscience

    pub_type: 杂志文章

    doi:10.1016/s0306-4522(00)00194-9

    authors: Newman MP,Féron F,Mackay-Sim A

    更新日期:2000-01-01 00:00:00

  • Visually guided reaching with the forelimb contralateral to a "blind" hemisphere in the monkey: contribution of the cerebellum.

    abstract::Metabolic activity was mapped in the cerebellar cortex and its major inputs and projection targets in monkeys performing visually guided reaching with the left forelimb. Normal monkeys and monkeys deprived of visual input to the right cerebral hemisphere by right optic tract section, combined in some cases with forebr...

    journal_title:Neuroscience

    pub_type: 杂志文章

    doi:10.1016/0306-4522(96)00258-8

    authors: Savaki HE,Kennedy C,Sokoloff L,Mishkin M

    更新日期:1996-11-01 00:00:00

  • Progesterone increases oligodendroglial cell proliferation in rat cerebellar slice cultures.

    abstract::We have previously demonstrated that progesterone significantly increases the rate of myelination in organotypic slice cultures of 7-day-old rat and mouse cerebellum. Here, we show that progesterone (20microM) stimulates the proliferation of oligodendrocyte precursors in cultured cerebellar slices of 7-day-old rats. T...

    journal_title:Neuroscience

    pub_type: 杂志文章

    doi:10.1016/j.neuroscience.2005.05.023

    authors: Ghoumari AM,Baulieu EE,Schumacher M

    更新日期:2005-01-01 00:00:00

  • Kainic acid microinjected into the cat raphe dorsal nucleus modulates the somatosensory evoked potentials and their cycles of excitability.

    abstract::Studies were made on the effect of the neuroexcitatory agent kainic acid, microinjected into raphe dorsal nucleus by glass micropipette and an air pressure system in doses ranging from 0.2 to 24.0 nmol (in volumes from 0.05 microliter to 0.47 microliter), on the somatosensory evoked potentials and their cycles of reco...

    journal_title:Neuroscience

    pub_type: 杂志文章

    doi:10.1016/0306-4522(87)90199-0

    authors: Moyanova S,Dimov S,Ivanova A

    更新日期:1987-07-01 00:00:00

  • Alteration of activator protein 1 DNA binding activity in gentamicin-induced hair cell degeneration.

    abstract::Sensorineural hearing loss is often associated with damage of cochlear hair cells and/or of the neurons of the auditory pathway. This damage can result from a variety of causes, e.g. genetic disorders, aging, exposure to certain drugs such as aminoglycosides, infectious disease and intense sound overexposure. Intracel...

    journal_title:Neuroscience

    pub_type: 杂志文章

    doi:10.1016/j.neuroscience.2005.10.010

    authors: Albinger-Hegyi A,Hegyi I,Nagy I,Bodmer M,Schmid S,Bodmer D

    更新日期:2006-02-01 00:00:00

  • Nerve-induced release of nitric oxide from the rabbit corpus cavernosum is modulated by cyclic guanosine 3',5'-monophosphate.

    abstract::Nitric oxide (NO) is a neurotransmitter of the autonomic nerves in the urogenital tract, in particular the release of NO in the cavernous tissue is of importance for maintaining erection. However, the regulation of NO formation in neurons of the corpus cavernosum is poorly understood. Here, we report, that upon electr...

    journal_title:Neuroscience

    pub_type: 杂志文章

    doi:10.1016/j.neuroscience.2005.02.015

    authors: Hallén K,Gustafsson LE,Wiklund NP

    更新日期:2005-01-01 00:00:00

  • Prenatal exposure to ethanol stimulates hypothalamic CCR2 chemokine receptor system: Possible relation to increased density of orexigenic peptide neurons and ethanol drinking in adolescent offspring.

    abstract::Clinical and animal studies indicate that maternal consumption of ethanol during pregnancy increases alcohol drinking in the offspring. Possible underlying mechanisms may involve orexigenic peptides, which are stimulated by prenatal ethanol exposure and themselves promote drinking. Building on evidence that ethanol st...

    journal_title:Neuroscience

    pub_type: 杂志文章

    doi:10.1016/j.neuroscience.2015.09.020

    authors: Chang GQ,Karatayev O,Leibowitz SF

    更新日期:2015-12-03 00:00:00

  • Differential Activation and Functional Plasticity of Multimodal Areas Associated with Acquired Musical Skill.

    abstract::Training of a musical skill is known to produce a distributed neural representation of the ability to perceive music and perform musical tasks. In the present study we tested the hypothesis that the audiovisual perception of music involves a wider activation of multimodal sensory and sensorimotor structures in the bra...

    journal_title:Neuroscience

    pub_type: 杂志文章

    doi:10.1016/j.neuroscience.2020.08.013

    authors: Srinivasan N,Bishop J,Yekovich R,Rosenfield DB,Helekar SA

    更新日期:2020-10-15 00:00:00

  • Neurotoxic effects of colchicine: differential susceptibility of CNS neuronal populations.

    abstract::Colchicine injected into the dentate gyrus of the hippocampus in adult rats preferentially destroys dentate granule cells. In the present study, we examine the light- and electron-microscopic correlates of the degeneration and evaluate whether the selectivity is preserved across the range of doses between 0.18 and 25 ...

    journal_title:Neuroscience

    pub_type: 杂志文章

    doi:10.1016/0306-4522(82)90075-6

    authors: Goldschmidt RB,Steward O

    更新日期:1982-03-01 00:00:00

  • Excitatory amino acid receptors in the periaqueductal gray mediate the cardiovascular response evoked by activation of dorsomedial hypothalamic neurons.

    abstract::Neurons in the region of dorsomedial hypothalamus are involved in the organization of the physiological responses to emotional stress. We have recently shown that the cardiovascular response evoked by activation of dorsomedial hypothalamus neurons is largely dependent on a synaptic relay with the lateral/dorsolateral ...

    journal_title:Neuroscience

    pub_type: 杂志文章

    doi:10.1016/j.neuroscience.2005.12.041

    authors: da Silva LG Jr,Menezes RC,Villela DC,Fontes MA

    更新日期:2006-01-01 00:00:00

  • Regulation of acetylcholinesterase in cultured muscle by chemical agents and electrical stimulation.

    abstract::Cultures of 11 day old chick embryo pectoral muscle were used to study the effects of direct electrical stimulation and neurochemicals such as acetylcholine, acetyl-beta-methylcholine, tetrodotoxin, and d-tubocurarine on the acetylcholinesterase levels of muscle. The results suggest that excitation-contraction is an i...

    journal_title:Neuroscience

    pub_type: 杂志文章

    doi:10.1016/0306-4522(76)90076-2

    authors: Walker CR,Wilson BW

    更新日期:1976-06-01 00:00:00

  • Focal Suppression of Epileptiform Activity in the Hippocampus by a High-frequency Magnetic Field.

    abstract::Electric current has been used for epilepsy treatment by targeting specific neural circuitries. Despite its success, direct contact between the electrode and tissue could cause side effects including pain, inflammation, and adverse biological reactions. Magnetic stimulation overcomes these limitations by offering adva...

    journal_title:Neuroscience

    pub_type: 杂志文章

    doi:10.1016/j.neuroscience.2020.02.018

    authors: Ye H,Chen VC,Helon J,Apostolopoulos N

    更新日期:2020-04-15 00:00:00

  • Trading new neurons for status: Adult hippocampal neurogenesis in eusocial Damaraland mole-rats.

    abstract::Diversity in social structures, from solitary to eusocial, is a prominent feature of subterranean African mole-rat species. Damaraland mole-rats are eusocial, they live in colonies that are characterized by a reproductive division of labor and a subdivision into castes based on physiology and behavior. Damaraland mole...

    journal_title:Neuroscience

    pub_type: 杂志文章

    doi:10.1016/j.neuroscience.2016.03.020

    authors: Oosthuizen MK,Amrein I

    更新日期:2016-06-02 00:00:00

  • Changes in lipid composition of neuroblastoma C1300 N18 cell during differentiation.

    abstract::Phospholipids and cholesterol were found to be the main lipids in mature and immature neuroblastoma cells. The ratios for the total cholesterol/phospholipids in these undifferentiated and differentiated cells were 0.33 and 0.52, respectively. The ratios of 0.45 and 0.62 were obtained with corresponding plasma membrane...

    journal_title:Neuroscience

    pub_type: 杂志文章

    doi:10.1016/0306-4522(89)90361-8

    authors: Gulaya NM,Volkov GL,Klimashevsky VM,Govseeva NN,Melnik AA

    更新日期:1989-01-01 00:00:00

  • Detection of homovanillic acid in vivo using microcomputer-controlled voltammetry: simultaneous monitoring of rat motor activity and striatal dopamine release.

    abstract::Linear sweep voltammograms recorded with carbon paste electrodes in the striatum of the unanaesthetised, unrestrained rat show three separate peaks. The effect on peak 3 of either unilateral 6-hydroxydopamine lesion of the substantia nigra or intraperitoneal administration of alpha-methyl-paratyrosine, supports our ea...

    journal_title:Neuroscience

    pub_type: 杂志文章

    doi:10.1016/0306-4522(85)90140-x

    authors: O'Neill RD,Fillenz M

    更新日期:1985-03-01 00:00:00

  • Immunohistochemical localization of protein-O-carboxylmethyltransferase in rat brain neurons.

    abstract::The distribution of the enzyme protein-O-carboxylmethyltransferase (EC 2.1.1.24) has been investigated in the rat brain using both immunohistochemical and biochemical techniques. The enzyme, which carboxylmethylates free aspartic and glutamic acid residues of protein substrates, was localized in neurons, but not other...

    journal_title:Neuroscience

    pub_type: 杂志文章

    doi:10.1016/0306-4522(85)90130-7

    authors: Billingsley ML,Kim S,Kuhn DM

    更新日期:1985-05-01 00:00:00

  • Ectopic uterine tissue as a chronic pain generator.

    abstract::While chronic pain is a main symptom in endometriosis, the underlying mechanisms and effective therapy remain elusive. We developed an animal model enabling the exploration of ectopic endometrium as a source of endometriosis pain. Rats were surgically implanted with autologous uterus in the gastrocnemius muscle. Withi...

    journal_title:Neuroscience

    pub_type: 杂志文章

    doi:10.1016/j.neuroscience.2012.08.033

    authors: Alvarez P,Chen X,Hendrich J,Irwin JC,Green PG,Giudice LC,Levine JD

    更新日期:2012-12-06 00:00:00

  • Choline acetyltransferase-like immunoreactivity in the hippocampal formation of control subjects and patients with Alzheimer's disease.

    abstract::A qualitative and quantitative immunohistochemical study of cholinergic systems in the human hippocampal formation was performed with an antibody against choline acetyltransferase. Four control subjects and six patients with Alzheimer's disease, matched for age and post-mortem delay, were examined. Immunoreactive nerv...

    journal_title:Neuroscience

    pub_type: 杂志文章

    doi:10.1016/0306-4522(89)90291-1

    authors: Ransmayr G,Cervera P,Hirsch E,Ruberg M,Hersh LB,Duyckaerts C,Hauw JJ,Delumeau C,Agid Y

    更新日期:1989-01-01 00:00:00

  • Expression of brain-derived neurotrophic factor protein in the adult rat central nervous system.

    abstract::We have generated and characterized a multi-functional polyclonal anti-brain-derived neurotrophic factor antibody. Western blot analysis, dorsal root ganglion neurite outgrowth and dorsal root ganglion neuron survival assays showed that this antibody specifically recognized brain-derived neurotrophic factor and not th...

    journal_title:Neuroscience

    pub_type: 杂志文章

    doi:10.1016/s0306-4522(96)00613-6

    authors: Yan Q,Rosenfeld RD,Matheson CR,Hawkins N,Lopez OT,Bennett L,Welcher AA

    更新日期:1997-05-01 00:00:00

  • Electrophysiological, pharmacological and molecular profile of the transient outward rectifying conductance in rat sympathetic preganglionic neurons in vitro.

    abstract::Transient outward rectifying conductances or A-like conductances in sympathetic preganglionic neurons (SPN) are prolonged, lasting for hundreds of milliseconds to seconds and are thought to play a key role in the regulation of SPN firing frequency. Here, a multidisciplinary electrophysiological, pharmacological and mo...

    journal_title:Neuroscience

    pub_type: 杂志文章

    doi:10.1016/j.neuroscience.2010.12.061

    authors: Whyment AD,Coderre E,Wilson JM,Renaud LP,O'Hare E,Spanswick D

    更新日期:2011-03-31 00:00:00

  • Inactivation of large-conductance, calcium-activated potassium channels in rat cortical neurons.

    abstract::Inside-out patch recordings from rat acutely dissociated cerebral cortical neurons revealed time and voltage-dependent activity of a large-conductance calcium-activated potassium channel. Channel activity inactivated within minutes following a depolarizing voltage step, and was recovered from inactivation by membrane ...

    journal_title:Neuroscience

    pub_type: 杂志文章

    doi:10.1016/s0306-4522(99)00425-x

    authors: Smith MA,Ashford ML

    更新日期:2000-01-01 00:00:00

  • Sex comparison of neuronal Fos immunoreactivity in the rat vomeronasal projection circuit after chemosensory stimulation.

    abstract::In rodents, reproductively relevant pheromonal cues are detected by receptors in the vomeronasal organ, which in turn transmit this information centrally via the accessory olfactory bulb, the medial nucleus of the amygdala, the posterior medial bed nucleus of the stria terminalis and the medial preoptic area. In the r...

    journal_title:Neuroscience

    pub_type: 杂志文章

    doi:10.1016/0306-4522(95)00493-9

    authors: Bressler SC,Baum MJ

    更新日期:1996-04-01 00:00:00

  • Long-term potentiation in visual cortical projections to the medial prefrontal cortex of the rat.

    abstract::In order to investigate neural mechanisms by which the prefrontal cortex adaptively modifies its activities based on past experience, we examined whether or not sensory cortical projections to the medial prefrontal cortex support long-term potentiation (LTP) in rats. Monosynaptic projections from the secondary visual ...

    journal_title:Neuroscience

    pub_type: 杂志文章

    doi:10.1016/s0306-4522(03)00021-6

    authors: Kim MJ,Chun SK,Kim YB,Mook-Jung I,Jung MW

    更新日期:2003-01-01 00:00:00

  • Developing a stable bilateral model of parkinsonism in rhesus monkeys.

    abstract::The non-human primate models of Parkinson's disease which have been developed using the neurotoxin MPTP (1-methyl-4-phenyl-1,2,3,6 tetrahydropyridine) have proven to be either unstable or variable, or to display only a limited subset of parkinsonian features. The present study examined a new two-stage lesion approach ...

    journal_title:Neuroscience

    pub_type: 杂志文章

    doi:10.1016/0306-4522(93)90176-g

    authors: Smith RD,Zhang Z,Kurlan R,McDermott M,Gash DM

    更新日期:1993-01-01 00:00:00

  • Muscle stiffness and continuous electromyographic activity in old rats; an animal model for spasticity?

    abstract::A mechanomyographic response of the hind foot to passive straightening and bending, as well as an electromyographic activity of the gastrocnemius and tibialis anterior muscles were recorded in old (35-44-month-old) and young female rats. In old rats, spontaneous, tonic electromyographic activity patterns were concurre...

    journal_title:Neuroscience

    pub_type: 杂志文章

    doi:10.1016/0306-4522(92)90481-g

    authors: Ossowska K,Schulze G,Wolfarth S,Coper H,Kaminska A,Hausmanowa-Petrusewicz I

    更新日期:1992-11-01 00:00:00

  • The development of lasting impairments: a mild pediatric brain injury alters gene expression, dendritic morphology, and synaptic connectivity in the prefrontal cortex of rats.

    abstract::Apart from therapeutic discovery, the study of mild traumatic brain injury (mTBI) has been focused on two challenges: why do a majority of individuals recover with little concern, while a considerable proportion suffer with persistent and often debilitating symptomology; and, how do mild injuries significantly increas...

    journal_title:Neuroscience

    pub_type: 杂志文章

    doi:10.1016/j.neuroscience.2014.12.034

    authors: Mychasiuk R,Hehar H,Ma I,Kolb B,Esser MJ

    更新日期:2015-03-12 00:00:00

  • A 'single toxin-double lesion' rat model of striatonigral degeneration by intrastriatal 1-methyl-4-phenylpyridinium ion injection: a motor behavioural analysis.

    abstract::Previous attempts to reproduce striatonigral degeneration, the core pathology underlying Parkinsonism in multiple system atrophy, have been impeded by interactions in the neurotoxins used to replicate striatal and nigral degeneration in rodents. To overcome these interactions, we have developed a new model of striaton...

    journal_title:Neuroscience

    pub_type: 杂志文章

    doi:10.1016/s0306-4522(02)00401-3

    authors: Ghorayeb I,Fernagut PO,Hervier L,Labattu B,Bioulac B,Tison F

    更新日期:2002-01-01 00:00:00