Abstract:
:Several lines of evidence suggest that the ubiquitin-proteasome pathway is involved in sepsis-induced muscle catabolism. The gene expression of ubiquitin and several of the proteasome subunits was increased in muscle from both septic rats and patients. In other studies, the activity of isolated 20S proteasomes was stimulated in septic muscles. Sepsis-induced increase in muscle total and myofibrillar protein breakdown was inhibited with specific proteasome blockers. Although the ubiquitin-proteasome pathway is upregulated in septic muscle, it is still unclear how the myofibrillar proteins actin and myosin are ubiquitinated and become substrates for the 26S proteasome. Recent studies suggest that a calcium-dependent, calpain-mediated process releases myofilaments from the Z-disks during sepsis. It is possible that this process exposes destabilizing N-terminal residues on actin and myosin, making them suitable substrates for the N-end rule pathway involving the 14 kD ubiquitin-conjugating enzyme E214k and the ubiquitin-protein ligase E3alpha.
journal_name
Mol Biol Repjournal_title
Molecular biology reportsauthors
Hasselgren POdoi
10.1023/a:1006916206260keywords:
subject
Has Abstractpub_date
1999-04-01 00:00:00pages
71-6issue
1-2eissn
0301-4851issn
1573-4978journal_volume
26pub_type
杂志文章,评审abstract::The oriental fruit moth, Grapholita molesta (Busck) (Lepidoptera: Tortricidae) currently is one of the economically most destructive pest species of stone and pome fruits worldwide. Here we sequenced the complete mitochondrial genome of this pest. This genome is 15,776 bp long, with an A + T content of 81.24%, contain...
journal_title:Molecular biology reports
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journal_title:Molecular biology reports
pub_type: 杂志文章
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pub_type: 杂志文章
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pub_type: 杂志文章
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journal_title:Molecular biology reports
pub_type: 杂志文章,meta分析
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journal_title:Molecular biology reports
pub_type: 杂志文章
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更新日期:2011-02-01 00:00:00
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journal_title:Molecular biology reports
pub_type: 杂志文章
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更新日期:2014-12-01 00:00:00
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journal_title:Molecular biology reports
pub_type: 杂志文章
doi:10.1007/BF00778522
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