当前位置： SCI文献检索 > THROMBOSIS AND HAEMOSTASIS期刊下所有文献 > Prevalence of three common polymorphisms in the A-subunit gene of factor XIII in patients with coronary artery disease.

Prevalence of three common polymorphisms in the A-subunit gene of factor XIII in patients with coronary artery disease.

Abstract：

:Activated blood coagulation factor XIII has an important role in the final stage of the clotting cascade by the covalent crosslinking of alpha- and gamma-fibrin chains. We have recently shown that a functional polymorphism in exon 2. codon 34 of the FXIII A-subunit gene is protective against myocardial infarction. To investigate the prevalence of three other common point mutations in the A-subunit gene (codon 564, C to T, 650 G to A and 651 G to C) and their association with FXIII activity and antigen levels, 275 patients with coronary artery disease and 196 controls were studied. There was no difference in the prevalence of the polymorphisms between patients and controls or between patients with or without MI. Only genotype at codon 564 was associated with FXIII activity with lower activities in subjects possessing the T allele. There was evidence of linkage disequilibrium between codon 34 and codon 564. These results suggest that FXIIIVal34Leu is the only common polymorphism in the coding region of the A-subunit gene of FXIII associated with coronary artery disease.

journal_name

Thromb Haemost

journal_title

Thrombosis and haemostasis

authors

Kohler HP,Futers TS,Grant PJ

keywords:

subject

Has Abstract

pub_date

1999-04-01 00:00:00

pages

511-5

issue

4

eissn

0340-6245

issn

2567-689X

pii

99040511

journal_volume

81

pub_type

杂志文章

相关文献

THROMBOSIS AND HAEMOSTASIS文献大全
  • Homozygous Pro74-->Arg mutation in the platelet glycoprotein Ibbeta gene associated with Bernard-Soulier syndrome.

    abstract：:Bernard-Soulier syndrome (BSS) is an autosomal recessive bleeding disorder due to quantitative or qualitative abnormalities in the glycoprotein (GP) Ib/IX/V complex, the platelet receptor for von Willebrand factor. This complex is composed of four subunits, GPIbalpha, GPIbbeta, GPIX and GPV. We describe here the genet...

    journal_title：Thrombosis and haemostasis

    pub_type： 杂志文章

    doi：

    authors： Kunishima S,Tomiyama Y,Honda S,Fukunishi M,Hara J,Inoue C,Kamiya T,Saito H

    更新日期：2000-07-01 00:00:00

  • Effect of altitude on thrombopoietin and the platelet count in healthy volunteers.

    abstract：:Although there is evidence that altitude increases the platelet count, its effect on the platelet precursor stimulating factor, thrombopoietin (TPO), is unclear. Unlike erythropoietin, TPO appears largely unresponsive to exogenous signals. In a study in 16 healthy volunteers, we report the effects of altitude exposure...

    journal_title：Thrombosis and haemostasis

    pub_type： 杂志文章

    doi：10.1160/TH04-02-0086

    authors： Hartmann S,Krafft A,Huch R,Breymann C

    更新日期：2005-01-01 00:00:00

  • Persistent hyperfibrinogenemia in acute ischemic stroke / transient ischemic attack (TIA).

    abstract：:Increased fibrinogen concentration is a well known phenomenon following acute ischemic stroke. However, the natural course of this hyperfibrinogenemia is uncertain. We aimed to clarify whether it is of a transient or more persistent nature in patients who harbor an underlying morbid biology of atherothrombo-inflammati...

    journal_title：Thrombosis and haemostasis

    pub_type： 杂志文章

    doi：10.1160/TH07-08-0484

    authors： Shenhar-Tsarfaty S,Ben Assayag E,Bova I,Shopin L,Cohen M,Berliner S,Shapira I,Bornstein NM

    更新日期：2008-01-01 00:00:00

  • The TF-603A/G gene promoter polymorphism and circulating monocyte tissue factor gene expression in healthy volunteers.

    abstract：:Three single nucleotide polymorphisms (-603A/G, -1322C/T, -1812C/T) and one deletion/insertion polymorphism (-1208D/I) are present in the tissue factor (TF) gene promoter sequence. These polymorphisms are in complete linkage disequilibrium, determining two haplotypes with almost equal frequency. The -603A/-1208D/-1322...

    journal_title：Thrombosis and haemostasis

    pub_type： 杂志文章

    doi：10.1160/TH03-09-0566

    authors： Reny JL,Laurendeau I,Fontana P,Bièche I,Dupont A,Remones V,Emmerich J,Vidaud M,Aiach M,Gaussem P

    更新日期：2004-02-01 00:00:00

  • Protective effect of ischaemic preconditioning on ischaemia/reperfusion-induced microvascular obstruction determined by on-line measurements of coronary pressure and blood flow in pigs.

    abstract：:We investigated the protective effect of ischaemic preconditioning (IP) on the maintenance of coronary patency using on-line measurements of coronary pressures and blood flow in a closed-chest reperfused acute myocardial infarction (MI) model in pigs. Catheter-based 90-min occlusion followed by 60-min reperfusion of t...

    journal_title：Thrombosis and haemostasis

    pub_type： 杂志文章

    doi：10.1160/TH09-03-0165

    authors： Posa A,Pavo N,Hemetsberger R,Csonka C,Csont T,Ferdinandy P,Petrási Z,Varga C,Pavo IJ,Laszlo F Jr,Huber K,Gyöngyösi M

    更新日期：2010-02-01 00:00:00

  • Atherosclerosis at arterial bifurcations: evidence for the role of haemodynamics and geometry.

    abstract：:Atherosclerotic plaques are found at distinct locations in the arterial system, despite the exposure to systemic risk factors of the entire vascular tree. From the study of arterial bifurcation regions, emerges ample evidence that haemodynamics are involved in the local onset and progression of the atherosclerotic dis...

    journal_title：Thrombosis and haemostasis

    pub_type： 杂志文章,评审

    doi：10.1160/TH15-07-0597

    authors： Morbiducci U,Kok AM,Kwak BR,Stone PH,Steinman DA,Wentzel JJ

    更新日期：2016-03-01 00:00:00

  • Occurrence of Soluble Very High Molecular Weight Fibrinogen Complexes in Hypercoagulable States. An in vitro and in vivo Study on their Features.

    abstract：:The gel-chromatography of the beta-alanine precipitate of human plasma and of purified fibrinogen shows the presence of different classes of fibrinogen complexes. A first class of complexes is detectable in correspondence with the ascending branch of the fibrinogen peak ("shoulder" complexes or high molecular weight f...

    journal_title：Thrombosis and haemostasis

    pub_type： 杂志文章

    doi：10.1055/s-0038-1657059

    authors： Serneri GGE,Gensini GF,Abbate R,Favilla S

    更新日期：1979-07-01 00:00:00

  • Heme oxygenase-1 inducer hemin prevents vascular thrombosis.

    abstract：:Hemin is a heme oxygenase-1 (HO-1) inducer which provides endogenous carbon monoxide known for playing roles in cell proliferation, inflammation or aggregation process. The objective of the current study was to examine the effect of prophylactic treatment with hemin in a thrombosis vascular model. Three groups of Wist...

    journal_title：Thrombosis and haemostasis

    pub_type： 杂志文章

    doi：

    authors： Desbuards N,Rochefort GY,Schlecht D,Machet MC,Halimi JM,Eder V,Hyvelin JM,Antier D

    更新日期：2007-09-01 00:00:00

  • Efficacy of Rivaroxaban for thromboprophylaxis after Knee Arthroscopy (ERIKA). A phase II, multicentre, double-blind, placebo-controlled randomised study.

    abstract：:Without thromboprophylaxis, knee arthroscopy (KA) carries a low to moderate risk of venous thromboembolism. Over 5 million arthroscopies are performed worldwide yearly. It was our study objective to assess the efficacy and safety of rivaroxaban for thromboprophylaxis after therapeutic KA. Patients undergoing KA in nin...

    journal_title：Thrombosis and haemostasis

    pub_type： 杂志文章,多中心研究,随机对照试验

    doi：10.1160/TH16-02-0118

    authors： Camporese G,Bernardi E,Noventa F,Bosco M,Monteleone G,Santoro L,Bortoluzzi C,Freguja S,Nardin M,Marullo M,Zanon G,Mazzola C,Damiani G,Maniscalco P,Imberti D,Lodigiani C,Becattini C,Tonello C,Agnelli G,ERIKA Study Gr

    更新日期：2016-08-01 00:00:00

  • A standard nomenclature for von Willebrand factor gene mutations and polymorphisms. On behalf of the ISTH SSC Subcommittee on von Willebrand factor.

    abstract：:Examination of the entire von Willebrand factor (VWF) gene for mutations, particularly in types 1 and 3 von Willebrand disease (VWD) is becoming more widely practised. The sequence of the entire VWF gene will soon be compiled as a single sequence. For these reasons, a clearly defined nomenclature to use for numbering ...

    journal_title：Thrombosis and haemostasis

    pub_type： 指南,杂志文章

    doi：

    authors： Goodeve AC,Eikenboom JC,Ginsburg D,Hilbert L,Mazurier C,Peake IR,Sadler JE,Rodeghiero F,ISTH SSC Subcommittee on von Willebrand factor.

    更新日期：2001-05-01 00:00:00

  • Antithrombotic activity of LB30057, a newly synthesized direct thrombin inhibitor.

    abstract：:An amidrazonophenylalanine derivative, LB30057, inhibits the catalytic activity of thrombin potently by interaction with the active site of thrombin, and has high water solubility. In the present study, we evaluated the effect of LB30057 on the biological activities of thrombin at various tissues, and determined wheth...

    journal_title：Thrombosis and haemostasis

    pub_type： 杂志文章

    doi：

    authors： Kang KT,Jung BI,Bae ON,Lee MY,Chung SM,Lee JY,Lee SK,Kim IC,Chung JH

    更新日期：2003-01-01 00:00:00

  • ARIC hemostasis study--IV. Intraindividual variability and reliability of hemostatic factors. The Atherosclerosis Risk in Communities (ARIC).

    abstract：:We have recently reported the short-term intraindividual variability of several coagulation factors and inhibitors included in the ARIC study (Chambless et al. Ann Epidemiol 1992; 2:723). In this paper, we reported the intraindividual variability results of additional hemostatic factors. Blood samples were collected f...

    journal_title：Thrombosis and haemostasis

    pub_type： 杂志文章

    doi：

    authors： Nguyen ND,Ghaddar H,Stinson V,Chambless LE,Wu KK

    更新日期：1995-02-01 00:00:00

  • TNK-tPA for acute myocardial infarction: the clinical experience.

    abstract：:Thrombolytic therapy has become the mainstay of treatment for acute transmural myocardial infarction. Present fibrinolytic regimens have a number of shortcomings, including the failure to induce early and sustained reperfusion in as many as 40-50% of the patients, and to prevent reocclusion in another 10-20% of the pa...

    journal_title：Thrombosis and haemostasis

    pub_type： 杂志文章,评审

    doi：

    authors： Pislaru SV,Van de Werf F

    更新日期：1999-09-01 00:00:00

  • Risk of venous thromboembolism in patients with splenic injury and splenectomy. A nationwide cohort study.

    abstract：:The spleen is a crucial organ in humans. However, little is known about the association of venous thromboembolism (VTE) with splenic injury and splenectomy in trauma patients. The aim of this study was to determine the subsequent risk of VTE following splenic injury and splenectomy. A nationwide retrospective cohort s...

    journal_title：Thrombosis and haemostasis

    pub_type： 杂志文章

    doi：10.1160/TH15-05-0381

    authors： Lin JN,Chen HJ,Lin MC,Lai CH,Lin HH,Yang CH,Kao CH

    更新日期：2016-01-01 00:00:00

  • Expression of the vitamin K-dependent proteins GAS6 and protein S and the TAM receptor tyrosine kinases in human atherosclerotic carotid plaques.

    abstract：:The GAS6/ProS-TAM system is composed of two vitamin K-dependent ligands (GAS6 and protein S) and their three protein tyrosine kinase receptors TYRO3, AXL and MERTK, known as the TAM receptors. The system plays a prominent role in conditions of injury, inflammation and repair. In murine models of atherosclerotic plaque...

    journal_title：Thrombosis and haemostasis

    pub_type： 杂志文章

    doi：10.1160/TH10-10-0630

    authors： Hurtado B,Muñoz X,Recarte-Pelz P,García N,Luque A,Krupinski J,Sala N,García de Frutos P

    更新日期：2011-05-01 00:00:00

  • Relationships of insulin and intact and split proinsulin to haemostatic function in young men with and without coronary artery disease.

    abstract：:Glucose intolerance, hyperinsulinaemia, dyslipoproteinaemia and multiple disturbances of haemostatic function are characteristics of young men with premature coronary artery disease. The relations between glucose, insulin and insulin propeptides, in the fasting state, and after an oral glucose load, and haemostatic fu...

    journal_title：Thrombosis and haemostasis

    pub_type： 杂志文章

    doi：

    authors： Båvenholm P,Proudler A,Silveira A,Crook D,Blombäck M,de Faire U,Hamsten A

    更新日期：1995-04-01 00:00:00

  • A comparative double-blind, randomised trial of a new second generation LMWH (bemiparin) and UFH in the prevention of post-operative venous thromboembolism. The Bemiparin Assessment group.

    abstract：:A randomised, prospective, double-blind trial was performed, to compare the safety and efficacy of a new low-molecular-weight heparin (LMWH) Bemiparin and standard unfractionated heparin (UFH), for the prophylaxis of postoperative venous thromboembolism. 300 patients scheduled to undergo elective hip arthroplasty were...

    journal_title：Thrombosis and haemostasis

    pub_type： 临床试验,杂志文章,随机对照试验

    doi：

    authors： Kakkar VV,Howes J,Sharma V,Kadziola Z

    更新日期：2000-04-01 00:00:00

  • Elevated D-dimer level is an independent risk factor for cardiovascular death in out-patients with symptoms compatible with heart failure.

    abstract：:D-dimer, a marker of fibrin turnover, exhibits many interesting properties as a biological marker of thrombosis. Some of the properties of D-dimer might also be used to provide additional information about patients with heart failure. In this study, we evaluate the prognostic information acquired from D-dimer concerni...

    journal_title：Thrombosis and haemostasis

    pub_type： 杂志文章

    doi：10.1160/TH04-05-0278

    authors： Alehagen U,Dahlström U,Lindahl TL

    更新日期：2004-12-01 00:00:00

  • Function of eltrombopag-induced platelets compared to platelets from control patients with immune thrombocytopenia.

    abstract：:Data on the in vivo function of platelets induced by the thrombopoietin receptor agonist eltrombopag are scarce. To assess a possible influence of eltrombopag we compared platelet function of eltrombopag-treated immune thrombocytopenia (ITP) patients (group 1; n=10) after treatment response to that from control ITP pa...

    journal_title：Thrombosis and haemostasis

    pub_type： 杂志文章

    doi：10.1160/TH12-07-0522

    authors： Haselboeck J,Kaider A,Pabinger I,Panzer S

    更新日期：2013-04-01 00:00:00

  • Fibrin glue for wound repair: facts and fancy.

    abstract：:In wound repair, fibrin has a multiplicity of activities, some of which are intrinsic to the protein itself and some attributable to other blood constituents associated with the fibrin clot. Fibrin sealants, which have been approved for hemostasis in the US and Europe, are occasionally used wounds to promote healing. ...

    journal_title：Thrombosis and haemostasis

    pub_type： 杂志文章,评审

    doi：10.1160/TH03-08-0526

    authors： Clark RA

    更新日期：2003-12-01 00:00:00

  • Abnormality of the N-terminal portion of von Willebrand factor in type IIA and IIC von Willebrand disease.

    abstract：:We have established a new analytical method which allows the characterization of von Willebrand factor (vWF) degradation fragments in minute amounts (10 microliters) of plasma, without the need for immunopurification of vWF. Plasma vWF was hydrolysed by S aureus V-8 protease (V-8 protease) and the cleaved fragments se...

    journal_title：Thrombosis and haemostasis

    pub_type： 杂志文章

    doi：

    authors： Takahashi Y,Kalafatis M,Girma JP,Meyer D

    更新日期：1988-12-22 00:00:00

  • Anticoagulation by constant subcutaneous heparin infusion.

    abstract：:A preliminary clinical trial was conducted to determine the feasibility of achieving and regulating therapeutic anticoagulation with heparin given by continuous subcutaneous infusion. Five patients with deep venous thrombosis confirmed by impedance plethysmography and/or venography were studied. All patients received ...

    journal_title：Thrombosis and haemostasis

    pub_type： 杂志文章

    doi：

    authors： Parrilla N,Ansell J

    更新日期：1982-02-26 00:00:00

  • Reliability of a single beta-thromboglobulin measurement in a diabetic population: importance of PGE1 in anticoagulant mixture. Damad Study Group.

    abstract：:During the collection of samples for plasma beta-thromboglobulin (beta-TG) determination, it is well established that artificially high values can be observed due to in-vitro release. To estimate the reliability of a single beta-TG measurement, blood samples were collected simultaneously from both arms on two separate...

    journal_title：Thrombosis and haemostasis

    pub_type： 杂志文章

    doi：

    authors： Scarabin PY,Strain L,Ludlam CA,Jones J,Kohner EM

    更新日期：1987-04-07 00:00:00

  • PDK1 selectively phosphorylates Thr(308) on Akt and contributes to human platelet functional responses.

    abstract：:3-phosphoinositide-dependent protein kinase 1 (PDK1), a member of the protein A,G and C (AGC) family of proteins, is a Ser/Thr protein kinase that can phosphorylate and activate other protein kinases from the AGC family, including Akt at Thr308, all of which play important roles in mediating cellular responses. The fu...

    journal_title：Thrombosis and haemostasis

    pub_type： 杂志文章

    doi：10.1160/TH13-06-0484

    authors： Dangelmaier C,Manne BK,Liverani E,Jin J,Bray P,Kunapuli SP

    更新日期：2014-03-03 00:00:00

  • Treatment with dabigatran or warfarin in patients with venous thromboembolism and cancer.

    abstract：:The efficacy and safety of dabigatran for treatment of venous thromboembolism (VTE) were demonstrated in two trials. It is unclear if the results pertain to patients with cancer and VTE. Data from two randomised trials comparing dabigatran and warfarin for acute VTE were pooled. Primary efficacy outcome was symptomati...

    journal_title：Thrombosis and haemostasis

    pub_type： 杂志文章

    doi：10.1160/TH14-11-0977

    authors： Schulman S,Goldhaber SZ,Kearon C,Kakkar AK,Schellong S,Eriksson H,Hantel S,Feuring M,Kreuzer J

    更新日期：2015-07-01 00:00:00

  • Edoxaban administration following enoxaparin: a pharmacodynamic, pharmacokinetic, and tolerability assessment in human subjects.

    abstract：:Edoxaban is an oral direct factor (F)Xa inhibitor in advanced stages of clinical development. The primary objective of the present study was to assess the pharmacodynamics (PD) and safety of enoxaparin 1 mg/kg followed 12 hours (h) post-dose by edoxaban 60 mg, which is the regimen being used in the phase III study of ...

    journal_title：Thrombosis and haemostasis

    pub_type： 杂志文章,随机对照试验

    doi：10.1160/TH11-09-0676

    authors： Zahir H,Matsushima N,Halim AB,He L,Zhang G,Lee F,Worland V,Mendell J

    更新日期：2012-07-01 00:00:00

  • In vitro and in vivo effects of adrenaline and phentolamine on platelet function.

    abstract：:In vitro and in vivo effects of adrenaline (ADR) on platelet aggregation, on platelet factor 3 (PF3) availability and on platelet factor 4 (PF4) release were studied in man. Inhibitory action of an alpha-blocker, phentolamine (PHEN) was investigated in the same conditions. The threshold concentration (TC) of ADR induc...

    journal_title：Thrombosis and haemostasis

    pub_type： 杂志文章

    doi：

    authors： Ponari O,Civardi E,Megha A,Pini M,Poti' R,Dettori AG

    更新日期：1978-10-31 00:00:00

  • Discrete functional motifs reside within the cytoplasmic tail of alphaV integrin subunit.

    abstract：:Previous studies have demonstrated that cell-permeable cytoplasmic tail (CT) alpha(II)beta peptides can modulate the activation of alpha(IIb)b(3). As alpha(V) CT contains an alpha(II)beta homologous region, a series of cell-permeable alpha(V) and alpha(IIb) peptides were generated to determine if alpha(V) CT can modul...

    journal_title：Thrombosis and haemostasis

    pub_type： 杂志文章

    doi：10.1160/TH07-08-0498

    authors： Haas TA

    更新日期：2008-01-01 00:00:00

  • Factor XIII activation peptide is released into plasma upon cleavage by thrombin and shows a different structure compared to its bound form.

    abstract：:The first step of coagulation factor XIII (FXIII) activation involves cleavage of the FXIII activation peptide (FXIII-AP) by thrombin. However, it is not known whether the FXIII-AP is released into plasma upon cleavage or remains attached to activated FXIII. The aim of the present work was to study the structure of fr...

    journal_title：Thrombosis and haemostasis

    pub_type： 杂志文章

    doi：

    authors： Schroeder V,Vuissoz JM,Caflisch A,Kohler HP

    更新日期：2007-06-01 00:00:00

  • Platelet activation by collagen is increased in retinal vein occlusion.

    abstract：:Retinal vein occlusion (RVO) is the most common retinal vascular disorder second to diabetic retinopathy. The main risk factors in patients with RVO are hypertension, diabetes, hyperlipidemia, increased blood viscosity and glaucoma. The pathogenesis of RVO has not yet been clarified. In these events platelets could pl...

    journal_title：Thrombosis and haemostasis

    pub_type： 杂志文章

    doi：

    authors： Leoncini G,Bruzzese D,Signorello MG,Armani U,Piana A,Ghiglione D,Camicione P

    更新日期：2007-02-01 00:00:00