The intravenous model of murine tuberculosis is less pathogenic than the aerogenic model owing to a more rapid induction of systemic immunity.

Abstract:

:The detection of mRNA in the murine model of tuberculosis for key cytokines involved in protective immunity in the lung tissues revealed a much faster emergence of the interferon (IFN)-gamma response in the intravenous route than in the aerosol route of inoculation. This slower response in the lungs was associated with a stronger inflammatory response, resulting in large granulomatous structures and eventual tissue damage.

journal_name

Scand J Immunol

authors

Cardona PJ,Cooper A,Luquín M,Ariza A,Filipo F,Orme IM,Ausina V

doi

10.1046/j.1365-3083.1999.00522.x

keywords:

subject

Has Abstract

pub_date

1999-04-01 00:00:00

pages

362-6

issue

4

eissn

0300-9475

issn

1365-3083

journal_volume

49

pub_type

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