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Cotinine replacement levels for a 21 mg/day transdermal nicotine patch in an outpatient treatment setting.

Abstract：

:This study examined plasma cotinine replacement levels of 56 outpatient smokers administered a 21 mg/day transdermal nicotine patch (Nicoderm CQ ). The percentage of cotinine replacement ranged from 35 to 232% (mean 107%; median 90.5%). Four subject variables were found to be significantly correlated with percentage of cotinine replacement-baseline cotinine level, prior quit attempts, gender, and the Fagerström Tolerance Questionnaire score. A two-variable model consisting of baseline cotinine level and gender provided the most powerful predictor combination. The percentage of cotinine replacement was not predictive of post-treatment smoking. The relatively high levels of cotinine replacement obtained using the Nicoderm CQ 21 mg/day patch suggest cautious use of higher dose treatment with this particular patch.

journal_name

Drug Alcohol Depend

journal_title

Drug and alcohol dependence

authors

Gariti P,Alterman AI,Barber W,Bedi N,Luck G,Cnaan A

doi

10.1016/s0376-8716(98)00163-x

keywords:

subject

Has Abstract

pub_date

1999-04-01 00:00:00

pages

111-6

issue

2

eissn

0376-8716

issn

1879-0046

pii

S037687169800163X

journal_volume

54

pub_type

临床试验,杂志文章,随机对照试验

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