Association between the sigma C protein of avian reovirus and virus-induced fusion of cells.

Abstract:

:Monoclonal antibodies (MAbs) against a 39 kDa (sigma C) protein of the avian reovirus RAM-1 strain inhibited virus-induced fusion of cells and the protein was expressed on the surface of infected cells. The fusion-inhibiting activity of the three MAbs reacting with the sigma C protein suggest two putative epitopes were involved: one epitope recognised by antibody 6H1 and involved in fusion of both Vero and CK cells and a second epitope recognised by antibody 1G1 involved in fusion of Vero cells but not CK cells. The activity of the MAb 6E2 was intermediate, suggesting it may have been located in an intermediate position between the two putative epitopes and inhibited fusion by steric hindrance.

journal_name

Arch Virol

journal_title

Archives of virology

authors

Meanger J,Wickramasinghe R,Enriquez CE,Wilcox GE

doi

10.1007/s007050050496

keywords:

subject

Has Abstract

pub_date

1999-01-01 00:00:00

pages

193-7

issue

1

eissn

0304-8608

issn

1432-8798

journal_volume

144

pub_type

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