Streptavidin facilitates internalization and pulmonary targeting of an anti-endothelial cell antibody (platelet-endothelial cell adhesion molecule 1): a strategy for vascular immunotargeting of drugs.

abstract：:Neural activity and neurotrophins induce synaptic remodeling in part by altering gene expression. A cDNA encoding a glycosylphoshatidylinositol-anchored protein was identified by screening for hippocampal genes that are induced by neural activity. This molecule, named neuritin, is expressed in postmitotic-differentiat...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Naeve GS,Ramakrishnan M,Kramer R,Hevroni D,Citri Y,Theill LE

更新日期：1997-03-18 00:00:00

abstract：:Activation energies for the individual steps of secretory and viral fusion are reported to be large [Oberhauser, A. F., Monck, J. R. & Fernandez, J. M. (1992) Biophys. J. 61, 800-809; Clague, M. J., Schoch, C., Zech, L. & Blumenthal, R. (1990) Biochemistry 29, 1303-1308]. Understanding the cause for these large activa...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Lee J,Lentz BR

更新日期：1998-08-04 00:00:00

abstract：:Mechanical injury to the adult mammalian spinal cord results in permanent loss of structural integrity at the lesion site and of the brain-controlled function distal to the lesion. Some of these consequences were permanently averted by altering the cellular constituents at the lesion site with x-irradiation delivered ...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Kalderon N,Fuks Z

更新日期：1996-10-01 00:00:00

abstract：:Preference behaviors are often established during early life, but the underlying neural circuit mechanisms remain unknown. Adapting a unique nesting behavior assay, we confirmed a "critical period" for developing music preference in C57BL/6 mice. Early music exposure between postnatal days 15 and 24 reversed their inn...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Yang EJ,Lin EW,Hensch TK

更新日期：2012-10-16 00:00:00

abstract：:Multiple-choice examinations play a critical role in university admissions across the world. A key question is whether imposing penalties for wrong answers on these examinations deters guessing from women more than men, disadvantaging female test-takers. We consider data from a large-scale, high-stakes policy change t...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Coffman KB,Klinowski D

更新日期：2020-04-21 00:00:00

abstract：:The functional unit molecular size of the intestinal brush border membrane-bound Na+/glucose cotransporter was determined by radiation inactivation. Purified brush border membrane vesicles preserved in cryoprotectant buffer were irradiated (-135 degrees C) with high-energy electrons from a 13-MeV (1 eV = 1.602 x 10(-1...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Stevens BR,Fernandez A,Hirayama B,Wright EM,Kempner ES

更新日期：1990-02-01 00:00:00

abstract：:Four macrocyclic cystine-knot peptides of 29-31 residues, kalata, circulin A and B (CirA and CirB), and cyclopsychotride, have been isolated from coffee plants but have undetermined physiological functions. These macrocycles and 10 of their analogs prepared by chemical synthesis were tested against nine strains of mic...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Tam JP,Lu YA,Yang JL,Chiu KW

更新日期：1999-08-03 00:00:00

abstract：:The p21 RAS subfamily of small GTPases, including KRAS, HRAS, and NRAS, regulates cell proliferation, cytoskeletal organization, and other signaling networks, and is the most frequent target of activating mutations in cancer. Activating germline mutations of KRAS and HRAS cause severe developmental abnormalities leadi...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Oliveira JB,Bidère N,Niemela JE,Zheng L,Sakai K,Nix CP,Danner RL,Barb J,Munson PJ,Puck JM,Dale J,Straus SE,Fleisher TA,Lenardo MJ

更新日期：2007-05-22 00:00:00

abstract：:The Late Heavy Bombardment (LHB), a hypothesized impact spike at ∼3.9 Ga, is one of the major scientific concepts to emerge from Apollo-era lunar exploration. A significant portion of the evidence for the existence of the LHB comes from histograms of (40)Ar/(39)Ar "plateau" ages (i.e., regions selected on the basis of...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Boehnke P,Harrison TM

更新日期：2016-09-27 00:00:00

abstract：:Human activities increasingly take place in online environments, providing novel opportunities for relating individual behaviors to population-level outcomes. In this paper, we introduce a simple generative model for the collective behavior of millions of social networking site users who are deciding between different...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Gleeson JP,Cellai D,Onnela JP,Porter MA,Reed-Tsochas F

更新日期：2014-07-22 00:00:00

abstract：:H2O2, in concentrations achieved in the proximity of stimulated leukocytes, induces injury and lysis of target cells. This may be an important aspect of inflammatory injury of tissues. Cell lysis in two target cells, the murine macrophage-like tumor cell line P388D1 and human peripheral lymphocytes, was found to be as...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Schraufstatter IU,Hyslop PA,Hinshaw DB,Spragg RG,Sklar LA,Cochrane CG

更新日期：1986-07-01 00:00:00

abstract：:Transarterial chemoembolization (TACE) is the main treatment for intermediate stage hepatocellular carcinoma (HCC) with Barcelona Clinic Liver Cancer classification because of its exclusive arterial blood supply. Although TACE achieves substantial necrosis of the tumor, complete tumor necrosis is uncommon, and the res...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Lin WH,Yeh SH,Yeh KH,Chen KW,Cheng YW,Su TH,Jao P,Ni LC,Chen PJ,Chen DS

更新日期：2016-10-18 00:00:00

abstract：:When the magnetic susceptibility of frozen aqueous solutions of human oxyhemoglobin was measured in the range between 25 and 250 K, it showed a temperature-dependent behavior typical of a thermal equilibrium between a ground singlet state and an excited triplet state for two electrons per heme, the energy separation b...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Cerdonio M,Congiu-Castellano A,Mogno F,Pispisa B,Romani GL,Vitale S

更新日期：1977-02-01 00:00:00

abstract：:In feeding, aphids inject saliva into plant tissues, gaining access to phloem sap and eliciting (and sometimes overcoming) plant responses. We are examining the involvement, in this aphid-plant interaction, of individual aphid proteins and enzymes, as identified in a salivary gland cDNA library. Here, we focus on a sa...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Mutti NS,Louis J,Pappan LK,Pappan K,Begum K,Chen MS,Park Y,Dittmer N,Marshall J,Reese JC,Reeck GR

更新日期：2008-07-22 00:00:00

abstract：:A number of rare copy number variants (CNVs), including both deletions and duplications, have been associated with developmental disorders, including schizophrenia, autism, intellectual disability, and epilepsy. Pathogenicity may derive from dosage sensitivity of one or more genes contained within the CNV locus. To un...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： McLysaght A,Makino T,Grayton HM,Tropeano M,Mitchell KJ,Vassos E,Collier DA

更新日期：2014-01-07 00:00:00

abstract：:In aqueous solution, aldehydes, and to a lesser extent ketones, hydrate to form geminal diols. We investigate the hydration of methylglyoxal (MG) in the gas phase, a process not previously considered to occur in water-restricted environments. In this study, we spectroscopically identified methylglyoxal diol (MGD) and ...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Axson JL,Takahashi K,De Haan DO,Vaida V

更新日期：2010-04-13 00:00:00

abstract：:Whole-cell voltage clamp was used to investigate the properties and spatial distribution of fast-deactivating (FD) Ca channels in squid giant fiber lobe (GFL) neurons. Squid FD Ca channels are reversibly blocked by the spider toxin omega-Agatoxin IVA with an IC50 of 240-420 nM with no effect on the kinetics of Ca chan...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： McFarlane MB,Gilly WF

更新日期：1996-05-14 00:00:00

abstract：:We have used in vitro motility assays to investigate the mechanism of kinetochore function in the budding yeast Saccharomyces cerevisiae. Functional centromeric DNA plus a tripartite centromere binding protein complex, CBF3, was found to be necessary but not sufficient for in vitro kinetochore activity. A fourth requi...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Middleton K,Carbon J

更新日期：1994-07-19 00:00:00

abstract：:The structure of the adeno-associated virus (AAV-2) has been determined to 3-A resolution by x-ray crystallography. AAV is being developed as a vector for gene therapy to treat diseases including hemophilia, cancer, and cystic fibrosis. As in the distantly related autonomous parvoviruses, the capsid protein has a beta...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Xie Q,Bu W,Bhatia S,Hare J,Somasundaram T,Azzi A,Chapman MS

更新日期：2002-08-06 00:00:00

abstract：:Evidence from more than 100 y of research indicates that conscientiousness (C) is the most potent noncognitive construct for occupational performance. However, questions remain about the magnitudes of its effect sizes across occupational variables, its defining characteristics and functions in occupational settings, a...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Wilmot MP,Ones DS

更新日期：2019-11-12 00:00:00

abstract：:We report a combined thermodynamic and structural characterization of a DNA tetraplex. Using spectroscopic and calorimetric techniques, we demonstrate that d(TG3T) and d(TG3T2G3T), in the presence of K+, form stable tetramolecular complexes. From differential scanning calorimetry measurements, we obtain the following ...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Jin R,Gaffney BL,Wang C,Jones RA,Breslauer KJ

更新日期：1992-09-15 00:00:00

abstract：:Whereas amyloid-β (Aβ) accumulates in the brain of normal animals dosed with low levels of copper (Cu), the mechanism is not completely known. Cu could contribute to Aβ accumulation by altering its clearance and/or its production. Because Cu homeostasis is altered in transgenic mice overexpressing Aβ precursor protein...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Singh I,Sagare AP,Coma M,Perlmutter D,Gelein R,Bell RD,Deane RJ,Zhong E,Parisi M,Ciszewski J,Kasper RT,Deane R

更新日期：2013-09-03 00:00:00

abstract：:In vitro tests for predicting the response of tumors to chemotherapeutic agents might be improved if they were modified to take into account tumor-cell heterogeneity. We have studied the heterogeneity of cellular growth rate and drug response in mouse fibroblast NIH 3T3 cells and in NIH 3T3 cells transformed with the ...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Kuczek T,Axelrod DE

更新日期：1987-07-01 00:00:00

abstract：:The covalent attachment of heme to apocytochrome c, and therefore the import of cytochrome c into mitochondria, is dependent on both NADH plus a cytosolic cofactor that has been identified to be FMN or FAD. NADH in concert with flavin nucleotides mediates the reduction of heme. Heme in the reduced state is a prerequis...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Nicholson DW,Neupert W

更新日期：1989-06-01 00:00:00

abstract：:We describe a new computer program, trilogy, for the automated discovery of sequence-structure patterns in proteins. trilogy implements a pattern discovery algorithm that begins with an exhaustive analysis of flexible three-residue patterns; a subset of these patterns are selected as seeds for an extension process in ...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Bradley P,Kim PS,Berger B

更新日期：2002-06-25 00:00:00

abstract：:Regulation of ion balance in spermatozoa has been shown to be essential for sperm motility and fertility. Control of intracellular ion levels requires the function of distinct ion-transport mechanisms at the cell plasma membrane. Active Na(+) and K(+) exchange in sperm is under the control of the Na,K-ATPase. Two mole...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Jimenez T,McDermott JP,Sánchez G,Blanco G

更新日期：2011-01-11 00:00:00

abstract：:Aggregation chimeras were formed between C57BL/6 mice heterozygous for the Apc(min) (Min) mutation and wild-type SWR mice, that differ in their Pla2g2a status, a modifier of Apc(min), and also in their resistance to intestinal polyp formation. Variation in the dolichos biflorus agglutinin-staining patterns of the inte...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Novelli MR,Wasan H,Rosewell I,Bee J,Tomlinson IP,Wright NA,Bodmer WF

更新日期：1999-10-26 00:00:00

abstract：:Multiple biological processes involve the stretching of nucleic acids (NAs). Stretching forces induce local changes in the molecule structure, inhibiting or promoting the binding of proteins, which ultimately affects their functionality. Understanding how a force induces changes in the structure of NAs at the atomic l...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Marin-Gonzalez A,Vilhena JG,Perez R,Moreno-Herrero F

更新日期：2017-07-03 00:00:00

abstract：:Niemann-Pick type C disease (NP-C) is an inherited neurovisceral lipid storage disorder characterized by progressive neurodegeneration. Most cases of NP-C result from inactivating mutations of NPC1, a recently identified member of a family of genes encoding membrane-bound proteins containing putative sterol sensing do...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Patel SC,Suresh S,Kumar U,Hu CY,Cooney A,Blanchette-Mackie EJ,Neufeld EB,Patel RC,Brady RO,Patel YC,Pentchev PG,Ong WY

更新日期：1999-02-16 00:00:00

abstract：:Little is known about how members of the indigenous microflora interact with their mammalian hosts to establish mutually beneficial relationships. We have used a gnotobiotic mouse model to show that Bacteroides thetaiotaomicron, a component of the intestinal microflora of mice and humans, uses a repressor, FucR, as a ...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Hooper LV,Xu J,Falk PG,Midtvedt T,Gordon JI

更新日期：1999-08-17 00:00:00