Iodine-containing organic carbonates as investigative radiopaque compounds.

Abstract:

:Carbonates containing an iodinated aromatic ring on one side of the carbonate linkage and an alkyl group on the other were prepared. The aromatic side consisted of p-iodophenyl, p-iodobenzyl, m-iodobenzyl, 3,5-diiodobenzyl, m-amino-2,4,6-triiodobenzyl, m-acetamido-2,4,6-triiodobenzyl, p-iodophenethyl, p-iodo-sec-phenethyl, 3-(p-iodophenyl)propyl, 3-(p-iodophenyl)butyl, 2-(p-iodobenzyl)butyl, and 2-(iodobenzyl)hexyl groups. The alkyl portion of the carbonates was derived from alkyl alcohols containing from two to ten carbon atoms. The approximate lethal dose of intraperitoneal injections ranged from less than 1 ml/kg to more than 15 ml/kg. An investigation into the use of these compounds as radiopaques for myelography, lymphography, bronchography, and salpingography is underway.

journal_name

J Med Chem

authors

Newton BN

doi

10.1021/jm00234a002

keywords:

subject

Has Abstract

pub_date

1976-12-01 00:00:00

pages

1362-6

issue

12

eissn

0022-2623

issn

1520-4804

journal_volume

19

pub_type

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