Non-pharmacological interventions for epilepsy in people with intellectual disabilities.


BACKGROUND:Approximately 30% of epilepsy patients remain refractory to drug treatment and continue to experience seizures whilst taking one or more antiepileptic drugs. There are a number of non-pharmacological interventions available to refractory patients which may be used in conjunction with or as an alternative to antiepileptic medication. In view of the fact that seizures in intellectually disabled people are often complex and refractory to pharmacological interventions it is evident that good quality randomised controlled trials (RCTs) assessing the efficacy of alternatives or adjuncts to pharmacological interventions are needed in this population. OBJECTIVES:The aim of our study was to assess the data available from randomised controlled trials of non-pharmacological interventions in patients with epilepsy and intellectual disabilities. SEARCH STRATEGY:We searched The Cochrane Central Register of Controlled Trials (CENTRAL) (The Cochrane Library Issue 4, 2006), MEDLINE OVID (1966 to October 2006) and PsychInfo OVID (1806 to October 2006). SELECTION CRITERIA:Randomised controlled trials of non-pharmacological interventions for people with epilepsy and intellectual disabilities DATA COLLECTION AND ANALYSIS:Two review authors independently applied inclusion criteria and extracted data. MAIN RESULTS:No RCTs were found for this study population. AUTHORS' CONCLUSIONS:This review has highlighted the need for well-designed randomised controlled trials to assess the effect of non-pharmacological interventions on seizure and behavioural outcomes in an intellectually disabled epilepsy population.


Beavis J,Kerr M,Marson AG




Has Abstract


2007-10-17 00:00:00








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    abstract::This is the protocol for a review and there is no abstract. The objectives are as follows: The objective of the review will be to determine the efficacy and tolerability of eletriptan compared to placebo and other active interventions in the treatment of acute migraine headaches in adults. ...

    journal_title:The Cochrane database of systematic reviews

    pub_type: 杂志文章


    authors: Derry S,Moore RA,McQuay HJ

    更新日期:2010-01-01 00:00:00

  • Primaquine alternative dosing schedules for preventing malaria relapse in people with Plasmodium vivax.

    abstract:BACKGROUND:Plasmodium vivax liver stages (hypnozoites) may cause relapses, prolonging morbidity, and impeding malaria control and elimination. The World Health Organization (WHO) recommends three schedules for primaquine: 0.25 mg/kg/day (standard), or 0.5 mg/kg/day (high standard) for 14 days, or 0.75 mg/kg once weekly...

    journal_title:The Cochrane database of systematic reviews

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    authors: Milligan R,Daher A,Villanueva G,Bergman H,Graves PM

    更新日期:2020-08-19 00:00:00

  • Surgery for lateral elbow pain.

    abstract:BACKGROUND:This review is one in a series of reviews of interventions for lateral elbow pain. Lateral elbow pain, or tennis elbow, is a common condition causing pain in the lateral elbow and forearm and lack of strength and function of the elbow and wrist. Surgery is sometimes recommended in treating chronic cases of l...

    journal_title:The Cochrane database of systematic reviews

    pub_type: 杂志文章,评审


    authors: Buchbinder R,Green S,Bell S,Barnsley L,Smidt N,Assendelft WJ

    更新日期:2002-01-01 00:00:00

  • Exercise-based rehabilitation for heart failure.

    abstract:BACKGROUND:Previous systematic reviews and meta-analyses consistently show the positive effect of exercise-based rehabilitation for heart failure (HF) on exercise capacity; however, the direction and magnitude of effects on health-related quality of life, mortality and hospital admissions in HF remain less certain. Thi...

    journal_title:The Cochrane database of systematic reviews

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    authors: Taylor RS,Sagar VA,Davies EJ,Briscoe S,Coats AJ,Dalal H,Lough F,Rees K,Singh S

    更新日期:2014-04-27 00:00:00

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    abstract:BACKGROUND:Vomiting caused by acute gastroenteritis is very common in children and adolescents. Treatment of vomiting in children can be problematic and the use of antiemetics remains a controversial issue. There have been concerns expressed about apparently unacceptable levels of side effects such as sedation and extr...

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    authors: Alhashimi D,Al-Hashimi H,Fedorowicz Z

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    abstract:BACKGROUND:Dysvascularity accounts for 75% of all lower limb amputations in the UK. Around 37% of these are at transfemoral level (mid-thigh), with the majority of people being over the age of 60 and having existing co-morbidities. A significant number of these amputees will be prescribed a lower limb prosthesis for wa...

    journal_title:The Cochrane database of systematic reviews

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    authors: Cumming JC,Barr S,Howe TE

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  • Granulocyte transfusions for neonates with confirmed or suspected sepsis and neutropaenia.

    abstract:BACKGROUND:Neonatal sepsis causes significant neonatal mortality and morbidity. Neonates, especially preterm infants, have an immaturity of granulopoeisis and have a limited capacity for progenitor cell proliferation. This results in the frequent occurrence of neutropaenia in septic neonates. Neutropaenic septic neonat...

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    authors: Mohan P,Brocklehurst P

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  • Ibuprofen and/or paracetamol (acetaminophen) for pain relief after surgical removal of lower wisdom teeth.

    abstract:BACKGROUND:Both paracetamol and ibuprofen are commonly used analgesics for the relief of pain following the surgical removal of lower wisdom teeth (third molars). In 2010, a novel analgesic (marketed as Nuromol) containing both paracetamol and ibuprofen in the same tablet was launched in the United Kingdom, this drug h...

    journal_title:The Cochrane database of systematic reviews

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    authors: Bailey E,Worthington HV,van Wijk A,Yates JM,Coulthard P,Afzal Z

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    authors: Singh N,Halliday HL,Stevens TP,Suresh G,Soll R,Rojas-Reyes MX

    更新日期:2015-12-21 00:00:00

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    abstract:BACKGROUND:Hirsutism is the presence of excessive hair growth in women and is an important cosmetic condition often resulting in severe distress. Hirsutism is most often caused by increased production of male sex hormones also known as androgens. It is also affected by increased sensitivity to androgens in the hair fol...

    journal_title:The Cochrane database of systematic reviews

    pub_type: 杂志文章,评审


    authors: Lee O,Farquhar C,Toomath R,Jepson R

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    abstract:BACKGROUND:Cardiac tamponade may occur following cardiac surgery as a result of blood or fluid collecting in the pericardial space compressing the heart and reducing cardiac output. Mediastinal chest drains (including pericardial drains) are inserted as standard post-operative practice following cardiac surgery to assi...

    journal_title:The Cochrane database of systematic reviews

    pub_type: 杂志文章,评审


    authors: Wallen M,Morrison A,Gillies D,O'Riordan E,Bridge C,Stoddart F

    更新日期:2004-10-18 00:00:00

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    abstract:BACKGROUND:A possible therapeutic effect of diagnostic tubal patency testing has been debated in the literature for half a century. Further debate surrounds whether oil-soluble or water-soluble contrast media might have the bigger fertility-enhancing effect. OBJECTIVES:To evaluate the effect of flushing a woman's fall...

    journal_title:The Cochrane database of systematic reviews

    pub_type: 杂志文章,meta分析,评审


    authors: Luttjeboer F,Harada T,Hughes E,Johnson N,Lilford R,Mol BW

    更新日期:2007-07-18 00:00:00

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    abstract:BACKGROUND:Cataract and glaucoma are leading causes of blindness worldwide, and their co-existence is common in elderly people. Glaucoma surgery can accelerate cataract progression, and performing both surgeries may increase the rate of postoperative complications and compromise the success of either surgery. However, ...

    journal_title:The Cochrane database of systematic reviews

    pub_type: 杂志文章,meta分析,评审


    authors: Zhang ML,Hirunyachote P,Jampel H

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    journal_title:The Cochrane database of systematic reviews

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    journal_title:The Cochrane database of systematic reviews

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  • Surgical interventions for the early management of Bell's palsy.

    abstract:BACKGROUND:Bell's palsy is an acute unilateral facial paralysis of unknown aetiology and should only be used as a diagnosis in the absence of any other pathology. As the proposed pathophysiology is swelling and entrapment of the nerve, some surgeons suggest surgical decompression of the nerve as a possible management o...

    journal_title:The Cochrane database of systematic reviews

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    authors: Menchetti I,McAllister K,Walker D,Donnan PT

    更新日期:2021-01-26 00:00:00

  • Medical versus surgical methods for first trimester termination of pregnancy.

    abstract:BACKGROUND:Induced abortions are very commonly practiced interventions worldwide. A variety of medical abortion methods have been introduced during the last decade in addition to existing surgical methods. In this review we systematically searched for and combined all evidence from randomised controlled trials comparin...

    journal_title:The Cochrane database of systematic reviews

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    authors: Say L,Kulier R,Gülmezoglu M,Campana A

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    abstract:BACKGROUND:Leg ulcers are open skin wounds that occur between the ankle and the knee that can last weeks, months or even years and are a consequence of arterial or venous valvular insufficiency. Negative pressure wound therapy (NPWT) is a technology that is currently used widely in wound care and is promoted for use on...

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    abstract:BACKGROUND:This is an update of a review first published in The Cochrane Library in Issue 3, 2013. Cancer-related pain places a heavy burden on public health with related high expenditure. Severe pain is associated with a decreased quality of life in patients with cancer. A significant proportion of patients with cance...

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    abstract:BACKGROUND:Tetanus is an acute, often fatal, disease caused by an exotoxin produced by Clostridium tetani. It occurs in newborn infants born to mothers who do not have sufficient circulating antibodies to protect the infant passively, by transplacental transfer. Prevention may be possible by the vaccination of pregnant...

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    abstract:BACKGROUND:Yoga is an ancient spiritual practice that originated in India and is currently accepted in the Western world as a form of relaxation and exercise. It has been of interest for people with schizophrenia to determine its efficacy as an adjunct to standard-care treatment. OBJECTIVES:To examine the effects of y...

    journal_title:The Cochrane database of systematic reviews

    pub_type: 杂志文章,meta分析,评审


    authors: Broderick J,Knowles A,Chadwick J,Vancampfort D

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  • Written and verbal information versus verbal information only for patients being discharged from acute hospital settings to home.

    abstract:BACKGROUND:It is becoming commonplace for patients to be discharged earlier from acute hospital settings to their own homes and be required to manage various aspects of their own care. This has increased the need for detailed information to be given to patients and/or significant others to enable them to effectively ma...

    journal_title:The Cochrane database of systematic reviews

    pub_type: 杂志文章,评审


    authors: Johnson A,Sandford J,Tyndall J

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    abstract:BACKGROUND:Most people admitted to hospitals worldwide require a vascular access device (VAD). Hundreds of millions of VADs are inserted annually in the USA with reports of over a billion peripheral intravenous catheters used annually worldwide. Numerous reports suggest that a team approach for the assessment, insertio...

    journal_title:The Cochrane database of systematic reviews

    pub_type: 杂志文章,评审


    authors: Carr PJ,Higgins NS,Cooke ML,Mihala G,Rickard CM

    更新日期:2018-03-20 00:00:00

  • Vaginal misoprostol for cervical ripening and induction of labour.

    abstract:BACKGROUND:Misoprostol (Cytotec, Searle) is a prostaglandin E1 analogue marketed for use in the prevention and treatment of peptic ulcer disease. It is inexpensive, easily stored at room temperature and has few systemic side effects. It is rapidly absorbed orally and vaginally. Although not registered for such use, mis...

    journal_title:The Cochrane database of systematic reviews

    pub_type: 杂志文章,评审


    authors: Hofmeyr GJ,Gulmezoglu AM

    更新日期:2001-01-01 00:00:00

  • WITHDRAWN: Periconceptional supplementation with folate and/or multivitamins for preventing neural tube defects.

    abstract:BACKGROUND:Neural tube defects arise during the development of the brain and spinal cord. OBJECTIVES:The objective of this review was to assess the effects of increased consumption of folate or multivitamins on the prevalence of neural tube defects periconceptionally (that is before pregnancy and in the first two mont...

    journal_title:The Cochrane database of systematic reviews

    pub_type: 杂志文章,评审


    authors: Lumley J,Watson L,Watson M,Bower C

    更新日期:2011-04-13 00:00:00

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    abstract:BACKGROUND:Patients with early stage cervical cancer (stages IA2, IB1 or IIA) with risk factors such as lymph node metastasis, lympho vascular space invasion, depth invasion of more than 10mm, microscopic parametrial invasion, non-squamous histology and positive surgical margins have a high risk of recurrence when comp...

    journal_title:The Cochrane database of systematic reviews

    pub_type: 杂志文章,meta分析,评审


    authors: Rosa DD,Medeiros LR,Edelweiss MI,Bozzetti MC,Pohlmann PR,Stein AT,Dickinson HO

    更新日期:2009-07-08 00:00:00

  • Antifibrinolytic drugs for acute traumatic injury.

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    journal_title:The Cochrane database of systematic reviews

    pub_type: 杂志文章,meta分析,评审


    authors: Ker K,Roberts I,Shakur H,Coats TJ

    更新日期:2015-05-09 00:00:00

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    journal_title:The Cochrane database of systematic reviews

    pub_type: 杂志文章,评审


    authors: Chilvers R,Macdonald GM,Hayes AA

    更新日期:2006-10-18 00:00:00

  • Continuous support for women during childbirth.

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    journal_title:The Cochrane database of systematic reviews

    pub_type: 杂志文章


    authors: Bohren MA,Hofmeyr GJ,Sakala C,Fukuzawa RK,Cuthbert A

    更新日期:2017-07-06 00:00:00