Activation of peripheral chemoreceptors causes positive inotropic effects in a working heart-brainstem preparation of the rat.

Abstract:

:1. The aim of the present study was to evaluate the effects of peripheral chemoreceptor activation on myocardial contractility in an anaesthetic-free decerebrated rat preparation. 2. In the decerebrated and retrogradely perfused working heart-brainstem preparation, we recorded phrenic nerve activity, left ventricular (LV) pressure (microtip Millar catheter), LV dP/dT, heart rate and aortic perfusion pressure before and after activating peripheral chemoreceptors with bolus intra-arterial injections of KCN. 3. Without cardiac pacing, chemoreflex activation caused falls in heart rate (-108 +/- 21 b.p.m.) and complex polyphasic changes in LV pressure and LV dP/dT. If the heart was paced, chemoreflex activation caused significant rises in LP pressure (+16 +/- 3 mmHg) and LV dP/dt (+778 +/- 93 mmHg/s). These positive inotropic effects were significantly and substantially attenuated by beta-adrenoceptor blockade with atenolol. In all instances, chemoreflex activation elicited potent tachypnoeic responses. 4. In conclusion, activation of peripheral chemoreceptors in non-anaesthetized rats evokes a positive inotropic response that is sympathetically mediated. This observation may be relevant for the evaluation of neurally induced effects of acute hypoxia on the ventricular myocardium.

authors

Braga VA,Zoccal DB,Soriano RN,Antunes VR,Paton JF,Machado BH,Nalivaiko E

doi

10.1111/j.1440-1681.2007.04699.x

subject

Has Abstract

pub_date

2007-11-01 00:00:00

pages

1156-9

issue

11

eissn

0305-1870

issn

1440-1681

pii

CEP4699

journal_volume

34

pub_type

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