Predictive Value of a Thyroid-Absorbed Dose with a Shorter Effective Half-Life on Efficacy in Graves Disease Patients Receiving Iodine-131 Therapy.

Abstract:

:BACKGROUND Although radioiodine therapy (RIT) efficacy is thoroughly validated for Graves disease (GD), there is a lack of research on the predictive factors of RIT, especially the optimal thyroid-absorbed dose (TD) with a shorter effective half-life (Teff ≤5 days). The goal of this study was to explore the predictive value of TD in GD patients receiving RIT with a shorter Teff. MATERIAL AND METHODS We studied 208 GD patients receiving RIT with a shorter Teff. Plotting the receiver-operating characteristic (ROC) curve verified the accuracy of TD for predicting RIT efficacy in GD patients. In addition, we conducted univariate and multivariate analyses to investigate the influence of 14 factors, including thyroid weight, TD, 24-h radioiodine uptake rate (RAIU), the highest RAIU, thyrotrophin receptor antibody level, thyroglobulin antibody level, thyroid peroxidase antibody level, and others, on curative effects of RIT. RESULTS Of the 208 study participants, complete remission and the total effectiveness rates were 68.3% and 92.3%, respectively. The threshold value of TD to predict RIT efficacy was 70.2 Gy, based on ROC analysis. Univariate analysis showed that 24-h RAIU, Teff, total iodine dose, iodine dose per gram of thyroid tissue, TD, and thyrotropin receptor antibody level were significantly associated with RIT efficacy. Multivariate analysis indicated that 24-h RAIU, total iodine dose, iodine dose per gram of thyroid tissue, and TD were significant independent predictors of RIT efficacy. CONCLUSIONS Predicting RIT efficacy from TD with a shorter Teff was feasible in GD patients, and TD above 70.2 Gy had an especially high predictive accuracy.

journal_name

Med Sci Monit

authors

Yu F,Zhang R,Zhang G,Meng Z,Liu X,He Y,Tan J,Wang R

doi

10.12659/MSM.928796

subject

Has Abstract

pub_date

2021-01-26 00:00:00

pages

e928796

eissn

1234-1010

issn

1643-3750

pii

928796

journal_volume

27

pub_type

杂志文章
  • MR proton spectroscopy in liver examinations of healthy individuals in vivo.

    abstract:BACKGROUND:Magnetic resonance proton spectroscopy ((1)H MRS) is a non-invasive method that provides in vivo measurement of metabolic concentrations in body tissue. However, relatively little is known about the potential of 1H MR spectroscopy for the quantification of liver metabolites. The aim of this study was to dete...

    journal_title:Medical science monitor : international medical journal of experimental and clinical research

    pub_type: 杂志文章

    doi:

    authors: Tarasów E,Siergiejczyk L,Panasiuk A,Kubas B,Dzienis W,Prokopowicz D,Walecki J

    更新日期:2002-02-01 00:00:00

  • Induction of osteoporosis with its influence on osteoporotic determinants and their interrelationships in rats by DEXA.

    abstract:BACKGROUND:As women are the population most affected by multifactorial osteoporosis, research is focused on unraveling the underlying mechanism of osteoporosis induction in rats by combining ovariectomy (OVX) either with calcium, phosphorus, vitamin C and vitamin D2/D3 deficiency, or by administration of glucocorticoid...

    journal_title:Medical science monitor : international medical journal of experimental and clinical research

    pub_type: 杂志文章

    doi:10.12659/msm.882895

    authors: Heiss C,Govindarajan P,Schlewitz G,Hemdan NY,Schliefke N,Alt V,Thormann U,Lips KS,Wenisch S,Langheinrich AC,Zahner D,Schnettler R

    更新日期:2012-06-01 00:00:00

  • Honokiol Suppression of Human Epidermal Growth Factor Receptor 2 (HER2)-Positive Gastric Cancer Cell Biological Activity and Its Mechanism.

    abstract::BACKGROUND The purpose of our study was to determine the effects and mechanisms of honokiol on human epidermal growth factor receptor 2 (HER2)-positive gastric cancer cells by in vitro study. MATERIAL AND METHODS We measured HER2 expression in different gastric cancer cell lines by real-time quantitative polymerase ch...

    journal_title:Medical science monitor : international medical journal of experimental and clinical research

    pub_type: 杂志文章

    doi:10.12659/MSM.923962

    authors: Yan Y,Xu J,Mao G

    更新日期:2020-08-30 00:00:00

  • Effect of Combined Use of Astragaloside IV (AsIV) and Atorvastatin (AV) on Expression of PPAR-γ and Inflammation-Associated Cytokines in Atherosclerosis Rats.

    abstract::BACKGROUND The aim of this study was to assess the effect of combined use of Astragaloside IV(AsIV) and atorvastatin (AV) on the expression of PPAR-γ and inflammation-associated cytokines in atherosclerosis rats. MATERIAL AND METHODS High-density lipoprotein cholesterol (HDL-C), total cholesterol (TC), and low-density...

    journal_title:Medical science monitor : international medical journal of experimental and clinical research

    pub_type: 杂志文章

    doi:10.12659/MSM.908480

    authors: Sun B,Rui R,Pan H,Zhang L,Wang X

    更新日期:2018-09-07 00:00:00

  • Changes in drug prescription utilization for diabetic and hypertensive outpatients after initiation of the National Health Insurance's Global Budget Program in Taiwan.

    abstract:BACKGROUND:To examine changes in medicine utilization and prescription trends for diabetic (DM) and hypertensive (HT) patients upon initiation of the National Health Insurance (NHI) global budget (GB) program in Taiwan. MATERIAL/METHODS:Data on hospital-based outpatient prescriptions for DM and HT from the Taipei bran...

    journal_title:Medical science monitor : international medical journal of experimental and clinical research

    pub_type: 杂志文章

    doi:

    authors: Chou CC,Hu KY,Wu NR,Cheng YH,Loh CH,Yeh MK

    更新日期:2008-05-01 00:00:00

  • Relationship Between Fat Mass and Obesity-Associated (FTO) Gene Polymorphisms with Obesity and Metabolic Syndrome in Ethnic Mongolians.

    abstract::BACKGROUND The distribution of fat mass and obesity-associated gene (FTO) genes rs9939609 and rs1421085 in obese and normal ethnic Mongolians was analyzed to investigate the association of FTO gene polymorphisms with obesity and metabolic syndrome in ethnic Mongolians. MATERIAL AND METHODS The genotypes of FTO genes r...

    journal_title:Medical science monitor : international medical journal of experimental and clinical research

    pub_type: 杂志文章

    doi:10.12659/MSM.910928

    authors: Zhang Q,Xia X,Fang S,Yuan X

    更新日期:2018-11-16 00:00:00

  • Predictive Value of Indocyanine Green Plasma Disappearance Rate on Liver Function and Complications After Liver Transplantation.

    abstract::BACKGROUND The aim of this study was to investigate the correlation between indocyanine green plasma disappearance rate (ICG-PDR) and allograft function as well as postoperative complications after liver transplantation. MATERIAL AND METHODS In this prospective study, 115 cases of adult liver transplantation performed...

    journal_title:Medical science monitor : international medical journal of experimental and clinical research

    pub_type: 杂志文章

    doi:10.12659/MSM.907783

    authors: Sun Y,Yu L,Liu Y

    更新日期:2018-06-01 00:00:00

  • Esophageal muscle cell interaction with biopolymers.

    abstract:BACKGROUND:The in vitro interactions of esophageal smooth muscle cells (SMCs) with synthetic absorbable polymers were tested and artificial muscle tissues harvested from subcutaneous implantation were examined. MATERIAL/METHODS:Esophageal tissue samples from adult and fetal (25-day gestational age) rabbits were cut in...

    journal_title:Medical science monitor : international medical journal of experimental and clinical research

    pub_type: 杂志文章

    doi:

    authors: Korkmaz M,Yakut T,Narci A,Güvenç BH,Güilten T,Yağmurca M,Yiğit B,Bilir A

    更新日期:2007-02-01 00:00:00

  • Clinical Features of 167 Inpatients with Autosomal Dominant Polycystic Kidney Disease at a Single Center in China.

    abstract::BACKGROUND The aim of this study was to describe the clinical characteristics of Chinese ADPKD inpatients and to identify the factors associated with disease severity. MATERIAL AND METHODS We included 167 hospitalized patients (inpatients) with ADPKD in this study. Multiple regression analyses were conducted to determ...

    journal_title:Medical science monitor : international medical journal of experimental and clinical research

    pub_type: 杂志文章

    doi:10.12659/MSM.910127

    authors: Meng J,Xu Y,Li A,Fan S,Shen X,Ma D,Zhang L,Hao Z,Zhang X,Liang C

    更新日期:2018-09-16 00:00:00

  • Clinical Significance of G Protein-Coupled Receptor 110 (GPR110) as a Novel Prognostic Biomarker in Osteosarcoma.

    abstract::BACKGROUND G protein-coupled receptor 110 (GPR110) belongs to the subfamily of the adhesion G protein-coupled receptors (GPCRs). The potential role of GPR110 has been correlated with cancer cell invasion in some tumors such as glioma. However, its expression and role in human osteosarcoma has not been identified. This...

    journal_title:Medical science monitor : international medical journal of experimental and clinical research

    pub_type: 杂志文章

    doi:10.12659/MSM.909555

    authors: Liu Z,Zhang G,Zhao C,Li J

    更新日期:2018-07-27 00:00:00

  • Diagnostic Value of Non-Real-Time Radial Probe Endobronchial Ultrasound (RP-EBUS) Guided Positioning Method for Peripheral Pulmonary Lesions.

    abstract::BACKGROUND The aim of this study was to analyze the diagnostic value of thin bronchoscopy lung biopsy for peripheral pulmonary lesions under non-real-time guidance of radial ultrasound (RP-EBUS). MATERIAL AND METHODS We used a retrospective analysis of ultrasound images of 165 patients with peripheral pulmonary diseas...

    journal_title:Medical science monitor : international medical journal of experimental and clinical research

    pub_type: 杂志文章

    doi:10.12659/MSM.918888

    authors: Li N,Peng Y,Chen Y,Lv Y,Xu G,Ruan T

    更新日期:2019-12-19 00:00:00

  • Aminophylline treatment of refractory bronchospasm in mechanically ventilated neonates: case report.

    abstract:BACKGROUND:The aim was to determine the effectiveness of continuous aminophylline infusion on refractory bronchospasm in long-term mechanically ventilated neonates. CASE REPORT:Presented are seven newborns with gestational ages from 24 to 38 weeks and mean age at treatment of 29.7 days. All were mechanically ventilate...

    journal_title:Medical science monitor : international medical journal of experimental and clinical research

    pub_type: 杂志文章

    doi:

    authors: Migliori C,Garzoli E,Spinoni V,Chirico G

    更新日期:2007-08-01 00:00:00

  • Prognostic factors for the time of occurrence and dynamics of distant metastases and local recurrences after radical treatment in patients with rectal cancer.

    abstract:BACKGROUND:A remarkable increase has been noted in the rate of incidence of rectal cancer. Post- or preoperative adjuvant treatment has significantly decreased the risk of local recurrence, but still only about 50% of all patients with rectal cancer treated radically can achieve a permanent cure. The majority of failur...

    journal_title:Medical science monitor : international medical journal of experimental and clinical research

    pub_type: 杂志文章

    doi:

    authors: Chmielarz A,Kryj M,Wloch J,Półtorak S,Sacher A,Lasek-Kryj M

    更新日期:2001-11-01 00:00:00

  • Substance P Inhibits the Collagen Synthesis of Rat Myocardial Fibroblasts Induced by Ang II.

    abstract::BACKGROUND The aim of this study was to explore the regulating effects of Substance P (SP) on the collagen synthesis of rat myocardial fibroblasts (CFBs) induced by angiotensin II (Ang II) and its potential mechanism. MATERIAL AND METHODS The CFBs of a neonatal SD rat were separately cultured and divided into the cont...

    journal_title:Medical science monitor : international medical journal of experimental and clinical research

    pub_type: 杂志文章

    doi:10.12659/msm.898454

    authors: Yang Z,Zhang X,Guo N,Li B,Zhao S

    更新日期:2016-12-16 00:00:00

  • Extra structurally abnormal chromosomes (ESACs)--presentation of 10 new cases.

    abstract:BACKGROUND:The goal of the presented studies as a retrospective reliability assessment of classical banding cytogenetic studies and of prognosing epicrises in a group of 14 cases, affected with additional marker chromosomes. MATERIAL AND METHODS:Having collected the study material from peripheral blood, by means of tr...

    journal_title:Medical science monitor : international medical journal of experimental and clinical research

    pub_type: 杂志文章

    doi:

    authors: Kałuzewski B,Helszer Z,Constantinou M,Burkholder SW,Coutinho WG,Skorski M,Corridori L,Anderson CE,Sherwood M,Debiec-Rychter M,Jackson LG

    更新日期:2001-05-01 00:00:00

  • Matrix metalloproteinase-2 in platelet adhesion to fibrinogen: interactions with nitric oxide.

    abstract:BACKGROUND:Matrix metalloproteinase-2 (MMP-2) has been shown to activate a non-thromboxane, non-ADP pathway of platelet aggregation. In contrast, nitric oxide (NO) is known to inhibit platelet adhesion and aggregation. Therefore, we have studied the release of MMP-2 during platelet adhesion to fibrinogen, the effects o...

    journal_title:Medical science monitor : international medical journal of experimental and clinical research

    pub_type: 杂志文章

    doi:

    authors: Martinez A,Salas E,Radomski A,Radomski MW

    更新日期:2001-07-01 00:00:00

  • Music alters constitutively expressed opiate and cytokine processes in listeners.

    abstract:BACKGROUND:Listening to music as a means of inducing a sense of calm and relaxation has been known for some time. Although these effects are robust, little research has been conducted into exploring the underlying neurochemical changes, which must occur to provide an individual with these objective sensations. MATERIA...

    journal_title:Medical science monitor : international medical journal of experimental and clinical research

    pub_type: 临床试验,杂志文章,随机对照试验

    doi:

    authors: Stefano GB,Zhu W,Cadet P,Salamon E,Mantione KJ

    更新日期:2004-06-01 00:00:00

  • Resveratrol Induces Endothelial Progenitor Cells Angiogenesis via MiR-542-3p by Targeting Angiopoietin-2 and Involves in Recanalization of Venous Thrombosis.

    abstract::BACKGROUND Endothelial progenitor cells (EPCs) play an important role in therapeutic angiogenesis. Besides, resveratrol (RSV) exerts many pharmacological functions in regulation of cell function. Furthermore, microRNAs (miRNAs) have been considered to be of great significance in biological process. In this study, we a...

    journal_title:Medical science monitor : international medical journal of experimental and clinical research

    pub_type: 杂志文章

    doi:10.12659/MSM.917013

    authors: Lu Z,Wang S,Zhu X,Yuan X,Zhan Y,Li Y,Wang W

    更新日期:2019-10-13 00:00:00

  • Acoustic rhinometry in the assessment of adenoid hypertrophy in allergic children.

    abstract:BACKGROUND:Due to the difficulties involved in assessing adenoidal tissue and the nasopharyngeal airway in children, it is necessary to find an accurate pre-operative method of measuring these structures. MATERIAL/METHODS:We used acoustic rhinometry and endoscopy both to the evaluate results of surgical and medical tr...

    journal_title:Medical science monitor : international medical journal of experimental and clinical research

    pub_type: 杂志文章

    doi:

    authors: Modrzyński M,Mierzwinski J,Zawisza E,Piziewicz A

    更新日期:2004-07-01 00:00:00

  • What is more damaging to vascular endothelial function: Diabetes, age, high BMI, or all of the above?

    abstract:BACKGROUND:It is well established that there is a reduction in the skin blood flow (SBF) in response to heat with age and diabetes. While it is known that high BMI creates a stress on the cardiovascular system and increases the risk of all cause of morbidity and mortality, little is known of the effect of high BMI on S...

    journal_title:Medical science monitor : international medical journal of experimental and clinical research

    pub_type: 杂志文章

    doi:10.12659/MSM.883878

    authors: Petrofsky JS,Alshammari F,Bains GS,Khowailed IA,Lee H,Kuderu YN,Lodha RD,Rodrigues S,Nguyen D,Potnis PA,Deshpande PP,Yim JE,Berk L

    更新日期:2013-04-10 00:00:00

  • miRNA-339-5p Plays an Important Role in Invasion and Migration of Pancreatic Cancer Cells.

    abstract::BACKGROUND This study aimed to investigate the role of miRNA-339-5p in pancreatic cancer cell invasion and migration. MATERIAL AND METHODS The differences between exosomal miRNAs of PANC02 and PANC02-H7 were studied by microarray analysis. We measured miRNA-339-5p expression in different groups; differences in cell in...

    journal_title:Medical science monitor : international medical journal of experimental and clinical research

    pub_type: 杂志文章

    doi:10.12659/MSM.917038

    authors: Yu Z,Zhao S,Wang L,Wang J,Zhou J

    更新日期:2019-10-07 00:00:00

  • Effect of Low Frequency Repetitive Transcranial Magnetic Stimulation on Depression and Cognition of Patients with Traumatic Brain Injury: A Randomized Controlled Trial.

    abstract::BACKGROUND This study was conducted to investigate the effects of low frequency repetitive transcranial magnetic stimulation (rTMS) of the right dorsolateral prefrontal cortex on depression and cognition in patients with traumatic brain injury. MATERIAL AND METHODS To accomplish this, 13 patients who were diagnosed wi...

    journal_title:Medical science monitor : international medical journal of experimental and clinical research

    pub_type: 杂志文章,随机对照试验

    doi:10.12659/MSM.911385

    authors: Lee SA,Kim MK

    更新日期:2018-12-04 00:00:00

  • A New Triage Method for Burn Disasters: Fast Triage in Burns (FTB).

    abstract::BACKGROUND There are few triage methods based on patient age and extent of burn. However, in case of mass casualties, age might be hard to define. Burn segregation in mass-casualty accidents requires an easy, fast, and effective method. Triage in burns should also segregate casualties requiring treatment in burn cente...

    journal_title:Medical science monitor : international medical journal of experimental and clinical research

    pub_type: 杂志文章

    doi:10.12659/msm.905197

    authors: Surowiecka-Pastewka A,Witkowski W,Kawecki M

    更新日期:2018-03-31 00:00:00

  • Effect of hydroxyethyl starch (HAES) on degree and kinetics of erythrocyte aggregation studied with dielectric spectroscopy method.

    abstract:BACKGROUND:Colloidal fluids, e.g. hydroxyethyl starch (HAES), used as blood plasma substitutes during acute controlled normovolemic hemodilution may cause erythrocyte aggregation. The aim of the presented study was to assess the degree and rate of erythrocyte aggregation in the media containing different concentrations...

    journal_title:Medical science monitor : international medical journal of experimental and clinical research

    pub_type: 杂志文章

    doi:

    authors: Jaroszyński W,Keslinka E,Wujtewicz M,Suchorzewska J,Kwiatkowski B

    更新日期:2002-07-01 00:00:00

  • Screening of Critical Genes and MicroRNAs in Blood Samples of Patients with Ruptured Intracranial Aneurysms by Bioinformatic Analysis of Gene Expression Data.

    abstract::BACKGROUND This study aimed to identify more potential genes and miRNAs associated with the pathogenesis of intracranial aneurysms (IAs). MATERIAL AND METHODS The dataset of GSE36791 (accession number) was downloaded from the Gene Expression Omnibus database. Differentially expressed genes (DEGs) were screened for in ...

    journal_title:Medical science monitor : international medical journal of experimental and clinical research

    pub_type: 杂志文章

    doi:10.12659/msm.902953

    authors: Bo L,Wei B,Wang Z,Kong D,Gao Z,Miao Z

    更新日期:2017-09-20 00:00:00

  • Echocardiographic Changes in Newly Diagnosed Type 2 Diabetes Mellitus Patients with and without Hypertension.

    abstract::BACKGROUND Whether type 2 diabetes mellitus (T2DM) is independently associated with structural heart abnormalities is controversial because of confounders associated with T2DM. This study aimed to investigate echocardiographic features in patients with newly diagnosed T2DM, exploring changes in cardiac structure and f...

    journal_title:Medical science monitor : international medical journal of experimental and clinical research

    pub_type: 杂志文章

    doi:10.12659/MSM.918972

    authors: Zhao Z,Hou C,Ye X,Cheng J

    更新日期:2020-01-26 00:00:00

  • Radiological and biomechanical analysis of humeral fractures occurring during arm wrestling.

    abstract:BACKGROUND:Arm wrestling has recently become one of the most popular sports among young people, mainly due to its simplicity and spectacularity. Yet, unfortunately it is also injury prone. The aim of the study was to perform a biomechanical analysis of the forces which act during arm wrestling, as well as to explain th...

    journal_title:Medical science monitor : international medical journal of experimental and clinical research

    pub_type: 杂志文章

    doi:10.12659/msm.882736

    authors: Kruczyński J,Jaszczur Nowicki J,Topoliński T,Srokowski G,Mańko G,Chantsoulis M,Frankowska M,Frankowski P

    更新日期:2012-05-01 00:00:00

  • The Clinical Relevance of Fragile Histidine Triad Protein (FHIT) in Patients with Bladder Cancer.

    abstract::BACKGROUND The present study aimed to investigate the clinical relevance of fragile histidine triad protein (FHIT) in patients with bladder cancer (BC). MATERIAL AND METHODS Three independent BC microarray studies were collected and reanalyzed. The expression of FHIT was evaluated between BC samples and normal bladder...

    journal_title:Medical science monitor : international medical journal of experimental and clinical research

    pub_type: 杂志文章

    doi:10.12659/MSM.906721

    authors: Liu XP,Yin XH,Yan XH,Zeng XT,Wang XH

    更新日期:2018-05-12 00:00:00

  • Direct MRI fistulography with hydrogen peroxide in patients with recurrent perianal fistulas: a new proposal of extended diagnostics.

    abstract:BACKGROUND:Perianal fistulas are malformations of the anorectal area. Accurate preoperative assessment of perianal fistula tract is a main assumption in diagnosis of the disease, affecting the operation efficiency. The aim of the study was to present our experience in application of a new diagnostic protocol based on t...

    journal_title:Medical science monitor : international medical journal of experimental and clinical research

    pub_type: 杂志文章

    doi:10.12659/MSM.891232

    authors: Waniczek D,Adamczyk T,Arendt J,Kluczewska E

    更新日期:2015-02-10 00:00:00

  • Comparison of iron and hematological indices in Giardia lamblia infection before and after treatment in 102 children in Ahwaz, Iran.

    abstract:BACKGROUND:Up to now there have been few reports about hematological alterations induced by Giardia lamblia infection. The aim of this study was to evaluate the effects of giardiasis treatment on hematological indices in children in the Khuzestan area by comparing these indices before and after treatment with metronida...

    journal_title:Medical science monitor : international medical journal of experimental and clinical research

    pub_type: 临床试验,杂志文章

    doi:

    authors: Monajemzadeh SM,Monajemzadeh M

    更新日期:2008-01-01 00:00:00