Abstract:
BACKGROUND:Hypospadias is a common birth defect that might be caused by inadequate fusion of the urethral folds in the process of male external genital development. We intended to discover the crucial long noncoding RNAs (lncRNAs) regulating autophagy from the gene expression profile of the genital tubercle (GT) of dibutyl phthalate (DBP) induced hypospadiac rats. METHODS:Whole transcriptome resequencing was used to determine the expression of the total RNA in GTs and cultured fibroblasts obtained from GTs of DBP-induced hypospadiac male rat fetuses. Autophagosomes and autolysosomes were examined under a transmission electron microscope after overexpression of lncRNA NONRATT008453.2 in the fibroblasts by adenovirus transfection. Finally, the protein expression levels of Atg5, Beclin-1, Atg7, and the LC3A/B-II:LC3A/B-I ratio were detected in the fibroblasts by western blotting. RESULTS:NONRATT008453.2 suppressed autophagy by promoting the expression of Atg7, but inhibited the expressions of Atg5, Beclin-1, and the LC3A/B-II:LC3A/B-I ratio in the GT fibroblasts. CONCLUSIONS:NONRATT008453.2 may have an influence on autophagy in the fibroblasts of the GT in DBP-induced hypospadiac rats.
journal_name
Birth Defects Resjournal_title
Birth defects researchauthors
Feng X,Huang E,Gao Y,Zhang Y,Zhou Ydoi
10.1002/bdr2.1863subject
Has Abstractpub_date
2021-01-15 00:00:00issn
2472-1727pub_type
杂志文章abstract:BACKGROUND:Antecedents for infantile hypertrophic pyloric stenosis (IHPS) vary across studies; therefore, we conducted a multistate, population-based retrospective study of the prevalence and descriptive epidemiology of IHPS in the United States (US). METHODS:Data for IHPS cases (n = 29,554) delivered from 1999-2010 a...
journal_title:Birth defects research
pub_type: 杂志文章
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更新日期:2019-02-01 00:00:00
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journal_title:Birth defects research
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journal_title:Birth defects research
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journal_title:Birth defects research
pub_type: 杂志文章
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journal_title:Birth defects research
pub_type: 杂志文章
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journal_title:Birth defects research
pub_type: 杂志文章,评审
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journal_title:Birth defects research
pub_type: 杂志文章
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journal_title:Birth defects research
pub_type: 杂志文章
doi:10.1002/bdr2.1155
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journal_title:Birth defects research
pub_type: 杂志文章,评审
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journal_title:Birth defects research
pub_type: 杂志文章
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journal_title:Birth defects research
pub_type: 杂志文章,评审
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abstract:BACKGROUND:To objectively describe craniofacial, visual, and neurological features associated with amniotic band syndrome (ABS) and discuss likely associated multifactorial etiology. METHODS:A retrospective review of patients identified with ABS and concomitant limb involvement and craniofacial features was conducted....
journal_title:Birth defects research
pub_type: 杂志文章
doi:10.1002/bdr2.1576
更新日期:2019-11-15 00:00:00
abstract:BACKGROUND:Obstetricians usually prescribe supplements during pregnancy without actual indication. The use of selenium during pregnancy has increased, due to its function in several antioxidant mechanisms. CASE:A pregnant woman received 200,000 micrograms (μg) per day of a selenium galenic formulation, since gestation...
journal_title:Birth defects research
pub_type: 杂志文章,评审
doi:10.1002/bdr2.1148
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journal_title:Birth defects research
pub_type: 杂志文章
doi:10.1002/bdr2.1107
更新日期:2017-11-01 00:00:00
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journal_title:Birth defects research
pub_type: 杂志文章
doi:10.1002/bdr2.1125
更新日期:2017-10-16 00:00:00
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journal_title:Birth defects research
pub_type: 杂志文章,评审
doi:10.1002/bdr2.1561
更新日期:2019-10-15 00:00:00
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journal_title:Birth defects research
pub_type: 杂志文章
doi:10.1002/bdr2.1815
更新日期:2021-01-01 00:00:00
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journal_title:Birth defects research
pub_type: 杂志文章
doi:10.1002/bdr2.1108
更新日期:2017-11-01 00:00:00
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journal_title:Birth defects research
pub_type: 杂志文章
doi:10.1002/bdr2.1817
更新日期:2020-12-01 00:00:00
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journal_title:Birth defects research
pub_type: 杂志文章
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journal_title:Birth defects research
pub_type: 杂志文章
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更新日期:2018-06-01 00:00:00
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journal_title:Birth defects research
pub_type: 杂志文章
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更新日期:2017-09-01 00:00:00
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journal_title:Birth defects research
pub_type: 杂志文章
doi:10.1002/bdr2.1793
更新日期:2020-12-01 00:00:00
abstract::Cannabis use during adolescence has been linked to deleterious effects on brain integrity. This article summarizes findings from two prospective investigations (3 and 6 years, on average) on adolescent cannabis use from our laboratory that utilize structural neuroimaging and neurocognitive assessment approaches. Acros...
journal_title:Birth defects research
pub_type: 杂志文章,评审
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更新日期:2019-10-15 00:00:00
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journal_title:Birth defects research
pub_type: 杂志文章
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更新日期:2017-01-30 00:00:00
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journal_title:Birth defects research
pub_type: 杂志文章
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更新日期:2020-09-01 00:00:00
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journal_title:Birth defects research
pub_type: 杂志文章
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pub_type: 杂志文章,评审
doi:10.1002/bdr2.1077
更新日期:2017-07-17 00:00:00
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journal_title:Birth defects research
pub_type: 杂志文章,评审
doi:10.1002/bdr2.1667
更新日期:2020-07-15 00:00:00