Association Between Plasma Metabolites and Psychometric Scores Among Children With Developmental Disabilities: Investigating Sex-Differences.

Abstract:

:Background: Developmental disabilities are defined by delays in learning, language, and behavior, yet growing evidence has revealed disturbances in metabolic systems that may also be present. Little is known about whether these metabolic issues contribute to the symptoms or severity of these disabilities, or whether sex plays a role in these associations, given that boys are disproportionately affected by some developmental disabilities. Here we sought to investigate the correlation between psychometric scores, sex, and the plasma metabolome. Methods: The plasma metabolomes of children with autism spectrum disorder (ASD; n = 167), idiopathic developmental delay (i-DD; n = 51), Down syndrome (DS; n = 31), and typically developing controls (TD; n = 193) were investigated using NMR spectroscopy. Spearman rank correlations and multiple linear regression models (adjusted for child's neurodevelopmental diagnosis, child's sex, child's age, child's race/ethnicity, maternal age at child's birth, and parental homeownership) were used to examine the association between plasma metabolites and sex in relation to psychometric measures of cognitive skills, adaptive behavior, and maladaptive behavior in our study population. Results: Higher levels of metabolites involved in cellular energy and mitochondrial function among children with ASD (fumarate and cis-aconitate), DS (lactate), and TD (pyruvate) are associated with poorer cognitive and adaptive subscales. Similarly, higher o-acetylcarnitine associated with deficits in cognitive subscales among all DS cases and TD boys, and carnitine correlated with increased maladaptive behavior among girls with ASD and girls with DS. Among children with DS, elevated myo-inositol, ornithine, and creatine correlated with poorer scores across several subscales. Even among TD cases, elevated 3-hydroxybutyrate correlated with decreased receptive language. In contrast, higher levels of glutamate were associated with better socialization skills among ASD cases. Even after adjusting for the child's neurodevelopmental diagnosis, sex, and other possible confounders, key metabolites including glycolysis metabolites (lactate and pyruvate), ketone bodies (3-hydroxybutyrate and acetoacetate), TCA cycle metabolites (cis-aconitate and fumarate), as well as ornithine were associated with deficits in multiple domains of cognitive function, adaptive skills, and aberrant behaviors. Conclusions: Our results highlight that some plasma metabolites may relate to specific functional subdomains within cognitive, adaptive, and behavioral development with some variation by diagnosis and sex.

journal_name

Front Psychiatry

journal_title

Frontiers in psychiatry

authors

Sotelo-Orozco J,Abbeduto L,Hertz-Picciotto I,Slupsky CM

doi

10.3389/fpsyt.2020.579538

subject

Has Abstract

pub_date

2020-12-22 00:00:00

pages

579538

issn

1664-0640

journal_volume

11

pub_type

杂志文章
  • Microglia and Brain Plasticity in Acute Psychosis and Schizophrenia Illness Course: A Meta-Review.

    abstract:Objective:Schizophrenia poses a tremendous health, social, and economic burden upon patients and society, indicating current treatment options remain inadequate. Recent findings from several lines of evidence have pointed to the importance of immune system involvement in not only premorbid neurodevelopmental but also s...

    journal_title:Frontiers in psychiatry

    pub_type: 杂志文章,评审

    doi:10.3389/fpsyt.2017.00238

    authors: De Picker LJ,Morrens M,Chance SA,Boche D

    更新日期:2017-11-16 00:00:00

  • Blue Light Deprivation Produces Depression-Like Responses in Mongolian Gerbils.

    abstract:Background:Depression is a leading cause of disability worldwide and is a major contributor to the overall global burden of disease, but its etiology is poorly understood. It has been reported that a disrupted biological rhythm, in terms of a shortened light duration and total darkness, can cause depression-like behavi...

    journal_title:Frontiers in psychiatry

    pub_type: 杂志文章

    doi:10.3389/fpsyt.2020.00233

    authors: Hu H,Kang C,Hou X,Zhang Q,Meng Q,Jiang J,Hao W

    更新日期:2020-04-08 00:00:00

  • Real World Implementation of a Transdiagnostic Risk Calculator for the Automatic Detection of Individuals at Risk of Psychosis in Clinical Routine: Study Protocol.

    abstract::Background: Primary indicated prevention in individuals at-risk for psychosis has the potential to improve the outcomes of this disorder. The ability to detect the majority of at-risk individuals is the main barrier toward extending benefits for the lives of many adolescents and young adults. Current detection strateg...

    journal_title:Frontiers in psychiatry

    pub_type: 杂志文章

    doi:10.3389/fpsyt.2019.00109

    authors: Fusar-Poli P,Oliver D,Spada G,Patel R,Stewart R,Dobson R,McGuire P

    更新日期:2019-03-13 00:00:00

  • No Laughing Matter: Presence, Consumption Trends, Drug Awareness, and Perceptions of "Hippy Crack" (Nitrous Oxide) among Young Adults in England.

    abstract::In clinical settings, nitrous oxide gas is a safe anesthetic used during childbirth, in dentistry, and to relieve anxiety in emergencies. Colloquially known as "hippy crack"' or "laughing gas," it is increasingly taken recreationally for its euphoric and relaxing effects and hallucinogenic properties. Using a self-rep...

    journal_title:Frontiers in psychiatry

    pub_type: 杂志文章

    doi:10.3389/fpsyt.2017.00312

    authors: Ehirim EM,Naughton DP,Petróczi A

    更新日期:2018-01-22 00:00:00

  • Bullying History and Mental Health In University Students: The Mediator Roles of Social Support, Personal Resilience, and Self-Efficacy.

    abstract::Bullying victimization by peers is highly prevalent in childhood and adolescence. There is convincing evidence that victimization is associated with adverse mental health consequences. In contrast, it has been found that perpetrators suffer no adverse mental health consequences. These findings originate from Western c...

    journal_title:Frontiers in psychiatry

    pub_type: 杂志文章

    doi:10.3389/fpsyt.2019.00960

    authors: Lin M,Wolke D,Schneider S,Margraf J

    更新日期:2020-01-14 00:00:00

  • Empathy at the Heart of Darkness: Empathy Deficits That Bind the Dark Triad and Those That Mediate Indirect Relational Aggression.

    abstract::The dark triad (DT) traits-psychopathy, narcissism and Machiavellianism-have collectively been linked to reduced empathy and increased aggression; however, their association with distinct empathic subtypes remains unclear; and unique links to indirect relational aggression (IRA) have not been delineated. Moreover, whe...

    journal_title:Frontiers in psychiatry

    pub_type: 杂志文章

    doi:10.3389/fpsyt.2019.00095

    authors: Heym N,Firth J,Kibowski F,Sumich A,Egan V,Bloxsom CAJ

    更新日期:2019-03-12 00:00:00

  • Modeling Trait Anxiety: From Computational Processes to Personality.

    abstract::Computational methods are increasingly being applied to the study of psychiatric disorders. Often, this involves fitting models to the behavior of individuals with subclinical character traits that are known vulnerability factors for the development of psychiatric conditions. Anxiety disorders can be examined with ref...

    journal_title:Frontiers in psychiatry

    pub_type: 杂志文章,评审

    doi:10.3389/fpsyt.2017.00001

    authors: Raymond JG,Steele JD,Seriès P

    更新日期:2017-01-23 00:00:00

  • The Gut Microbiome in Anorexia Nervosa: Friend or Foe?

    abstract::The human gut microbiome is emerging as a key modulator of homeostasis, with far-reaching implications for various multifactorial diseases, including anorexia nervosa (AN). Despite significant morbidity and mortality, the underlying mechanisms of this eating disorder are poorly understood, but the classical view defin...

    journal_title:Frontiers in psychiatry

    pub_type: 杂志文章,评审

    doi:10.3389/fpsyt.2020.611677

    authors: Ghenciulescu A,Park RJ,Burnet PWJ

    更新日期:2021-01-12 00:00:00

  • Transcranial direct current stimulation reduces negative affect but not cigarette craving in overnight abstinent smokers.

    abstract::Transcranial direct current stimulation (tDCS) can enhance cognitive control functions including attention and top-down regulation over negative affect and substance craving in both healthy and clinical populations, including early abstinent (∼1.5 h) smokers. The aim of this study was to assess whether tDCS modulates ...

    journal_title:Frontiers in psychiatry

    pub_type: 杂志文章

    doi:10.3389/fpsyt.2013.00112

    authors: Xu J,Fregni F,Brody AL,Rahman AS

    更新日期:2013-09-20 00:00:00

  • Opposite Epigenetic Associations With Alcohol Use and Exercise Intervention.

    abstract::Alcohol use disorder (AUD) is a devastating public health problem in which both genetic and environmental factors play a role. Growing evidence supports that epigenetic regulation is one major mechanism in neuroadaptation that contributes to development of AUD. Meanwhile, epigenetic patterns can be modified by various...

    journal_title:Frontiers in psychiatry

    pub_type: 杂志文章

    doi:10.3389/fpsyt.2018.00594

    authors: Chen J,Hutchison KE,Bryan AD,Filbey FM,Calhoun VD,Claus ED,Lin D,Sui J,Du Y,Liu J

    更新日期:2018-11-15 00:00:00

  • The BDNF Val66Met Polymorphism Has No Effect on Encoding-Related Hippocampal Response But Influences Recall in Remitted Patients With Bipolar Disorder.

    abstract::Background: Cognitive impairments in bipolar disorder (BD) such as memory deficits are associated with poor functional outcomes and it has been suggested that the brain-derived neurotrophic factor (BDNF) Val66Met polymorphism contributes to individual variability in memory function in BD. The current study investigate...

    journal_title:Frontiers in psychiatry

    pub_type: 杂志文章

    doi:10.3389/fpsyt.2019.00845

    authors: Hørlyck LD,Macoveanu J,Vinberg M,Kessing LV,Siebner HR,Miskowiak KW

    更新日期:2019-12-06 00:00:00

  • Exploring Mental Health Status and Syndrome Patterns Among Young Refugee Children in Germany.

    abstract::Refugee children share a large number of pre-, peri-, and post-migration risk factors, which make them vulnerable for developing mental health concerns. Within the last few years, a large number of families with young children have sought refuge in Germany. However, children's mental health status in Germany is mostly...

    journal_title:Frontiers in psychiatry

    pub_type: 杂志文章

    doi:10.3389/fpsyt.2018.00212

    authors: Buchmüller T,Lembcke H,Busch J,Kumsta R,Leyendecker B

    更新日期:2018-05-25 00:00:00

  • Alteration of Brain Structure With Long-Term Abstinence of Methamphetamine by Voxel-Based Morphometry.

    abstract::Background: A large portion of previous studies that have demonstrated brain gray matter reduction in individuals who use methamphetamine (MA) have focused on short-term abstinence, but few studies have focused on the effects of long-term abstinence of methamphetamine on brain structures. Materials and Methods: Our st...

    journal_title:Frontiers in psychiatry

    pub_type: 杂志文章

    doi:10.3389/fpsyt.2018.00722

    authors: Zhang Z,He L,Huang S,Fan L,Li Y,Li P,Zhang J,Liu J,Yang R

    更新日期:2018-12-20 00:00:00

  • Autism Spectrum Disorder and Schizophrenia Are Better Differentiated by Positive Symptoms Than Negative Symptoms.

    abstract::Autism spectrum disorder (ASD) and schizophrenia (SZ) are heterogenous neurodevelopmental disorders that overlap in symptom presentation. The purpose of this study was to specify overlapping symptom domains and to identify symptoms that can reliably differentiate adults with ASD (n = 53), SZ (n = 39), and typical deve...

    journal_title:Frontiers in psychiatry

    pub_type: 杂志文章

    doi:10.3389/fpsyt.2020.00548

    authors: Trevisan DA,Foss-Feig JH,Naples AJ,Srihari V,Anticevic A,McPartland JC

    更新日期:2020-06-11 00:00:00

  • Effects of COVID-19 Epidemic Lockdown on Postpartum Depressive Symptoms in a Sample of Italian Mothers.

    abstract::The extraordinary health emergency of the COVID-19 pandemic represents a new challenge for mental health researchers and clinical practitioners. The related containment measures may be a risk factor for psychological distress and mood disorders, especially in at-risk populations. This study aims to explore the impact ...

    journal_title:Frontiers in psychiatry

    pub_type: 杂志文章

    doi:10.3389/fpsyt.2020.589916

    authors: Spinola O,Liotti M,Speranza AM,Tambelli R

    更新日期:2020-11-17 00:00:00

  • A Novel Network Pharmacology Strategy to Decode Metabolic Biomarkers and Targets Interactions for Depression.

    abstract::Depression is one of the most prevalent and serious mental disorders with a worldwide significant health burden. Metabolic abnormalities and disorders in patients with depression have attracted great research attention. Thirty-six metabolic biomarkers of clinical plasma metabolomics were detected by platform technolog...

    journal_title:Frontiers in psychiatry

    pub_type: 杂志文章

    doi:10.3389/fpsyt.2020.00667

    authors: Gao Y,Xu T,Zhao YX,Ling-Hu T,Liu SB,Tian JS,Qin XM

    更新日期:2020-07-15 00:00:00

  • Interleukin-6 in Schizophrenia-Is There a Therapeutic Relevance?

    abstract::Renewing interest in immune aspects of schizophrenia and new findings about the brain-fat axis encourage us to discuss the possible role of interleukin-6 (IL-6) in schizophrenia. Previously, it was suggested that a primary alteration of the innate immune system may be relevant in schizophrenia. Functional dichotomy of...

    journal_title:Frontiers in psychiatry

    pub_type: 杂志文章,评审

    doi:10.3389/fpsyt.2017.00221

    authors: Borovcanin MM,Jovanovic I,Radosavljevic G,Pantic J,Minic Janicijevic S,Arsenijevic N,Lukic ML

    更新日期:2017-11-06 00:00:00

  • COVID-19 Neurological Manifestations and Underlying Mechanisms: A Scoping Review.

    abstract:Background:In the Corona Virus Disease 2019 (COVID-19) pandemic, the primary problem is respiratory-related, but there also is increasing evidence of central nervous system (CNS) involvement. This study aims to summarize the literature on neurological manifestations of COVID-19, underlying mechanisms of CNS involvement...

    journal_title:Frontiers in psychiatry

    pub_type: 杂志文章,评审

    doi:10.3389/fpsyt.2020.00860

    authors: Wenting A,Gruters A,van Os Y,Verstraeten S,Valentijn S,Ponds R,de Vugt M

    更新日期:2020-08-21 00:00:00

  • Characterizing Treatment-Resistant Anorexia Nervosa.

    abstract::Background: The issue of treatment resistance in eating disorder care is controversial. Prior research has identified multiple failed treatment attempts as a common criterion for severe and enduring anorexia nervosa, but little is known about patients who have multiple failed treatment attempts. This study was designe...

    journal_title:Frontiers in psychiatry

    pub_type: 杂志文章

    doi:10.3389/fpsyt.2020.542206

    authors: Smith S,Woodside DB

    更新日期:2021-01-08 00:00:00

  • Utility of Machine-Learning Approaches to Identify Behavioral Markers for Substance Use Disorders: Impulsivity Dimensions as Predictors of Current Cocaine Dependence.

    abstract:BACKGROUND:Identifying objective and accurate markers of cocaine dependence (CD) can innovate its prevention and treatment. Existing evidence suggests that CD is characterized by a wide range of cognitive deficits, most notably by increased impulsivity. Impulsivity is multidimensional and it is unclear which of its var...

    journal_title:Frontiers in psychiatry

    pub_type: 杂志文章

    doi:10.3389/fpsyt.2016.00034

    authors: Ahn WY,Ramesh D,Moeller FG,Vassileva J

    更新日期:2016-03-10 00:00:00

  • Employment, Studies and Feelings: Two to Nine Years After a Personalized Program of Cognitive Remediation in Psychiatric Patients.

    abstract::Employment rate in psychiatry is around 10 to 30%. Cognitive remediation (CR) associated with psychosocial rehabilitation shows good functional outcomes, with a high level of satisfaction in participants provided by tailored CR. However, few studies looked at the long-term outcome in participants who experienced such ...

    journal_title:Frontiers in psychiatry

    pub_type: 杂志文章

    doi:10.3389/fpsyt.2020.00609

    authors: Amado I,Moualla M,Jouve J,Brénugat-Herné L,Attali D,Willard D,Rigaut B,Malangin B,Kern L,Meyniel C,Gaillard R,Plaze M,Perquier F,Yannick M

    更新日期:2020-07-03 00:00:00

  • IPS in Supported Housing: Fidelity and Employment Outcomes Over a 4 Year Period.

    abstract::Background: People with severe mental illness have difficulties finding and maintaining competitive employment. This is particularly so for those living in supported housing who, by definition, have significant day-to-day support needs: in the Netherlands only 3 to 5% of people with serious mental health problems who ...

    journal_title:Frontiers in psychiatry

    pub_type: 杂志文章

    doi:10.3389/fpsyt.2020.622061

    authors: Roeg D,de Winter L,Bergmans C,Couwenbergh C,McPherson P,Killaspy H,van Weeghel J

    更新日期:2021-01-14 00:00:00

  • The Impact of Hypomania on Aerobic Capacity and Cardiopulmonary Functioning-A Case Report.

    abstract::Background: Hypomanic episodes are characterized by increased goal-directed behavior and psychomotor agitation. While the affective, cognitive, and behavioral manifestations of such episodes are well-documented, their physiological influence on aerobic capacity and cardiopulmonary functioning are unknown. Methods: We ...

    journal_title:Frontiers in psychiatry

    pub_type:

    doi:10.3389/fpsyt.2018.00729

    authors: Shoval A,Armstrong HF,Vakhrusheva J,Ballon JS,Bartels MN,Kimhy D

    更新日期:2018-12-21 00:00:00

  • Cogmed Working Memory Training Presents Unique Implementation Challenges in Adults With ADHD.

    abstract::Cogmed Working Memory Training (CWMT), an online cognitive training program developed for children, is an increasingly popular non-pharmacological intervention for ADHD amongst all ages, despite limited supporting evidence. The initial objective of the present work was to examine the short- and long-term impacts of CW...

    journal_title:Frontiers in psychiatry

    pub_type: 杂志文章

    doi:10.3389/fpsyt.2018.00388

    authors: Marcelle ET,Ho EJ,Kaplan MS,Adler LA,Castellanos FX,Milham MP

    更新日期:2018-08-28 00:00:00

  • Personality and Psychological Factors of Problematic Internet Gamers Seeking Hospital Treatment.

    abstract::Introduction: Previous studies on internet gaming disorder (IGD) have reported an association between personality traits and impulsive or problematic use of the internet or internet games, but the results obtained were inconsistent. Our study's hypothesis was that personality traits are associated with the individual'...

    journal_title:Frontiers in psychiatry

    pub_type: 杂志文章

    doi:10.3389/fpsyt.2019.00583

    authors: Seong W,Hong JS,Kim S,Kim SM,Han DH

    更新日期:2019-08-28 00:00:00

  • Association Between 5-HTTLPR Polymorphism and the Risk of Autism: A Meta-Analysis Based on Case-Control Studies.

    abstract::Background: Recently, many case-control studies have reported the association between 5-HTTLPR polymorphism and autism risk. However, the results are inconclusive and conflicting. To investigate the genetic association of 5-HTTLPR polymorphism and autism risk, we conducted a comprehensive meta-analysis based on previo...

    journal_title:Frontiers in psychiatry

    pub_type: 杂志文章

    doi:10.3389/fpsyt.2019.00051

    authors: Wang H,Yin F,Gao J,Fan X

    更新日期:2019-02-13 00:00:00

  • Glutamatergic Dysfunction and Glutamatergic Compounds for Major Psychiatric Disorders: Evidence From Clinical Neuroimaging Studies.

    abstract::Excessive glutamate release has been linked to stress and many neurodegenerative diseases. Evidence indicates abnormalities of glutamatergic neurotransmission or glutamatergic dysfunction as playing an important role in the development of many major psychiatric disorders (e.g., schizophrenia, bipolar disorder, and maj...

    journal_title:Frontiers in psychiatry

    pub_type: 杂志文章,评审

    doi:10.3389/fpsyt.2018.00767

    authors: Li CT,Yang KC,Lin WC

    更新日期:2019-01-24 00:00:00

  • Characteristics of Adolescents Affected by Mass Psychogenic Illness Outbreaks in Schools in Nepal: A Case-Control Study.

    abstract::This paper presents the first systematic case-control study of correlates of mass psychogenic illness (MPI) in an adolescent school population. MPI is generally construed as a dissociative phenomenon spread by social contagion to individuals who are prone to dissociation. We sought to test if the correlates of dissoci...

    journal_title:Frontiers in psychiatry

    pub_type: 杂志文章

    doi:10.3389/fpsyt.2020.493094

    authors: Sapkota RP,Brunet A,Kirmayer LJ

    更新日期:2020-11-17 00:00:00

  • Freedom Restrictive Coercive Measures in Forensic Psychiatry.

    abstract::Background: In Germany, people suffering from severe mental illness who have committed serious offenses and have considerably reduced or suspended criminal responsibility can be detained and treated in forensic psychiatric hospitals. In the German federal state of Baden-Wuerttemberg, all psychiatric hospitals includin...

    journal_title:Frontiers in psychiatry

    pub_type: 杂志文章

    doi:10.3389/fpsyt.2020.00146

    authors: Flammer E,Frank U,Steinert T

    更新日期:2020-03-05 00:00:00

  • Mediators Linking Childhood Adversities and Trauma to Suicidality in Individuals at Risk for Psychosis.

    abstract::Suicidality is highly prevalent in patients at clinical high risk (CHR) for psychosis. Childhood adversities and trauma are generally predictive of suicidality. However, the differential effects of adversity/trauma-domains and CHR-criteria, i.e., ultra-high risk and basic symptom criteria, on suicidality remain unclea...

    journal_title:Frontiers in psychiatry

    pub_type: 杂志文章

    doi:10.3389/fpsyt.2017.00242

    authors: Schmidt SJ,Schultze-Lutter F,Bendall S,Groth N,Michel C,Inderbitzin N,Schimmelmann BG,Hubl D,Nelson B

    更新日期:2017-11-20 00:00:00