Investigation of Deep-Learning-Driven Identification of Multiple Sclerosis Patients Based on Susceptibility-Weighted Images Using Relevance Analysis.

Abstract:

:The diagnosis of multiple sclerosis (MS) is usually based on clinical symptoms and signs of damage to the central nervous system, which is assessed using magnetic resonance imaging. The correct interpretation of these data requires excellent clinical expertise and experience. Deep neural networks aim to assist clinicians in identifying MS using imaging data. However, before such networks can be integrated into clinical workflow, it is crucial to understand their classification strategy. In this study, we propose to use a convolutional neural network to identify MS patients in combination with attribution algorithms to investigate the classification decisions. The network was trained using images acquired with susceptibility-weighted imaging (SWI), which is known to be sensitive to the presence of paramagnetic iron components and is routinely applied in imaging protocols for MS patients. Different attribution algorithms were used to the trained network resulting in heatmaps visualizing the contribution of each input voxel to the classification decision. Based on the quantitative image perturbation method, we selected DeepLIFT heatmaps for further investigation. Single-subject analysis revealed veins and adjacent voxels as signs for MS, while the population-based study revealed relevant brain areas common to most subjects in a class. This pattern was found to be stable across different echo times and also for a multi-echo trained network. Intensity analysis of the relevant voxels revealed a group difference, which was found to be primarily based on the T1w magnitude images, which are part of the SWI calculation. This difference was not observed in the phase mask data.

journal_name

Front Neurosci

authors

Lopatina A,Ropele S,Sibgatulin R,Reichenbach JR,Güllmar D

doi

10.3389/fnins.2020.609468

subject

Has Abstract

pub_date

2020-12-18 00:00:00

pages

609468

eissn

1662-4548

issn

1662-453X

journal_volume

14

pub_type

杂志文章
  • Building Bridges between Perceptual and Economic Decision-Making: Neural and Computational Mechanisms.

    abstract::Investigation into the neural and computational bases of decision-making has proceeded in two parallel but distinct streams. Perceptual decision-making (PDM) is concerned with how observers detect, discriminate, and categorize noisy sensory information. Economic decision-making (EDM) explores how options are selected ...

    journal_title:Frontiers in neuroscience

    pub_type: 杂志文章

    doi:10.3389/fnins.2012.00070

    authors: Summerfield C,Tsetsos K

    更新日期:2012-05-24 00:00:00

  • Down Syndrome Is a Metabolic Disease: Altered Insulin Signaling Mediates Peripheral and Brain Dysfunctions.

    abstract::Down syndrome (DS) is the most frequent chromosomal abnormality that causes intellectual disability, resulting from the presence of an extra complete or segment of chromosome 21 (HSA21). In addition, trisomy of HSA21 contributes to altered energy metabolism that appears to be a strong determinant in the development of...

    journal_title:Frontiers in neuroscience

    pub_type: 杂志文章,评审

    doi:10.3389/fnins.2020.00670

    authors: Dierssen M,Fructuoso M,Martínez de Lagrán M,Perluigi M,Barone E

    更新日期:2020-07-08 00:00:00

  • Speech Discrimination Tasks: A Sensitive Sensory and Cognitive Measure in Early and Mild Multiple Sclerosis.

    abstract::There is a need for reliable and objective measures of early and mild symptomology in multiple sclerosis (MS), as deficits can be subtle and difficult to quantify objectively in patients without overt physical deficits. We hypothesized that a speech-in-noise (SiN) task would be sensitive to demyelinating effects on pr...

    journal_title:Frontiers in neuroscience

    pub_type: 杂志文章

    doi:10.3389/fnins.2020.604991

    authors: Iva P,Fielding J,Clough M,White O,Godic B,Martin R,Rajan R

    更新日期:2020-12-23 00:00:00

  • Benchmarking neuromorphic vision: lessons learnt from computer vision.

    abstract::Neuromorphic Vision sensors have improved greatly since the first silicon retina was presented almost three decades ago. They have recently matured to the point where they are commercially available and can be operated by laymen. However, despite improved availability of sensors, there remains a lack of good datasets,...

    journal_title:Frontiers in neuroscience

    pub_type: 杂志文章

    doi:10.3389/fnins.2015.00374

    authors: Tan C,Lallee S,Orchard G

    更新日期:2015-10-13 00:00:00

  • Spiking Neural Networks Based on OxRAM Synapses for Real-Time Unsupervised Spike Sorting.

    abstract::In this paper, we present an alternative approach to perform spike sorting of complex brain signals based on spiking neural networks (SNN). The proposed architecture is suitable for hardware implementation by using resistive random access memory (RRAM) technology for the implementation of synapses whose low latency (<...

    journal_title:Frontiers in neuroscience

    pub_type: 杂志文章

    doi:10.3389/fnins.2016.00474

    authors: Werner T,Vianello E,Bichler O,Garbin D,Cattaert D,Yvert B,De Salvo B,Perniola L

    更新日期:2016-11-03 00:00:00

  • COINSTAC: A Privacy Enabled Model and Prototype for Leveraging and Processing Decentralized Brain Imaging Data.

    abstract::The field of neuroimaging has embraced the need for sharing and collaboration. Data sharing mandates from public funding agencies and major journal publishers have spurred the development of data repositories and neuroinformatics consortia. However, efficient and effective data sharing still faces several hurdles. For...

    journal_title:Frontiers in neuroscience

    pub_type: 杂志文章

    doi:10.3389/fnins.2016.00365

    authors: Plis SM,Sarwate AD,Wood D,Dieringer C,Landis D,Reed C,Panta SR,Turner JA,Shoemaker JM,Carter KW,Thompson P,Hutchison K,Calhoun VD

    更新日期:2016-08-19 00:00:00

  • Plasma Extracellular Vesicles Enriched for Neuronal Origin: A Potential Window into Brain Pathologic Processes.

    abstract::Our team has been a pioneer in harvesting extracellular vesicles (EVs) enriched for neuronal origin from peripheral blood and using them as a biomarker discovery platform for neurological disorders. This methodology has demonstrated excellent diagnostic and predictive performance for Alzheimer's and other neurodegener...

    journal_title:Frontiers in neuroscience

    pub_type: 杂志文章

    doi:10.3389/fnins.2017.00278

    authors: Mustapic M,Eitan E,Werner JK Jr,Berkowitz ST,Lazaropoulos MP,Tran J,Goetzl EJ,Kapogiannis D

    更新日期:2017-05-22 00:00:00

  • Intrapancreatic Ganglia and Neural Regulation of Pancreatic Endocrine Secretion.

    abstract::Extrapancreatic nerves project to pancreatic islets directly or converge onto intrapancreatic ganglia. Intrapancreatic ganglia constitute a complex information-processing center that contains various neurotransmitters and forms an endogenous neural network. Both intrapancreatic ganglia and extrapancreatic nerves have ...

    journal_title:Frontiers in neuroscience

    pub_type: 杂志文章,评审

    doi:10.3389/fnins.2019.00021

    authors: Li W,Yu G,Liu Y,Sha L

    更新日期:2019-02-20 00:00:00

  • Chronic Tinnitus Exhibits Bidirectional Functional Dysconnectivity in Frontostriatal Circuit.

    abstract:Purpose:The phantom sound of tinnitus is considered to be associated with abnormal functional coupling between the nucleus accumbens (NAc) and the prefrontal cortex, which may form a frontostriatal top-down gating system to evaluate and modulate sensory signals. Resting-state functional magnetic resonance imaging (fMRI...

    journal_title:Frontiers in neuroscience

    pub_type: 杂志文章

    doi:10.3389/fnins.2019.01299

    authors: Xu JJ,Cui J,Feng Y,Yong W,Chen H,Chen YC,Yin X,Wu Y

    更新日期:2019-12-06 00:00:00

  • Walking the Tightrope: A Proposed Model of Chronic Pain and Stress.

    abstract::Pain and stress are both phenomena that challenge an individual's homeostasis and have significant overlap in conceptual and physiological processes. Allostasis is the ability to adapt to pain and stress and maintain homeostasis; however, if either process becomes chronic, it may result in negative long-term outcomes....

    journal_title:Frontiers in neuroscience

    pub_type: 杂志文章,评审

    doi:10.3389/fnins.2020.00270

    authors: Lunde CE,Sieberg CB

    更新日期:2020-03-26 00:00:00

  • Brain Map of Intrinsic Functional Flexibility in Anesthetized Monkeys and Awake Humans.

    abstract::Emerging neuroimaging studies emphasize the dynamic organization of spontaneous brain activity in both human and non-human primates, even under anesthesia. In a recent study, we were able to characterize the heterogeneous architecture of intrinsic functional flexibility in the awake, resting human brain using time-res...

    journal_title:Frontiers in neuroscience

    pub_type: 杂志文章

    doi:10.3389/fnins.2019.00174

    authors: Yin D,Zhang Z,Wang Z,Zeljic K,Lv Q,Cai D,Wang Y,Wang Z

    更新日期:2019-02-28 00:00:00

  • Non-invasive Neurophysiology in Learning and Training: Mechanisms and a SWOT Analysis.

    abstract::Although many scholars deem non-invasive measures of neurophysiology to have promise in assessing learning, these measures are currently not widely applied, neither in educational settings nor in training. How can non-invasive neurophysiology provide insight into learning and how should research on this topic move for...

    journal_title:Frontiers in neuroscience

    pub_type: 杂志文章,评审

    doi:10.3389/fnins.2020.00589

    authors: Tinga AM,de Back TT,Louwerse MM

    更新日期:2020-06-05 00:00:00

  • Pumilio Regulates Sleep Homeostasis in Response to Chronic Sleep Deprivation in Drosophila melanogaster.

    abstract::Recent studies have identified the Drosophila brain circuits involved in the sleep/wake switch and have pointed to the modulation of neuronal excitability as one of the underlying mechanisms triggering sleep need. In this study we aimed to explore the link between the homeostatic regulation of neuronal excitability an...

    journal_title:Frontiers in neuroscience

    pub_type: 杂志文章

    doi:10.3389/fnins.2020.00319

    authors: De Jesús-Olmo LA,Rodríguez N,Francia M,Alemán-Rios J,Pacheco-Agosto CJ,Ortega-Torres J,Nieves R,Fuenzalida-Uribe N,Ghezzi A,Agosto JL

    更新日期:2020-04-17 00:00:00

  • sPyNNaker: A Software Package for Running PyNN Simulations on SpiNNaker.

    abstract::This work presents sPyNNaker 4.0.0, the latest version of the software package for simulating PyNN-defined spiking neural networks (SNNs) on the SpiNNaker neuromorphic platform. Operations underpinning realtime SNN execution are presented, including an event-based operating system facilitating efficient time-driven ne...

    journal_title:Frontiers in neuroscience

    pub_type: 杂志文章

    doi:10.3389/fnins.2018.00816

    authors: Rhodes O,Bogdan PA,Brenninkmeijer C,Davidson S,Fellows D,Gait A,Lester DR,Mikaitis M,Plana LA,Rowley AGD,Stokes AB,Furber SB

    更新日期:2018-11-20 00:00:00

  • Brain dynamics that correlate with effects of learning on auditory distance perception.

    abstract::Accuracy in auditory distance perception can improve with practice and varies for sounds differing in familiarity. Here, listeners were trained to judge the distances of English, Bengali, and backwards speech sources pre-recorded at near (2-m) and far (30-m) distances. Listeners' accuracy was tested before and after t...

    journal_title:Frontiers in neuroscience

    pub_type: 杂志文章

    doi:10.3389/fnins.2014.00396

    authors: Wisniewski MG,Mercado E 3rd,Church BA,Gramann K,Makeig S

    更新日期:2014-12-09 00:00:00

  • Neuroscientific and neuroanthropological perspectives in music therapy research and practice with patients with disorders of consciousness.

    abstract::A growing understanding of music therapy with patients with disorders of consciousness (DOC) has developed from observing behavioral changes and using these to gain new ways of experiencing this research environment and setting. Neuroscience provides further insight into the effects of music therapy; however, various ...

    journal_title:Frontiers in neuroscience

    pub_type: 杂志文章

    doi:10.3389/fnins.2015.00273

    authors: Vogl J,Heine AM,Steinhoff N,Weiss K,Tucek G

    更新日期:2015-08-04 00:00:00

  • Short-Term Sensorimotor Deprivation Impacts Feedforward and Feedback Processes of Motor Control.

    abstract::Sensory loss involves irreversible behavioral and neural changes. Paradigms of short-term limb immobilization mimic deprivation of proprioceptive inputs and motor commands, which occur after the loss of limb use. While several studies have shown that short-term immobilization induced motor control impairments, the ori...

    journal_title:Frontiers in neuroscience

    pub_type: 杂志文章

    doi:10.3389/fnins.2020.00696

    authors: Scotto CR,Meugnot A,Casiez G,Toussaint L

    更新日期:2020-07-01 00:00:00

  • Transcranial Static Magnetic Field Stimulation of the Motor Cortex in Children.

    abstract:Background:Non-invasive neuromodulation is an emerging therapy for children with early brain injury but is difficult to apply to preschoolers when windows of developmental plasticity are optimal. Transcranial static magnetic field stimulation (tSMS) decreases primary motor cortex (M1) excitability in adults but effects...

    journal_title:Frontiers in neuroscience

    pub_type: 杂志文章

    doi:10.3389/fnins.2020.00464

    authors: Hollis A,Zewdie E,Nettel-Aguirre A,Hilderley A,Kuo HC,Carlson HL,Kirton A

    更新日期:2020-05-19 00:00:00

  • A P300 Brain-Computer Interface With a Reduced Visual Field.

    abstract::A P300 brain-computer interface (BCI) is a paradigm, where text characters are decoded from event-related potentials (ERPs). In a popular implementation, called P300 speller, a subject looks at a display where characters are flashing and selects one character by attending to it. The selection is recognized as the item...

    journal_title:Frontiers in neuroscience

    pub_type: 杂志文章

    doi:10.3389/fnins.2020.604629

    authors: Kirasirova L,Bulanov V,Ossadtchi A,Kolsanov A,Pyatin V,Lebedev M

    更新日期:2020-12-03 00:00:00

  • A framework to analyze cerebral mean diffusivity using surface guided diffusion mapping in diffusion tensor imaging.

    abstract::The mean diffusivity (MD) value has been used to describe microstructural properties in Diffusion Tensor Imaging (DTI) in cortical gray matter (GM). Recently, researchers have applied a cortical surface generated from the T1-weighted volume. When the DTI data are analyzed using the cortical surface, it is important to...

    journal_title:Frontiers in neuroscience

    pub_type: 杂志文章

    doi:10.3389/fnins.2015.00236

    authors: Kwon OH,Park H,Seo SW,Na DL,Lee JM

    更新日期:2015-07-14 00:00:00

  • Diffusion Tensor Imaging and Chemical Exchange Saturation Transfer MRI Evaluation on the Long-Term Effects of Pulsed Focused Ultrasound and Microbubbles Blood Brain Barrier Opening in the Rat.

    abstract::Blood-brain barrier opening (BBBO) with pulsed Focused Ultrasound (pFUS) and microbubbles (MB) has received increasing interest as a method for neurotherapeutics of the central nervous system. In general, conventional MRI [i.e., T2w, T2∗w, gadolinium (Gd) enhanced T1w] is used to monitor the effects of pFUS+MB on BBBO...

    journal_title:Frontiers in neuroscience

    pub_type: 杂志文章

    doi:10.3389/fnins.2020.00908

    authors: Tu TW,Kovacs ZI,Sundby M,Witko JA,Papadakis GZ,Reid WC,Hammoud DA,Frank JA

    更新日期:2020-08-25 00:00:00

  • No Effects of Non-invasive Brain Stimulation on Multiple Sessions of Object-Location-Memory Training in Healthy Older Adults.

    abstract::Object-location memory (OLM) is known to decline with normal aging, a process accelerated in pathological conditions like mild cognitive impairment (MCI). In order to maintain cognitive health and to delay the transition from healthy to pathological conditions, novel strategies are being explored. Tentative evidence s...

    journal_title:Frontiers in neuroscience

    pub_type: 杂志文章

    doi:10.3389/fnins.2017.00746

    authors: Külzow N,Cavalcanti de Sousa AV,Cesarz M,Hanke JM,Günsberg A,Harder S,Koblitz S,Grittner U,Flöel A

    更新日期:2018-01-10 00:00:00

  • Virtual Balancing for Studying and Training Postural Control.

    abstract::Postural control during free stance has been frequently interpreted in terms of balancing an inverted pendulum. This even holds, if subjects do not balance their own, but an external body weight. We introduce here a virtual balancing apparatus, which produces torque in the ankle joint as a function of ankle angle rese...

    journal_title:Frontiers in neuroscience

    pub_type: 杂志文章

    doi:10.3389/fnins.2017.00531

    authors: Buettner D,Dalin D,Wiesmeier IK,Maurer C

    更新日期:2017-09-26 00:00:00

  • An Axiology of Information Security for Futuristic Neuroprostheses: Upholding Human Values in the Context of Technological Posthumanization.

    abstract::Previous works exploring the challenges of ensuring information security for neuroprosthetic devices and their users have typically built on the traditional InfoSec concept of the "CIA Triad" of confidentiality, integrity, and availability. However, we argue that the CIA Triad provides an increasingly inadequate found...

    journal_title:Frontiers in neuroscience

    pub_type: 杂志文章

    doi:10.3389/fnins.2017.00605

    authors: Gladden ME

    更新日期:2017-11-07 00:00:00

  • The Impact of Vision Loss on Allocentric Spatial Coding.

    abstract::Several works have demonstrated that visual experience plays a critical role in the development of allocentric spatial coding. Indeed, while children with a typical development start to code space by relying on allocentric landmarks from the first year of life, blind children remain anchored to an egocentric perspecti...

    journal_title:Frontiers in neuroscience

    pub_type: 杂志文章

    doi:10.3389/fnins.2020.00565

    authors: Martolini C,Cappagli G,Luparia A,Signorini S,Gori M

    更新日期:2020-06-16 00:00:00

  • Synaptic Plasticity Dynamics for Deep Continuous Local Learning (DECOLLE).

    abstract::A growing body of work underlines striking similarities between biological neural networks and recurrent, binary neural networks. A relatively smaller body of work, however, addresses the similarities between learning dynamics employed in deep artificial neural networks and synaptic plasticity in spiking neural networ...

    journal_title:Frontiers in neuroscience

    pub_type: 杂志文章

    doi:10.3389/fnins.2020.00424

    authors: Kaiser J,Mostafa H,Neftci E

    更新日期:2020-05-12 00:00:00

  • Natural Diterpenoid Oridonin Ameliorates Experimental Autoimmune Neuritis by Promoting Anti-inflammatory Macrophages Through Blocking Notch Pathway.

    abstract::The diterpenoid compound, Oridonin, extracted from the Chinese herb, Rabdosia rubescens, possesses multiple biological activities and properties. Oridonin exhibited efficient anti-inflammatory activity by inducing a switch in macrophage polarization to the anti-inflammatory phenotype through inhibition of the Notch pa...

    journal_title:Frontiers in neuroscience

    pub_type: 杂志文章

    doi:10.3389/fnins.2019.00272

    authors: Xu L,Li L,Zhang CY,Schluesener H,Zhang ZY

    更新日期:2019-04-02 00:00:00

  • Isolation Syndrome after Cardiac Arrest and Therapeutic Hypothermia.

    abstract::Here, we present the first description of an isolation syndrome in a patient who suffered prolonged cardiac arrest and underwent a standard therapeutic hypothermia protocol. Two years after the arrest, the patient demonstrated no motor responses to commands, communication capabilities, or visual tracking at the bedsid...

    journal_title:Frontiers in neuroscience

    pub_type:

    doi:10.3389/fnins.2016.00259

    authors: Forgacs PB,Fridman EA,Goldfine AM,Schiff ND

    更新日期:2016-06-09 00:00:00

  • Pathophysiological Changes of Physical Barriers of Peripheral Nerves After Injury.

    abstract::Peripheral nerves are composed of complex layered anatomical structures, including epineurium, perineurium, and endoneurium. Perineurium and endoneurium contain many physical barriers, including the blood-nerve barrier at endoneurial vessels and the perineurial barrier. These physical barriers help to eliminate flux p...

    journal_title:Frontiers in neuroscience

    pub_type: 杂志文章,评审

    doi:10.3389/fnins.2018.00597

    authors: Liu Q,Wang X,Yi S

    更新日期:2018-08-23 00:00:00

  • Reshaping of Gait Coordination by Robotic Intervention in Myelopathy Patients After Surgery.

    abstract::The Ossification of the Posterior Longitudinal Ligament (OPLL) is an idiopathic degenerative spinal disease which may cause motor deficit. For patients presenting myelopathy or severe stenosis, surgical decompression is the treatment of choice; however, despite adequate decompression residual motor impairment is found...

    journal_title:Frontiers in neuroscience

    pub_type: 杂志文章

    doi:10.3389/fnins.2018.00099

    authors: Puentes S,Kadone H,Kubota S,Abe T,Shimizu Y,Marushima A,Sankai Y,Yamazaki M,Suzuki K

    更新日期:2018-03-02 00:00:00