Damage in the Thalamocortical Tracts is Associated With Subsequent Thalamus Atrophy in Early Multiple Sclerosis.

Abstract:

:Background: In early multiple sclerosis (MS), thalamus atrophy and decreased integrity of the thalamocortical white matter (WM) tracts have been observed. Objective: To investigate the temporal association between thalamus volume and WM damage in the thalamocortical tract in subjects with early MS. Methods: At two time points, 72 subjects with early MS underwent T1, FLAIR and diffusion tensor imaging. Thalamocortical tracts were identified with probabilistic tractography using left and right thalamus as seed regions. Regression analysis was performed to identify predictors of annual percentage change in both thalamus volumes and integrity of the connected tracts. Results: Significant atrophy was seen in left and right thalamus (p < 0.001) over the follow-up period (13.7 ± 4.8 months), whereas fractional anisotropy (FA) and mean diffusivity (MD) changes of the left and right thalamus tracts were not significant, although large inter-subject variability was seen. Annual percentage change in left thalamus volume was significantly predicted by baseline FA of the left thalamus tracts F(1.71) = 4.284, p = 0.042; while no such relation was found for the right thalamus. Annual percentage change in FA or MD of the thalamus tracts was not predicted by thalamus volume or any of the demographic parameters. Conclusion: Over a short follow-up time, thalamus atrophy could be predicted by decreased integrity of the thalamic tracts, but changes in the integrity of the thalamic tracts could not be predicted by thalamus volume. This is the first study showing directionality in the association between thalamus atrophy and connected WM tract damage. These results need to be verified over longer follow-up periods.

journal_name

Front Neurol

journal_title

Frontiers in neurology

authors

Weeda MM,Pruis IJ,Westerveld ASR,Brouwer I,Bellenberg B,Barkhof F,Vrenken H,Lukas C,Schneider R,Pouwels PJW

doi

10.3389/fneur.2020.575611

subject

Has Abstract

pub_date

2020-11-17 00:00:00

pages

575611

issn

1664-2295

journal_volume

11

pub_type

杂志文章
  • Brain Amyloid Burden and Resting-State Functional Connectivity in Late Middle-Aged Hispanics.

    abstract::Non-linear relations of brain amyloid beta (Aβ) with task- based functional connectivity (tbFC) measured with functional magnetic resonance imaging (fMRI) have been reported in late middle age. Our objective was to examine the association between brain Aβ and resting-state functional connectivity (rsFC) in late middle...

    journal_title:Frontiers in neurology

    pub_type: 杂志文章

    doi:10.3389/fneur.2020.529930

    authors: Tahmi M,Rippon B,Palta P,Soto L,Ceballos F,Pardo M,Sherwood G,Hernandez G,Arevalo R,He H,Sedaghat A,Arabshahi S,Teresi J,Moreno H,Brickman AM,Razlighi QR,Luchsinger JA

    更新日期:2020-10-06 00:00:00

  • Sex as a Biological Variable in Preclinical Modeling of Blast-Related Traumatic Brain Injury.

    abstract::Approaches to furthering our understanding of the bioeffects, behavioral changes, and treatment options following exposure to blast are a worldwide priority. Of particular need is a more concerted effort to employ animal models to determine possible sex differences, which have been reported in the clinical literature....

    journal_title:Frontiers in neurology

    pub_type: 杂志文章,评审

    doi:10.3389/fneur.2020.541050

    authors: McCabe JT,Tucker LB

    更新日期:2020-09-30 00:00:00

  • Meta-analysis of Vascular Imaging Features to Predict Outcome Following Intravenous rtPA for Acute Ischemic Stroke.

    abstract:BACKGROUND:The present review investigated which findings in vascular imaging techniques can be used to predict clinical outcome and the risk of symptomatic intracerebral hemorrhage (sICH) in patients who underwent intravenous thrombolytic treatment. METHODS:Publications were searched, and the inclusion criteria were ...

    journal_title:Frontiers in neurology

    pub_type: 杂志文章,评审

    doi:10.3389/fneur.2016.00077

    authors: Nogueira RC,Bor-Seng-Shu E,Saeed NP,Teixeira MJ,Panerai RB,Robinson TG

    更新日期:2016-05-18 00:00:00

  • Body Mass Index and Prognosis in Ischemic Stroke Patients With Type 2 Diabetes Mellitus.

    abstract::Background: Overweight contributes to type 2 diabetes mellitus (T2DM) development. Although the obesity paradox has been suggested in many vascular diseases, little information is available about stroke patients with T2DM. We investigated whether body mass index (BMI) has a differential impact on the incidence of majo...

    journal_title:Frontiers in neurology

    pub_type: 杂志文章

    doi:10.3389/fneur.2019.00563

    authors: Park H,Lee HW,Yoo J,Lee HS,Nam HS,Kim YD,Heo JH

    更新日期:2019-06-05 00:00:00

  • Drug-Resistant Epilepsy: Multiple Hypotheses, Few Answers.

    abstract::Epilepsy is a common neurological disorder that affects over 70 million people worldwide. Despite the recent introduction of new antiseizure drugs (ASDs), about one-third of patients with epilepsy have seizures refractory to pharmacotherapy. Early identification of patients who will become refractory to ASDs could hel...

    journal_title:Frontiers in neurology

    pub_type: 杂志文章,评审

    doi:10.3389/fneur.2017.00301

    authors: Tang F,Hartz AMS,Bauer B

    更新日期:2017-07-06 00:00:00

  • Cell-Based Therapies for Stroke: Are We There Yet?

    abstract::Stroke is the second leading cause of death and physical disability, with a global lifetime incidence rate of 1 in 6. Currently, the only FDA approved treatment for ischemic stroke is the administration of tissue plasminogen activator (tPA). Stem cell clinical trials for stroke have been underway for close to two deca...

    journal_title:Frontiers in neurology

    pub_type: 杂志文章,评审

    doi:10.3389/fneur.2019.00656

    authors: Krause M,Phan TG,Ma H,Sobey CG,Lim R

    更新日期:2019-06-25 00:00:00

  • A Heartbeat Away From Consciousness: Heart Rate Variability Entropy Can Discriminate Disorders of Consciousness and Is Correlated With Resting-State fMRI Brain Connectivity of the Central Autonomic Network.

    abstract::Background: Disorders of consciousness are challenging to diagnose, with inconsistent behavioral responses, motor and cognitive disabilities, leading to approximately 40% misdiagnoses. Heart rate variability (HRV) reflects the complexity of the heart-brain two-way dynamic interactions. HRV entropy analysis quantifies ...

    journal_title:Frontiers in neurology

    pub_type: 杂志文章

    doi:10.3389/fneur.2018.00769

    authors: Riganello F,Larroque SK,Bahri MA,Heine L,Martial C,Carrière M,Charland-Verville V,Aubinet C,Vanhaudenhuyse A,Chatelle C,Laureys S,Di Perri C

    更新日期:2018-09-12 00:00:00

  • Microangiopathy-A Potential Contributing Factor to Idiopathic Polyneuropathy: A Mini Review.

    abstract::Chronic idiopathic axonal polyneuropathy (CIAP) is a slowly progressive predominantly sensory axonal polyneuropathy. The prevalence of CIAP increases with age. The pathogenic cause of CIAP is unknown although there are several prevailing etiological hypotheses. In this mini review, we focus on the hypothesis of distur...

    journal_title:Frontiers in neurology

    pub_type: 杂志文章,评审

    doi:10.3389/fneur.2018.00043

    authors: Samuelsson K,Press R

    更新日期:2018-02-12 00:00:00

  • Considerations for Experimental Animal Models of Concussion, Traumatic Brain Injury, and Chronic Traumatic Encephalopathy-These Matters Matter.

    abstract::Animal models of concussion, traumatic brain injury (TBI), and chronic traumatic encephalopathy (CTE) are widely available and routinely deployed in laboratories around the world. Effective animal modeling requires careful consideration of four basic principles. First, animal model use must be guided by clarity of def...

    journal_title:Frontiers in neurology

    pub_type: 杂志文章,评审

    doi:10.3389/fneur.2017.00240

    authors: Wojnarowicz MW,Fisher AM,Minaeva O,Goldstein LE

    更新日期:2017-06-01 00:00:00

  • Acupuncture Effect and Mechanism for Treating Pain in Patients With Parkinson's Disease.

    abstract::Non-motor symptoms of Parkinson's disease (PD) have been receiving increasing attention. Approximately half of patients with PD have experience PD-related pain. We investigated the effect and mechanism of acupuncture in patients with PD who have pain. PD patients with pain were divided into acupuncture group and contr...

    journal_title:Frontiers in neurology

    pub_type: 杂志文章

    doi:10.3389/fneur.2019.01114

    authors: Yu SW,Lin SH,Tsai CC,Chaudhuri KR,Huang YC,Chen YS,Yeh BY,Wu YR,Wang JJ

    更新日期:2019-10-22 00:00:00

  • Longitudinal Recordings Reveal Transient Increase of Alpha/Low-Beta Power in the Subthalamic Nucleus Associated With the Onset of Parkinsonian Rest Tremor.

    abstract::Functional magnetic resonance imaging studies suggest that different subcortico-cortical circuits control different aspects of Parkinsonian rest tremor. The basal ganglia were proposed to drive tremor onset, and the cerebellum was suggested to be responsible for tremor maintenance ("dimmer-switch" hypothesis). Althoug...

    journal_title:Frontiers in neurology

    pub_type: 杂志文章

    doi:10.3389/fneur.2019.00145

    authors: Hirschmann J,Abbasi O,Storzer L,Butz M,Hartmann CJ,Wojtecki L,Schnitzler A

    更新日期:2019-03-07 00:00:00

  • The Role of Decompressive Craniectomy in the Context of Severe Traumatic Brain Injury: Summary of Results and Analysis of the Confidence Level of Conclusions From Systematic Reviews and Meta-Analyses.

    abstract::Introduction: Traumatic brain injury (TBI) is a global epidemic. The incidence of TBI in low and middle-income countries (LMICs) is three times greater than in high-income countries (HICs). Decompressive craniectomy (DC) is a surgical procedure to reduce intracranial pressure (ICP) and prevent secondary injury. Multip...

    journal_title:Frontiers in neurology

    pub_type: 杂志文章,评审

    doi:10.3389/fneur.2019.01063

    authors: Rubiano AM,Carney N,Khan AA,Ammirati M

    更新日期:2019-10-10 00:00:00

  • Case Report: Endovascular Treatment of a Giant Distal PICA Aneurysm in Association With a Cerebellar AVM: A Report on Treatment Considerations and a Literature Review.

    abstract::Background: Distal posterior inferior cerebellar artery (PICA) aneurysms are uncommon intracranial vascular lesions. The coincidence of these aneurysms and Arteriovenous malformation (AVM) is even more rare. Since 1956, a total of 57 cases of distal PICA aneurysms associated with AVM have been reported with clear and ...

    journal_title:Frontiers in neurology

    pub_type:

    doi:10.3389/fneur.2020.611377

    authors: Khayat HA,Hawkes CM,Algird AR

    更新日期:2020-12-18 00:00:00

  • A Case of Acoustic Shock with Post-trauma Trigeminal-Autonomic Activation.

    abstract::This study reports the case of an acoustic shock injury (ASI), which did not result in a significant hearing loss, but was followed by manifold chronic symptoms both within (tinnitus, otalgia, tingling in the ear, tension in the ear, and red tympanum) and outside the ears (blocked nose, pain in the neck/temporal regio...

    journal_title:Frontiers in neurology

    pub_type:

    doi:10.3389/fneur.2017.00420

    authors: Londero A,Charpentier N,Ponsot D,Fournier P,Pezard L,Noreña AJ

    更新日期:2017-08-16 00:00:00

  • Frequency-Dependent Changes in Interhemispheric Functional Connectivity Measured by Resting-State fMRI in Children With Idiopathic Generalized Epilepsy.

    abstract::Epilepsy is associated with abnormal spatiotemporal changes in resting-state brain connectivity, but how these changes are characterized in interhemispheric coupling remains unclear. This study aimed to characterize frequency-dependent alterations in voxel-wise mirrored homotopic connectivity (VMHC) measured by restin...

    journal_title:Frontiers in neurology

    pub_type: 杂志文章

    doi:10.3389/fneur.2020.00645

    authors: Jiang L,Ma X,Li S,Luo H,Zhang G,Wang Y,Zhang T

    更新日期:2020-07-29 00:00:00

  • Could cord blood cell therapy reduce preterm brain injury?

    abstract::Major advances in neonatal care have led to significant improvements in survival rates for preterm infants, but this occurs at a cost, with a strong causal link between preterm birth and neurological deficits, including cerebral palsy (CP). Indeed, in high-income countries, up to 50% of children with CP were born pret...

    journal_title:Frontiers in neurology

    pub_type: 杂志文章,评审

    doi:10.3389/fneur.2014.00200

    authors: Li J,McDonald CA,Fahey MC,Jenkin G,Miller SL

    更新日期:2014-10-09 00:00:00

  • Brain Structural and Functional Imaging Findings in Medication-Overuse Headache.

    abstract::This chapter overviews research neuroimaging findings of patients with medication-overuse headache (MOH). Results indicate; (i) correlations between neuropathology and medication-overuse; (ii) changes in brain morphology and cortical function; and (iii) brain recovery subsequent to withdrawal of medication that was ov...

    journal_title:Frontiers in neurology

    pub_type: 杂志文章,评审

    doi:10.3389/fneur.2019.01336

    authors: Chong CD

    更新日期:2020-01-28 00:00:00

  • Tau Filament Self-Assembly and Structure: Tau as a Therapeutic Target.

    abstract::Tau plays an important pathological role in a group of neurodegenerative diseases called tauopathies, including Alzheimer's disease, Pick's disease, chronic traumatic encephalopathy and corticobasal degeneration. In each disease, tau self-assembles abnormally to form filaments that deposit in the brain. Tau is a nativ...

    journal_title:Frontiers in neurology

    pub_type: 杂志文章,评审

    doi:10.3389/fneur.2020.590754

    authors: Oakley SS,Maina MB,Marshall KE,Al-Hilaly YK,Harrington CR,Wischik CM,Serpell LC

    更新日期:2020-11-12 00:00:00

  • Isolated Cervical Dystonia: Management and Barriers to Care.

    abstract::Background: Cervical dystonia (CD) is a rare disorder, and health care providers might be unfamiliar with its presentation, thus leading to delay in the initial diagnosis. The lack of awareness displays the need to highlight the clinical features and treatment in cervical dystonia. In our cohort, we have identified an...

    journal_title:Frontiers in neurology

    pub_type: 杂志文章

    doi:10.3389/fneur.2020.591418

    authors: Supnet ML,Acuna P,Carr SJ,Kristoper de Guzman J,Al Qahtani X,Multhaupt-Buell T,Francoeur T,Aldykiewicz GE,Alluri PR,Campion L,Paul L,Ozelius L,Penney EB,Stephen CD,Dy-Hollins M,Sharma N

    更新日期:2020-11-27 00:00:00

  • Erratum: Standards in Pupillography.

    abstract::[This corrects the article DOI: 10.3389/fneur.2019.00129.]. ...

    journal_title:Frontiers in neurology

    pub_type: 杂志文章,已发布勘误

    doi:10.3389/fneur.2019.00371

    authors: Frontiers Production Office.

    更新日期:2019-03-27 00:00:00

  • Biases in the Visual and Haptic Subjective Vertical Reveal the Role of Proprioceptive/Vestibular Priors in Child Development.

    abstract::Investigation of the perception of verticality permits to disclose the perceptual mechanisms that underlie balance control and spatial navigation. Estimation of verticality in unusual body orientation with respect to gravity (e.g., laterally tilted in the roll plane) leads to biases that change depending on the encodi...

    journal_title:Frontiers in neurology

    pub_type: 杂志文章

    doi:10.3389/fneur.2018.01151

    authors: Cuturi LF,Gori M

    更新日期:2019-01-07 00:00:00

  • Alterations of Elastic Property of Spastic Muscle With Its Joint Resistance Evaluated From Shear Wave Elastography and Biomechanical Model.

    abstract::This study aims to quantify passive muscle stiffness of spastic wrist flexors in stroke survivors using shear wave elastography (SWE) and to correlate with neural and non-neural contributors estimated from a biomechanical model to hyper-resistance measured during passive wrist extension. Fifteen hemiplegic individuals...

    journal_title:Frontiers in neurology

    pub_type: 杂志文章

    doi:10.3389/fneur.2019.00736

    authors: Leng Y,Wang Z,Bian R,Lo WLA,Xie X,Wang R,Huang D,Li L

    更新日期:2019-07-10 00:00:00

  • Joint and Muscle Assessments of the Separate Effects of Botulinum NeuroToxin-A and Lower-Leg Casting in Children With Cerebral Palsy.

    abstract::Botulinum NeuroToxin-A (BoNT-A) injections to the medial gastrocnemius (MG) and lower-leg casts are commonly combined to treat ankle equinus in children with spastic cerebral palsy (CP). However, the decomposed treatment effects on muscle or tendon structure, stretch reflexes, and joint are unknown. In this study, BoN...

    journal_title:Frontiers in neurology

    pub_type: 杂志文章

    doi:10.3389/fneur.2020.00210

    authors: Peeters N,Van Campenhout A,Hanssen B,Cenni F,Schless SH,Van den Broeck C,Desloovere K,Bar-On L

    更新日期:2020-04-21 00:00:00

  • Photolysis of Caged-GABA Rapidly Terminates Seizures In Vivo: Concentration and Light Intensity Dependence.

    abstract::The therapy of focal epilepsy remains unsatisfactory for as many as 25% of patients. The photolysis of caged-γ-aminobutyric acid (caged-GABA) represents a novel and alternative option for the treatment of intractable epilepsy. Our previous experimental results have demonstrated that the use of blue light produced by l...

    journal_title:Frontiers in neurology

    pub_type: 杂志文章

    doi:10.3389/fneur.2017.00215

    authors: Wang D,Yu Z,Yan J,Xue F,Ren G,Jiang C,Wang W,Piao Y,Yang X

    更新日期:2017-05-18 00:00:00

  • A Novel Sonification Approach to Support the Diagnosis of Alzheimer's Dementia.

    abstract::Alzheimer's disease is the most common neurodegenerative form of dementia that steadily worsens and eventually leads to death. Its set of symptoms include loss of cognitive function and memory decline. Structural and functional imaging methods such as CT, MRI, and PET scans play an essential role in the diagnosis proc...

    journal_title:Frontiers in neurology

    pub_type: 杂志文章

    doi:10.3389/fneur.2017.00647

    authors: Gionfrida L,Roginska A

    更新日期:2017-12-07 00:00:00

  • Efficacy and the Safety of Granulocyte Colony-Stimulating Factor Treatment in Patients with Muscular Dystrophy: A Non-Randomized Clinical Trial.

    abstract:Introduction:The current standard treatment for patients with Duchenne muscular dystrophy (DMD) involves corticosteroids. Granulocyte colony-stimulating factor (G-CSF) induces the proliferation of satellite cells and myoblasts and, in turn, muscle regeneration. Beneficial effects of G-CSF were also described for skelet...

    journal_title:Frontiers in neurology

    pub_type: 杂志文章

    doi:10.3389/fneur.2017.00566

    authors: Sienkiewicz D,Kułak W,Okurowska-Zawada B,Paszko-Patej G,Wojtkowski J,Sochoń K,Kalinowska A,Okulczyk K,Sienkiewicz J,McEachern E

    更新日期:2017-10-26 00:00:00

  • lop-DWI: A Novel Scheme for Pre-Processing of Diffusion-Weighted Images in the Gradient Direction Domain.

    abstract::We describe and evaluate a pre-processing method based on a periodic spiral sampling of diffusion-gradient directions for high angular resolution diffusion magnetic resonance imaging. Our pre-processing method incorporates prior knowledge about the acquired diffusion-weighted signal, facilitating noise reduction. Peri...

    journal_title:Frontiers in neurology

    pub_type: 杂志文章

    doi:10.3389/fneur.2014.00290

    authors: Sepehrband F,Choupan J,Caruyer E,Kurniawan ND,Gal Y,Tieng QM,McMahon KL,Vegh V,Reutens DC,Yang Z

    更新日期:2015-01-12 00:00:00

  • Benefits of hemicraniectomy seen many years after malignant stroke in a young patient.

    abstract::The benefits of hemicraniectomy for malignant middle cerebral artery (MCA) stroke may not be apparent in the 3- to 6-months in which final outcomes are assessed in research studies. We present the case of a 15-year-old who underwent hemicraniectomy for malignant MCA stroke and was significantly disabled 3 and 6 months...

    journal_title:Frontiers in neurology

    pub_type: 杂志文章

    doi:10.3389/fneur.2012.00123

    authors: Mittal A,Mittal G,Partikian A,Liebeskind D,Sanossian N

    更新日期:2012-08-02 00:00:00

  • Hemorrhagic transformation: a review of the rate of hemorrhage in the major clinical trials of acute ischemic stroke.

    abstract::Acute ischemic stroke is a devastating disease that is often complicated by hemorrhagic transformation. While significant advances have been made over the past two decades with regard to emergent treatment of AIS, many of the therapeutic options are limited by an increased risk of hemorrhage. Here, we sought to review...

    journal_title:Frontiers in neurology

    pub_type: 杂志文章

    doi:10.3389/fneur.2013.00069

    authors: Sussman ES,Connolly ES Jr

    更新日期:2013-06-10 00:00:00

  • Cellular High-Energy Cavitation Trauma - Description of a Novel In Vitro Trauma Model in Three Different Cell Types.

    abstract::The mechanisms involved in traumatic brain injury have yet to be fully characterized. One mechanism that, especially in high-energy trauma, could be of importance is cavitation. Cavitation can be described as a process of vaporization, bubble generation, and bubble implosion as a result of a decrease and subsequent in...

    journal_title:Frontiers in neurology

    pub_type: 杂志文章

    doi:10.3389/fneur.2016.00010

    authors: Cao Y,Risling M,Malm E,Sondén A,Bolling MF,Sköld MK

    更新日期:2016-02-01 00:00:00