On the Digital Psychopharmacology of Valproic Acid in Mice.

abstract：:In the present review, we deliver an overview of the involvement of metabotropic glutamate receptor 5 (mGluR5) activity and density in pathological anxiety, mood disorders and addiction. Specifically, we will describe mGluR5 studies in humans that employed Positron Emission Tomography (PET) and combined the findings w...

journal_title：Frontiers in neuroscience

authors： Terbeck S,Akkus F,Chesterman LP,Hasler G

更新日期：2015-03-18 00:00:00

abstract：:Artificial neural networks (ANNs) trained using backpropagation are powerful learning architectures that have achieved state-of-the-art performance in various benchmarks. Significant effort has been devoted to developing custom silicon devices to accelerate inference in ANNs. Accelerating the training phase, however, ...

journal_title：Frontiers in neuroscience

authors： Mostafa H,Pedroni B,Sheik S,Cauwenberghs G

更新日期：2017-09-06 00:00:00

abstract：:Uncovering brain activity from magnetoencephalography (MEG) data requires solving an ill-posed inverse problem, greatly confounded by noise, interference, and correlated sources. Sparse reconstruction algorithms, such as Champagne, show great promise in that they provide focal brain activations robust to these confoun...

journal_title：Frontiers in neuroscience

authors： Owen JP,Sekihara K,Nagarajan SS

更新日期：2012-12-26 00:00:00

abstract：:In order to characterize the genetic architecture of epilepsy in a pediatric population from the Iberian Peninsula (including the Canary Islands), we conducted targeted exome sequencing of 246 patients with infantile-onset seizures with or without neurodevelopmental delay. We detected 107 variants in 48 different gene...

journal_title：Frontiers in neuroscience

authors： Fernández-Marmiesse A,Roca I,Díaz-Flores F,Cantarín V,Pérez-Poyato MS,Fontalba A,Laranjeira F,Quintans S,Moldovan O,Felgueroso B,Rodríguez-Pedreira M,Simón R,Camacho A,Quijada P,Ibanez-Mico S,Domingno MR,Benito C,Calvo

更新日期：2019-11-08 00:00:00

abstract：:Natural experience can cause complex changes in gene expression in brain centers for cognition and perception, but the mechanisms that link perceptual experience and neurogenomic regulation are not understood. MicroRNAs (miRNAs or miRs) have the potential to regulate large gene expression networks, and a previous stud...

journal_title：Frontiers in neuroscience

authors： Lin YC,Balakrishnan CN,Clayton DF

更新日期：2014-12-16 00:00:00

abstract：:Some toxins and drugs can trigger lasting neuroprotective mechanisms that enable neurons to resist a subsequent severe insult. This "pharmacological preconditioning" has far-reaching implications for conditions in which blood flow to the brain is interrupted. We have previously shown that in vitro preconditioning with...

journal_title：Frontiers in neuroscience

authors： Goulton CS,Patten AR,Kerr JR,Kerr DS

更新日期：2010-08-03 00:00:00

abstract：:We constructed a near infrared spectroscopy-based real-time feedback system to estimate the subjects' emotional states using the changes in oxygenated hemoglobin concentration [Δ(oxy-Hb)] in the prefrontal cortex (PFC). Using this system, we investigated the influences of continual mild and equivocal stimuli consistin...

journal_title：Frontiers in neuroscience

authors： Hori S,Mori K,Mashimo T,Seiyama A

更新日期：2017-06-09 00:00:00

abstract：:Vagal neurocircuits are vitally important in the co-ordination and modulation of GI reflexes and homeostatic functions. 5-hydroxytryptamine (5-HT; serotonin) is critically important in the regulation of several of these autonomic gastrointestinal (GI) functions including motility, secretion and visceral sensitivity. W...

journal_title：Frontiers in neuroscience

authors： Browning KN

更新日期：2015-10-29 00:00:00

abstract：:Many complex brain disorders, such as autism spectrum disorders, exhibit a wide range of symptoms and disability. To understand how brain communication is impaired in such conditions, functional connectivity studies seek to understand individual differences in brain network structure in terms of covariates that measur...

journal_title：Frontiers in neuroscience

authors： Narayan M,Allen GI

更新日期：2016-04-12 00:00:00

abstract：:Tapping in time to a metronome beat (hereafter beat synchronization) shows considerable variability in child populations, and individual differences in beat synchronization are reliably related to reading development. Children with developmental dyslexia show impairments in beat synchronization. These impairments may ...

journal_title：Frontiers in neuroscience

authors： Colling LJ,Noble HL,Goswami U

更新日期：2017-07-12 00:00:00

abstract：:There is increasing evidence that metabolic dysfunction plays an important role in Alzheimer's disease (AD). Brain insulin resistance and subsequent impairment of insulin and insulin-like growth factor (IGF) signaling are associated with the neurodegenerative and clinical features of AD. Nevertheless, how the brain in...

journal_title：Frontiers in neuroscience

authors： Bonham LW,Geier EG,Steele NZR,Holland D,Miller BL,Dale AM,Desikan RS,Yokoyama JS,Alzheimer’s Disease Neuroimaging Initiative.

更新日期：2018-07-16 00:00:00

abstract：:Changes in cerebral blood flow (CBF) during a hyperglycemic challenge were mapped, using perfusion-weighted MRI, in a group of non-human primates. Seven female baboons were fasted for 16 h prior to 1-h imaging experiment, performed under general anesthesia, that consisted of a 20-min baseline, followed by a bolus infu...

journal_title：Frontiers in neuroscience

authors： Kochunov P,Wey HY,Fox PT,Lancaster JL,Davis MD,Wang DJ,Lin AL,Bastarrachea RA,Andrade MC,Mattern V,Frost P,Higgins PB,Comuzzie AG,Voruganti VS

更新日期：2017-02-14 00:00:00

abstract：:Adult neurogenesis is a tightly regulated process continuously taking place in the central nervous system of most mammalian species. In neuroscience research, transgenic animals bearing the tamoxifen-inducible CreERT2-Lox system are widely used. In this study, we made use of a Nestin-CreERT2/R26R-YFP transgenic mouse ...

journal_title：Frontiers in neuroscience

authors： Rotheneichner P,Romanelli P,Bieler L,Pagitsch S,Zaunmair P,Kreutzer C,König R,Marschallinger J,Aigner L,Couillard-Després S

更新日期：2017-02-01 00:00:00

abstract：:Newborn neurons are continuously added to the hippocampal dentate gyrus throughout adulthood. In this review, we analyze the maturational stages that newborn granule neurons go through, with a focus on their unique morphological features during each stage under both physiological and pathological circumstances. In add...

journal_title：Frontiers in neuroscience

authors： Llorens-Martín M,Rábano A,Ávila J

更新日期：2016-01-19 00:00:00

abstract：:Environmental sounds form part of our daily life. With the advancement of deep learning models and the abundance of training data, the performance of automatic sound classification (ASC) systems has improved significantly in recent years. However, the high computational cost, hence high power consumption, remains a ma...

journal_title：Frontiers in neuroscience

authors： Wu J,Chua Y,Zhang M,Li H,Tan KC

更新日期：2018-11-19 00:00:00

abstract：:Metabolic confusion has been linked to the pathogenesis of Parkinson's disease (PD), while the dynamic changes associated with the onset and progression of PD remain unclear. Herein, dynamic changes in metabolites were detected from the initiation to the development of 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPT...

journal_title：Frontiers in neuroscience

authors： Lu Y,Zhang X,Zhao L,Yang C,Pan L,Li C,Liu K,Bai G,Gao H,Yan Z

更新日期：2018-02-20 00:00:00

abstract：:Spike-Timing-Dependent Plasticity (STDP) is a bio-inspired local incremental weight update rule commonly used for online learning in spike-based neuromorphic systems. In STDP, the intensity of long-term potentiation and depression in synaptic efficacy (weight) between neurons is expressed as a function of the relative...

journal_title：Frontiers in neuroscience

authors： Pedroni BU,Joshi S,Deiss SR,Sheik S,Detorakis G,Paul S,Augustine C,Neftci EO,Cauwenberghs G

更新日期：2019-04-24 00:00:00

abstract：:Social memory, including the ability to recognize faces and voices, is essential for social relationships. It has a large heritable component, but the knowledge about the contributing genes is sparse. The genetic variation underlying inter-individual differences in social memory was investigated in an exploratory samp...

journal_title：Frontiers in neuroscience

authors： Henningsson S,Zettergren A,Hovey D,Jonsson L,Svärd J,Cortes DS,Melke J,Ebner NC,Laukka P,Fischer H,Westberg L

更新日期：2015-10-21 00:00:00

abstract：:People generally prefer risky options, which have fully specified outcome probabilities, to ambiguous options, which have unspecified probabilities. This preference, formalized in economics, is strong enough that people will reliably prefer a risky option to an ambiguous option with a greater expected value. Explanati...

journal_title：Frontiers in neuroscience

authors： Hayden BY,Heilbronner SR,Platt ML

更新日期：2010-09-17 00:00:00

abstract：:The motor neuron degenerative disease spinal muscular atrophy (SMA) remains one of the most frequently inherited causes of infant mortality. Afflicted patients loose the survival motor neuron 1 (SMN1) gene but retain one or more copies of SMN2, a homolog that is incorrectly spliced. Primary treatment strategies for SM...

journal_title：Frontiers in neuroscience

authors： Borg R,Cauchi RJ

更新日期：2014-10-15 00:00:00

abstract：:Resting-state functional magnetic resonance imaging (rsfMRI) is being widely used for charting brain connectivity and dynamics in healthy and diseased brains. However, the resting state paradigm allows an unconstrained fluctuation of brain arousal, which may have profound effects on resting-state fMRI signals and asso...

journal_title：Frontiers in neuroscience

authors： Gu Y,Han F,Liu X

更新日期：2019-11-05 00:00:00

abstract：:Poisoning with organophosphorus compounds (OPCs) is a major problem worldwide. Standard therapy with atropine and established oxime-type enzyme reactivators (pralidoxime, obidoxime) is unsatisfactory. In search of more efficacious broad-spectrum oximes, new bispyridinium (K-) oximes have been synthesized, with K027 be...

journal_title：Frontiers in neuroscience

authors： Lorke DE,Petroianu GA

更新日期：2019-05-22 00:00:00

abstract：:Neurofibrillary pathology comprised of pathological tau protein is closely tied to a range of neurodegenerative disorders, the most common of which is Alzheimer's disease. While they are individually rarer, a range of other disorders, the tauopathies (including Pick's disease, progressive supranuclear palsy, corticoba...

journal_title：Frontiers in neuroscience

authors： Novak P,Kontsekova E,Zilka N,Novak M

更新日期：2018-11-02 00:00:00

abstract：:Spinal cord injury (SCI), one of the most severe types of neurological damage, results in persistent motor and sensory dysfunction and involves complex gene alterations. Circular RNAs (circRNAs) are a recently discovered class of regulatory molecules, and their roles in SCI still need to be addressed. This study compr...

journal_title：Frontiers in neuroscience

authors： Wu R,Mao S,Wang Y,Zhou S,Liu Y,Liu M,Gu X,Yu B

更新日期：2019-12-10 00:00:00

abstract：Introduction:Low back pain (LBP) is a complex and growing global health problem in need of more effective pain management strategies. Spinal mobilization (SM) is a non-pharmacological approach recommended by most clinical guidelines for LBP, but greater utilization and treatment optimization are hampered by a lack of m...

journal_title：Frontiers in neuroscience

authors： Reed WR,Little JW,Lima CR,Sorge RE,Yarar-Fisher C,Eraslan M,Hurt CP,Ness TJ,Gu JG,Martins DF,Li P

更新日期：2020-04-30 00:00:00

abstract：:Wireless electroencephalography (EEG) of small animal subjects typically utilizes miniaturized EEG devices which require a robust recording and electrode assembly that remains in place while also being well-tolerated by the animal so as not to impair the ability of the animal to perform normal living activities or exp...

journal_title：Frontiers in neuroscience

authors： Vogler EC,Flynn DT,Busciglio F,Bohannan RC,Tran A,Mahavongtrakul M,Busciglio JA

更新日期：2017-11-14 00:00:00

abstract：:Background: Significant progress toward the recovery of useful vision in blind patients with severe degenerative retinal diseases caused by photoreceptor death has been achieved with the development of visual prostheses that stimulate the retina electrically. However, currently used prostheses do not provide feedback ...

journal_title：Frontiers in neuroscience

authors： Rincón Montes V,Gehlen J,Lück S,Mokwa W,Müller F,Walter P,Offenhäusser A

更新日期：2019-04-30 00:00:00

abstract：:Event-related potentials (ERPs) are often used in brain-computer interfaces (BCIs) for communication or system control for enhancing or regaining control for motor-disabled persons. Especially results from single-trial EEG classification approaches for BCIs support correlations between single-trial ERP detection perfo...

journal_title：Frontiers in neuroscience

authors： Kirchner EA,Kim SK

更新日期：2018-03-27 00:00:00

abstract：:The characterization of the functional network of the brain dynamics has become a prominent tool to illuminate novel aspects of brain functioning. Due to its excellent time resolution, such research is oftentimes based on electroencephalographic recordings (EEG). However, a particular EEG-reference might cause crucial...

journal_title：Frontiers in neuroscience

authors： Ríos-Herrera WA,Olguín-Rodríguez PV,Arzate-Mena JD,Corsi-Cabrera M,Escalona J,Marín-García A,Ramos-Loyo J,Rivera AL,Rivera-López D,Zapata-Berruecos JF,Müller MF

更新日期：2019-09-12 00:00:00

abstract：:Understanding the complex neural mechanisms controlling urinary bladder activity is an extremely important topic in both neuroscience and urology. Simultaneously recording of the bladder activity and neural activity in related brain regions will largely advance this field. However, such recording approach has long bee...

journal_title：Frontiers in neuroscience

authors： Yao J,Li Q,Li X,Qin H,Liang S,Liao X,Chen X,Li W,Yan J

更新日期：2019-06-25 00:00:00