Anti-CD20-Mediated B Cell Depletion Is Associated With Bone Preservation in Lymphoma Patients and Bone Mass Increase in Mice.

abstract：:Antigen-specific CD8+ tissue-resident memory T cells (TRM cells) persist in the lung following resolution of a respiratory virus infection and provide first-line defense against reinfection. In contrast to other memory T cell populations, such as central memory T cells that circulate between lymph and blood, and effec...

journal_title：Frontiers in immunology

authors： Takamura S,Kohlmeier JE

更新日期：2019-04-05 00:00:00

abstract：:The immune system is composed of two subsystems-the innate immune system and the adaptive immune system. The innate immune system is the first to respond to pathogens and does not retain memory of previous responses. Innate immune responses are evolutionarily older than adaptive responses and elements of innate immuni...

journal_title：Frontiers in immunology

authors： Smith NC,Rise ML,Christian SL

更新日期：2019-10-10 00:00:00

abstract：:Platelets (PLTs) are the major source of high-mobility group box 1 (HMGB1), a protein that is involved in sterile inflammation of blood vessels and thrombosis. Megakaryocytes (MKs) synthesize HMGB1 and transfer both protein and mRNA into PLTs and PLT-derived microvesicles (MV). Free HMGB1 found in supernatants of in v...

journal_title：Frontiers in immunology

authors： Mardente S,Mari E,Massimi I,Tafani M,Guerriero R,Morsilli O,Pulcinelli FM,Bianchi ME,Zicari A

更新日期：2018-01-12 00:00:00

abstract：:The lymphatic vasculature plays a crucial role in regulating the inflammatory response by influencing drainage of extravasated fluid, inflammatory mediators, and leukocytes. Lymphatic vessels undergo pronounced enlargement in inflamed tissue and display increased leakiness, indicating reduced functionality. Interferin...

journal_title：Frontiers in immunology

authors： Schwager S,Detmar M

更新日期：2019-02-26 00:00:00

abstract：:Protective vaccines for hypervariable pathogens are urgently needed. It has been proposed that amputating highly variable epitopes from vaccine antigens would induce the production of broadly protective antibodies targeting conserved epitopes. However, so far, these approaches have failed, partially because conserved ...

journal_title：Frontiers in immunology

authors： Mosa AI

更新日期：2020-09-11 00:00:00

abstract：:Compared to naive T cells, differentiated T cells are thought to be less dependent on CD28 costimulation for full activation. To revisit the role of CD28 costimulation in mouse T cell recall responses, we adoptively transferred in vitro generated OT-II T helper (Th) 1 cells into C57BL/6 mice (Thy1.2+) and then either ...

journal_title：Frontiers in immunology

authors： Langenhorst D,Haack S,Göb S,Uri A,Lühder F,Vanhove B,Hünig T,Beyersdorf N

更新日期：2018-05-16 00:00:00

abstract：:IFN-γ-producing CD4+ T (Th1) cells and IL-17-producing CD4+ T (Th17) cells play a critical role in the pathogenesis of chronic obstructive pulmonary disease (COPD). However, the immune regulation between Th1 and Th17 cells remains unclear. Previous studies have demonstrated that interleukin-27 (IL-27)/WSX-1 exerted pr...

journal_title：Frontiers in immunology

authors： Qiu SL,Duan MC,Liang Y,Tang HJ,Liu GN,Zhang LM,Yang CM

更新日期：2016-12-05 00:00:00

abstract：:Dendritic cell (DCs) activation by Toll-like receptor (TLR) agonist induces robust metabolic rewiring toward glycolysis. Recent findings in the field identified mechanistic details governing these metabolic adaptations. However, it is unknown whether a switch to glycolysis from oxidative phosphorylation (OXPHOS) is a ...

journal_title：Frontiers in immunology

authors： Basit F,de Vries IJM

更新日期：2019-10-15 00:00:00

abstract：:Anti-tumor immunity is limited by a number of factors including the lack of fully activated T-cells, insufficient antigenic stimulation and the immune-suppressive tumor microenvironment. We addressed these hurdles by developing a novel class of immunoconjugates, Antibody-Targeted Pathogen-derived Peptides (ATPPs), whi...

journal_title：Frontiers in immunology

authors： Sefrin JP,Hillringhaus L,Mundigl O,Mann K,Ziegler-Landesberger D,Seul H,Tabares G,Knoblauch D,Leinenbach A,Friligou I,Dziadek S,Offringa R,Lifke V,Lifke A

更新日期：2019-08-21 00:00:00

abstract：:Iron is an essential micronutrient for most living species. In mammals, hemoglobin (Hb) stores more than two thirds of the body's iron content. In the bloodstream, haptoglobin (Hp) and hemopexin (Hpx) sequester free Hb or heme. Pathogenic microorganisms usually acquire iron from their hosts and have evolved complex sy...

journal_title：Frontiers in immunology

authors： Mozzi A,Forni D,Clerici M,Cagliani R,Sironi M

更新日期：2018-09-11 00:00:00

abstract：:All animals develop in association with complex microbial communities. It is now well established that commensal microbiota is essential for the correct functionality of each organ in the host. Particularly, the commensal gastro-intestinal microbiota (CGIM) is a key factor for development, immunity and nutrient conver...

journal_title：Frontiers in immunology

authors： Montalban-Arques A,De Schryver P,Bossier P,Gorkiewicz G,Mulero V,Gatlin DM 3rd,Galindo-Villegas J

更新日期：2015-10-09 00:00:00

abstract：:The inappropriate retention of neutrophils at inflammatory sites is a major driver of the excessive tissue damage characteristic of respiratory inflammatory diseases including COPD, ARDS, and cystic fibrosis. The molecular programmes which orchestrate neutrophil recruitment to inflammatory sites through chemotactic gu...

journal_title：Frontiers in immunology

authors： Isles HM,Herman KD,Robertson AL,Loynes CA,Prince LR,Elks PM,Renshaw SA

更新日期：2019-07-31 00:00:00

abstract：:Sepsis is characterized by injury of pulmonary microvascular endothelial cells (PMVEC) leading to barrier dysfunction. Multiple mechanisms promote septic PMVEC barrier dysfunction, including interaction with circulating leukocytes and PMVEC apoptotic death. Our previous work demonstrated a strong correlation between s...

journal_title：Frontiers in immunology

authors： Wang L,Mehta S,Ahmed Y,Wallace S,Pape MC,Gill SE

更新日期：2018-08-02 00:00:00

abstract：:β-glucan, the most abundant fungal cell wall polysaccharide, has gained much attention from the scientific community in the last few decades for its fascinating but not yet fully understood immunobiology. Study of this molecule has been motivated by its importance as a pathogen-associated molecular pattern upon fungal...

journal_title：Frontiers in immunology

authors： Camilli G,Tabouret G,Quintin J

更新日期：2018-04-16 00:00:00

abstract：:B cells are implicated in rheumatoid arthritis (RA) based on the presence of autoantibodies and the therapeutic response to B cell depletion. IL-21 has a significant role in B cell development and function. Here we assess B cell responses to IL-21 and the mechanisms responsible for altered IL-21R expression in RA. Flo...

journal_title：Frontiers in immunology

authors： Dam EM,Maier AC,Hocking AM,Carlin J,Ng B,Buckner JH

更新日期：2018-09-05 00:00:00

abstract：:Lower respiratory tract infections and tuberculosis are responsible for the death of about 4.5 million people each year and are the main causes of mortality in children under 5 years of age. Streptococcus pneumoniae is the most common bacterial pathogen associated with severe pneumonia, although other Gram-positive an...

journal_title：Frontiers in immunology

authors： Vázquez R,García E,García P

更新日期：2018-10-16 00:00:00

abstract：:Macrophages, as professional phagocytes of the immune system, possess the ability to detect and clear invading pathogens and apoptotic cells through phagocytosis. Phagocytosis involves membrane reorganization and remodeling events on the cell surface, which play an essential role in innate immunity and tissue homeosta...

journal_title：Frontiers in immunology

authors： Rubio JM,Astudillo AM,Casas J,Balboa MA,Balsinde J

更新日期：2018-07-24 00:00:00

abstract：:Malaria infections remain a serious global health problem in the world, particularly among children and pregnant women in Sub-Saharan Africa. Moreover, malaria control and elimination is hampered by rapid development of resistance by the parasite and the vector to commonly used antimalarial drugs and insecticides, res...

journal_title：Frontiers in immunology

authors： Kengne-Ouafo JA,Sutherland CJ,Binka FN,Awandare GA,Urban BC,Dinko B

更新日期：2019-02-11 00:00:00

abstract：:New biomarkers are needed for discriminating active tuberculosis (TB) from latent TB infection (LTBI), especially in vulnerable groups representing the major diagnostic challenge. This pilot study was carried out to explore the diagnostic potential of selected genes, IFN-γ, IL-17, IL-4, and FoxP3, associated with TB i...

journal_title：Frontiers in immunology

authors： Savolainen LE,Kantele A,Knuuttila A,Pusa L,Karttunen R,Valleala H,Tuuminen T

更新日期：2016-06-14 00:00:00

abstract：:Background: Chagas cardiomyopathy is the main fibrosing myocarditis among known heart diseases. Development of cardiomyopathy has been related to extracellular matrix (ECM) remodeling, which are controlled by matrix metalloproteinases (MMPs) and cytokines, especially interleukin (IL)-1β. The convertion of 31KDa inacti...

journal_title：Frontiers in immunology

authors： Medeiros NI,Pinto BF,Elói-Santos SM,Teixeira-Carvalho A,Magalhães LMD,Dutra WO,Correa-Oliveira R,Gomes JAS

更新日期：2019-04-18 00:00:00

abstract：:Cancer is a complex disease and a leading cause of death worldwide. Immunity is critical for cancer control. Cancer cells exhibit high mutational rates and therefore altered self or neo-antigens, eliciting an immune response to promote tumor eradication. Failure to mount a proper immune response leads to cancer progre...

journal_title：Frontiers in immunology

authors： Guri Y,Nordmann TM,Roszik J

更新日期：2018-03-27 00:00:00

abstract：:Tumor-induced remodeling of the microenvironment in lymph nodes (LNs) includes the formation of blood vessels, which goes beyond the regulation of metabolism, and shaping a survival niche for tumor cells. In contrast to solid tumors, which primarily rely on neo-angiogenesis, hematopoietic malignancies usually grow wit...

journal_title：Frontiers in immunology

authors： Menzel L,Höpken UE,Rehm A

更新日期：2020-12-03 00:00:00

abstract：:The heterotrimeric globular head (gC1q) domain of human C1q is made up of the C-terminal ends of the three individual chains, ghA, ghB, and ghC. A candidate receptor for the gC1q domain is a multi-functional pattern recognition protein, gC1qR. Since understanding of gC1qR and gC1q interaction could provide an insight ...

journal_title：Frontiers in immunology

authors： Pednekar L,Pathan AA,Paudyal B,Tsolaki AG,Kaur A,Abozaid SM,Kouser L,Khan HA,Peerschke EI,Shamji MH,Stenbeck G,Ghebrehiwet B,Kishore U

更新日期：2016-12-13 00:00:00

abstract：:B cell activation via the B cell receptor (BCR) signalosome involves participation of signaling molecules such as BTK and BLNK. Genetic defects in these molecules are known to impair B cell differentiation and subsequently lead to agammaglobulinemia. Here we identified novel mutations in BTK and BLNK in two unrelated ...

journal_title：Frontiers in immunology

authors： Geier CB,Sauerwein KMT,Leiss-Piller A,Zmek I,Fischer MB,Eibl MM,Wolf HM

更新日期：2018-12-18 00:00:00

abstract：:Ataxia telangiectasia (AT) is a genetic condition caused by mutations involving ATM (Ataxia Telangiectasia Mutated). This gene is responsible for the expression of a DNA double stranded break repair kinase, the ATM protein kinase. The syndrome encompasses combined immunodeficiency and various degrees of neurological a...

journal_title：Frontiers in immunology

authors： Mandola AB,Reid B,Sirror R,Brager R,Dent P,Chakroborty P,Bulman DE,Roifman CM

更新日期：2019-12-20 00:00:00

abstract：:Degenerative disc disease is associated with increased expression of pro-inflammatory cytokines in the intervertebral disc (IVD). However, it is not completely clear how inflammation arises in the IVD and which cellular compartments are involved in this process. Recently, the endoplasmic reticulum (ER) has emerged as ...

journal_title：Frontiers in immunology

authors： Krupkova O,Sadowska A,Kameda T,Hitzl W,Hausmann ON,Klasen J,Wuertz-Kozak K

更新日期：2018-08-17 00:00:00

abstract：:Crystallopathies are a heterogeneous group of diseases caused by intrinsic or environmental microparticles or crystals, promoting tissue inflammation and scarring. Certain proteins interfere with crystal formation and growth, e.g., with intrarenal calcium oxalate (CaOx) crystal formation, a common cause of kidney ston...

journal_title：Frontiers in immunology

authors： Steiger S,Grill JF,Ma Q,Bäuerle T,Jordan J,Smolle M,Böhland C,Lech M,Anders HJ

更新日期：2018-03-29 00:00:00

abstract：:Recently, a second individual (the "London patient") with HIV-1 infection and concomitant leukemia was cured of both diseases by a conditioning myeloablative regimen followed by transplantation of stem cells bearing the homozygous CCR5 Δ32 mutation. The substantial risks and cost associated with this procedure render ...

journal_title：Frontiers in immunology

authors： Gavegnano C,Savarino A,Owanikoko T,Marconi VC

更新日期：2019-10-04 00:00:00

abstract：:Tissue-resident phagocytes are responsible for the routine binding, engulfment, and resolution of their meals. Such populations of cells express appropriate surface receptors that are tailored to recognize the phagocytic targets of their niche and initiate the actin polymerization that drives internalization. Tissue-r...

journal_title：Frontiers in immunology

authors： Kwon W,Freeman SA

更新日期：2020-11-13 00:00:00

abstract：:Immune activation is the driving force behind the occurrence of AIDS and non-AIDS events, and is only partially reduced by antiretroviral therapy (ART). Soon after HIV infection, intestinal CD4+ T cells are depleted leading to epithelial gut damage and subsequent translocation of microbes and/or their products into sy...

journal_title：Frontiers in immunology

authors： Ramendra R,Isnard S,Mehraj V,Chen J,Zhang Y,Finkelman M,Routy JP

更新日期：2019-03-18 00:00:00