Predictive Biomarkers of Immune Checkpoint Inhibitors-Related Toxicities.

abstract：:Short-chain fatty acids (SCFAs), such as acetate, butyrate, and propionate, modulate immune responses in the gut. However, the effect of SCFAs on mucosal vaccine-induced immune cell migration is poorly understood. Here, we investigated whether SCFAs modulate chemokine expression induced by the killed whole-cell oral c...

journal_title：Frontiers in immunology

authors： Sim JR,Kang SS,Lee D,Yun CH,Han SH

更新日期：2018-01-29 00:00:00

abstract：:Dendritic cells (DCs) are the guardians of the immune system since they are located in the majority of peripheral tissues. In addition, they are crucial for the induction of an effective immune response based on their unique capacity to stimulate naive T cells. During co-evolution, the human pathogen herpes simplex vi...

journal_title：Frontiers in immunology

authors： Birzer A,Krawczyk A,Draßner C,Kuhnt C,Mühl-Zürbes P,Heilingloh CS,Steinkasserer A,Popella L

更新日期：2020-08-26 00:00:00

abstract：:The T cell population in an individual needs to avoid harmful activation by self peptides while maintaining the ability to respond to an unknown set of foreign peptides. This property is acquired by a combination of thymic and extra-thymic mechanisms. We extend current models for the development of self/non-self discr...

journal_title：Frontiers in immunology

authors： Best K,Chain B,Watkins C

更新日期：2015-08-07 00:00:00

abstract：:M1 and M2 macrophage-type responses kill or repair in vivo. The unique ability of macrophages to make these polar opposite type of responses provides primary host protection and maintains tissue homeostasis throughout the animal kingdom. In humans and other higher animals, M1 and M2-type macrophage responses also init...

journal_title：Frontiers in immunology

authors： Mills CD

更新日期：2015-05-05 00:00:00

abstract：:Plasmodium vivax is the most common species that cause malaria outside of the African continent. The development of an efficacious vaccine would contribute greatly to control malaria. Recently, using bacterial and adenoviral recombinant proteins based on the P. vivax circumsporozoite protein (CSP), we demonstrated the...

journal_title：Frontiers in immunology

authors： Gimenez AM,Lima LC,Françoso KS,Denapoli PMA,Panatieri R,Bargieri DY,Thiberge JM,Andolina C,Nosten F,Renia L,Nussenzweig RS,Nussenzweig V,Amino R,Rodrigues MM,Soares IS

更新日期：2017-10-11 00:00:00

abstract：:Antibodies are commonly used in organ transplant induction therapy and to treat autoimmune disorders. The effects of some biologics on the human immune system remain incompletely characterized and a deeper understanding of their mechanisms of action may provide useful insights for their clinical application. The goal ...

journal_title：Frontiers in immunology

authors： Binder C,Sellberg F,Cvetkovski F,Berglund E,Berglund D

更新日期：2020-11-11 00:00:00

abstract：:Systemic lupus erythematosus (SLE) and antiphospholipid syndrome (APS) are two autoimmune diseases that can occur together or separately. Insights into the pathogenesis have revealed similarities, such as development of autoantibodies targeting subcellular antigens as well as a shared increased risk of cardiovascular ...

journal_title：Frontiers in immunology

authors： Wirestam L,Arve S,Linge P,Bengtsson AA

更新日期：2019-11-22 00:00:00

abstract：:We recently reported that the treatment with nanoparticles (NPs) loaded with tolerogenic cytokines suppressed the manifestations of lupus-like disease induced by the transfer of donor CD4+ T cells from DBA/2 mice into (C57BL/6 × DBA/2)F1 (BDF1) mice. Although the protective effects were ascribed to the induction of ad...

journal_title：Frontiers in immunology

authors： Horwitz DA,Liu A,Bickerton S,Castaldo G,Matarese G,Fahmy TM,La Cava A

更新日期：2020-12-16 00:00:00

abstract：:The transfer of maternal immune factors to the newborn is critical for protection from infectious disease in early life. Maternally acquired passive immunity provides protection until the infant is beyond early life's increased susceptibility to severe infections or until active immunity is achieved following infant's...

journal_title：Frontiers in immunology

authors： Abu-Raya B,Smolen KK,Willems F,Kollmann TR,Marchant A

更新日期：2016-08-31 00:00:00

abstract：:Heterogeneous populations of myeloid regulatory cells (MRC), including monocytes, macrophages, dendritic cells, and neutrophils, are found in cancer and infectious diseases. The inflammatory environment in solid tumors as well as infectious foci with persistent pathogens promotes the development and recruitment of MRC...

journal_title：Frontiers in immunology

authors： Dorhoi A,Du Plessis N

更新日期：2018-01-04 00:00:00

abstract：:As cutaneous melanoma (CM) currently remains with a bleak prognosis, thorough investigation of new treatment options are of utmost relevance. In the phase II/III randomized clinical trial (CASVAC-0401), the repeated immunization of stages IIB-III CM patients with the irradiated, allogeneic cellular CSF-470 vaccine plu...

journal_title：Frontiers in immunology

authors： Pampena MB,Cartar HC,Cueto GR,Levy EM,Blanco PA,Barrio MM,Mordoh J

更新日期：2018-11-02 00:00:00

abstract：:COVID-19 is a distinctive infection characterized by elevated inter-human transmission and presenting from absence of symptoms to severe cytokine storm that can lead to dismal prognosis. Like for HIV, lymphopenia and drastic reduction of CD4+ T cell counts in COVID-19 patients have been linked with poor clinical outco...

journal_title：Frontiers in immunology

authors： Peng X,Ouyang J,Isnard S,Lin J,Fombuena B,Zhu B,Routy JP

更新日期：2020-12-15 00:00:00

abstract：:Celiac Disease (CD) is a multifactorial, autoimmune enteropathy activated by cereal proteins in genetically predisposed individuals carrying HLA DQ2/8 genes. A heterogenous gene combination of the cereal prolamins is documented in different wheat genotypes, which is suggestive of their variable immunogenic potential. ...

journal_title：Frontiers in immunology

authors： Grover J,Chhuneja P,Midha V,Ghia JE,Deka D,Mukhopadhyay CS,Sood N,Mahajan R,Singh A,Verma R,Bansal E,Sood A

更新日期：2019-02-04 00:00:00

abstract：:About 8% of our genome is composed of sequences with viral origin, namely human Endogenous Retroviruses (HERVs). HERVs are relics of ancient infections that affected the primates' germ line along the last 100 million of years, and became stable elements at the interface between self and foreign DNA. Intriguingly, HERV...

journal_title：Frontiers in immunology

authors： Grandi N,Tramontano E

更新日期：2018-09-10 00:00:00

abstract：:Studying the evolutionary diversification of mammalian antiviral defenses is of main importance to better understand our innate immune repertoire. The small HERC proteins are part of a multigene family, including HERC5 and HERC6, which have probably diversified through complex evolutionary history in mammals. Here, we...

journal_title：Frontiers in immunology

authors： Jacquet S,Pontier D,Etienne L

更新日期：2020-12-18 00:00:00

abstract：:Primary immunodeficiency diseases (PID) area heterogeneous group of disorders caused by genetic defects of the immune system, which manifest clinically as recurrent infections, autoimmune diseases or malignancies. Early detection of PID remains a challenge, particularly in older children with milder and less specific ...

journal_title：Frontiers in immunology

authors： Korsunskiy I,Blyuss O,Gordukova M,Davydova N,Zaikin A,Zinovieva N,Zimin S,Molchanov R,Salpagarova A,Eremeeva A,Filipenko M,Prodeus A,Korsunskiy A,Hsu P,Munblit D

更新日期：2020-03-03 00:00:00

abstract：:Intravesical instillation of bacillus Calmette-Guérin (BCG) is used to treat superficial bladder cancer, either papillary tumors (after transurethral resection) or high-grade flat carcinomas (carcinoma in situ), reducing recurrence in about 70% of patients. Initially, BCG was proposed to work through an inflammatory r...

journal_title：Frontiers in immunology

authors： García-Cuesta EM,López-Cobo S,Álvarez-Maestro M,Esteso G,Romera-Cárdenas G,Rey M,Cassady-Cain RL,Linares A,Valés-Gómez A,Reyburn HT,Martínez-Piñeiro L,Valés-Gómez M

更新日期：2015-06-08 00:00:00

abstract：:Infections are considered important environmental triggers of autoimmunity and can contribute to autoimmune disease onset and severity. Nucleic acids and the complexes that they form with proteins-including chromatin and ribonucleoproteins-are the main autoantigens in the autoimmune disease systemic lupus erythematosu...

journal_title：Frontiers in immunology

authors： Qiu CC,Caricchio R,Gallucci S

更新日期：2019-11-08 00:00:00

abstract：:Multiple sclerosis is a chronic auto-inflammatory disease of the central nervous system affecting patients worldwide. Neuroinflammation in multiple sclerosis is mainly driven by peripheral immune cells which invade the central nervous system and cause neurodegenerative inflammation. To enter the target tissue, immune ...

journal_title：Frontiers in immunology

authors： Zondler L,Herich S,Kotte P,Körner K,Schneider-Hohendorf T,Wiendl H,Schwab N,Zarbock A

更新日期：2020-12-14 00:00:00

abstract：:For over 60 years, hematopoietic stem cell transplantation has been the major curative therapy for several hematological and genetic disorders, but its efficacy is limited by the secondary disease called graft versus host disease (GvHD). Huge advances have been made in successful transplantation in order to improve pa...

journal_title：Frontiers in immunology

authors： Ghimire S,Weber D,Mavin E,Wang XN,Dickinson AM,Holler E

更新日期：2017-03-20 00:00:00

abstract：:Dendritic cells (DCs) are central to the adoptive immune response, and their function is regulated by diverse signals in a context-specific manner. Different DCs have been described in physiologic conditions, inflammation, and cancer, prompting a series of questions on how adoptive immune responses, or tolerance, deve...

journal_title：Frontiers in immunology

authors： Palombo F,Focaccetti C,Barnaba V

更新日期：2014-01-06 00:00:00

abstract：:Fasciola hepatica, also known as the liver fluke, is a trematode that infects livestock and humans causing fasciolosis, a zoonotic disease of increasing importance due to its worldwide distribution and high economic losses. This parasite immunoregulates the host immune system by inducing a strong Th2 and regulatory T ...

journal_title：Frontiers in immunology

authors： Carasi P,Rodríguez E,da Costa V,Frigerio S,Brossard N,Noya V,Robello C,Anegón I,Freire T

更新日期：2017-07-26 00:00:00

abstract：:A transplanted organ is usually rejected without any major immunosuppressive treatment because of vigorous alloimmune responsiveness. However, continuous global immunosuppression may cause severe side effects, including nephrotoxicity, tumors, and infections. Therefore, it is necessary to seek novel immunosuppressive ...

journal_title：Frontiers in immunology

authors： Zeng Q,Qiu F,Chen Y,Liu C,Liu H,Liang CL,Zhang Q,Dai Z

更新日期：2019-04-01 00:00:00

abstract：:Allogeneic hematopoietic stem cell transplantation (allo-HSCT) is the only treatment with curative potential for certain aggressive hematopoietic malignancies. Its success is limited by acute graft-versus-host disease (GVHD), a life-threatening complication that occurs when allo-reactive donor T cells attack recipient...

journal_title：Frontiers in immunology

authors： Heidegger S,van den Brink MR,Haas T,Poeck H

更新日期：2014-07-18 00:00:00

abstract：:Red blood cells (RBCs) have a well-defined lifespan, indicating a mechanism by which senescent cells of a certain age are removed from circulation. However, the specifics by which senescent cells are recognized and removed are poorly understood. There are multiple competing hypotheses for this process, perhaps the mos...

journal_title：Frontiers in immunology

authors： Hudson KE,de Wolski K,Kapp LM,Richards AL,Schniederjan MJ,Zimring JC

更新日期：2017-10-30 00:00:00

abstract：:In this review we discuss how the competition for cytokines between different cells of the immune system can shape the system wide immune response. We focus on interleukin-2 (IL-2) secretion by activated effector T cells (T(eff)) and on the competition for IL-2 consumption between T(eff) and regulatory T cells (T(reg)...

journal_title：Frontiers in immunology

authors： Höfer T,Krichevsky O,Altan-Bonnet G

更新日期：2012-09-05 00:00:00

abstract：:This study develops an original co-infection model in mice using Brucella melitensis, the most frequent cause of human brucellosis, and Trypanosoma brucei, the agent of African trypanosomiasis. Although the immunosuppressive effects of T. brucei in natural hosts and mice models are well established, we observed that t...

journal_title：Frontiers in immunology

authors： Machelart A,Van Vyve M,Potemberg G,Demars A,De Trez C,Tima HG,Vanwalleghem G,Romano M,Truyens C,Letesson JJ,Muraille E

更新日期：2017-07-31 00:00:00

abstract：:Objectives: Fibrosis is a hallmark of systemic sclerosis (SSc), an intractable disease where innovative strategies are still being sought. Among novel anti-fibrotic approaches, mesenchymal stromal/stem cell (MSC)-based therapy appears promising. Previously, we reported anti-fibrotic effects of MSC in an experimental m...

journal_title：Frontiers in immunology

authors： Maria ATJ,Rozier P,Fonteneau G,Sutra T,Maumus M,Toupet K,Cristol JP,Jorgensen C,Guilpain P,Noël D

更新日期：2018-12-21 00:00:00

abstract：:The latest advancements in oncology research are focused on autologous immune cell therapy. However, the effectiveness of this type of immunotherapy for cancer remediation is not equivalent for all patients or cancer types. This suggests the need for better preclinical screening models that more closely recapitulate i...

journal_title：Frontiers in immunology

authors： Sherman H,Gitschier HJ,Rossi AE

更新日期：2018-04-23 00:00:00

abstract：:The adaptive immune response begins when CD4+ T cells recognize antigenic peptides bound to class II molecules of the Major Histocompatibility Complex (MHCII). The interaction between peptides and MHCII has been historically interpreted as a rigid docking event. However, this model has been challenged by the evidence ...

journal_title：Frontiers in immunology

authors： Ferrante A

更新日期：2013-10-01 00:00:00