Sex as a Biological Variable in Preclinical Modeling of Blast-Related Traumatic Brain Injury.

abstract：:Increasing evidence suggests an association between gastrointestinal (GI) disorders and susceptibility and progress of Parkinson's disease (PD). Gut-brain axis has been proposed to play important roles in the pathogenesis of PD, though the exact pathophysiologic mechanism has yet to be elucidated. Here, we discuss the...

journal_title：Frontiers in neurology

authors： Chao YX,Gulam MY,Chia NSJ,Feng L,Rotzschke O,Tan EK

更新日期：2020-08-25 00:00:00

abstract：:Background: Tract-based spatial statistics (TBSS) is suitable for the assessment of voxel-wise changes in fiber integrity in WM tracts in the entire brain. Longitudinal TBSS analyses of early multiple sclerosis (MS) using 3 Tesla magnetic resonance imaging (MRI) are not common. Objective: To characterize microstructur...

journal_title：Frontiers in neurology

authors： Schneider R,Genç E,Ahlborn C,Gold R,Lukas C,Bellenberg B

更新日期：2019-11-05 00:00:00

abstract：:Objective: Status epilepticus is a major emergency condition. The choice of antiepileptic drugs for second-line treatment after benzodiazepine remains controversial, including levetiracetam vs. fosphenytoin. We compare the safety of intravenous levetiracetam and fosphenytoin as a second-line treatment in patients with...

journal_title：Frontiers in neurology

authors： Nakamura K,Ohbe H,Matsui H,Takahashi Y,Marushima A,Inoue Y,Fushimi K,Yasunaga H

更新日期：2020-07-02 00:00:00

abstract：:Huntington's disease (HD) is an autosomal dominant neurodegenerative genetic disorder characterized by motor, cognitive, and psychiatric symptoms. It is well established that regular physical activity supports brain health, benefiting cognitive function, mental health as well as brain structure and plasticity. Exercis...

journal_title：Frontiers in neurology

authors： Paré MF,Jasmin BJ

更新日期：2017-09-27 00:00:00

abstract：:Inconsistent gender differences in the outcome of TBI have been reported. The mechanism is unknown. In a recent male animal study, repeated stress followed by TBI had synergistic effects on brain gene expression and caused greater behavioral deficits. Because females are more likely to develop anxiety after stress and...

journal_title：Frontiers in neurology

authors： Xing G,Carlton J,Jiang X,Wen J,Jia M,Li H

更新日期：2014-08-28 00:00:00

abstract：BACKGROUND:Sudden unexpected death in epilepsy (SUDEP) is common among young people with epilepsy. Individuals who are at high risk of SUDEP exhibit regional brain structural and functional connectivity (FC) alterations compared with low-risk patients. However, less is known about network-based FC differences among cri...

journal_title：Frontiers in neurology

authors： Allen LA,Harper RM,Kumar R,Guye M,Ogren JA,Lhatoo SD,Lemieux L,Scott CA,Vos SB,Rani S,Diehl B

更新日期：2017-10-16 00:00:00

abstract：:α-synuclein is involved in the pathogenesis of multiple system atrophy (MSA) and can be regulated by peripheral immune activation (PIA). We aimed to clarify the correlations between PIA and the prevalence of MSA and to analyze the role of PIA in the progression of the disease. A total of 321 patients with probable MSA...

journal_title：Frontiers in neurology

authors： Cao B,Chen X,Zhang L,Wei Q,Liu H,Feng W,Chen Y,Shang H

更新日期：2020-07-07 00:00:00

abstract：:Autosomal dominant polycystic kidney disease (ADPKD) is a genetic disorder characterized by the presence of renal cysts and specific extrarenal abnormalities. ADPKD is caused by mutations in either PKD1 or PKD2 genes that encode for integral membrane proteins Polycystin-1 (PC1) and Polycystin-2 (PC2), respectively. Ex...

journal_title：Frontiers in neurology

authors： Thomas C,Zühlsdorf A,Hörtnagel K,Mulahasanovic L,Grauer OM,Kümpers P,Wiendl H,Meuth SG

更新日期：2018-05-25 00:00:00

abstract：:Subcortical circuits mediating sleep-wake functions have been well characterized in animal models, and corroborated by more recent human studies. Disruptions in these circuits have been identified in hypersomnia disorders (HDs) such as narcolepsy and Kleine-Levin Syndrome, as well as in neurodegenerative disorders exp...

journal_title：Frontiers in neurology

authors： Larson-Prior LJ,Ju YE,Galvin JE

更新日期：2014-09-11 00:00:00

abstract：:Cocaine use is associated with the transmission of human immunodeficiency (HIV) virus through risky sexual behavior. In HIV+ individuals, cocaine use is linked with poor health outcomes, including HIV-medication non-adherence and faster disease progression. Both HIV and cocaine dependence are associated with reduced i...

journal_title：Frontiers in neurology

authors： Wakim KM,Molloy CJ,Bell RP,Ross LA,Foxe JJ

更新日期：2017-10-31 00:00:00

abstract：:Objective: The aim of the present observational study is to report on the data from a large sample of inpatients, clinical staff and other workers at an Italian neurorehabilitation hospital dealing with SARS-CoV-2 infections, in order to analyze how it might have affected the management and the effectiveness of neuror...

journal_title：Frontiers in neurology

authors： Salvia A,Morone G,Iosa M,Balice MP,Paolucci S,Grasso MG,Traballesi M,Nocentini U,Formisano R,Molinari M,Rossini A,Caltagirone C

更新日期：2020-10-09 00:00:00

abstract：:Background: Spinocerebellar ataxia type 3/Machado-Joseph disease (SCA3/MJD) is one of the nine polyglutamine (polyQ) diseases and is caused by a CAG repeat expansion within the coding sequence of the ATXN3 gene. Few multimodal imaging analyses of the macro- and micro-structural changes have been performed. Methods: In...

journal_title：Frontiers in neurology

authors： Peng H,Liang X,Long Z,Chen Z,Shi Y,Xia K,Meng L,Tang B,Qiu R,Jiang H

更新日期：2019-09-24 00:00:00

abstract：:Background: Regional cerebral oxygen saturation (rScO2) measured by near-infrared spectroscopy (NIRS) can be used to monitor brain oxygenation in extracorporeal membrane oxygenation (ECMO). ECMO patients that develop acute brain injuries (ABIs) are observed to have worse outcomes. We evaluated the association between ...

journal_title：Frontiers in neurology

authors： Khan I,Rehan M,Parikh G,Zammit C,Badjatia N,Herr D,Kon Z,Hogue C,Mazzeffi M

更新日期：2018-11-23 00:00:00

abstract：:Skeletal muscle is an essential regulator of energy homeostasis and a potent coordinator of exercise-induced adaptations in other organs including the liver, fat or the brain. Skeletal muscle-initiated crosstalk with other tissues is accomplished though the secretion of myokines, protein hormones which can exert autoc...

journal_title：Frontiers in neurology

authors： Delezie J,Handschin C

更新日期：2018-08-24 00:00:00

abstract：:Autoimmune encephalitis often causes acute psychiatric symptoms and epileptic seizures. However, it is becoming increasingly clear that depending on the target antigen both symptoms and disease severity may vary. Furthermore, the identification and characterization of antibody subtypes are highly relevant for personal...

journal_title：Frontiers in neurology

authors： Edwin Thanarajah S,Prüss H,Warnke C,Barbe MT,Schroeter M,Fink GR,Onur OA

更新日期：2019-03-05 00:00:00

abstract：:Objective: Hemorrhagic transformation (HT) in ischemic moyamoya disease (MMD), reasonably defined as hemorrhage events in patients with ischemic onset manifestation, leads to a poor outcome. This study aims to reveal factors associated with HT in patients with ischemic onset manifestation and to assess the outcome of ...

journal_title：Frontiers in neurology

authors： Lu J,Li Z,Zhao Y,Chen X,Shi G,Zhao J

更新日期：2020-06-25 00:00:00

abstract：:Background: This study aims to investigate the association between blood pressure (BP) at the time of recanalization and hemorrhagic transformation in large vessel occlusion (LVO) patients following mechanical thrombectomy (MT) with general anesthesia. Methods: We retrospectively reviewed our data base for patients wi...

journal_title：Frontiers in neurology

authors： Cheng H,Xu C,Jin X,Chen Y,Zheng X,Shi F,He X,Hao Y,Jiang Y,Zhang J,Chen Z

更新日期：2020-11-17 00:00:00

abstract：:Background: Recent developments in mobile technology have enabled the investigation of human movements and mobility under natural conditions, i.e., in the home environment. Iron accumulation in the basal ganglia is deleterious in Parkinson's disease (i.e., iron accumulation with lower striatal level of dopamine). The ...

journal_title：Frontiers in neurology

authors： Hopfner F,Hobert MA,Maetzler C,Hansen C,Pham MH,Moreau C,Berg D,Devos D,Maetzler W,Fair-Park II study group.

更新日期：2019-08-08 00:00:00

abstract：:Background: In functional movement disorders, explicit movements are impaired, while implicit movements are preserved. Furthermore, there is evidence that the sense of agency is abnormal. Aim: We aimed to investigate how motor responses and sense of agency were affected by subliminal or supraliminal cues in people wit...

journal_title：Frontiers in neurology

authors： Huys AML,Edwards MJ,Bhatia KP,Haggard P

更新日期：2020-09-11 00:00:00

abstract：:Single time point positron emission tomography (PET) studies of patients with amyotrophic lateral sclerosis and frontotemporal dementia (ALS-FTD), have demonstrated hypometabolism or hypermetabolism in certain brain regions. To determine whether longitudinal (at baseline and 20.4 months later) PET and magnetic resonan...

journal_title：Frontiers in neurology

authors： Rajagopalan V,Pioro EP

更新日期：2019-03-19 00:00:00

abstract：:Moderate-severe traumatic brain injury (TBI) may result in difficulty with emotion recognition, which has negative implications for social functioning. As aspects of social cognition have been linked to resting-state functional connectivity (RSFC) in the default mode network (DMN), we sought to determine whether DMN c...

journal_title：Frontiers in neurology

authors： Lancaster K,Venkatesan UM,Lengenfelder J,Genova HM

更新日期：2019-08-09 00:00:00

abstract：:Annual cycles of physiology and behavior are highly prevalent in organisms inhabiting temperate and polar regions. Examples in mammals include changes in appetite and body fat composition, hibernation and torpor, growth of antlers, pelage and horns, and seasonal reproduction. The timing of these seasonal cycles reflec...

journal_title：Frontiers in neurology

authors： Lewis JE,Ebling FJ

更新日期：2017-03-10 00:00:00

abstract：:Primary progressive aphasia (PPA) is a neurodegenerative disease characterized by declining language ability. However, the difficulty in defining the central clinical features in its earliest stage and establishing the dynamics of its progression has led to controversy. We report a 71-year-old man with Han language su...

journal_title：Frontiers in neurology

authors： Liu X,He F,Chen Z,Liu P,Peng G

更新日期：2018-02-16 00:00:00

abstract：:Fatigue is one of the most disabling side effects in people with multiple sclerosis. While this fact is well known, there has been a remarkable lack of progress in determining the pathophysiological mechanisms behind fatigue and the establishment of effective treatments. The main barrier has been the lack of a unified...

journal_title：Frontiers in neurology

authors： Rudroff T,Kindred JH,Ketelhut NB

更新日期：2016-08-02 00:00:00

abstract：:Background: Following aneurysmal subarachnoid hemorrhage, peripherally-drawn lactic acid has been associated with poor outcomes; however, its clinical significance is unknown. We investigated admission factors and patient outcomes associated with serum lactic acid in this population. Methods: This was a retrospective ...

journal_title：Frontiers in neurology

authors： Poblete RA,Cen SY,Zheng L,Emanuel BA

更新日期：2018-07-23 00:00:00

abstract：:Lifestyle factors such as intellectual stimulation, cognitive and social engagement, nutrition, and various types of exercise appear to reduce the risk for common age-associated disorders such as Alzheimer's disease (AD) and vascular dementia. In fact, many studies have suggested that promoting physical activity can h...

journal_title：Frontiers in neurology

authors： Foster PP,Rosenblatt KP,Kuljiš RO

更新日期：2011-05-06 00:00:00

abstract：:Penetrating brain trauma commonly results in occult neurovascular injury. Detailed cerebrovascular imaging can evaluate the relationship of intracranial foreign bodies to major vascular structures, assess for traumatic pseudoaneurysms, and ensure hemostasis during surgical removal. We report a case of a self-inflicted...

journal_title：Frontiers in neurology

authors： Rennert RC,Steinberg JA,Sack J,Pannell JS,Khalessi AA

更新日期：2016-07-14 00:00:00

abstract：:Amyotrophic lateral sclerosis (ALS) is a late-onset neurodegenerative condition, most widely characterized by the selective vulnerability of motor neurons and the poor life expectancy of afflicted patients. Limited disease-modifying therapies currently exist, which only further attests to the substantial heterogeneity...

journal_title：Frontiers in neurology

authors： Gaur N,Perner C,Witte OW,Grosskreutz J

更新日期：2020-05-27 00:00:00

abstract：:Given the increasing use of regenerative free muscle flaps for various reconstructive procedures and neuroprosthetic applications, there is great interest and value in their enhanced regeneration, revascularization, and reinnervation for improved functional recovery. Here, we implant polyimide-based mircroelectrodes o...

journal_title：Frontiers in neurology

authors： Srinivasan S,Vyas K,McAvoy M,Calvaresi P,Khan OF,Langer R,Anderson DG,Herr H

更新日期：2019-03-22 00:00:00

abstract：:Background: Differentiating idiopathic Parkinson's disease (IPD) from atypical Parkinsonian disorders (APD) is challenging, especially in early disease stages. Postural instability and gait difficulty (PIGD) are substantial motor impairments of IPD and APD. Clinical evidence implies that patients with APD have larger ...

journal_title：Frontiers in neurology

authors： Gaßner H,Raccagni C,Eskofier BM,Klucken J,Wenning GK

更新日期：2019-01-22 00:00:00