Abstract:
:Microvilli are finger-like membrane protrusions, supported by the actin cytoskeleton, and found on almost all cell types. A growing body of evidence suggests that the dynamic lymphocyte microvilli, with their highly curved membranes, play an important role in signal transduction leading to immune responses. Nevertheless, challenges in modulating local membrane curvature and monitoring the high dynamicity of microvilli hampered the investigation of the curvature-generation mechanism and its functional consequences in signaling. These technical barriers have been partially overcome by recent advancements in adapted super-resolution microscopy. Here, we review the up-to-date progress in understanding the mechanisms and functional consequences of microvillus formation in T cell signaling. We discuss how the deformation of local membranes could potentially affect the organization of signaling proteins and their biochemical activities. We propose that curved membranes, together with the underlying cytoskeleton, shape microvilli into a unique compartment that sense and process signals leading to lymphocyte activation.
journal_name
Front Immunoljournal_title
Frontiers in immunologyauthors
Orbach R,Su Xdoi
10.3389/fimmu.2020.02187subject
Has Abstractpub_date
2020-09-11 00:00:00pages
2187issn
1664-3224journal_volume
11pub_type
杂志文章,评审abstract::Clematichinenoside AR (C-AR) is a triterpene saponin isolated from the root of Clematis manshurica Rupr., which is a herbal medicine used in traditional Chinese medicine for the treatment of arthritis. C-AR exerts anti-inflammatory and immunosuppressive properties, but little is known about its action in the suppressi...
journal_title:Frontiers in immunology
pub_type: 杂志文章
doi:10.3389/fimmu.2016.00532
更新日期:2016-12-07 00:00:00
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journal_title:Frontiers in immunology
pub_type: 杂志文章,评审
doi:10.3389/fimmu.2015.00313
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journal_title:Frontiers in immunology
pub_type: 杂志文章
doi:10.3389/fimmu.2018.02200
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journal_title:Frontiers in immunology
pub_type: 杂志文章,评审
doi:10.3389/fimmu.2016.00261
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pub_type: 杂志文章
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pub_type: 杂志文章,评审
doi:10.3389/fimmu.2014.00060
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pub_type: 杂志文章,评审
doi:10.3389/fimmu.2014.00637
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journal_title:Frontiers in immunology
pub_type: 杂志文章,评审
doi:10.3389/fimmu.2018.00813
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doi:10.3389/fimmu.2019.00215
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journal_title:Frontiers in immunology
pub_type: 杂志文章
doi:10.3389/fimmu.2019.00733
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pub_type: 杂志文章
doi:10.3389/fimmu.2018.01371
更新日期:2018-06-15 00:00:00
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journal_title:Frontiers in immunology
pub_type: 杂志文章
doi:10.3389/fimmu.2012.00297
更新日期:2012-09-26 00:00:00
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journal_title:Frontiers in immunology
pub_type: 杂志文章,评审
doi:10.3389/fimmu.2018.01607
更新日期:2018-07-12 00:00:00
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journal_title:Frontiers in immunology
pub_type: 杂志文章
doi:10.3389/fimmu.2018.01350
更新日期:2018-06-14 00:00:00
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pub_type: 杂志文章,评审
doi:10.3389/fimmu.2020.576347
更新日期:2020-09-23 00:00:00
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journal_title:Frontiers in immunology
pub_type: 杂志文章,评审
doi:10.3389/fimmu.2019.00491
更新日期:2019-03-18 00:00:00
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journal_title:Frontiers in immunology
pub_type: 杂志文章
doi:10.3389/fimmu.2018.02126
更新日期:2018-09-25 00:00:00
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journal_title:Frontiers in immunology
pub_type: 杂志文章
doi:10.3389/fimmu.2020.02081
更新日期:2020-08-26 00:00:00
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pub_type: 杂志文章
doi:10.3389/fimmu.2018.02101
更新日期:2018-09-12 00:00:00
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journal_title:Frontiers in immunology
pub_type: 杂志文章
doi:10.3389/fimmu.2015.00536
更新日期:2015-11-06 00:00:00
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pub_type: 杂志文章
doi:10.3389/fimmu.2018.01358
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pub_type: 杂志文章,评审
doi:10.3389/fimmu.2013.00406
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journal_title:Frontiers in immunology
pub_type: 杂志文章
doi:10.3389/fimmu.2018.00109
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journal_title:Frontiers in immunology
pub_type: 临床试验,杂志文章,多中心研究
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更新日期:2018-12-17 00:00:00
abstract::[This corrects the article DOI: 10.3389/fimmu.2019.01135.]. ...
journal_title:Frontiers in immunology
pub_type: 已发布勘误
doi:10.3389/fimmu.2019.01755
更新日期:2019-07-24 00:00:00
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pub_type: 杂志文章
doi:10.3389/fimmu.2017.00742
更新日期:2017-06-29 00:00:00
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journal_title:Frontiers in immunology
pub_type: 杂志文章
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pub_type: 杂志文章
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pub_type: 杂志文章,评审
doi:10.3389/fimmu.2017.01124
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