Pharmacological Inhibition of Amyloidogenic APP Processing and Knock-Down of APP in Primary Human Macrophages Impairs the Secretion of Cytokines.

abstract：:Neddylation is a type of post-translational protein modifications, in which neural precursor cell expressed developmentally downregulated protein 8 (NEDD8) is covalently conjugated to the lysine residues of target substrates. The best characterized principal substrates of neddylation are the cullin-RING ligases (CRLs)...

journal_title：Frontiers in immunology

authors： Yu G,Liu X,Tang J,Xu C,Ouyang G,Xiao W

更新日期：2019-06-25 00:00:00

abstract：:The size and composition of the T lymphocyte compartment is subject to strict homeostatic regulation and is remarkably stable throughout life in spite of variable dynamics in cell production and death during T cell development and immune responses. Homeostasis is achieved by careful orchestration of lymphocyte surviva...

journal_title：Frontiers in immunology

authors： Hapuarachchi T,Lewis J,Callard RE

更新日期：2013-11-11 00:00:00

abstract：:TLR8 is an endosomal sensor of RNA degradation products in human phagocytes, and is involved in the recognition of viral and bacterial pathogens. We previously showed that in human primary monocytes and monocyte derived macrophages, TLR8 senses entire Staphylococcus aureus and Streptococcus agalactiae (group B strepto...

journal_title：Frontiers in immunology

authors： Moen SH,Ehrnström B,Kojen JF,Yurchenko M,Beckwith KS,Afset JE,Damås JK,Hu Z,Yin H,Espevik T,Stenvik J

更新日期：2019-05-31 00:00:00

abstract：:Currently, liver transplantation is the most effective treatment for end-stage liver disease. Immunosuppressive agents are required to be taken after the operations, which have significantly reduced rejection rates and improved the short-term (<1 year) survival rates. However, post-transplant complications related to ...

journal_title：Frontiers in immunology

authors： Huang H,Lu Y,Zhou T,Gu G,Xia Q

更新日期：2018-11-09 00:00:00

abstract：:Glycoproteins perform extra- and intracellular functions in innate and adaptive immunity by lectin-based interactions to exposed glyco-determinants. Herein, we document and mechanistically explain the formation of subcellular-specific N-glycosylation determinants on glycoproteins trafficking through the shared biosynt...

journal_title：Frontiers in immunology

authors： Lee LY,Lin CH,Fanayan S,Packer NH,Thaysen-Andersen M

更新日期：2014-08-25 00:00:00

abstract：:Aim: We assessed whether different complement factors and complement activation products were associated with poor outcome in patients with necrotizing soft-tissue infection (NSTI). Methods: We conducted a prospective, observational study in an intensive care unit where treatment of NSTI is centralized at a national l...

journal_title：Frontiers in immunology

authors： Kristensen MK,Hansen MB,Madsen MB,Hansen CB,Pilely K,Hyldegaard O,Garred P

更新日期：2020-01-31 00:00:00

abstract：:Allogeneic hematopoietic stem cell transplantation is a potentially curative procedure for many malignant diseases. Donor T cells prevent disease recurrence via graft-versus-leukemia (GVL) effect. Donor T cells also contribute to graft-versus-host disease (GVHD), a debilitating and potentially fatal complication. Nove...

journal_title：Frontiers in immunology

authors： Mammadli M,Huang W,Harris R,Sultana A,Cheng Y,Tong W,Pu J,Gentile T,Dsouza S,Yang Q,Bah A,August A,Karimi M

更新日期：2020-11-26 00:00:00

abstract：:Construction of an optimal vaccine against tumors relies on the availability of appropriate tumor-specific antigens capable to stimulate CD4+ T helper cells (TH) and CD8+ cytolytic T cells (CTL). CTL are considered the major effectors of the anti-tumor adaptive immune response as they recognize antigens presented on M...

journal_title：Frontiers in immunology

authors： Accolla RS,Ramia E,Tedeschi A,Forlani G

更新日期：2019-07-30 00:00:00

abstract：:The natural cysteine to serine variation at position 31 of Tat in HIV-1C disrupts the dicysteine motif attenuating the chemokine function of Tat. We ask if there exists a trade-off in terms of a gain of function for HIV-1C Tat due to this natural variation. We constructed two Tat-expression vectors encoding Tat protei...

journal_title：Frontiers in immunology

authors： Menon M,Budhwar R,Shukla RN,Bankar K,Vasudevan M,Ranga U

更新日期：2020-09-25 00:00:00

abstract：:Dendritic cells (DC) are specialized sentinel cells that bridge the innate and adaptive immune response and play a crucial role in shaping the adaptive immune response. Vitamin D, a known epidemiological risk factor for the development of several autoimmune diseases, influences the development of dendritic cells. Cons...

journal_title：Frontiers in immunology

authors： Saul L,Mair I,Ivens A,Brown P,Samuel K,Campbell JDM,Soong DY,Kamenjarin N,Mellanby RJ

更新日期：2019-03-28 00:00:00

abstract：:Atopic dermatitis (AD) is a complex multifactorial inflammatory skin disease that affects ~280 million people worldwide. About 85% of AD cases begin in childhood, a significant portion of which can persist into adulthood. Moreover, a typical progression of children with AD to food allergy, asthma or allergic rhinitis ...

journal_title：Frontiers in immunology

authors： Ghosh D,Bernstein JA,Khurana Hershey GK,Rothenberg ME,Mersha TB

更新日期：2018-12-12 00:00:00

abstract：:Tumor necrosis factor (TNF)-α is a major pro-inflammatory cytokine produced in response to toll-like receptor stimulation. TNF-α release is controlled by the activity of TNF-α converting enzyme (TACE) that cut membrane-bound TNF-α to shed its ectodomain as a soluble cytokine. The purinergic receptor P2X ligand-gated i...

journal_title：Frontiers in immunology

authors： Barberà-Cremades M,Gómez AI,Baroja-Mazo A,Martínez-Alarcón L,Martínez CM,de Torre-Minguela C,Pelegrín P

更新日期：2017-07-24 00:00:00

abstract：:Natural killer cells (NK) represent a population of lymphocytes involved in innate immune response. In addition to their role in anti-viral and anti-tumor defense, they also regulate several aspects of the allo-immune response in kidney transplant recipients. Growing evidence suggests a key role of NK cells in the pat...

journal_title：Frontiers in immunology

authors： Pontrelli P,Rascio F,Castellano G,Grandaliano G,Gesualdo L,Stallone G

更新日期：2020-07-23 00:00:00

abstract：:Recent genome-wide studies have revealed the presence of thousands of long non-protein-coding RNAs (lncRNAs), some of which may play critical roles in the cell. We have previously shown that a large number of lncRNAs show differential expression in response to interferon (IFN)α stimulation in primary human cells. Here...

journal_title：Frontiers in immunology

authors： Kambara H,Gunawardane L,Zebrowski E,Kostadinova L,Jobava R,Krokowski D,Hatzoglou M,Anthony DD,Valadkhan S

更新日期：2015-01-30 00:00:00

abstract：:It was recently reported that acute influenza infection of the lung promoted distal melanoma growth in the dermis of mice. Melanoma-specific CD8+ T cells were shunted to the lung in the presence of the infection, where they expressed high levels of inflammation-induced cell-activation blocker PD-1, and became incapabl...

journal_title：Frontiers in immunology

authors： Nikolaev EV,Zloza A,Sontag ED

更新日期：2019-01-28 00:00:00

abstract：:Hemophagocytic lymphohistiocytosis (HLH) is a heterogeneous hyperinflammatory syndrome with different pathways of pathogenesis resulting in similar clinical presentations. It is best defined and understood if presenting in the context of genetic immunodeficiencies associated with defects of lymphocyte cytotoxicity. In...

journal_title：Frontiers in immunology

authors： Wegehaupt O,Wustrau K,Lehmberg K,Ehl S

更新日期：2020-05-08 00:00:00

abstract：:Recent clinical observations indicate that bacterial vaccines induce cross-protection against infections produced by different microorganisms. MV130, a polyvalent bacterial sublingual preparation designed to prevent recurrent respiratory infectious diseases, reduces the infection rate in patients with recurrent respir...

journal_title：Frontiers in immunology

authors： Vázquez A,Fernández-Sevilla LM,Jiménez E,Pérez-Cabrera D,Yañez R,Subiza JL,Varas A,Valencia J,Vicente A

更新日期：2020-11-19 00:00:00

abstract：:Transcriptional activation and repression of genes that are developmentally regulated or exhibit cell-type specific expression patterns is largely achieved by modifying the chromatin template at a gene locus. Complex formation of stable epigenetic histone marks, loss or gain of DNA methylation, alterations in chromoso...

journal_title：Frontiers in immunology

authors： Aune TM,Collins PL,Collier SP,Henderson MA,Chang S

更新日期：2013-05-16 00:00:00

abstract：:Secondary lymphoid tissues such as lymph nodes are essential for the interactions between antigen presenting cells and lymphocytes that result in adaptive immune responses that protect the host against invading pathogens. The specialized architecture of these organs facilitates the cognate interactions between antigen...

journal_title：Frontiers in immunology

authors： Brendolan A,Caamaño JH

更新日期：2012-12-14 00:00:00

abstract：:Antibodies against HLA and non-HLA are associated with transplantation outcome. Recently, pretransplant serum IgG antibody levels against apoptotic cells were found to correlate with kidney allograft loss. We investigated the presence of these antibodies in lung transplantation (LTx) patients and evaluated the correla...

journal_title：Frontiers in immunology

authors： Budding K,van de Graaf EA,Kardol-Hoefnagel T,Oudijk ED,Kwakkel-van Erp JM,Hack CE,Otten HG

更新日期：2017-03-21 00:00:00

abstract：:Studies to develop cell-based therapies for cancer and other diseases have consistently shown that purified human natural killer (NK) cells secrete cytokines and kill target cells after in vitro culture with high concentrations of cytokines. However, these assays poorly reflect the conditions that are likely to prevai...

journal_title：Frontiers in immunology

authors： Nielsen CM,Wolf AS,Goodier MR,Riley EM

更新日期：2016-03-22 00:00:00

abstract：:Endocytosis by myeloid antigen presenting cells such as dendritic cells and macrophages regulates both antigen processing and major histocompatibility complex (MHC) molecule trafficking during antigen presentation. The molecular machinery of macroautophagy, a catabolic pathway that delivers cytoplasmic constituents to...

journal_title：Frontiers in immunology

authors： Münz C

更新日期：2018-11-27 00:00:00

abstract：:Epidermal growth factor receptor (EGFR) tyrosine kinase inhibitors (TKIs) have been recommended as the first-line therapy for non-small cell lung cancer (NSCLC) patients harboring EGFR mutations. However, acquired resistance to EGFR-TKIs is inevitable. Although immune checkpoint blockades (ICBs) targeting the programm...

journal_title：Frontiers in immunology

authors： Wu D,Liu Y,Li X,Liu Y,Yang Q,Liu Y,Wu J,Tian C,Zeng Y,Zhao Z,Xiao Y,Gu F,Zhang K,Hu Y,Liu L

更新日期：2020-07-23 00:00:00

abstract：:A transplanted organ is usually rejected without any major immunosuppressive treatment because of vigorous alloimmune responsiveness. However, continuous global immunosuppression may cause severe side effects, including nephrotoxicity, tumors, and infections. Therefore, it is necessary to seek novel immunosuppressive ...

journal_title：Frontiers in immunology

authors： Zeng Q,Qiu F,Chen Y,Liu C,Liu H,Liang CL,Zhang Q,Dai Z

更新日期：2019-04-01 00:00:00

abstract：:It is now well established that the effector T cell (Teff) response is regulated by a series of metabolic switches. Quiescent T cells predominantly require adenosine triphosphate-generating processes, whereas proliferating Teff require high metabolic flux through growth-promoting pathways, such as glycolysis. Pathways...

journal_title：Frontiers in immunology

authors： Coe DJ,Kishore M,Marelli-Berg F

更新日期：2014-11-18 00:00:00

abstract：:Despite significant breakthroughs in understanding of immunological and physiological features of autoimmune diseases, there is currently no specific therapeutic option with prolonged remission. Cell-based therapy using engineered-T cells has attracted tremendous attention as a practical treatment for autoimmune disea...

journal_title：Frontiers in immunology

authors： Sadeqi Nezhad M,Seifalian A,Bagheri N,Yaghoubi S,Karimi MH,Adbollahpour-Alitappeh M

更新日期：2020-11-26 00:00:00

abstract：:Whether and how γδT cells play a protective role in immunity against Plasmodium infection remain open questions. γδT cells expand in patients and mice infected with Plasmodium spp, and cytokine production and cytotoxic responses against blood-stage parasites are observed in vitro. Their expansion is associated with pr...

journal_title：Frontiers in immunology

authors： Deroost K,Langhorne J

更新日期：2018-12-20 00:00:00

abstract：:Immune activation is the driving force behind the occurrence of AIDS and non-AIDS events, and is only partially reduced by antiretroviral therapy (ART). Soon after HIV infection, intestinal CD4+ T cells are depleted leading to epithelial gut damage and subsequent translocation of microbes and/or their products into sy...

journal_title：Frontiers in immunology

authors： Ramendra R,Isnard S,Mehraj V,Chen J,Zhang Y,Finkelman M,Routy JP

更新日期：2019-03-18 00:00:00

abstract：:Gamma-delta (γδ) T cells are a subset of T cells that promote the inflammatory responses of lymphoid and myeloid lineages, and are especially vital to the initial inflammatory and immune responses. Given the capability to connect crux inflammations of adaptive and innate immunity, γδ T cells are responsive to multiple...

journal_title：Frontiers in immunology

authors： Wo J,Zhang F,Li Z,Sun C,Zhang W,Sun G

更新日期：2020-10-23 00:00:00

abstract：:Inflammasomes are intracellular protein complexes of pattern recognition receptors and caspase-1, with essential functions in regulating inflammatory responses of macrophages and dendritic cells. The primary role of inflammasomes is to catalyze processing and secretion of pro-inflammatory cytokines IL-1β and IL-18. Re...

journal_title：Frontiers in immunology

authors： Cypryk W,Nyman TA,Matikainen S

更新日期：2018-09-25 00:00:00