β-Arrestin 1 in Thyrotropin Receptor Signaling in Bone: Studies in Osteoblast-Like Cells.

Abstract:

:A direct action of thyrotropin (TSH, thyroid-stimulating hormone) on bone precursors in humans is controversial. Studies in rodent models have provided conflicting findings. We used cells derived from a moderately differentiated osteosarcoma stably overexpressing human TSH receptors (TSHRs) as a model of osteoblast precursors (U2OS-TSHR cells) to investigate TSHR-mediated effects in bone differentiation in human cells. We review our findings that (1) TSHR couples to several different G proteins to induce upregulation of genes associated with osteoblast activity-interleukin 11 (IL-11), osteopontin (OPN), and alkaline phosphatase (ALPL) and that the kinetics of the induction and the G protein-mediated signaling pathways involved were different for these genes; (2) TSH can stimulate β-arrestin-mediated signal transduction and that β-arrestin 1 in part mediates TSH-induced pre-osteoblast differentiation; and (3) TSHR/insulin-like growth factor 1 (IGF1) receptor (IGF1R) synergistically increased OPN secretion by TSH and IGF1 and that this crosstalk was mediated by physical association of these receptors in a signaling complex that uses β-arrestin 1 as a scaffold. These findings were complemented using a novel β-arrestin 1-biased agonist of TSHR. We conclude that TSHR can signal via several transduction pathways leading to differentiation of this model system of human pre-osteoblast cells and, therefore, that TSH can directly regulate these bone cells.

authors

Boutin A,Gershengorn MC,Neumann S

doi

10.3389/fendo.2020.00312

subject

Has Abstract

pub_date

2020-05-20 00:00:00

pages

312

issn

1664-2392

journal_volume

11

pub_type

杂志文章,评审
  • The IGF/Insulin-IGFBP Axis in Corneal Development, Wound Healing, and Disease.

    abstract::The insulin-like growth factor (IGF) family plays key roles in growth and development. In the cornea, IGF family members have been implicated in proliferation, differentiation, and migration, critical events that maintain a smooth refracting surface that is essential for vision. The IGF family is composed of multiple ...

    journal_title:Frontiers in endocrinology

    pub_type: 杂志文章,评审

    doi:10.3389/fendo.2020.00024

    authors: Stuard WL,Titone R,Robertson DM

    更新日期:2020-03-03 00:00:00

  • Hashimoto's Disease and Thyroid Cancer in Children: Are They Associated?

    abstract::Hashimoto's thyroiditis (HT) is the most common cause of thyroid disease in children and adolescents. Along with significant modifications of thyroid function, HT in pediatric age can be accompanied by relevant thyroid structural alterations. Over time, benign thyroid nodules, carcinoma and, rarely, primary non-Hodgki...

    journal_title:Frontiers in endocrinology

    pub_type: 杂志文章,评审

    doi:10.3389/fendo.2018.00565

    authors: Penta L,Cofini M,Lanciotti L,Leonardi A,Principi N,Esposito S

    更新日期:2018-10-09 00:00:00

  • Thyrotropin Receptor Epitope and Human Leukocyte Antigen in Graves' Disease.

    abstract::Graves' disease (GD) is an organ-specific autoimmune disease, and thyrotropin (TSH) receptor (TSHR) is a major autoantigen in this condition. Since the extracellular domain of human TSHR (TSHR-ECD) is shed into the circulation, TSHR-ECD is a preferentially immunogenic portion of TSHR. Both genetic factors and environm...

    journal_title:Frontiers in endocrinology

    pub_type: 杂志文章,评审

    doi:10.3389/fendo.2016.00120

    authors: Inaba H,De Groot LJ,Akamizu T

    更新日期:2016-08-23 00:00:00

  • The Association Between Long-Term Acenocoumarol Treatment and Vitamin D Deficiency.

    abstract:Objective:Both vitamin D and K2 are involved in a number of metabolic processes, including bone metabolism; however, associations between the vitamins are not fully understood. The aim of the study was to evaluate serum concentrations of 25-hydroxyvitamin D [25(OH)D] in adult patients receiving long-term acenocoumarol ...

    journal_title:Frontiers in endocrinology

    pub_type: 杂志文章

    doi:10.3389/fendo.2018.00226

    authors: Sawicka-Powierza J,Konstantynowicz J,Jablonska E,Zelazowska-Rutkowska B,Jelski W,Abramowicz P,Sasinowski C,Chlabicz S

    更新日期:2018-05-04 00:00:00

  • Non-Mammalian Vertebrates: Distinct Models to Assess the Role of Ion Gradients in Energy Expenditure.

    abstract::Animals store metabolic energy as electrochemical gradients. At least 50% of mammalian energy is expended to maintain electrochemical gradients across the inner mitochondrial membrane (H+), the sarcoplasmic reticulum (Ca++), and the plasma membrane (Na+/K+). The potential energy of these gradients can be used to perfo...

    journal_title:Frontiers in endocrinology

    pub_type: 杂志文章,评审

    doi:10.3389/fendo.2017.00224

    authors: Geisler CE,Kentch KP,Renquist BJ

    更新日期:2017-09-01 00:00:00

  • Association of BRCA Mutations and Anti-müllerian Hormone Level in Young Breast Cancer Patients.

    abstract::Background: Several preclinical and clinical studies have suggested that BRCA-mutation carriers may have decreased ovarian reserve. However, data in this area are limited and inconsistent, especially in young breast cancer patients. Objective: This study evaluated the association between BRCA mutation status and serum...

    journal_title:Frontiers in endocrinology

    pub_type: 杂志文章

    doi:10.3389/fendo.2019.00235

    authors: Son KA,Lee DY,Choi D

    更新日期:2019-04-11 00:00:00

  • Genetic Associations With Diabetic Retinopathy and Coronary Artery Disease in Emirati Patients With Type-2 Diabetes Mellitus.

    abstract::Aim: Type 2 Diabetes Mellitus (T2DM) is associated with both microvascular complications such as diabetic retinopathy (DR), and macrovascular complications like coronary artery disease (CAD). Genetic risk factors have a role in the development of these complications. In the present case-control study, we investigated ...

    journal_title:Frontiers in endocrinology

    pub_type: 杂志文章

    doi:10.3389/fendo.2019.00283

    authors: Azzam SK,Osman WM,Lee S,Khalaf K,Khandoker AH,Almahmeed W,Jelinek HF,Al Safar HS

    更新日期:2019-05-03 00:00:00

  • RXFP1 is Targeted by Complement C1q Tumor Necrosis Factor-Related Factor 8 in Brain Cancer.

    abstract::The relaxin-like RXFP1 ligand-receptor system has important functions in tumor growth and tissue invasion. Recently, we have identified the secreted protein, CTRP8, a member of the C1q/tumor necrosis factor-related protein (CTRP) family, as a novel ligand of the relaxin receptor, RXFP1, with functions in brain cancer....

    journal_title:Frontiers in endocrinology

    pub_type: 杂志文章,评审

    doi:10.3389/fendo.2015.00127

    authors: Thanasupawat T,Glogowska A,Burg M,Wong GW,Hoang-Vu C,Hombach-Klonisch S,Klonisch T

    更新日期:2015-08-13 00:00:00

  • The Sexual Dimorphism of Lipid Kinetics in Humans.

    abstract::In addition to the obvious differences in body shape, there are substantial differences in lipid metabolism between men and women. These differences include how dietary fatty acids are handled, the secretion and clearance of very low-density lipoprotein-triglycerides, the release rates of free fatty acids (FFA) from a...

    journal_title:Frontiers in endocrinology

    pub_type: 杂志文章,评审

    doi:10.3389/fendo.2015.00103

    authors: Santosa S,Jensen MD

    更新日期:2015-07-02 00:00:00

  • Corrigendum: Central Control of Feeding Behavior by the Secretin, PACAP, and Glucagon Family of Peptides.

    abstract::[This corrects the article DOI: 10.3389/fendo.2017.00018.]. ...

    journal_title:Frontiers in endocrinology

    pub_type: 杂志文章,已发布勘误

    doi:10.3389/fendo.2018.00395

    authors: Sekar R,Wang L,Chow BKC

    更新日期:2018-07-18 00:00:00

  • Altered Gray Matter Volume in Patients With Type 1 Diabetes Mellitus.

    abstract::Background and Purpose: Many imaging studies have reported structure alterations in patients with type 1 diabetes mellitus (T1DM) by using voxel-based morphometry (VBM). Nevertheless, the results reported were inconsistent and had not been reviewed quantitatively. Accordingly, the quantitative meta-analysis which incl...

    journal_title:Frontiers in endocrinology

    pub_type: 杂志文章

    doi:10.3389/fendo.2020.00045

    authors: Liu J,Fan W,Jia Y,Su X,Wu W,Long X,Sun X,Liu J,Sun W,Zhang T,Gong Q,Shi H,Zhu Q,Wang J

    更新日期:2020-02-13 00:00:00

  • Impact of Gut Microbiota on Host Glycemic Control.

    abstract::Given that obesity and associated disorder type II diabetes mellitus have reached epidemic proportions worldwide, the development of efficient prevention and therapeutic interventions is a global public health interest. There is now a large body of evidence suggesting that the micro-organisms colonizing the human gut,...

    journal_title:Frontiers in endocrinology

    pub_type: 杂志文章,评审

    doi:10.3389/fendo.2019.00029

    authors: Gérard C,Vidal H

    更新日期:2019-01-30 00:00:00

  • Incretin hormones as immunomodulators of atherosclerosis.

    abstract::Atherosclerosis results from endothelial cell dysfunction and inflammatory processes affecting both macro- and microvasculature which are involved in vascular diabetic complications. Glucagon-like peptide-1 (GLP-1) is an incretin hormone responsible for amplification of insulin secretion when nutrients are given orall...

    journal_title:Frontiers in endocrinology

    pub_type: 杂志文章

    doi:10.3389/fendo.2012.00112

    authors: Alonso N,Julián MT,Puig-Domingo M,Vives-Pi M

    更新日期:2012-09-07 00:00:00

  • Application and Utility of Continuous Glucose Monitoring in Pregnancy: A Systematic Review.

    abstract::Background: In the past decade, continuous glucose monitoring (CGM) has been proven to have similar accuracy to self-monitoring of blood glucose (SMBG) and yet provides better therapy optimization and detects trends in glucose values due to higher frequency of testing. Even though the feasibility and utility of CGM ha...

    journal_title:Frontiers in endocrinology

    pub_type:

    doi:10.3389/fendo.2019.00697

    authors: Yu Q,Aris IM,Tan KH,Li LJ

    更新日期:2019-10-11 00:00:00

  • Hypothyroidism and Adverse Endpoints in Diabetic Patients: A Systematic Review and Meta-Analysis.

    abstract::Background: This study investigated the relationship strength between hypothyroidism and cardiovascular and renal outcomes in diabetic patients. Methods: The electronic databases PubMed, EmBase, and Cochrane library were screened for relevant studies published before November 2018. The outcomes included major cardiova...

    journal_title:Frontiers in endocrinology

    pub_type:

    doi:10.3389/fendo.2019.00889

    authors: Zhang S,Feng G,Kang F,Guo Y,Ti H,Hao L,Gao P,Gao J

    更新日期:2020-01-10 00:00:00

  • Effects of Neuroendocrine CB1 Activity on Adult Leydig Cells.

    abstract::Endocannabinoids control male reproduction acting at central and local level via cannabinoid receptors. The cannabinoid receptor CB1 has been characterized in the testis, in somatic and germ cells of mammalian and non-mammalian animal models, and its activity related to Leydig cell differentiation, steroidogenesis, sp...

    journal_title:Frontiers in endocrinology

    pub_type: 杂志文章,评审

    doi:10.3389/fendo.2016.00047

    authors: Cobellis G,Meccariello R,Chianese R,Chioccarelli T,Fasano S,Pierantoni R

    更新日期:2016-06-03 00:00:00

  • The Regulation of Peripheral Metabolism by Gut-Derived Hormones.

    abstract::Enteroendocrine cells lining the gut epithelium constitute the largest endocrine organ in the body and secrete over 20 different hormones in response to cues from ingested foods and changes in nutritional status. Not only do these hormones convey signals from the gut to the brain via the gut-brain axis, they also act ...

    journal_title:Frontiers in endocrinology

    pub_type: 杂志文章,评审

    doi:10.3389/fendo.2018.00754

    authors: Sun EWL,Martin AM,Young RL,Keating DJ

    更新日期:2019-01-04 00:00:00

  • Thyroxine Treatment With Softgel Capsule Formulation: Usefulness in Hypothyroid Patients Without Malabsorption.

    abstract:Background:Levothyroxine sodium (LT4) is the therapy of choice for hypothyroidism. In the last decade, new LT4 formulations, such as liquid and softgel capsules, became available. Even if some evidence has been reached in the efficacy of liquid LT4 in patients with suboptimal TSH on tablet LT4, the usefulness of softge...

    journal_title:Frontiers in endocrinology

    pub_type: 杂志文章

    doi:10.3389/fendo.2018.00118

    authors: Trimboli P,Virili C,Centanni M,Giovanella L

    更新日期:2018-03-21 00:00:00

  • Transient Thyroiditis after Surgery for Tertiary Hyperparathyroidism: A Case Report.

    abstract::Parathyroid (PTH) exploration surgery carries the risk of developing post-operative thyroiditis due to vigorous manual manipulation of the thyroid gland during surgery. Post-operative thyroiditis has a wide spectrum of clinical manifestations. However, it remains underreported. Here, we describe a case of post-operati...

    journal_title:Frontiers in endocrinology

    pub_type:

    doi:10.3389/fendo.2015.00123

    authors: Hakami YA

    更新日期:2015-08-18 00:00:00

  • MicroRNA-17-92 Regulates Beta-Cell Restoration After Streptozotocin Treatment.

    abstract::Objective: To clarify the role and mechanism of miR-17-92 cluster in islet beta-cell repair after streptozotocin intervention. Methods: Genetically engineered mice (miR-17-92βKO) and control RIP-Cre mice were intraperitoneally injected with multiple low dose streptozotocin. Body weight, random blood glucose (RBG), fas...

    journal_title:Frontiers in endocrinology

    pub_type: 杂志文章

    doi:10.3389/fendo.2020.00009

    authors: Wan S,Zhang J,Chen X,Lang J,Li L,Chen F,Tian L,Meng Y,Yu X

    更新日期:2020-01-23 00:00:00

  • Coexistence of Myelolipoma and Primary Bilateral Macronodular Adrenal Hyperplasia With GIP-Dependent Cushing's Syndrome.

    abstract::Introduction: Adrenal myelolipomas are usually isolated benign adrenal lesions, but can be adjacent to steroid-secreting adrenocortical tumors. We studied the aberrant regulation of cortisol secretion in a 61 year-old woman with combined bilateral myelolipomas and primary bilateral macronodular adrenal hyperplasia (BM...

    journal_title:Frontiers in endocrinology

    pub_type:

    doi:10.3389/fendo.2019.00618

    authors: Larose S,Bondaz L,Mermejo LM,Latour M,Prosmanne O,Bourdeau I,Lacroix A

    更新日期:2019-09-11 00:00:00

  • Integrated Analysis of Multiple Microarray Studies to Identify Novel Gene Signatures in Non-alcoholic Fatty Liver Disease.

    abstract::Background: Non-alcoholic fatty liver disease (NAFLD) is a well-known cause of liver dysfunction and has become a common chronic liver disease in many countries. However, the intrinsic molecular mechanisms underlying the pathogenesis of NAFLD have not yet been fully elucidated. Methods: We obtained the gene expression...

    journal_title:Frontiers in endocrinology

    pub_type: 杂志文章

    doi:10.3389/fendo.2019.00599

    authors: Jia X,Zhai T

    更新日期:2019-08-30 00:00:00

  • Behavioral Abnormalities in Knockout and Humanized Tau Mice.

    abstract::Microtubule-associated protein tau assists in stabilizing microtubules and has been particularly implicated in Alzheimer's disease (AD). Given the importance of tau to AD pathogenesis and therapies, it is important to understand non-classic physiological functions for this protein inside and outside the central nervou...

    journal_title:Frontiers in endocrinology

    pub_type: 杂志文章

    doi:10.3389/fendo.2020.00124

    authors: Gonçalves RA,Wijesekara N,Fraser PE,De Felice FG

    更新日期:2020-03-12 00:00:00

  • 3,5-T2-A Janus-Faced Thyroid Hormone Metabolite Exerts Both Canonical T3-Mimetic Endocrine and Intracrine Hepatic Action.

    abstract::Over the last decades, thyroid hormone metabolites (THMs) received marked attention as it has been demonstrated that they are bioactive compounds. Their concentrations were determined by immunoassay or mass-spectrometry methods. Among those metabolites, 3,5-diiodothyronine (3,5-T2), occurs at low nanomolar concentrati...

    journal_title:Frontiers in endocrinology

    pub_type: 杂志文章

    doi:10.3389/fendo.2019.00787

    authors: Köhrle J,Lehmphul I,Pietzner M,Renko K,Rijntjes E,Richards K,Anselmo J,Danielsen M,Jonklaas J

    更新日期:2020-01-08 00:00:00

  • Zebrafish as an Emerging Model for Osteoporosis: A Primary Testing Platform for Screening New Osteo-Active Compounds.

    abstract::Osteoporosis is metabolic bone disease caused by an altered balance between bone anabolism and catabolism. This dysregulated balance is responsible for fragile bones that fracture easily after minor falls. With an aging population, the incidence is rising and as yet pharmaceutical options to restore this imbalance is ...

    journal_title:Frontiers in endocrinology

    pub_type: 杂志文章,评审

    doi:10.3389/fendo.2019.00006

    authors: Bergen DJM,Kague E,Hammond CL

    更新日期:2019-01-29 00:00:00

  • Opportunistic QCT Bone Mineral Density Measurements Predicting Osteoporotic Fractures: A Use Case in a Prospective Clinical Cohort.

    abstract:Purpose:To assess whether volumetric vertebral bone mineral density (BMD) measured with opportunistic quantitative computed tomography (QCT) (i.e., CT acquired for other reasons) can predict osteoporotic fracture occurrence in a prospective clinical cohort and how this performs in comparison to dual-energy X-ray absorp...

    journal_title:Frontiers in endocrinology

    pub_type: 杂志文章

    doi:10.3389/fendo.2020.586352

    authors: Leonhardt Y,May P,Gordijenko O,Koeppen-Ursic VA,Brandhorst H,Zimmer C,Makowski MR,Baum T,Kirschke JS,Gersing AS,Seifert-Klauss V,Schwaiger BJ

    更新日期:2020-11-09 00:00:00

  • G Protein-Coupled Estrogen Receptor Immunoreactivity Fluctuates During the Estrous Cycle and Show Sex Differences in the Amygdala and Dorsal Hippocampus.

    abstract::G protein-coupled estrogen receptor (GPER) in the amygdala and the dorsal hippocampus mediates actions of estradiol on anxiety, social recognition and spatial memory. In addition, GPER participates in the estrogenic regulation of synaptic function in the amygdala and in the process of adult neurogenesis in the dentate...

    journal_title:Frontiers in endocrinology

    pub_type: 杂志文章

    doi:10.3389/fendo.2020.00537

    authors: Llorente R,Marraudino M,Carrillo B,Bonaldo B,Simon-Areces J,Abellanas-Pérez P,Rivero-Aguilar M,Fernandez-Garcia JM,Pinos H,Garcia-Segura LM,Collado P,Grassi D

    更新日期:2020-08-07 00:00:00

  • Pharmacotherapy for the Treatment of Overweight and Obesity in Children, Adolescents, and Young Adults in a Large Health System in the US.

    abstract::Lifestyle modifications focused on diet, physical activity, and behavior have a modest impact on weight reduction in children, adolescents, and young adults (YA) with overweight and obesity. Several anti-obesity medications (AOMs) have been approved by the Food and Drug Administration (FDA) for use among adult patient...

    journal_title:Frontiers in endocrinology

    pub_type: 杂志文章

    doi:10.3389/fendo.2020.00290

    authors: Czepiel KS,Perez NP,Campoverde Reyes KJ,Sabharwal S,Stanford FC

    更新日期:2020-05-13 00:00:00

  • Dietary Protein Intake, Meat Consumption, and Dairy Consumption in the Year Preceding Pregnancy and During Pregnancy and Their Associations With the Risk of Gestational Diabetes Mellitus: A Prospective Cohort Study in Southwest China.

    abstract::Background: Gestational diabetes mellitus (GDM) has become a public health problem in China. Objective: To examine the association of dietary protein intake before and during pregnancy with the risk of GDM. Design: Dietary intake before pregnancy and during the first and second trimesters of pregnancy was assessed usi...

    journal_title:Frontiers in endocrinology

    pub_type: 杂志文章

    doi:10.3389/fendo.2018.00596

    authors: Liang Y,Gong Y,Zhang X,Yang D,Zhao D,Quan L,Zhou R,Bao W,Cheng G

    更新日期:2018-10-11 00:00:00

  • High Adiposity Is Associated With Higher Nocturnal and Diurnal Glycaemia, but Not With Glycemic Variability in Older Individuals Without Diabetes.

    abstract:Background:It is well known that adiposity is a risk factor for insulin resistance and type 2 diabetes mellitus. In the present study, we aimed to investigate the associations of measures of adiposity with indices of glycemia and of glycemic variability over a 72-h period in non-diabetic older adults. Methods:This cro...

    journal_title:Frontiers in endocrinology

    pub_type: 杂志文章

    doi:10.3389/fendo.2018.00238

    authors: Noordam R,Huurman NC,Wijsman CA,Akintola AA,Jansen SWM,Stassen S,Beekman M,van de Rest O,Slagboom PE,Mooijaart SP,van Heemst D

    更新日期:2018-05-14 00:00:00