The Antagonism of 5-HT6 Receptor Attenuates Current-Induced Spikes and Improves Long-Term Potentiation via the Regulation of M-Currents in a Pilocarpine-Induced Epilepsy Model.

abstract：:Objective: San-Cao granule (SCG), a traditional Chinese herb formula, has been used for treating autoimmune hepatitis (AIH) in our clinics for a long time. However, its active ingredients and mechanisms of action were still unknown due to its complicated chemical compositions. In the present study, the pharmacological...

journal_title：Frontiers in pharmacology

authors： Yang Y,Zhang P,Wang Y,Wei S,Zhang L,Wang J,Lu X,Zhou H,Li R,Wen J,Zhou X,Li H,Li K,Zhao Y

更新日期：2018-06-12 00:00:00

abstract：:We evaluated the prevalence of and risk factors for hypersensitivity reactions related to carboplatin, which is commonly used to treat gynecological malignancies. All women with pathologically documented ovarian, fallopian tube, or primary peritoneal cancer treated with carboplatin alone or a carboplatin-based combina...

journal_title：Frontiers in pharmacology

authors： Tai YH,Tai YJ,Hsu HC,Lee SP,Chen YY,Chiang YC,Chen YL,Chen CA,Cheng WF

更新日期：2017-11-06 00:00:00

abstract：:Neuropathic pain is still an extremely important problem in today's medicine because opioids, which are commonly used to reduce pain, have limited efficacy in this type of pathology. Therefore, complementary therapy is needed. Our experiments were performed in rats to evaluate the contribution of the purinergic system...

journal_title：Frontiers in pharmacology

authors： Jurga AM,Piotrowska A,Makuch W,Przewlocka B,Mika J

更新日期：2017-02-16 00:00:00

abstract：:Statin therapy may induce skeletal muscle damage ranging from myalgia to severe rhabdomyolysis. Our previous preclinical studies showed that statin treatment in rats involves the reduction of skeletal muscle ClC-1 chloride channel expression and related chloride conductance (gCl). An increase of the activity of protei...

journal_title：Frontiers in pharmacology

authors： Camerino GM,Musumeci O,Conte E,Musaraj K,Fonzino A,Barca E,Marino M,Rodolico C,Tricarico D,Camerino C,Carratù MR,Desaphy JF,De Luca A,Toscano A,Pierno S

更新日期：2017-07-27 00:00:00

abstract：:The exponential growth of the Internet of Things and the global popularity and remarkable decline in cost of the mobile phone is driving the digital transformation of medical practice. The rapidly maturing digital, non-medical world of mobile (wireless) devices, cloud computing and social networking is coalescing with...

journal_title：Frontiers in pharmacology

authors： Loizou GD

更新日期：2016-07-21 00:00:00

abstract：:Natural brain repair after stroke is extremely limited, and current therapeutic options are even more scarce with no clinical break-through in sight. Despite restricted regeneration in the central nervous system, we have previously proved that human umbilical cord blood mono-nuclear cells (UCB-MC) transduced with aden...

journal_title：Frontiers in pharmacology

authors： Sokolov ME,Bashirov FV,Markosyan VA,Povysheva TV,Fadeev FO,Izmailov AA,Kuztetsov MS,Safiullov ZZ,Shmarov MM,Naroditskyi BS,Palotás A,Islamov RR

更新日期：2018-02-15 00:00:00

abstract：:Several studies have pointed to soluble oligomers of beta amyloid peptide (SOAβ) as the principal neurotoxic agents responsible for the generation of synaptotoxic events that can explain the main symptoms of Alzheimer's disease (AD). Among the toxic features associated with SOAβ, one of the most notorious is the forma...

journal_title：Frontiers in pharmacology

authors： Godoy PA,Ramírez-Molina O,Fuentealba J

更新日期：2019-11-07 00:00:00

abstract：:Zinc doped copper oxide nanocomposites (Zn-CuO NPs) is a novel doped metal nanomaterial synthesized by our group using the sonochemical method. Our previous studies have shown that Zn-CuO NPs could inhibit cancer cell proliferation by inducing apoptosis via ROS-mediated pathway. In the present study, we studied the an...

journal_title：Frontiers in pharmacology

authors： Li X,Xu H,Li C,Qiao G,Farooqi AA,Gedanken A,Liu X,Lin X

更新日期：2019-04-02 00:00:00

abstract：:Objective: The aim of the present study was to encapsulate vancomycin in different liposomal formulations and compare the in vitro antimicrobial activity against Staphylococcus aureus biofilms. Methods: Large unilamellar vesicles of conventional (LUV VAN), fusogenic (LUVfuso VAN), and cationic (LUVcat VAN) liposomes e...

journal_title：Frontiers in pharmacology

authors： Scriboni AB,Couto VM,Ribeiro LNM,Freires IA,Groppo FC,de Paula E,Franz-Montan M,Cogo-Müller K

更新日期：2019-11-29 00:00:00

abstract：:Inwardly rectifying potassium (Kir) channel subunits Kir4.1 are specifically expressed in astrocytes and regulate neuronal excitability by mediating spatial potassium buffering. In addition, it is now known that astrocytic Kir4.1 channels are closely involved in the pathogenesis of epilepsy. Here, to explore the role ...

journal_title：Frontiers in pharmacology

authors： Mukai T,Kinboshi M,Nagao Y,Shimizu S,Ono A,Sakagami Y,Okuda A,Fujimoto M,Ito H,Ikeda A,Ohno Y

更新日期：2018-08-06 00:00:00

abstract：:Type III and IV Bartter syndromes (BS) are rare kidney tubulopathies caused by loss-of-function mutations in the CLCNKB and BSND genes coding respectively for the ClC-Kb chloride channels and accessory subunit barttin. ClC-K channels are expressed in the Henle's loop, distal convoluted tubule, and cortical collecting ...

journal_title：Frontiers in pharmacology

authors： Sahbani D,Strumbo B,Tedeschi S,Conte E,Camerino GM,Benetti E,Montini G,Aceto G,Procino G,Imbrici P,Liantonio A

更新日期：2020-03-17 00:00:00

abstract：:Purpose: The present study compared the risk of ischemic stroke in atrial fibrillation (AF) patients receiving digoxin and amiodarone. Methods: A retrospective cohort study was conducted using the longitudinal population-based database of Taiwan's National Health Insurance program. Patients with AF who received amioda...

journal_title：Frontiers in pharmacology

authors： Lai KC,Chen SJ,Lin CS,Yang FC,Lin CL,Hsu CW,Huang WC,Kao CH

更新日期：2018-05-07 00:00:00

abstract：:Background: Plasminogen activator inhibitor (PAI)-1 levels and activity are known to increase during metabolic syndrome and obesity. In addition, previous studies have implicated PAI-1 in adipose tissue (AT) expansion while also contributing to insulin resistance. As inflammation is also known to occur in AT during ob...

journal_title：Frontiers in pharmacology

authors： Wang L,Chen L,Liu Z,Liu Y,Luo M,Chen N,Deng X,Luo Y,He J,Zhang L,Hill MA,Li R,Wu J

更新日期：2018-09-26 00:00:00

abstract：Aim:To investigate the variations and the frequencies of the SLCO1B1 gene in the Thai population. Methods:Collected samples were categorized into five regions of Thailand. DNA samples were genotyped for two variants, c.388A>G and c.521T>C of the SLCO1B1, using TaqMan® real-time PCR. Results:The minor allele frequenci...

journal_title：Frontiers in pharmacology

authors： Na Nakorn C,Waisayarat J,Dejthevaporn C,Srisawasdi P,Wongwaisayawan S,Sukasem C

更新日期：2020-06-05 00:00:00

abstract：:Rodent models of human disease can be valuable for understanding the mechanisms of a disease and for identifying novel therapies. However, it is critical that these models be vetted prior to committing resources to developing novel therapeutics. Failure to confirm the model can lead to significant losses in time and r...

journal_title：Frontiers in pharmacology

authors： Caudle RM,Caudle SL,Flenor ND,Rohrs EL,Neubert JK

更新日期：2020-12-03 00:00:00

abstract：:The serotonin [5-hydroxytryptamine (5-HT)] system has been implicated in the pathogenesis of major depressive disorder (MDD). Among the 5-HT receptor subtypes, 5-HT2 is one of the major pharmacological therapeutic targets for MDD. There have been inconsistent findings in previous pharmacogenetic studies investigating ...

journal_title：Frontiers in pharmacology

authors： Kao CF,Kuo PH,Yu YW,Yang AC,Lin E,Liu YL,Tsai SJ

更新日期：2020-12-03 00:00:00

abstract：:Classically, the endocannabinoid system (ECS) consists of endogenous lipids, of which the best known are anandamide (AEA) and 2 arachidonoylglycerol (2-AG), their enzyme machinery for synthesis and degradation and their specific receptors, cannabinoid receptor one (CB1) and cannabinoid receptor two (CB2). However, end...

journal_title：Frontiers in pharmacology

authors： Riquelme-Sandoval A,de Sá-Ferreira CO,Miyakoshi LM,Hedin-Pereira C

更新日期：2020-12-09 00:00:00

abstract：:6-(methylsulfinyl) hexyl isothiocyanate (6-MITC), is the main bioactive compound present in Wasabia japonica rhizome. Several scientific studies have shown that 6-MITC possesses interesting antimicrobial, anti-inflammatory, antiplatelet and antioxidant properties which therefore suggested us it could have an interesti...

journal_title：Frontiers in pharmacology

authors： Cocchi V,Hrelia P,Lenzi M

更新日期：2020-08-18 00:00:00

abstract：:The skin is the main barrier that protects us against environmental stressors (physical, chemical, and biological). These stressors, combined with internal factors, are responsible for cutaneous aging. Furthermore, they negatively affect the skin and increase the risk of cutaneous diseases, particularly skin cancer. T...

journal_title：Frontiers in pharmacology

authors： Parrado C,Mercado-Saenz S,Perez-Davo A,Gilaberte Y,Gonzalez S,Juarranz A

更新日期：2019-07-09 00:00:00

abstract：:Background: Tanshinone IIA (Tan IIA), a lipophilic constituent from Salvia miltiorrhiza Bunge, has shown a promising cardioprotective effect including anti-atherosclerosis. This study aims at exploring Tan IIA's anti-inflammatory and immune-regulating roles in stabilizing vulnerable atherosclerotic plaque in ApoE-defi...

journal_title：Frontiers in pharmacology

authors： Chen Z,Gao X,Jiao Y,Qiu Y,Wang A,Yu M,Che F,Li S,Liu J,Li J,Zhang H,Yu C,Li G,Gao Y,Pan L,Sun W,Guo J,Cao B,Zhu Y,Xu H

更新日期：2019-07-26 00:00:00

abstract：:With multiple omics strategies being applied to several cancer genomics projects, researchers have the opportunity to develop a rational planning of targeted cancer therapy. The investigation of such numerous and diverse pharmacogenomic datasets is a complex task. It requires biological knowledge and skills on a set o...

journal_title：Frontiers in pharmacology

authors： Belizário JE,Sangiuliano BA,Perez-Sosa M,Neyra JM,Moreira DF

更新日期：2016-09-29 00:00:00

abstract：:Kappa receptor activation by dynorphins contributes to the anxiogenic, dysphoric, and cognitive disrupting effects of repeated stress, suggesting that kappa receptor antagonists might have therapeutic utility in the treatment of stress disorders. Three classes of kappa antagonists have been distinguished: non-selectiv...

journal_title：Frontiers in pharmacology

authors： Chavkin C,Cohen JH,Land BB

更新日期：2019-02-06 00:00:00

abstract：:The ecto-5'-nucleotidase (ecto-5'NT/CD73) represents a crucial enzyme for endogenous adenosine generation. Several findings have shown that CD73 plays an important role in regulating vascular permeability and immune cell function. Adenosine 5'-(α,β-methylene)diphosphate (APCP) is a CD73 inhibitor, widely used as pharm...

journal_title：Frontiers in pharmacology

authors： Caiazzo E,Morello S,Carnuccio R,Ialenti A,Cicala C

更新日期：2019-07-11 00:00:00

abstract：:Calcium-calmodulin/dependent protein kinase II (CaMKII) plays an essential role in LTP induction, but since it has the capacity to remain persistently activated even after the decay of external stimuli it has been proposed that it can also be necessary for LTP maintenance and therefore for memory persistence. It has b...

journal_title：Frontiers in pharmacology

authors： Juárez-Muñoz Y,Ramos-Languren LE,Escobar ML

更新日期：2017-11-14 00:00:00

abstract：:Βeta-cyclodextrin (β-CD) with a hydrophobic cavity enables the formation of inclusion complexes with organic molecules. The formation of host-guest complexes makes the application of β-CD popular in many fields, but their interaction with organisms is poorly understood. In the present study, the effect of β-CD on gut ...

journal_title：Frontiers in pharmacology

authors： Lv S,Zhang X,Feng Y,Jiang Q,Niu C,Yang Y,Wang X

更新日期：2021-01-14 00:00:00

abstract：:Cervical cancer is the fourth most common cancer that affects women, mainly through human papilloma virus (HPV) infection with high-risk HPV16 and HPV18. The present study investigated the in vitro anticancer activity and mechanism of action of a proanthocyanidin polymer-rich fraction of Stryphnodendron adstringens (F...

journal_title：Frontiers in pharmacology

authors： Kaplum V,Ramos AC,Consolaro MEL,Fernandez MA,Ueda-Nakamura T,Dias-Filho BP,Silva SO,de Mello JCP,Nakamura CV

更新日期：2018-07-03 00:00:00

abstract：:Despite an improved understanding of the genetic background and the pathomechanisms of amyotrophic lateral sclerosis (ALS) no novel disease-modifying therapies have been successfully implemented in clinical routine. Riluzole still remains the only clinically approved substance in human ALS treatment with limited effic...

journal_title：Frontiers in pharmacology

authors： Günther R,Balck A,Koch JC,Nientiedt T,Sereda M,Bähr M,Lingor P,Tönges L

更新日期：2017-01-31 00:00:00

abstract：:Pregnant women appear to be more susceptible to infectious diseases than women in reproductive age. According to the California Department of Public Health pregnant women were 9.6-folds more likely to be hospitalized during the 2009 influenza outbreak when compared to non-pregnant women in reproductive age. In contras...

journal_title：Frontiers in pharmacology

authors： Acosta-Elias J,Espinosa-Tanguma R

更新日期：2020-07-16 00:00:00

abstract：:Radiotherapy and chemotherapy are widespread clinical modalities for cancer treatment. Among other biological influences, hypoxia is a main factor limiting the efficacy of radiotherapy, primarily because oxygen is involved in the stabilization of the DNA damage caused by ionizing radiations. Radiobiological hypoxia is...

journal_title：Frontiers in pharmacology

authors： Jordan BF,Sonveaux P

更新日期：2012-05-21 00:00:00

abstract：:Background and Objectives: Although the relationship between the use of proton pump inhibitors (PPIs) and pulmonary tuberculosis (TB) in Taiwan published in 2014. Due to just only one article and not enough comprehensively, we explore this issue. Methods: We conducted a population-based case-control study to identify ...

journal_title：Frontiers in pharmacology

authors： Cheng KC,Liao KF,Lin CL,Lai SW

更新日期：2017-07-19 00:00:00