Role of Regulatory T Cells in Disturbed Immune Homeostasis in Patients With Chronic Obstructive Pulmonary Disease.

abstract：:The small GTPase Rab5 is one of the master regulators of vesicular trafficking that participates in early stages of the endocytic pathway, such as endocytosis and endosome maturation. Three Rab5 isoforms (a, b, and c) share high sequence identity, and exhibit complex functions. However, the role of Rab5c in virus infe...

journal_title：Frontiers in immunology

authors： Wang L,Li C,Zhang X,Yang M,Wei S,Huang Y,Qin Q,Wang S

更新日期：2020-09-02 00:00:00

abstract：:MR1-restricted T (MR1T) cells are defined by their recognition of metabolite antigens presented by the monomorphic MHC class 1-related molecule, MR1, the most highly conserved MHC class I related molecule in mammalian species. Mucosal-associated invariant T (MAIT) cells are the predominant subset of MR1T cells express...

journal_title：Frontiers in immunology

authors： Swarbrick GM,Gela A,Cansler ME,Null MD,Duncan RB,Nemes E,Shey M,Nsereko M,Mayanja-Kizza H,Kiguli S,Koh J,Hanekom WA,Hatherill M,Lancioni C,Lewinsohn DM,Scriba TJ,Lewinsohn DA

更新日期：2020-09-16 00:00:00

abstract：:Plasminogen activation is essential for fibrinolysis-the breakdown of fibrin polymers in blood clots. Besides this important function, plasminogen activation participates in a wide variety of inflammatory conditions. One of these conditions is hereditary angioedema (HAE), a rare disease with characteristic attacks of ...

journal_title：Frontiers in immunology

authors： Maas C

更新日期：2019-08-27 00:00:00

abstract：:Mechanisms driving acute graft-versus-host disease (aGVHD) onset in patients undergoing allogeneic hematopoietic stem cell transplantation (allo-HSCT) are still poorly understood. To provide a detailed characterization of tissue-infiltrating T lymphocytes (TL) and search for eventual site-specific specificities, we de...

journal_title：Frontiers in immunology

authors： Alhaj Hussen K,Michonneau D,Biajoux V,Keita S,Dubouchet L,Nelson E,Setterblad N,Le Buanec H,Bouaziz JD,Guimiot F,Socié G,Canque B

更新日期：2020-11-24 00:00:00

abstract：:FcγRIIa is an activating FcγR, unique to humans and non-human primates. It induces antibody-dependent proinflammatory responses and exists predominantly as FcγRIIa1. A unique splice variant, we designated FcγRIIa3, has been reported to be associated with anaphylactic reactions to intravenous immunoglobulins (IVIg) the...

journal_title：Frontiers in immunology

authors： Anania JC,Trist HM,Palmer CS,Tan PS,Kouskousis BP,Chenoweth AM,Kent SJ,Mackay GA,Hoi A,Koelmeyer R,Slade C,Bryant VL,Hodgkin PD,Aui PM,van Zelm MC,Wines BD,Hogarth PM

更新日期：2018-08-20 00:00:00

abstract：:Differentiation of Natural Killer (NK) cells is a stepwise process having its origin in the bone marrow and proceeding in the periphery, where these cells follow organ specific trajectories. Several soluble factors and cytokines regulate the distinct stages of NK cell differentiation, and ultimately, their functional ...

journal_title：Frontiers in immunology

authors： Scarno G,Pietropaolo G,Di Censo C,Gadina M,Santoni A,Sciumè G

更新日期：2019-10-17 00:00:00

abstract：:Our immune system bears the tremendous task of mounting effective anti-microbial responses whilst maintaining immunoregulatory functions to avoid autoimmunity. In order to quickly respond to pathogens, Dendritic cells (DC) are armed with pattern recognition receptors (PRRs), allowing them to recognize highly conserved...

journal_title：Frontiers in immunology

authors： Ng D,Gommerman JL

更新日期：2013-04-22 00:00:00

abstract：:Immunotherapies that can either activate or suppress innate immune responses are being investigated as treatments against infectious diseases and the pathology they can cause. The objective of these therapies is to elicit protective immune responses thereby limiting the harm inflicted by the pathogen. The Toll-like re...

journal_title：Frontiers in immunology

authors： Mifsud EJ,Tan AC,Jackson DC

更新日期：2014-03-03 00:00:00

abstract：:We have previously shown that the human obese adipose tissue (AT) contributes to increased secretion of adipocyte-specific IgG antibodies in individuals with obesity. This occurs without any exogenous stimulation, because the ongoing process of cell death in the obese AT leads to the release of "self" antigens able to...

journal_title：Frontiers in immunology

authors： Frasca D,Diaz A,Romero M,Garcia D,Jayram D,Thaller S,Del Carmen Piqueras M,Bhattacharya S,Blomberg BB

更新日期：2020-02-28 00:00:00

abstract：:COVID-19 is a global pandemic currently in an acute phase of rapid expansion. While public health measures remain the most effective protection strategy at this stage, when the peak passes, it will leave in its wake important health problems. Historically, very few viruses have ever been eradicated. Instead, the virus...

journal_title：Frontiers in immunology

authors： Sviridov D,Miller YI,Ballout RA,Remaley AT,Bukrinsky M

更新日期：2020-09-29 00:00:00

abstract：:Recent studies have demonstrated that combination of modulatory immune strategies may potentiate tumor cell elimination. Most strategies rely on the use of monoclonal antibodies that can block cell surface receptors to overcome tumor-induced immunosuppression or acting as costimulatory ligands to boost activation of T...

journal_title：Frontiers in immunology

authors： Manrique-Rincón AJ,Beraldo CM,Toscaro JM,Bajgelman MC

更新日期：2017-09-19 00:00:00

abstract：:Rheumatoid arthritis (RA) associated anti-citrullinated protein autoantibodies (ACPA) target a wide range of modified proteins. Citrullination occurs during physiological processes such as apoptosis, yet little is known about the interaction of ACPA with nuclear antigens or apoptotic cells. Since uncleared apoptotic c...

journal_title：Frontiers in immunology

authors： Lloyd KA,Wigerblad G,Sahlström P,Garimella MG,Chemin K,Steen J,Titcombe PJ,Marklein B,Zhou D,Stålesen R,Ossipova E,Lundqvist C,Ekwall O,Rönnelid J,Mueller DL,Karlsson MCI,Kaplan MJ,Skriner K,Klareskog L,Wermeling F

更新日期：2019-01-04 00:00:00

abstract：:KIR2DL5 (CD158f) is the most recently identified inhibitory member of human killer-cell Ig-like receptors (KIRs), which enable NK cells to sense self-HLA. Unlike KIR2DL1-3, recognizing HLA-C allotypes through Ig-like domains of the D1-D2 type, KIR2DL5 shares a D0-D2 configuration with KIR2DL4, and its ligands have not...

journal_title：Frontiers in immunology

authors： Cisneros E,Estefanía E,Vilches C

更新日期：2017-01-17 00:00:00

abstract：:Disturbed homeostasis as a result of tissue stress can provoke leukocyte responses enabling recovery. Since mild hypothermia displays specific clinically relevant tissue-protective properties and interleukin (IL)-22 promotes healing at host/environment interfaces, effects of lowered ambient temperature on IL-22 were s...

journal_title：Frontiers in immunology

authors： Chichelnitskiy E,Himmelseher B,Bachmann M,Pfeilschifter J,Mühl H

更新日期：2017-06-29 00:00:00

abstract：:The receptor for advanced glycation endproducts (RAGE) can engage a diverse class of ligands and contribute to the immune and inflammatory response to infection and injury. It is known to be a pathogenic receptor in many inflammatory diseases, including ischemia/reperfusion (IR) injuries in several tissues; however, i...

journal_title：Frontiers in immunology

authors： Wu MC,Gilmour TD,Mantovani S,Woodruff TM

更新日期：2015-12-07 00:00:00

abstract：:Previous studies have shown targeting different tissues via the transcutaneous (TC) and intramuscular injection (IM) with or without electroporation (EP) has the potential to trigger immune responses to DNA vaccination. The CUTHIVTHER 001 Phase I/II randomized controlled clinical trial was designed to determine whethe...

journal_title：Frontiers in immunology

authors： Haidari G,Day S,Wood M,Ridgers H,Cope AV,Fleck S,Yan C,Reijonen K,Hannaman D,Spentzou A,Hayes P,Vogt A,Combadiere B,Cook A,McCormack S,Shattock RJ

更新日期：2019-12-13 00:00:00

abstract：:Natural killer (NK) cells have a central role within the innate immune system, eliminating virally infected, foreign and transformed cells through their natural cytotoxic capacity. Release of their cytotoxic granules is tightly controlled through the balance of a large repertoire of inhibitory and activating receptors...

journal_title：Frontiers in immunology

authors： Pfefferle A,Jacobs B,Haroun-Izquierdo A,Kveberg L,Sohlberg E,Malmberg KJ

更新日期：2020-05-12 00:00:00

abstract：:Allergic contact dermatitis (ACD) is a common inflammatory skin disease with a prevalence of approximately 20% in the European population. ACD is caused by contact allergens that are reactive chemicals able to modify non-immunogenic self-proteins to become immunogenic proteins. The most frequent contact allergens are ...

journal_title：Frontiers in immunology

authors： Mraz V,Geisler C,Bonefeld CM

更新日期：2020-05-19 00:00:00

abstract：:Genetic mismatches in protein coding genes between allogeneic hematopoietic stem cell transplantation (allo-HSCT) recipient and donor can elicit an alloimmunity response via peptides presented by the recipient HLA receptors as minor histocompatibility antigens (mHAs). While the impact of individual mHAs on allo-HSCT o...

journal_title：Frontiers in immunology

authors： Ritari J,Hyvärinen K,Koskela S,Niittyvuopio R,Nihtinen A,Salmenniemi U,Putkonen M,Volin L,Kwan T,Pastinen T,Itälä-Remes M,Partanen J

更新日期：2019-07-16 00:00:00

abstract：:HIV infection profoundly affects many parameters of the immune system and ultimately leads to AIDS, yet which factors are most important for determining resistance, pathology, and response to antiretroviral treatment - and how best to monitor them - remain unclear. We develop a quantitative high-throughput sequencing ...

journal_title：Frontiers in immunology

authors： Heather JM,Best K,Oakes T,Gray ER,Roe JK,Thomas N,Friedman N,Noursadeghi M,Chain B

更新日期：2016-01-11 00:00:00

abstract：:The autoimmune regulator AIRE controls the negative selection of self-reactive T-cells as well as the induction of regulatory T-cells in the thymus by mastering the transcription and presentation of tissue restricted antigens (TRAs) in thymic cells. However, extrathymic AIRE expression of hitherto unknown clinical sig...

journal_title：Frontiers in immunology

authors： Bergström B,Lundqvist C,Vasileiadis GK,Carlsten H,Ekwall O,Ekwall AH

更新日期：2019-06-18 00:00:00

abstract：:[This corrects the article DOI: 10.3389/fimmu.2020.562282.]. ...

journal_title：Frontiers in immunology

authors： Sadiq A,Bostan N

更新日期：2020-12-16 00:00:00

abstract：:A hallmark of cystic fibrosis (CF) chronic respiratory disease is an extensive neutrophil infiltrate in the mucosa filling the bronchial lumen, starting early in life for CF infants. The genetic defect of the CF Transmembrane conductance Regulator (CFTR) ion channel promotes dehydration of the airway surface liquid, a...

journal_title：Frontiers in immunology

authors： Cabrini G,Rimessi A,Borgatti M,Lampronti I,Finotti A,Pinton P,Gambari R

更新日期：2020-08-04 00:00:00

abstract：:Adult-onset primary immunodeficiency is characterized by recurrent infections, hypogammaglobulinemia, and poor antibody response to vaccines. In this study, we have analyzed targeted gene panel sequencing results of 270 patients diagnosed with antibody deficiency and identified five disease-associated variants in NFKB...

journal_title：Frontiers in immunology

authors： Schröder C,Sogkas G,Fliegauf M,Dörk T,Liu D,Hanitsch LG,Steiner S,Scheibenbogen C,Jacobs R,Grimbacher B,Schmidt RE,Atschekzei F

更新日期：2019-11-14 00:00:00

abstract：:Acute graft-vs.-host disease (GVHD) limits the efficacy of allogeneic hematopoietic stem cell transplantation (allo-HSCT), a main therapy to treat various hematological disorders. Despite rapid progress in understanding GVHD pathogenesis, broad immunosuppressive agents are most often used to prevent and remain the fir...

journal_title：Frontiers in immunology

authors： Thangavelu G,Blazar BR

更新日期：2019-03-06 00:00:00

abstract：:Alpha-1 antitrypsin (AAT) is an inhibitor of neutrophil elastase and a member of the serine proteinase inhibitor (serpin) superfamily, and little is known about its activity in sickle cell disease (SCD). We hypothesize that AAT may undergo changes in SCD because of the high oxidative stress and inflammation associated...

journal_title：Frontiers in immunology

authors： Carvalho MOS,Souza ALCS,Carvalho MB,Pacheco APAS,Rocha LC,do Nascimento VML,Figueiredo CVB,Guarda CC,Santiago RP,Adekile A,Goncalves MS

更新日期：2017-11-06 00:00:00

abstract：:Pulmonary edema, a major complication of lung injury and inflammation, is defined as accumulation of extravascular fluid in the lungs leading to impaired diffusion of respiratory gases. Lung fluid balance across the alveolar epithelial barrier protects the distal airspace from excess fluid accumulation and is mainly r...

journal_title：Frontiers in immunology

authors： Weidenfeld S,Kuebler WM

更新日期：2017-04-07 00:00:00

abstract：:Multiple myeloma (MM) and its pre-cancerous stage monoclonal gammopathy of undetermined significance (MGUS) allow to study immune responses and the chronology of inflammation in the context of blood malignancies. Both diseases are characterized by the production of a monoclonal immunoglobulin (mc Ig) which for subsets...

journal_title：Frontiers in immunology

authors： Bosseboeuf A,Allain-Maillet S,Mennesson N,Tallet A,Rossi C,Garderet L,Caillot D,Moreau P,Piver E,Girodon F,Perreault H,Brouard S,Nicot A,Bigot-Corbel E,Hermouet S,Harb J

更新日期：2017-10-19 00:00:00

abstract：:West Nile (WN) virus infection of humans is frequently asymptomatic, but can also lead to WN fever or neuroinvasive disease. CD4 T cells and B cells are critical in the defense against WN virus, and neutralizing antibodies, which are directed against the viral glycoprotein E, are an accepted correlate of protection. F...

journal_title：Frontiers in immunology

authors： Koblischke M,Spitzer FS,Florian DM,Aberle SW,Malafa S,Fae I,Cassaniti I,Jungbauer C,Knapp B,Laferl H,Fischer G,Baldanti F,Stiasny K,Heinz FX,Aberle JH

更新日期：2020-01-23 00:00:00

abstract：:Immune checkpoint blockade therapy has prevailed for several types of cancer; however, its effectiveness as a single therapy is still limited. In principle, dendritic cells (DCs) should be able to control the post-therapy immune response, in particular since they can link the two major arms of the immune system: innat...

journal_title：Frontiers in immunology

authors： Fujii SI,Shimizu K

更新日期：2017-07-31 00:00:00