The Ratiometric Transcript Signature MX2/GPR183 Is Consistently Associated With RTS,S-Mediated Protection Against Controlled Human Malaria Infection.

abstract：:In human brucellosis, the liver is frequently affected. Brucella abortus triggers a profibrotic response on hepatic stellate cells (HSCs) characterized by inhibition of MMP-9 with concomitant collagen deposition and TGF-β1 secretion through type 4 secretion system (T4SS). Taking into account that it has been reported ...

journal_title：Frontiers in immunology

authors： Arriola Benitez PC,Pesce Viglietti AI,Gomes MTR,Oliveira SC,Quarleri JF,Giambartolomei GH,Delpino MV

更新日期：2020-01-21 00:00:00

abstract：:Sepsis is one of the well-established diseases with specific patterns of neutrophil dysfunctions. Previous studies demonstrated sepsis-related neutrophil dysfunctions in comparison with subjects without infection. Since sepsis and infection are recently recognized as distinctive processes, whether these neutrophil dys...

journal_title：Frontiers in immunology

authors： Seree-Aphinan C,Vichitkunakorn P,Navakanitworakul R,Khwannimit B

更新日期：2020-12-23 00:00:00

abstract：:The fundamental problem of autoimmune diseases is the failure of the immune system to downregulate its own potentially dangerous cells, which leads to destruction of tissue expressing the relevant autoantigens. Current immunosuppressive therapies offer relief but fail to restore the basic condition of self-tolerance. ...

journal_title：Frontiers in immunology

authors： van Eden W,Jansen MAA,Ludwig I,van Kooten P,van der Zee R,Broere F

更新日期：2017-11-21 00:00:00

abstract：:Intracellular metabolic programs tightly regulate the functions of macrophages, and previous studies have shown that serine mainly shapes the macrophage function via one-carbon metabolism. However, it is unknown whether serine modulates the macrophage function independent of one-carbon metabolism. Here, we find that s...

journal_title：Frontiers in immunology

authors： Chen S,Xia Y,He F,Fu J,Xin Z,Deng B,He L,Zhou X,Ren W

更新日期：2020-08-27 00:00:00

abstract：Background:The immune regulatory properties of semaphorin3A (sema3A) (both innate and adaptive) are well established in many in vitro studies. The injection of sema3A into a mice model of rheumatoid arthritis was proven to be highly beneficial, both in attenuating clinical symptoms and in decreasing inflammatory mechan...

journal_title：Frontiers in immunology

authors： Bejar J,Kessler O,Sabag AD,Sabo E,Itzhak OB,Neufeld G,Vadasz Z

更新日期：2018-04-04 00:00:00

abstract：:Cross-presentation of endocytosed antigen as peptide/class I major histocompatibility complex complexes plays a central role in the elicitation of CD8(+) T cell clones that mediate anti-viral and anti-tumor immune responses. While it has been clear that there are specific subsets of professional antigen presenting cel...

journal_title：Frontiers in immunology

authors： Compeer EB,Flinsenberg TW,van der Grein SG,Boes M

更新日期：2012-03-07 00:00:00

abstract：:CD4+ T cells play a central role in orchestrating protective immunity and autoimmunity. The activation and differentiation of myelin-reactive CD4+ T cells into effector (Th1 and Th17) and regulatory (Tregs) subsets at the peripheral tissues, and their subsequent transmigration across the blood-brain barrier (BBB) into...

journal_title：Frontiers in immunology

authors： Sonar SA,Lal G

更新日期：2017-11-29 00:00:00

abstract：:Adenosine triphosphate (ATP) is released by bacteria and host cells during bacterial infection as well as sterile tissue injury, acting as an inducer of inflammasome activation. Previous studies have shown that ATP treatment leads to AMP-activated protein kinase (AMPK) activation. However, it is unclear whether AMPK s...

journal_title：Frontiers in immunology

authors： Zha QB,Wei HX,Li CG,Liang YD,Xu LH,Bai WJ,Pan H,He XH,Ouyang DY

更新日期：2016-12-12 00:00:00

abstract：:Nephritic factors comprise a heterogeneous group of autoantibodies against neoepitopes generated in the C3 and C5 convertases of the complement system, causing its dysregulation. Classification of these autoantibodies can be clustered according to their stabilization of different convertases either from the classical ...

journal_title：Frontiers in immunology

authors： Corvillo F,Okrój M,Nozal P,Melgosa M,Sánchez-Corral P,López-Trascasa M

更新日期：2019-04-24 00:00:00

abstract：:We have developed a therapeutic vaccine consisting of a mixture of lethally-irradiated allogeneic cutaneous melanoma cell lines with BCG and GM-CSF as adjuvants. The CSF-470 vaccine is currently being assayed in a Phase II-III trial against medium-dose IFN-α2b. All vaccinated patients immunized intradermally developed...

journal_title：Frontiers in immunology

authors： Aris M,Bravo AI,Barrio MM,Mordoh J

更新日期：2015-03-30 00:00:00

abstract：:The identification of recurrent human leukocyte antigen (HLA) neoepitopes driving T cell responses against tumors poses a significant bottleneck in the development of approaches for precision cancer therapeutics. Here, we employ a bioinformatics method, Prediction of T Cell Epitopes for Cancer Therapy, to analyze sequ...

journal_title：Frontiers in immunology

authors： Toor JS,Rao AA,McShan AC,Yarmarkovich M,Nerli S,Yamaguchi K,Madejska AA,Nguyen S,Tripathi S,Maris JM,Salama SR,Haussler D,Sgourakis NG

更新日期：2018-01-30 00:00:00

abstract：:Tuberculosis (TB) is one of the prevalent causes of death worldwide, with 95% of these deaths occurring in developing countries, like India. The causative agent, Mycobacterium tuberculosis (MTb) has the tenacious ability to circumvent the host's immune system for its own advantage. Macrophages are one of the phagocyti...

journal_title：Frontiers in immunology

authors： Ahluwalia PK,Pandey RK,Sehajpal PK,Prajapati VK

更新日期：2017-02-08 00:00:00

abstract：:Immune checkpoint inhibitors that block the programmed cell death protein 1/PD-L1 pathway have significantly improved the survival of patients with advanced melanoma. Immunotherapies are only effective in 15-40% of melanoma patients and resistance is associated with defects in antigen presentation and interferon signa...

journal_title：Frontiers in immunology

authors： Alavi S,Stewart AJ,Kefford RF,Lim SY,Shklovskaya E,Rizos H

更新日期：2018-06-21 00:00:00

abstract：:[This corrects the article on p. 125 in vol. 6, PMID: 25852693.]. ...

journal_title：Frontiers in immunology

authors： Dalai SK,Yadav N,Patidar M,Patel H,Singh AP

更新日期：2015-06-22 00:00:00

abstract：:Innate immunity is one of the main protection mechanisms against viral infections, but how this system works at the maternal-fetal interface, especially during HIV infection, is still poorly known. In this study, we investigated the relationship between pregnancy and innate mechanisms associated with HIV immunity by e...

journal_title：Frontiers in immunology

authors： Pereira NZ,Branco ACCC,Manfrere KCG,de Lima JF,Yoshikawa FSY,Milanez HMBPM,Pereira NV,Sotto MN,Duarte AJDS,Sato MN

更新日期：2020-08-25 00:00:00

abstract：:During the entire processes of thymus organogenesis, maturation, and involution, gene regulation occurs post-transcriptionally via recently discovered microRNA (miRNA) transcripts. Numerous reports indicate that miRNAs may be involved in the construction of a normal thymic microenvironment, which constitutes a critica...

journal_title：Frontiers in immunology

authors： Xu M,Gan T,Ning H,Wang L

更新日期：2018-09-11 00:00:00

abstract：:Despite effective antiretroviral therapy (ART), HIV-infected individuals with apparently similar clinical and immunological characteristics can vary in responsiveness to vaccinations. However, molecular mechanisms responsible for such impairment, as well as biomarkers able to predict vaccine responsiveness in HIV-infe...

journal_title：Frontiers in immunology

authors： Cotugno N,De Armas L,Pallikkuth S,Rinaldi S,Issac B,Cagigi A,Rossi P,Palma P,Pahwa S

更新日期：2017-09-11 00:00:00

abstract：:A new paradigm of mucosal vaccination against human immunodeficiency virus (HIV) infection has been investigated in the macaque model. A vaccine consisting of inactivated simian immunodeficiency virus (SIV)mac239 particles together with a living bacterial adjuvant (either the Calmette and Guerin bacillus, Lactobacillu...

journal_title：Frontiers in immunology

authors： Andrieu JM,Chen S,Lai C,Guo W,Lu W

更新日期：2014-06-30 00:00:00

abstract：:Polyunsaturated fatty acids (PUFAs) are important for immune function. Limited evidence indicates that immune cell activation involves endogenous PUFA synthesis, but this has not been characterised. To address this, we measured metabolism of 18:3n-3 in quiescent and activated peripheral blood mononuclear cells (PBMCs)...

journal_title：Frontiers in immunology

authors： Sibbons CM,Irvine NA,Pérez-Mojica JE,Calder PC,Lillycrop KA,Fielding BA,Burdge GC

更新日期：2018-03-05 00:00:00

abstract：:Aim: We assessed whether different complement factors and complement activation products were associated with poor outcome in patients with necrotizing soft-tissue infection (NSTI). Methods: We conducted a prospective, observational study in an intensive care unit where treatment of NSTI is centralized at a national l...

journal_title：Frontiers in immunology

authors： Kristensen MK,Hansen MB,Madsen MB,Hansen CB,Pilely K,Hyldegaard O,Garred P

更新日期：2020-01-31 00:00:00

abstract：:Platelets are non-nucleated cells that play central roles in the processes of hemostasis, innate immunity, and inflammation; however, several reports show that these distinct functions are more closely linked than initially thought. Platelets express numerous receptors and contain hundreds of secretory products. These...

journal_title：Frontiers in immunology

authors： Cognasse F,Nguyen KA,Damien P,McNicol A,Pozzetto B,Hamzeh-Cognasse H,Garraud O

更新日期：2015-03-02 00:00:00

abstract：:Interleukin-10 plays important, yet contrasting, roles in host protection against bacterial infections and in the septic response. To determine the role of IL-10 in the host defense against Acinetobacter baumannii infection, wild-type (WT) and IL-10-deficient mice were infected intranasally with the bacteria. IL-10-de...

journal_title：Frontiers in immunology

authors： Kang MJ,Jang AR,Park JY,Ahn JH,Lee TS,Kim DY,Lee MS,Hwang S,Jeong YJ,Park JH

更新日期：2020-02-21 00:00:00

abstract：:Fibroblastic reticular cells (FRCs) are the specialized lymphoid stromal cells initially identified as triggering T-cell recruitment and dynamic motion in secondary lymphoid organs. Interestingly, FRCs also display antigen presentation capacities and support lymphocyte survival. CXCR5+CD4+ follicular T cells are impor...

journal_title：Frontiers in immunology

authors： Misiak J,Jean R,Rodriguez S,Deleurme L,Lamy T,Tarte K,Amé-Thomas P

更新日期：2020-10-02 00:00:00

abstract：:The immune system evolved to respond to foreign invaders and prevent autoimmunity to self-antigens. Several types of regulatory T cells facilitate the latter process. These include a subset of Foxp3(-) CD4(+) T cells able to secrete IL-10 in an antigen-specific manner, type 1 regulatory (Tr1) T cells. Although their s...

journal_title：Frontiers in immunology

authors： White AM,Wraith DC

更新日期：2016-09-14 00:00:00

abstract：:Exposure to traumatic or infectious insults results in a rapid activation of the complement cascade as major fluid defense system of innate immunity. The complement system acts as a master alarm system during the molecular danger response after trauma and significantly contributes to the clearance of DAMPs and PAMPs. ...

journal_title：Frontiers in immunology

authors： Karasu E,Nilsson B,Köhl J,Lambris JD,Huber-Lang M

更新日期：2019-03-21 00:00:00

abstract：:T cells play a vital role in eliminating pathogenic infections. To activate, naïve T cells search lymph nodes (LNs) for dendritic cells (DCs). Positioning and movement of T cells in LNs is influenced by chemokines including CCL21 as well as multiple cell types and structures in the LNs. Previous studies have suggested...

journal_title：Frontiers in immunology

authors： Tasnim H,Fricke GM,Byrum JR,Sotiris JO,Cannon JL,Moses ME

更新日期：2018-07-26 00:00:00

abstract：:The ubiquitously expressed, monomorphic MHC class Ib molecule MHC class I-related protein 1 (MR1) presents microbial metabolites to mucosal-associated invariant T (MAIT) cells. However, recent work demonstrates that both the ligands bound by MR1 and the T cells restricted by it are more diverse than originally thought...

journal_title：Frontiers in immunology

authors： Kulicke C,Karamooz E,Lewinsohn D,Harriff M

更新日期：2020-09-02 00:00:00

abstract：:Bullous pemphigoid (BP) is an autoimmune blistering disease characterized by autoantibodies targeting cellular adhesion molecules. While IgE autoantibodies are occasionally reported in other autoimmune blistering diseases, BP is unique in that most BP patients develop an IgE autoantibody response. It is not known why ...

journal_title：Frontiers in immunology

authors： Messingham KN,Crowe TP,Fairley JA

更新日期：2019-10-04 00:00:00

abstract：:Hepatitis B virus (HBV) infection is regarded as the main etiological risk factor in the process of hepatocellular carcinoma (HCC), as it promotes an immunosuppressive microenvironment that is partially mediated by the programmed cell death protein 1 (PD-1)/programmed death-ligand 1 (PD-L1) signaling pathway. The tumo...

journal_title：Frontiers in immunology

authors： Li B,Yan C,Zhu J,Chen X,Fu Q,Zhang H,Tong Z,Liu L,Zheng Y,Zhao P,Jiang W,Fang W

更新日期：2020-05-28 00:00:00

abstract：:A central objective in organ transplantation and the treatment or prevention of autoimmune disease is the achievement of antigen-specific immune tolerance. An additional challenge in bone marrow transplantation for the treatment of hematological malignancies is the prevention of graft-vs-host disease (GVHD) while main...

journal_title：Frontiers in immunology

authors： Hillhouse EE,Delisle JS,Lesage S

更新日期：2013-01-24 00:00:00