Composition and Functionality of Lipid Emulsions in Parenteral Nutrition: Examining Evidence in Clinical Applications.

abstract：:Objectives: The purpose of this study is to investigate the anti-inflammatory activity of a hexa-herbal Chinese formula (HHCF) using spontaneously immortalized human epidermal keratinocytes (HaCaT) and to predict the active components by correlating the LC-MS-based metabolite profiles of the HHCF and its 12 varied for...

journal_title：Frontiers in pharmacology

authors： Chang JB,Lane ME,Yang M,Heinrich M

更新日期：2018-10-05 00:00:00

abstract：:Choroid plexus carcinomas (CPCs) are rare, aggressive pediatric brain tumors with no established curative therapy for relapsed disease, and poor survival rates. TP53 Mutation or dysfunction correlates with poor or no survival outcome in CPCs. Here, we report the case of a 4 month-old female who presented with dissemin...

journal_title：Frontiers in pharmacology

authors： Cornelius A,Foley J,Bond J,Nagulapally AB,Steinbrecher J,Hendricks WPD,Rich M,Yendrembam S,Bergendahl G,Trent JM,Sholler GS

更新日期：2017-09-25 00:00:00

abstract：:Depression is a widespread chronic medical illness affecting thoughts, mood, and physical health. However, the limited and delayed therapeutic efficacy of monoaminergic drugs has led to intensive research efforts to develop novel antidepressants. ARN-3236 is the first potent and selective inhibitor of salt-inducible k...

journal_title：Frontiers in pharmacology

authors： Liu Y,Tang W,Ji C,Gu J,Chen Y,Huang J,Zhao X,Sun Y,Wang C,Guan W,Liu J,Jiang B

更新日期：2021-01-14 00:00:00

abstract：:Fibrosis is a common, persistent and potentially debilitating complication of chemotherapy and radiation regimens used for the treatment of cancer. The molecular mechanisms underlying fibrosis have been well studied and reveal overall processes that are largely ubiquitous. However, it is important to note that althoug...

journal_title：Frontiers in pharmacology

authors： Mancini ML,Sonis ST

更新日期：2014-03-27 00:00:00

abstract：:Marantodes pumilum (Primulaceae) has been used in Malaysian folk medicine to help women regain strength after delivery and for "sickness in the bones." It was previously revealed that its extracts inhibited xanthine oxidase (XO) activity in vitro. The leaves and roots of M. pumilum var. alata (MPA), var. pumila (MPP),...

journal_title：Frontiers in pharmacology

authors： Rahmi EP,Kumolosasi E,Jalil J,Husain K,Buang F,Abd Razak AF,Jamal JA

更新日期：2020-03-17 00:00:00

abstract：:Objective: The purpose of this study was to evaluate the anticancer effects of Ophiopogonin D' (OPD', a natural product extracted from a traditional Chinese medicine (Radix Ophiopogonis) against androgen-independent prostate cancer cells and to explore the underlying molecular mechanism(s) of action. Methods: The CCK-...

journal_title：Frontiers in pharmacology

authors： Lu Z,Wang H,Zhu M,Song W,Wang J,Wu C,Kong Y,Guo J,Li N,Liu J,Li Y,Xu H

更新日期：2018-04-30 00:00:00

abstract：:Zinc doped copper oxide nanocomposites (Zn-CuO NPs) is a novel doped metal nanomaterial synthesized by our group using the sonochemical method. Our previous studies have shown that Zn-CuO NPs could inhibit cancer cell proliferation by inducing apoptosis via ROS-mediated pathway. In the present study, we studied the an...

journal_title：Frontiers in pharmacology

authors： Li X,Xu H,Li C,Qiao G,Farooqi AA,Gedanken A,Liu X,Lin X

更新日期：2019-04-02 00:00:00

abstract：:Phenethyl isothiocyanate is widely present in cruciferous vegetables with multiple biological effects. Here we reported the antiatherogenic effects and the underlying mechanisms of JC-5411 (Phenethyl isothiocyanate formulation) in vitro and in vivo. Luciferase reporter assay showed that JC-5411 increased the activity ...

journal_title：Frontiers in pharmacology

authors： Jiang X,Li Y,Wang W,Han X,Han J,Chen M,Zhang J,Wang C,Li S,Luo J,Wang X,Xu Y,Xu Y,Cheng J,Si S

更新日期：2020-11-16 00:00:00

abstract：:We evaluated the prevalence of and risk factors for hypersensitivity reactions related to carboplatin, which is commonly used to treat gynecological malignancies. All women with pathologically documented ovarian, fallopian tube, or primary peritoneal cancer treated with carboplatin alone or a carboplatin-based combina...

journal_title：Frontiers in pharmacology

authors： Tai YH,Tai YJ,Hsu HC,Lee SP,Chen YY,Chiang YC,Chen YL,Chen CA,Cheng WF

更新日期：2017-11-06 00:00:00

abstract：:Cannabis has been used for medicinal purposes for thousands of years. The prohibition of cannabis in the middle of the 20th century has arrested cannabis research. In recent years there is a growing debate about the use of cannabis for medical purposes. The term 'medical cannabis' refers to physician-recommended use o...

journal_title：Frontiers in pharmacology

authors： Vučković S,Srebro D,Vujović KS,Vučetić Č,Prostran M

更新日期：2018-11-13 00:00:00

abstract：Background:As the original compound of many podophyllotoxin derivatives, podophyllotoxin has a beneficial antitumor effect. The mechanism of podophyllotoxin activity in triple-negative breast cancer still needs to be explored. Methods:We used cell proliferation assay, scratch and transwell experiments, and cell cycle ...

journal_title：Frontiers in pharmacology

authors： Zhang W,Liu C,Li J,Liu R,Zhuang J,Feng F,Yao Y,Sun C

更新日期：2020-08-07 00:00:00

abstract：:Saponins are natural compounds and possess the most promising anti-cancer function. Here, a saponin gleditsia saponin C (GSC), extracted from gleditsiae fructus abnormalis, could induce apoptosis of lung tumor cell line A549 via caspase dependent cascade and this effect could be prevented by the caspase inhibitors. In...

journal_title：Frontiers in pharmacology

authors： Cheng Y,He W,He Y

更新日期：2018-01-15 00:00:00

abstract：:Drug resistance is one of the main reasons of chemotherapy failure. Therefore, overcoming drug resistance is an invaluable approach to identify novel anticancer drugs that have the potential to bypass or overcome resistance to established drugs and to substantially increase life span of cancer patients for effective c...

journal_title：Frontiers in pharmacology

authors： Kadioglu O,Saeed M,Kuete V,Greten HJ,Efferth T

更新日期：2018-04-16 00:00:00

abstract：:A growing set of observations points to mitochondrial dysfunction, iron accumulation, oxidative damage and chronic inflammation as common pathognomonic signs of a number of neurodegenerative diseases that includes Alzheimer's disease, Huntington disease, amyotrophic lateral sclerosis, Friedrich's ataxia and Parkinson'...

journal_title：Frontiers in pharmacology

authors： Urrutia PJ,Mena NP,Núñez MT

更新日期：2014-03-10 00:00:00

abstract：:Pancreatic cancer is an aggressive malignancy with poor survival. Research has indicated the association of few genetic aberrations with pancreatic cancer. The data regarding the prevalence of microsatellite instability in pancreatic cancer is diverse and controversial. However, it could be an actionable target in pan...

journal_title：Frontiers in pharmacology

authors： Kamatham S,Shahjehan F,Kasi PM

更新日期：2020-02-10 00:00:00

abstract：:Chronic obstructive pulmonary disease (COPD) is the major leading cause of disease with high-mortality worldwide. Cigarette smoke (CS) is a major factor for COPD. CS causes chronic inflammation and oxidative stress, which contributes to lung dysfunction in COPD. Isoliquiritigenin (ILG), a natural flavonoid derived fro...

journal_title：Frontiers in pharmacology

authors： Yu D,Liu X,Zhang G,Ming Z,Wang T

更新日期：2018-09-20 00:00:00

abstract：:[This corrects the article on p. 161 in vol. 3, PMID: 22993507.]. ...

journal_title：Frontiers in pharmacology

authors： Villalba-Galea CA

更新日期：2015-05-29 00:00:00

abstract：:[This retracts the article DOI: 10.3389/fphar.2018.00987.]. ...

journal_title：Frontiers in pharmacology

authors： Frontiers Editorial Office.

更新日期：2019-02-07 00:00:00

abstract：:Gene targeting strategies have become a powerful technology for elucidating mammalian gene function. The recently generated knockout (KO)-first strategy produces a KO at the RNA processing level and also allows for the generation of conditional KO alleles by combining FLP/FRT and Cre/loxP systems, thereby providing hi...

journal_title：Frontiers in pharmacology

authors： Hanstein R,Negoro H,Patel NK,Charollais A,Meda P,Spray DC,Suadicani SO,Scemes E

更新日期：2013-05-09 00:00:00

abstract：:The inhibitors for EGF receptor tyrosine kinase (EGFR-TKIs) such as gefitinib have been used as a standard treatment for non-small cell lung cancer (NSCLC), but the increasingly occurrence of drug resistance, the associated adverse effects and the enrichment of cancer stem cells significantly impedes its clinical appl...

journal_title：Frontiers in pharmacology

authors： Cheng H,Ge X,Zhuo S,Gao Y,Zhu B,Zhang J,Shang W,Xu D,Ge W,Shi L

更新日期：2018-11-30 00:00:00

abstract：:Background: Xuebijing injection (XBJ), transforming from Xuefuzhuyu decoction, is the only Chinese medicine injection approved for sepsis. XBJ and ulinastatin (UTI) combination therapy is supposed to be beneficial for sepsis patients. To fill the gap between the lack of evidence for the efficacy of combination therapy...

journal_title：Frontiers in pharmacology

authors： Chen G,Gao Y,Jiang Y,Yang F,Li S,Tan D,Ma Q

更新日期：2018-07-24 00:00:00

abstract：:Pregnant women appear to be more susceptible to infectious diseases than women in reproductive age. According to the California Department of Public Health pregnant women were 9.6-folds more likely to be hospitalized during the 2009 influenza outbreak when compared to non-pregnant women in reproductive age. In contras...

journal_title：Frontiers in pharmacology

authors： Acosta-Elias J,Espinosa-Tanguma R

更新日期：2020-07-16 00:00:00

abstract：:We have previously discovered a synergistically therapeutic combination of two Toll-like receptor ligands, an oligodeoxynucleotide (ODN) and Pam2CSK4. Aerosolization of these ligands stimulates innate immunity within the lungs to prevent pneumonia from bacterial and viral pathogens. Here we examined the safety and tol...

journal_title：Frontiers in pharmacology

authors： Alfaro VY,Goldblatt DL,Valverde GR,Munsell MF,Quinton LJ,Walker AK,Dantzer R,Varadhachary A,Scott BL,Evans SE,Tuvim MJ,Dickey BF

更新日期：2014-02-06 00:00:00

abstract：:Background: Rheumatoid arthritis is a type of systemic and complex autoimmune other disease characterized by chronic joint inflammation. Spleen tyrosine kinase (Syk) inhibitors are regarded as an effective alternative to existing drugs for the treatment of this disease. However, studies evaluating fostamatinib, a new ...

journal_title：Frontiers in pharmacology

authors： Kang Y,Jiang X,Qin D,Wang L,Yang J,Wu A,Huang F,Ye Y,Wu J

更新日期：2019-08-14 00:00:00

abstract：:Targeting metabolic enzymes is believed to provide new therapeutic opportunities for cancer therapy. Phosphoglycerate mutase 1 (PGAM1) is a glycolytic enzyme that importantly coordinates glycolysis, pentose phosphate pathway (PPP) flux and serine biosynthesis in cancer cells and hence gains increasing interest of inhi...

journal_title：Frontiers in pharmacology

authors： Li X,Tang S,Wang QQ,Leung EL,Jin H,Huang Y,Liu J,Geng M,Huang M,Yuan S,Yao XJ,Ding J

更新日期：2017-05-30 00:00:00

abstract：:Calcium ions (Ca2+) play a major role in the cardiac excitation-contraction coupling. Intracellular Ca2+ concentration increases during systole and falls in diastole thereby determining cardiac contraction and relaxation. Normal cardiac function also requires perfect organization of the ion currents at the cellular le...

journal_title：Frontiers in pharmacology

authors： Kistamás K,Veress R,Horváth B,Bányász T,Nánási PP,Eisner DA

更新日期：2020-02-25 00:00:00

abstract：:We aimed to ascertain the mechanism underlying the effects of acteoside (ACT) from Ligustrum robustum (Roxb.) Blume (Oleaceae) on lipid metabolism and synthesis. ACT, a water-soluble phenylpropanoid glycoside, is the most abundant and major active component of L. robustum; the leaves of L. robustum, known as kudingcha...

journal_title：Frontiers in pharmacology

authors： Sun L,Yu F,Yi F,Xu L,Jiang B,Le L,Xiao P

更新日期：2019-05-24 00:00:00

abstract：:Shuxuening injection (SXNI) is a widely prescribed herbal medicine of Ginkgo biloba extract (EGB) for cerebral and cardiovascular diseases in China. However, its curative effects on ischemic stroke and heart diseases and the underlying mechanisms remain unknown. Taking an integrated approach of RNA-seq and network pha...

journal_title：Frontiers in pharmacology

authors： Lyu M,Cui Y,Zhao T,Ning Z,Ren J,Jin X,Fan G,Zhu Y

更新日期：2018-04-06 00:00:00

abstract：:Dysregulation of the complement system is central to age-related macular degeneration (AMD), the leading cause of blindness in the developed world. Most of the genetic variation associated with AMD resides in complement genes, with the greatest risk associated with polymorphisms in the complement factor H (CFH) gene; ...

journal_title：Frontiers in pharmacology

authors： Stravalaci M,Davi F,Parente R,Gobbi M,Bottazzi B,Mantovani A,Day AJ,Clark SJ,Romano MR,Inforzato A

更新日期：2020-11-26 00:00:00

abstract：:A growing body of research indicates that cortisol, the glucocorticoid product of the activation of the hypothalamic-pituitary-adrenal axis, plays a role in the pathophysiology of metabolic syndrome. In this regard, chronic exposure to cortisol is associated with risk factors related to metabolic syndrome like weight ...

journal_title：Frontiers in pharmacology

authors： Díaz-Castro F,Monsalves-Álvarez M,Rojo LE,Del Campo A,Troncoso R

更新日期：2020-04-24 00:00:00