Physical exercise promotes astrocyte coverage of microvessels in a model of chronic cerebral hypoperfusion.

abstract：BACKGROUND:The CD133(+) stem cell population in recurrent gliomas is associated with clinical features such as therapy resistance, blood-brain barrier disruption and, hence, tumor infiltration. Screening of a large panel of glioma samples increasing histological grade demonstrated frequencies of CD133(+) cells which co...

journal_title：Journal of neuroinflammation

authors： Annabi B,Laflamme C,Sina A,Lachambre MP,Béliveau R

更新日期：2009-03-09 00:00:00

abstract：BACKGROUND:The chemokine interleukin-8 (IL-8) and its receptor CXCR2 contribute to chemotactic responses in Alzheimer's disease (AD); however, properties of the ligand and receptor have not been characterized in animal models of disease. The primary aim of our study was to examine effects of pharmacological antagonism ...

journal_title：Journal of neuroinflammation

authors： Ryu JK,Cho T,Choi HB,Jantaratnotai N,McLarnon JG

更新日期：2015-08-09 00:00:00

abstract：BACKGROUND:Elevated levels of oncostatin M (OSM), an interleukin-6 cytokine family member, have been observed in HIV-1-associated neurocognitive disorders (HAND) and Alzheimer's disease. However, the function of OSM in these disease conditions is unclear. Since deficient glutamate uptake by astrocytes is instrumental i...

journal_title：Journal of neuroinflammation

authors： Moidunny S,Matos M,Wesseling E,Banerjee S,Volsky DJ,Cunha RA,Agostinho P,Boddeke HW,Roy S

更新日期：2016-06-10 00:00:00

abstract：BACKGROUND:Plasminogen activation is a ubiquitous source of fibrinolytic and proteolytic activity. Besides its role in prevention of thrombosis, plasminogen is involved in inflammatory reactions in the central nervous system. Plasminogen has been detected in the cerebrospinal fluid (CSF) of patients with inflammatory d...

journal_title：Journal of neuroinflammation

authors： Mezzapesa A,Orset C,Plawinski L,Doeuvre L,Martinez de Lizarrondo S,Chimienti G,Vivien D,Mansour A,Matà S,Pepe G,Anglés-Cano E

更新日期：2014-09-16 00:00:00

abstract：:BACKGROUND: Oligodendrocytes, neurons, astrocytes, microglia, and endothelial cells are capable of synthesizing complement inhibitor proteins. Oligodendrocytes are vulnerable to complement attack, which is particularly observed in multiple sclerosis. This vulnerability may be related to a deficiency in their ability t...

journal_title：Journal of neuroinflammation

authors： Hosokawa M,Klegeris A,McGeer PL

更新日期：2004-08-24 00:00:00

abstract：BACKGROUND:Monocyte infiltration is involved in the pathogenesis of many retinal degenerative conditions. This process traditionally depends on local expression of chemokines, though the roles of many of these in the degenerating retina are unclear. Here, we investigate expression and in situ localization of the broad ...

journal_title：Journal of neuroinflammation

authors： Rutar M,Natoli R,Chia RX,Valter K,Provis JM

更新日期：2015-01-17 00:00:00

abstract：:Traumatic brain injury (TBI) is an important cause of disability and mortality in the western world. While the initial injury sustained results in damage, it is the subsequent secondary cascade that is thought to be the significant determinant of subsequent outcomes. The changes associated with the secondary injury do...

journal_title：Journal of neuroinflammation

authors： Hammad A,Westacott L,Zaben M

更新日期：2018-01-22 00:00:00

abstract：BACKGROUND:Ventral root avulsion is a proximal nerve root lesion in which ventral motor nerve rootlets are torn from surface of the spinal cord, resulting in extensive death of motoneurons. It has been previously shown that if such lesioning is performed in an animal with experimental autoimmune encephalomyelitis (EAE)...

journal_title：Journal of neuroinflammation

authors： Barbizan R,Oliveira AL

更新日期：2010-05-04 00:00:00

abstract：BACKGROUND:Parkinson's disease (PD) is frequently associated with gastrointestinal (GI) symptoms, including constipation and defecatory dysfunctions. The mechanisms underlying such disorders are still largely unknown, although the occurrence of a bowel inflammatory condition has been hypothesized. This study examined t...

journal_title：Journal of neuroinflammation

authors： Pellegrini C,Fornai M,Colucci R,Tirotta E,Blandini F,Levandis G,Cerri S,Segnani C,Ippolito C,Bernardini N,Cseri K,Blandizzi C,Haskó G,Antonioli L

更新日期：2016-06-13 00:00:00

abstract：BACKGROUND:The cellular prion protein (PrPC) is an evolutionary conserved protein abundantly expressed not only in the central nervous system but also peripherally including the immune system. A line of Norwegian dairy goats naturally devoid of PrPC (PRNP Ter/Ter) provides a novel model for studying PrPC physiology. M...

journal_title：Journal of neuroinflammation

authors： Salvesen Ø,Reiten MR,Espenes A,Bakkebø MK,Tranulis MA,Ersdal C

更新日期：2017-05-22 00:00:00

abstract：BACKGROUND:Alzheimer's disease (AD) is characterized by extracellular β-amyloid (Aβ) plaques, neurofibrillary tangles (NFTs), and microglia-dominated neuroinflammation. The Nogo/NgR signal pathway is involved in AD pathological features, but the detailed mechanism needs further investigation. Our previous studies have ...

journal_title：Journal of neuroinflammation

authors： Fang Y,Yao L,Li C,Wang J,Wang J,Chen S,Zhou XF,Liao H

更新日期：2016-03-03 00:00:00

abstract：:Interleukin (IL)-18 is a cytokine isolated as an important modulator of immune responses and subsequently shown to be pleiotropic. IL-18 and its receptors are expressed in the central nervous system (CNS) where they participate in neuroinflammatory/neurodegenerative processes but also influence homeostasis and behavio...

journal_title：Journal of neuroinflammation

authors： Alboni S,Cervia D,Sugama S,Conti B

更新日期：2010-01-29 00:00:00

abstract：BACKGROUND:Cranial radiotherapy is used to treat tumors of the central nervous system (CNS), as well as non-neoplastic conditions such as arterio-venous malformations; however, its use is limited by the tolerance of adjacent normal CNS tissue, which can lead to devastating long-term sequelae for patients. Despite decad...

journal_title：Journal of neuroinflammation

authors： Moravan MJ,Olschowka JA,Williams JP,O'Banion MK

更新日期：2016-02-03 00:00:00

abstract：BACKGROUND:Neuroinflammation and demyelination have been suggested as mechanisms causing HIV-1 associated neurocognitive disorder (HAND). This cross-sectional cohort study explores the potential role of antibodies to myelin oligodendrocyte glycoprotein (MOG), a putative autoantigen in multiple sclerosis, in the pathoge...

journal_title：Journal of neuroinflammation

authors： Lackner P,Kuenz B,Reindl M,Morandell M,Berger T,Schmutzhard E,Eggers C

更新日期：2010-11-17 00:00:00

abstract：BACKGROUND:Traumatic brain injury (TBI) initiates a neuroinflammatory cascade that contributes to substantial neuronal damage and behavioral impairment, and Toll-like receptor 4 (TLR4) is an important mediator of thiscascade. In the current study, we tested the hypothesis that curcumin, a phytochemical compound with po...

journal_title：Journal of neuroinflammation

authors： Zhu HT,Bian C,Yuan JC,Chu WH,Xiang X,Chen F,Wang CS,Feng H,Lin JK

更新日期：2014-03-27 00:00:00

abstract：BACKGROUND:Multiple sclerosis (MS) is an autoimmune demyelinating disease that affects the central nervous system (CNS), leading to neurodegeneration and chronic disability. Accumulating evidence points to a key role for neuroinflammation, oxidative stress, and excitotoxicity in this degenerative process. System xc- or...

journal_title：Journal of neuroinflammation

authors： Merckx E,Albertini G,Paterka M,Jensen C,Albrecht P,Dietrich M,Van Liefferinge J,Bentea E,Verbruggen L,Demuyser T,Deneyer L,Lewerenz J,van Loo G,De Keyser J,Sato H,Maher P,Methner A,Massie A

更新日期：2017-01-13 00:00:00

abstract：BACKGROUND:Interleukin-33 (IL-33) is increasingly being recognized as a key immunomodulatory cytokine in many neurological diseases. METHODS:In the present study, wild-type (WT) and IL-33-/- mice received intracerebroventricular (i.c.v.) injection of lipopolysaccharide (LPS) to induce neuroinflammation. Intravital mic...

journal_title：Journal of neuroinflammation

authors： Cao K,Liao X,Lu J,Yao S,Wu F,Zhu X,Shi D,Wen S,Liu L,Zhou H

更新日期：2018-05-04 00:00:00

abstract：BACKGROUND:Systemic bacterial infections often result in enduring cognitive impairment and are a risk factor for dementia. There are currently no effective treatments for infection-induced cognitive impairment. Previous studies have shown that intermittent fasting (IF) can increase the resistance of neurons to injury a...

journal_title：Journal of neuroinflammation

authors： Vasconcelos AR,Yshii LM,Viel TA,Buck HS,Mattson MP,Scavone C,Kawamoto EM

更新日期：2014-05-06 00:00:00

abstract：BACKGROUND:Traumatic brain injury (TBI) results in long-term neurological deficits, which may be mediated in part by pro-inflammatory responses in both the injured brain and the circulation. Inflammation may be involved in the subsequent development of neurodegenerative diseases and post-injury seizures. The p75 neurot...

journal_title：Journal of neuroinflammation

authors： Lee S,Mattingly A,Lin A,Sacramento J,Mannent L,Castel MN,Canolle B,Delbary-Gossart S,Ferzaz B,Morganti JM,Rosi S,Ferguson AR,Manley GT,Bresnahan JC,Beattie MS

更新日期：2016-04-22 00:00:00

abstract：BACKGROUND:Complement activation via the lectin activation pathway (LP) has been identified as the key mechanism behind post-ischemic tissue inflammation causing ischemia-reperfusion injury (IRI) which can significantly impact the clinical outcome of ischemic disease. This work defines the contributions of each of the ...

journal_title：Journal of neuroinflammation

authors： Orsini F,Chrysanthou E,Dudler T,Cummings WJ,Takahashi M,Fujita T,Demopulos G,De Simoni MG,Schwaeble W

更新日期：2016-08-30 00:00:00

abstract：:Although neuroinflammation has been studied extensively in animal models of cerebral ischemia, their contrasting functions are still not completely understood. A major participant in neuroinflammation is microglia and microglial activation usually regulated by the chemokine CX3CL1 (fractalkine) and its receptor, CX3CR...

journal_title：Journal of neuroinflammation

authors： Briones TL,Woods J,Wadowska M

更新日期：2014-01-22 00:00:00

abstract：BACKGROUND:Pneumococcal meningitis is the most common and severe form of bacterial meningitis. Fatality rates are substantial, and long-term sequelae develop in about half of survivors. Disease outcome has been related to the severity of the pro-inflammatory response in the subarachnoid space. The complement system, wh...

journal_title：Journal of neuroinflammation

authors： Kasanmoentalib ES,Valls Seron M,Ferwerda B,Tanck MW,Zwinderman AH,Baas F,van der Ende A,Schwaeble WJ,Brouwer MC,van de Beek D

更新日期：2017-01-03 00:00:00

abstract：BACKGROUND:Immunoglobulin G (IgG) effector functions are regulated by the composition of glycans attached to a conserved N-glycosylation site in the Fc part. Intrathecal production of IgG, especially IgG1, is a hallmark of multiple sclerosis (MS), but nothing is known about IgG Fc glycosylation in MS and in cerebrospin...

journal_title：Journal of neuroinflammation

authors： Wuhrer M,Selman MH,McDonnell LA,Kümpfel T,Derfuss T,Khademi M,Olsson T,Hohlfeld R,Meinl E,Krumbholz M

更新日期：2015-12-18 00:00:00

abstract：:We report on a serum autoantibody associated with cerebellar ataxia. Immunohistochemical studies of sera from four patients referred for autoantibody testing revealed binding of high-titer (up to 1:5,000) IgG antibodies, mainly IgG1, to the molecular layer, Purkinje cell layer, and white matter on mouse, rat, porcine,...

journal_title：Journal of neuroinflammation

authors： Jarius S,Scharf M,Begemann N,Stöcker W,Probst C,Serysheva II,Nagel S,Graus F,Psimaras D,Wildemann B,Komorowski L

更新日期：2014-12-11 00:00:00

abstract：BACKGROUND:Usutu virus (USUV) is an emerging neurotropic arthropod-borne virus recently involved in massive die offs of wild birds predominantly reported in Europe. Although primarily asymptomatic or presenting mild clinical signs, humans infected by USUV can develop neuroinvasive pathologies (including encephalitis an...

journal_title：Journal of neuroinflammation

authors： Clé M,Constant O,Barthelemy J,Desmetz C,Martin MF,Lapeyre L,Cadar D,Savini G,Teodori L,Monaco F,Schmidt-Chanasit J,Saiz JC,Gonzales G,Lecollinet S,Beck C,Gosselet F,Van de Perre P,Foulongne V,Salinas S,Simonin Y

更新日期：2021-01-06 00:00:00

abstract：INTRODUCTION:We have demonstrated previously that the intravenous delivery of multipotent adult progenitor cells (MAPC) after traumatic brain injury affords neuroprotection via interaction with splenocytes, leading to an increase in systemic anti-inflammatory cytokines. We hypothesize that the observed modulation of th...

journal_title：Journal of neuroinflammation

authors： Walker PA,Bedi SS,Shah SK,Jimenez F,Xue H,Hamilton JA,Smith P,Thomas CP,Mays RW,Pati S,Cox CS Jr

更新日期：2012-09-28 00:00:00

abstract：BACKGROUND:Recent evidence suggests that exposure to intrauterine inflammation causes acute fetal brain injury and is linked to a spectrum of neurobehavioral disorders. In a rodent model of intrauterine inflammation induced by lipopolysaccharide (LPS) exposure in utero, activated microglia can be detected in the hippoc...

journal_title：Journal of neuroinflammation

authors： Kelley MH,Wu WW,Lei J,McLane M,Xie H,Hart KD,Pereira L,Burd I,Maylie J

更新日期：2017-09-05 00:00:00

abstract：BACKGROUND:The loss of locus coeruleus noradrenergic (LC/NE) neurons in the brainstem is reported in multiple neurodegenerative disorders, including Parkinson's disease (PD). However, the mechanisms remain unclear. Strong evidence suggested that microglia-mediated neuroinflammation contributes to neurodegeneration in P...

journal_title：Journal of neuroinflammation

authors： Hou L,Qu X,Qiu X,Huang R,Zhao X,Wang Q

更新日期：2020-05-06 00:00:00

abstract：BACKGROUND:Tumor necrosis factor-α (TNF-α) is an important inflammatory factor produced by activated macrophages and monocytes and plays an important role in the pathogenesis of diabetic peripheral neuropathy (DPN). To evaluate the effect of TNF-α signaling suppression and the potential of TNF-α in the treatment of DPN...

journal_title：Journal of neuroinflammation

authors： Shi X,Chen Y,Nadeem L,Xu G

更新日期：2013-06-04 00:00:00

abstract：BACKGROUND:The glutamine synthetase (GS), an astrocyte-specific enzyme, is involved in lipopolysaccharide (LPS)-induced inflammation which activates the mitogen-activated protein kinase (MAPK) signaling. Endocannabinoid 2-arachidonyl glycerol (2-AG) has been described to serve as an endogenous mediator of analgesia and...

journal_title：Journal of neuroinflammation

authors： Wang S,Zhang H,Geng B,Xie Q,Li W,Deng Y,Shi W,Pan Y,Kang X,Wang J

更新日期：2018-08-03 00:00:00