Faces of Resistance: Using Real-World Patients and Their Advocates to Teach Medical Students About Antimicrobial Stewardship.

abstract：BACKGROUND:Immune activation persists despite suppressive antiretroviral therapy (ART) in human immunodeficiency virus (HIV) infection and predicts non-Acquired Immune Deficiency Syndrome (AIDS) comorbidities including cardiovascular disease. Activated platelets play a key role in atherothrombosis and inflammation, and...

journal_title：Open forum infectious diseases

authors： O'Brien MP,Hunt PW,Kitch DW,Klingman K,Stein JH,Funderburg NT,Berger JS,Tebas P,Clagett B,Moisi D,Utay NS,Aweeka F,Aberg JA

更新日期：2017-01-19 00:00:00

abstract：Background:This study aims to estimate the disease burden of vertically acquired hepatitis C virus (HCV) in a large Midwestern hospital and to identify factors associated with HCV diagnostic testing among high-risk infants. Methods:This is a retrospective analysis of an infant cohort (n = 58 427) born from 2014 to 201...

journal_title：Open forum infectious diseases

authors： Protopapas S,Murrison LB,Wexelblatt SL,Blackard JT,Hall ES

更新日期：2019-10-21 00:00:00

abstract：:Splenic infarction is a rare complication of infectious mononucleosis. We describe 3 cases of splenic infarction attributed to infectious mononucleosis that we encountered within a 2-month period. We underscore the awareness of this potential complication of infectious mononucleosis and discuss the differential diagno...

journal_title：Open forum infectious diseases

authors： Li Y,George A,Arnaout S,Wang JP,Abraham GM

更新日期：2018-02-17 00:00:00

abstract：Background:Direct acting antiviral hepatitis C virus (HCV) therapies are highly effective but costly. Wider adoption of an 8-week ledipasvir/sofosbuvir treatment regimen could result in significant savings, but may be less efficacious compared with a 12-week regimen. We evaluated outcomes under a constrained budget and...

journal_title：Open forum infectious diseases

authors： Morgan JR,Kim AY,Naggie S,Linas BP

更新日期：2017-12-08 00:00:00

abstract：:Naegleria fowleri is a thermophilic free-living amoeba that is found in warm, fresh water and causes primary amebic meningoencephalitis (PAM). The following report demonstrates the rapid and destructive clinical features of PAM in an 8-year-old male who presented with severe headaches approximately 12 days after swimm...

journal_title：Open forum infectious diseases

authors： Vareechon C,Tarro T,Polanco C,Anand V,Pannaraj PS,Dien Bard J

更新日期：2019-07-29 00:00:00

abstract：BACKGROUND:Human immunodeficiency virus controllers (HICs) form a heterogeneous group of patients with regard to formal definitions, immunologic characteristics, and changes over time in viral load. PATIENTS AND METHODS:The HICs with undetectable viral load ([uHICs] ie, for whom a viral load had never been detected wi...

journal_title：Open forum infectious diseases

authors： Canouï E,Lécuroux C,Avettand-Fenoël V,Gousset M,Rouzioux C,Saez-Cirion A,Meyer L,Boufassa F,Lambotte O,Noël N,and the ANRS CO21 CODEX Study Group.

更新日期：2017-04-03 00:00:00

abstract：:This article provides a comprehensive review of currently available treatment options for infections due to carbapenem-resistant Enterobacteriaceae (CRE). Antimicrobial resistance in Gram-negative bacteria is an emerging and serious global public health threat. Carbapenems have been used as the "last-line" treatment f...

journal_title：Open forum infectious diseases

authors： Morrill HJ,Pogue JM,Kaye KS,LaPlante KL

更新日期：2015-05-05 00:00:00

abstract：BACKGROUND:Monitoring of immune function, measured by CD4 cell count, is an essential service for people with Human Immunodeficiency Virus (HIV). Prescription of antiretroviral (ARV) medications is contingent on CD4 cell count; patients without regular CD4 monitoring are unlikely to receive ARVs when indicated. This st...

journal_title：Open forum infectious diseases

authors： Davis AC,Watson G,Pourat N,Kominski GF,Roby DH

更新日期：2014-06-05 00:00:00

abstract：BACKGROUND:Disseminated strongyloidiasis in solid organ transplant recipients is a rare but devastating infection. In our center, we implemented a universal screening of all candidates for kidney transplantation. We assessed the seroprevalence and utility of universal screening for strongyloidiasis in our center. METH...

journal_title：Open forum infectious diseases

authors： Al-Obaidi M,Hasbun R,Vigil KJ,Edwards AR,Chavez V,Hall DR,Dar WA,De Golovine A,Ostrosky-Zeichner L,Bynon JS,Nigo M

更新日期：2019-07-01 00:00:00

abstract：:Immune suppression is a recognized risk factor for necrotizing fasciitis. In patients with hematological malignancies, a profoundly immunocompromised group, the predominant causative organisms are Gram negative. Clinical presentation and outcomes in these patients are similar to the immunocompetent. The Laboratory Ris...

journal_title：Open forum infectious diseases

authors： Foo RM,Tung ML,Poon LM,Chan D,Smitasin N,Koh LP,Chng WJ,Chai LY

更新日期：2015-06-12 00:00:00

abstract：:Using data from 3 private healthcare claims repositories, we evaluated the incidence of pneumococcal disease among adults with US Advisory Committee on Immunization Practices (ACIP) defined at-risk conditions or rheumatoid arthritis, lupus, Crohn's disease, and neuromuscular disorder/seizures and those with traditiona...

journal_title：Open forum infectious diseases

authors： Pelton SI,Shea KM,Weycker D,Farkouh RA,Strutton DR,Edelsberg J

更新日期：2015-03-20 00:00:00

abstract：Background:Short-term recurrence of positive severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) ribonucleic acid (RNA) polymerase chain reaction (PCR) in discharged coronavirus disease 2019 (COVID-19) patients attracts the public's concern. This study aimed to determine the clinical and epidemiological result...

journal_title：Open forum infectious diseases

authors： Chen SL,Xu H,Feng HY,Sun JF,Li X,Zhou L,Song WL,Huang SS,He JL,Deng YY,Wang RJ,Fang M

更新日期：2020-09-13 00:00:00

abstract：BACKGROUND:Postoperative infections are a common and often preventable complication of surgery. S. aureus is a prevalent organism cultured in these infections and is associated with morbidity, mortality, and increased healthcare utilization. However, the long-term burden of S. aureus infection in surgical patients is n...

journal_title：Open forum infectious diseases

authors： O'Brien WJ,Gupta K,Itani KMF

更新日期：2019-08-13 00:00:00

abstract：Background:New approaches are needed to provide care to persons with HIV who do not engage in conventionally organized HIV clinics. The Max Clinic in Seattle, Washington, is a walk-in, incentivized HIV care model located in a public health STD clinic that provides care in collaboration with a comprehensive HIV primary ...

journal_title：Open forum infectious diseases

authors： Dombrowski JC,Galagan SR,Ramchandani M,Dhanireddy S,Harrington RD,Moore A,Hara K,Eastment M,Golden MR

更新日期：2019-06-26 00:00:00

abstract：Background:Few studies have investigated predictors of serological response to syphilis treatment in people living with HIV (PLWH). Methods:This was a retrospective, longitudinal study on PLWH who were diagnosed with and treated for syphilis who had an assessable serological response between January 2004 and June 2016...

journal_title：Open forum infectious diseases

authors： Spagnuolo V,Poli A,Galli L,Nozza S,Bossolasco S,Cernuschi M,Maillard M,Hasson H,Gianotti N,Guffanti M,Lazzarin A,Castagna A

更新日期：2018-11-30 00:00:00

abstract：:Health-related quality of life (HRQoL) in outpatient parenteral antimicrobial therapy (OPAT) has not been well characterized in the United States. In an OPAT cohort, the short-form-12's median physical component score and mental component score were 40.3 and 54.4, respectively. HRQoL measures could be helpful in studi...

journal_title：Open forum infectious diseases

authors： Keller SC,Williams D,Levering M,Cosgrove SE

更新日期：2018-06-20 00:00:00

abstract：Background:Cutaneous leishmaniasis (CL) caused by L. braziliensis is characterized by 1 or multiple well-limited ulcerated lesions. Diabetes mellitus (DM) impairs neutrophil and monocyte function, and there is a report of vegetative lesions in a patient with both diseases in Morocco. Here we evaluate the influence of D...

journal_title：Open forum infectious diseases

authors： Lago AS,Lima FR,Carvalho AM,Sampaio C,Lago N,Guimarães LH,Lago J,Machado PRL,Carvalho LP,Arruda S,Carvalho EM

更新日期：2020-10-19 00:00:00

abstract：BACKGROUND:Avian influenza A/H5N1 has threatened human health for nearly 2 decades. Avian influenza A vaccine without adjuvant is poorly immunogenic. A flexible rapid tactic for mass vaccination will be needed if a pandemic occurs. METHODS:A multicenter, randomized, blinded phase 1 clinical trial evaluated safety and ...

journal_title：Open forum infectious diseases

authors： Mulligan MJ,Bernstein DI,Frey S,Winokur P,Rouphael N,Dickey M,Edupuganti S,Spearman P,Anderson E,Graham I,Noah DL,Mangal B,Kim S,Hill H,Whitaker J,Emery W,Beck A,Stephens K,Hartwell B,Ogilvie M,Rimann N,Osinski

更新日期：2014-11-18 00:00:00

abstract：Background:Although existing literature supports durations of 5-7 days for skin and soft tissue infections (SSTIs), longer durations are commonly used. Obesity and heart failure (HF) have been associated with increased risk for treatment failure of SSTIs; however, whether prolonged antibiotic durations reduce the risk ...

journal_title：Open forum infectious diseases

authors： Ihm C,Sutton JD,Timbrook TT,Spivak ES

更新日期：2019-05-07 00:00:00

abstract：:Background.  Practicing antimicrobial stewardship in the setting of widespread antimicrobial resistance among gram-negative bacilli, particularly in urban areas, is challenging. Methods.  We conducted a retrospective cross-sectional study at a tertiary care hospital with an established antimicrobial stewardship progra...

journal_title：Open forum infectious diseases

authors： Vora NM,Kubin CJ,Furuya EY

更新日期：2015-02-19 00:00:00

abstract：:Passive surveillance data had signaled the possibility of gastrointestinal adverse events occurring after the administration of high-dose inactivated influenza vaccine (IIV-HD). However, in a large, prospective randomized clinical trial, rates of serious gastrointestinal events were no greater among IIV-HD recipients ...

journal_title：Open forum infectious diseases

authors： Talbot HK,Dunning AJ,Robertson CA,Landolfi VA,Greenberg DP,DiazGranados CA

更新日期：2018-05-22 00:00:00

abstract：:Toxoplasma encephalitis is a well recognized complication of acquired immune deficiency syndrome, solid organ transplantation, and allogeneic hematopoietic stem cell transplantation (HSCT). However, patients with hematologic malignancies not treated with allogeneic HSCT may also develop this condition, which requires ...

journal_title：Open forum infectious diseases

authors： Morjaria S,Epstein DJ,Romero FA,Taur Y,Seo SK,Papanicolaou GA,Hatzoglou V,Rosenblum M,Perales MA,Scordo M,Kaltsas A

更新日期：2016-03-30 00:00:00

abstract：:Human immunodeficiency virus-infected women with central adiposity switched to raltegravir-based antiretroviral therapy immediately or after 24 weeks. No statistically significant changes in computed tomography-quantified visceral adipose tissue (VAT) or subcutaneous fat were observed, although 48 weeks of raltegravir...

journal_title：Open forum infectious diseases

authors： Lake JE,McComsey GA,Hulgan T,Wanke CA,Mangili A,Walmsley SL,Currier JS

更新日期：2015-04-26 00:00:00

abstract：Background:Malaria transmission through blood transfusion is an accidental but preventable cause of malaria infection and is increasingly becoming a matter of concern for blood transfusion services. This systematic review was conducted to provide a summary of evidence about the prevalence of Plasmodium infection in asy...

journal_title：Open forum infectious diseases

authors： Ahmadpour E,Foroutan-Rad M,Majidiani H,Moghaddam SM,Hatam-Nahavandi K,Hosseini SA,Rahimi MT,Barac A,Rubino S,Zarean M,Mathioudakis AG,Cevik M

更新日期：2019-06-11 00:00:00

abstract：Background:Antibiotic stewardship programs (ASPs) are required at every hospital regardless of size. We conducted a qualitative study across different hospital settings to examine perspectives of physician and pharmacist stewards about the dynamics within their team and contextual factors that facilitate the success of...

journal_title：Open forum infectious diseases

authors： Barlam TF,Childs E,Zieminski SA,Meshesha TM,Jones KE,Butler JM,Damschroder LJ,Goetz MB,Madaras-Kelly K,Reardon CM,Samore MH,Shen J,Stenehjem E,Zhang Y,Drainoni ML

更新日期：2020-06-15 00:00:00

abstract：:Methods.  In a cross-sectional substudy of the Multicenter AIDS Cohort Study, noncontrast cardiac computed tomography (CT) scanning for coronary artery calcium (CAC) scoring was performed on all men, and, for men with normal renal function, coronary CT angiography (CTA) was performed. Associations between fat depots (...

journal_title：Open forum infectious diseases

authors： Palella FJ Jr,McKibben R,Post WS,Li X,Budoff M,Kingsley L,Witt MD,Jacobson LP,Brown TT

更新日期：2016-06-16 00:00:00

abstract：:Infection secondary to rapidly growing mycobacteria (RGM) is associated with significant morbidity and mortality, especially in individuals with underlying structural lung disease or immune compromise. Such infections, particularly those caused by the Mycobacterium abscessus group, are challenging to treat due to high...

journal_title：Open forum infectious diseases

authors： McGuffin SA,Pottinger PS,Harnisch JP

更新日期：2017-07-20 00:00:00

abstract：:Ebola virus (EBOV) is a highly pathogenic filovirus that causes outbreaks of a severe hemorrhagic fever known as EBOV disease (EVD). Ebola virus disease is characterized in part by a dysregulated immune response and massive production of both pro- and anti-inflammatory cytokines. To better understand the immune respon...

journal_title：Open forum infectious diseases

authors： Banadyga L,Siragam V,Zhu W,He S,Cheng K,Qiu X

更新日期：2019-02-06 00:00:00

abstract：Background:Intestinal fatty acid binding protein (I-FABP) has been shown to be a marker of intestinal damage among people living with HIV. We hypothesized that I-FABP would be increased in chronically HIV-infected patents more than elite controllers and would relate to specific nutrient intake and body composition. Me...

journal_title：Open forum infectious diseases

authors： Cheru LT,Park EA,Saylor CF,Burdo TH,Fitch KV,Looby S,Weiner J,Robinson JA,Hubbard J,Torriani M,Lo J

更新日期：2018-11-05 00:00:00

abstract：:Suspicion of an infection without localizing signs or symptoms is a common problem. A chest x-ray (CXR) is often performed to rule out pneumonia. Our prospective cross-sectional study suggests that a CXR has no diagnostic value in patients without respiratory signs or symptoms, if a reliable medical history can be obt...

journal_title：Open forum infectious diseases

authors： de Stoppelaar SF,Pereverzeva L,Hafkamp B,Lips N,Tielbeke F,Rustenburg L,Hoogerheide-Wiegerinck C,de Heer K

更新日期：2020-06-08 00:00:00