Circulating Tumor DNA-Based Detection of Microsatellite Instability and Response to Immunotherapy in Pancreatic Cancer.


:Pancreatic cancer is an aggressive malignancy with poor survival. Research has indicated the association of few genetic aberrations with pancreatic cancer. The data regarding the prevalence of microsatellite instability in pancreatic cancer is diverse and controversial. However, it could be an actionable target in pancreatic cancer especially due to availability of immune checkpoint inhibitors which has demonstrated promising results in different types of cancers. We present a case of pancreatic cancer whose microsatellite instability status was identified on liquid biopsy (circulating tumor DNA testing). Our patient showed a dramatic ongoing durable response to immunotherapy. We were able to do serial monitoring with liquid biopsy that showed clinical utility and validity.


Front Pharmacol


Kamatham S,Shahjehan F,Kasi PM




Has Abstract


2020-02-10 00:00:00








  • The LRRC8A Mediated "Swell Activated" Chloride Conductance Is Dispensable for Vacuolar Homeostasis in Neutrophils.

    abstract::The dialysis of human and mouse neutrophils in patch clamp experiments in the conventional whole-cell mode induces the emergence of a chloride (Cl-) current that appeared to be primarily regulated by cytoplasmic ionic strength. The characteristics of this current resembled that of the classical, and ubiquitous volume-...

    journal_title:Frontiers in pharmacology

    pub_type: 杂志文章


    authors: Behe P,Foote JR,Levine AP,Platt CD,Chou J,Benavides F,Geha RS,Segal AW

    更新日期:2017-05-12 00:00:00

  • Effect of Cognitive Style on Learning and Retrieval of Navigational Environments.

    abstract::Field independence (FI) has been found to correlate with a wide range of cognitive processes requiring cognitive restructuring. Cognitive restructuring, that is going beyond the information given by the setting, is pivotal in creating stable mental representations of the environment, the so-called "cognitive maps," an...

    journal_title:Frontiers in pharmacology

    pub_type: 杂志文章


    authors: Boccia M,Vecchione F,Piccardi L,Guariglia C

    更新日期:2017-07-25 00:00:00

  • Pulmonary Rehabilitation and Asthma.

    abstract::Asthma is a chronic inflammatory disease characterized by airflow limitation and variable respiratory symptoms. It is characterized by variable symptoms such as cough, wheeze, chest tightness, and shortness of breath which vary in intensity and time. In order to reach a comprehensive approach of disease management, th...

    journal_title:Frontiers in pharmacology

    pub_type: 杂志文章,评审


    authors: Zampogna E,Zappa M,Spanevello A,Visca D

    更新日期:2020-05-06 00:00:00

  • Promises and pitfalls of a Pannexin1 transgenic mouse line.

    abstract::Gene targeting strategies have become a powerful technology for elucidating mammalian gene function. The recently generated knockout (KO)-first strategy produces a KO at the RNA processing level and also allows for the generation of conditional KO alleles by combining FLP/FRT and Cre/loxP systems, thereby providing hi...

    journal_title:Frontiers in pharmacology

    pub_type: 杂志文章


    authors: Hanstein R,Negoro H,Patel NK,Charollais A,Meda P,Spray DC,Suadicani SO,Scemes E

    更新日期:2013-05-09 00:00:00

  • Extracts From Hypericum hircinum subsp. majus Exert Antifungal Activity Against a Panel of Sensitive and Drug-Resistant Clinical Strains.

    abstract::During the last two decades incidences of fungal infections dramatically increased and the often accompanying failure of available antifungal therapies represents a substantial clinical problem. The urgent need for novel antimycotics called particular attention to the study of natural products. The genus Hypericum inc...

    journal_title:Frontiers in pharmacology

    pub_type: 杂志文章


    authors: Tocci N,Perenzoni D,Iamonico D,Fava F,Weil T,Mattivi F

    更新日期:2018-04-20 00:00:00

  • Therapeutic Effects of Wenxin Keli in Cardiovascular Diseases: An Experimental and Mechanism Overview.

    abstract::Cardiovascular diseases (CVDs) are the major public health problem and a leading cause of morbidity and mortality on a global basis. Wenxin Keli (WXKL), a formally classical Chinese patent medicine with obvious efficacy and favorable safety, plays a great role in the management of patients with CVDs. Accumulating evid...

    journal_title:Frontiers in pharmacology

    pub_type: 杂志文章,评审


    authors: Tian G,Sun Y,Liu S,Li C,Chen S,Qiu R,Zhang X,Li Y,Li M,Shang H

    更新日期:2018-09-05 00:00:00

  • Bavachin Protects Human Aortic Smooth Muscle Cells Against β-Glycerophosphate-Mediated Vascular Calcification and Apoptosis via Activation of mTOR-Dependent Autophagy and Suppression of β-Catenin Signaling.

    abstract::Vascular calcification is a major complication of cardiovascular disease and chronic renal failure. Autophagy help to maintain a stable internal and external environment that is important for modulating arteriosclerosis, but its pathogenic mechanism is far from clear. Here, we aimed to identify the bioactive compounds...

    journal_title:Frontiers in pharmacology

    pub_type: 杂志文章


    authors: He HQ,Law BYK,Zhang N,Qiu CL,Qu YQ,Wu AG,Han Y,Song Q,Zheng WL,Liu Y,He YZ,Wong VKW

    更新日期:2019-12-19 00:00:00

  • Pharmacological Characterization of Orofacial Nociception in Female Rats Following Nitroglycerin Administration.

    abstract::Rodent models of human disease can be valuable for understanding the mechanisms of a disease and for identifying novel therapies. However, it is critical that these models be vetted prior to committing resources to developing novel therapeutics. Failure to confirm the model can lead to significant losses in time and r...

    journal_title:Frontiers in pharmacology

    pub_type: 杂志文章


    authors: Caudle RM,Caudle SL,Flenor ND,Rohrs EL,Neubert JK

    更新日期:2020-12-03 00:00:00

  • Nanomaterials for Autophagy-Related miRNA-34a Delivery in Cancer Treatment.

    abstract::Autophagy is an evolutionary conserved physiological process with a fundamental role during development, differentiation, and survival of eukaryotic cells. On the other hand, autophagy dysregulation is observed in many pathological conditions, including cancer. In particular, tumor growth and progression are accompani...

    journal_title:Frontiers in pharmacology

    pub_type: 杂志文章,评审


    authors: Sharma P,Dando I,Strippoli R,Kumar S,Somoza A,Cordani M,Tafani M

    更新日期:2020-07-24 00:00:00

  • Lithraea caustic (Litre) Extract Promotes an Antitumor Response Against B16 Melanoma.

    abstract::Melanoma immunotherapy, specifically the autotransplant of dendritic cells charged with tumors antigens, has shown promising results in clinical trials. The positive clinical effects of this therapy have been associated to increased Th17 response and delayed-type hypersensitivity (DTH) against to tumor antigens. Some ...

    journal_title:Frontiers in pharmacology

    pub_type: 杂志文章


    authors: Robles-Planells C,Michelson SA,Mena J,Escrig D,Rojas JL,Sanchez-Guerrero G,Hernández R,Barrera-Avalos C,Rojo LE,Sauma D,Kalergis AM,Imarai M,Fernández R,Robles CA,Leiva-Salcedo E,Santander R,Escobar A,Acuña-Castillo C

    更新日期:2019-10-22 00:00:00

  • Rb1, the Primary Active Ingredient in Panax ginseng C.A. Meyer, Exerts Antidepressant-Like Effects via the BDNF-Trkb-CREB Pathway.

    abstract::Panax ginseng C.A. Meyer (Araliaceae), a popular tonic and dietetic herbal medicine, has been traditionally prescribed in China and other countries to treat affective disorders. The medicinal parts of ginseng, the roots and flower buds, have become increasingly popular as dietary supplements due to the current holisti...

    journal_title:Frontiers in pharmacology

    pub_type: 杂志文章


    authors: Wang G,Lei C,Tian Y,Wang Y,Zhang L,Zhang R

    更新日期:2019-09-13 00:00:00

  • Quinoxaline 1,4-di-N-Oxides: Biological Activities and Mechanisms of Actions.

    abstract::Quinoxaline 1,4-di-N-oxides (QdNOs) have manifold biological properties, including antimicrobial, antitumoral, antitrypanosomal and antiinflammatory/antioxidant activities. These diverse activities endow them broad applications and prospects in human and veterinary medicines. As QdNOs arouse widespread interest, the e...

    journal_title:Frontiers in pharmacology

    pub_type: 杂志文章,评审


    authors: Cheng G,Sa W,Cao C,Guo L,Hao H,Liu Z,Wang X,Yuan Z

    更新日期:2016-03-21 00:00:00

  • Corrigendum: Protein kinases as switches for the function of upstream stimulatory factors: implications for tissue injury and cancer.

    abstract::[This corrects the article on p. 3 in vol. 6, PMID: 25741280.]. ...

    journal_title:Frontiers in pharmacology

    pub_type: 已发布勘误


    authors: Horbach T,Götz C,Kietzmann T,Dimova EY

    更新日期:2016-04-05 00:00:00

  • Three-Dimensional Culture Promotes the Differentiation of Human Dental Pulp Mesenchymal Stem Cells Into Insulin-Producing Cells for Improving the Diabetes Therapy.

    abstract:Introduction:Diabetes is a metabolic disease with a high incidence and serious harm to human health. Islet β-cell function defects can occur in the late stage of type 1 diabetes and type 2 diabetes. Studies have shown that stem cell is a promising new approach in bioengineering regenerative medicine. In the study of st...

    journal_title:Frontiers in pharmacology

    pub_type: 杂志文章


    authors: Xu B,Fan D,Zhao Y,Li J,Wang Z,Wang J,Wang X,Guan Z,Niu B

    更新日期:2020-01-24 00:00:00

  • Metformin Modulates High Glucose-Incubated Human Umbilical Vein Endothelial Cells Proliferation and Apoptosis Through AMPK/CREB/BDNF Pathway.

    abstract::Cardiovascular disease (CVD) is a leading cause of mortality and morbidity among patients with diabetes. Endothelial dysfunction is an early physiological event in CVD. Metformin, a common oral antihyperglycemic agent, has been demonstrated to directly affect endothelial cell function. Brain-derived neurotrophic facto...

    journal_title:Frontiers in pharmacology

    pub_type: 杂志文章


    authors: Han X,Wang B,Sun Y,Huang J,Wang X,Ma W,Zhu Y,Xu R,Jin H,Liu N

    更新日期:2018-11-06 00:00:00

  • Non-Targeted Metabolomic Profiling of Coronary Heart Disease Patients With Taohong Siwu Decoction Treatment.

    abstract::Traditional Chinese medicine is one of the complementary and alternative therapies to improve the prognosis of coronary heart disease (CHD). Taohong Siwu Decoction (THSWD), a classical traditional Chinese medication that promotes blood circulation, is clinically beneficial in CHD. However, the underlying mechanism of ...

    journal_title:Frontiers in pharmacology

    pub_type: 杂志文章


    authors: Tao T,He T,Mao H,Wu X,Liu X

    更新日期:2020-05-08 00:00:00

  • Danhong Injection Protects Hemorrhagic Brain by Increasing Peroxiredoxin 1 in Aged Rats.

    abstract::Intracerebral hemorrhage (ICH) is a severe cerebrovascular disease with a high incidence, mortality and disability rate. Danhong injection (DHI) is beneficial for ischemic stroke, but is prohibited for ICH due to risk of bleeding. The present study aims to explore the potential therapeutic time window and molecular me...

    journal_title:Frontiers in pharmacology

    pub_type: 杂志文章


    authors: Wang S,Yu L,Sun G,Liu Y,Hu W,Liu Y,Peng T,Wang X,Cheng J,Sr A,Qin B,Lu H

    更新日期:2020-03-25 00:00:00

  • Fructus mume Extracts Alleviate Diarrhea in Breast Cancer Patients Receiving the Combination Therapy of Lapatinib and Capecitabine.

    abstract::Lapatinib and capecitabine have been widely used in the therapy of breast cancer. However, long-term use of lapatinib and capecitabine often causes the most common side effect diarrhea, which limit the medicine use. Fructus mume (F. mume) has been proved to be effective to treat chronic diarrhea with few side effects....

    journal_title:Frontiers in pharmacology

    pub_type: 杂志文章


    authors: Xing H,Zhang L,Ma J,Liu Z,Song C,Liu Y

    更新日期:2018-05-23 00:00:00

  • Serum Testosterone and Cortisol Concentrations After Single-Dose Administration of 100-Mg Transdermal Testosterone in Healthy Men.

    abstract::The growing interest in testosterone's effects on men's social behaviors, in particular aggressive, risk-taking, or status maintenance behaviors, is accompanied by a paucity of dose-dependent pharmacokinetic data. Examining the neurophysiological effects of transdermal testosterone typically includes a 4h delay before...

    journal_title:Frontiers in pharmacology

    pub_type: 杂志文章


    authors: Puiu AA,Radke S,Votinov M,Habel U,Herpertz-Dahlmann B,Turetsky B,Konrad K

    更新日期:2019-11-21 00:00:00

  • Dual Behavior of Long-Chain Fatty Acids and Their Cyclooxygenase/Lipoxygenase Metabolites on Human Intestinal Caco-2 Cell Growth.

    abstract::Etiology of colorectal cancer (CRC) is related, at least in part, with nutritional profile and epidemiological data indicating a key role of dietary fat on CRC pathogenesis. Moreover, inflammation and eicosanoids produced from arachidonic acid might have a pivotal role in CRC development. However, the effect of specif...

    journal_title:Frontiers in pharmacology

    pub_type: 杂志文章


    authors: Storniolo CE,Cabral M,Busquets MA,Martín-Venegas R,Moreno JJ

    更新日期:2020-09-04 00:00:00

  • Identification of Epigallocatechin-3- Gallate as an Inhibitor of Phosphoglycerate Mutase 1.

    abstract::Targeting metabolic enzymes is believed to provide new therapeutic opportunities for cancer therapy. Phosphoglycerate mutase 1 (PGAM1) is a glycolytic enzyme that importantly coordinates glycolysis, pentose phosphate pathway (PPP) flux and serine biosynthesis in cancer cells and hence gains increasing interest of inhi...

    journal_title:Frontiers in pharmacology

    pub_type: 杂志文章


    authors: Li X,Tang S,Wang QQ,Leung EL,Jin H,Huang Y,Liu J,Geng M,Huang M,Yuan S,Yao XJ,Ding J

    更新日期:2017-05-30 00:00:00

  • Trends in qualifying biomarkers in drug safety. Consensus of the 2011 meeting of the spanish society of clinical pharmacology.

    abstract::In this paper we discuss the consensus view on the use of qualifying biomarkers in drug safety, raised within the frame of the XXIV meeting of the Spanish Society of Clinical Pharmacology held in Málaga (Spain) in October, 2011. The widespread use of biomarkers as surrogate endpoints is a goal that scientists have lon...

    journal_title:Frontiers in pharmacology

    pub_type: 杂志文章


    authors: Agúndez JA,Del Barrio J,Padró T,Stephens C,Farré M,Andrade RJ,Badimon L,García-Martín E,Vilahur G,Lucena MI

    更新日期:2012-01-19 00:00:00

  • Evolutionary Trends in RNA Base Selectivity Within the RNase A Superfamily.

    abstract::There is a growing interest in the pharmaceutical industry to design novel tailored drugs for RNA targeting. The vertebrate-specific RNase A superfamily is nowadays one of the best characterized family of enzymes and comprises proteins involved in host defense with specific cytotoxic and immune-modulatory properties. ...

    journal_title:Frontiers in pharmacology

    pub_type: 杂志文章


    authors: Prats-Ejarque G,Lu L,Salazar VA,Moussaoui M,Boix E

    更新日期:2019-10-09 00:00:00

  • Parecoxib Shortens the Duration of Acute Postoperative Pain After Laparoscopic-Assisted Vaginal Hysterectomy.

    abstract::The effect of parecoxib sodium on the duration and severity of acute postoperative pain after laparoscopic-assisted vaginal hysterectomy has been inadequately studied. This randomized, controlled trial compared the effects of parecoxib, methylprednisolone, and placebo on the duration of acute postoperative pain after ...

    journal_title:Frontiers in pharmacology

    pub_type: 杂志文章


    authors: Yang S,Xiao W,Wang S,Meng L,Zhou L,Wan A,Liu Y,Feng S,Wang T

    更新日期:2019-06-18 00:00:00

  • β-Sheet Breaker Peptide-HPYD for the Treatment of Alzheimer's Disease: Primary Studies on Behavioral Test and Transcriptional Profiling.

    abstract::Background: Alzheimer's disease (AD), is a progressive neurodegenerative disease that is characterized by cognitive loss. Most researchers believe that aggregation and accumulation of β-amyloid peptides (Aβ) in brain cells are the central pathological hallmark of this disease. Methods: Based on the amyloid hypothesis,...

    journal_title:Frontiers in pharmacology

    pub_type: 杂志文章


    authors: Liu W,Sun F,Wan M,Jiang F,Bo X,Lin L,Tang H,Xu S

    更新日期:2018-01-08 00:00:00

  • Advanced Therapy Medicinal Products and Exemptions to the Regulation 1394/2007: How Confident Can We be? An Exploratory Analysis.

    abstract::The market authorization procedure for medicinal products for human use is relying on their demonstrated efficacy, safety, and pharmaceutical quality. This applies to all medicinal products whether of chemical or biological origin. Since October 2009, the first advanced therapy medicinal product (ATMP) has been author...

    journal_title:Frontiers in pharmacology

    pub_type: 杂志文章


    authors: Van Wilder P

    更新日期:2012-02-14 00:00:00

  • Conditioned Serum Enhances the Chondrogenic and Immunomodulatory Behavior of Mesenchymal Stem Cells.

    abstract::Osteoarthritis is one of the most common chronic health conditions associated with pain and disability. Advanced therapies based on mesenchymal stem cells have become valuable options for the treatment of these pathologies. Conditioned serum (CS, "Orthokine") has been used intra-articularly for osteoarthritic patients...

    journal_title:Frontiers in pharmacology

    pub_type: 杂志文章


    authors: Blázquez R,Sánchez-Margallo FM,Reinecke J,Álvarez V,López E,Marinaro F,Casado JG

    更新日期:2019-06-28 00:00:00

  • Safety of Anticancer Agents Used in Children: A Focus on Their Off-Label Use Through Data From the Spontaneous Reporting System.

    abstract:Background:Among factors influencing the higher risk of developing unknown or rare adverse drug reactions (ADRs) among children and adolescents, there is the frequent off-label use of drugs that seems to be very common in pediatric oncological patients. Our study aim to collect and evaluate data on the safety profile o...

    journal_title:Frontiers in pharmacology

    pub_type: 杂志文章


    authors: Mascolo A,Scavone C,Bertini M,Brusco S,Punzo F,Pota E,Di Martino M,Di Pinto D,Rossi F

    更新日期:2020-05-07 00:00:00

  • The Trials and Tribulations of Structure Assisted Design of KCa Channel Activators.

    abstract::Calcium-activated K+ channels constitute attractive targets for the treatment of neurological and cardiovascular diseases. To explain why certain 2-aminobenzothiazole/oxazole-type KCa activators (SKAs) are KCa3.1 selective we previously generated homology models of the C-terminal calmodulin-binding domain (CaM-BD) of ...

    journal_title:Frontiers in pharmacology

    pub_type: 杂志文章


    authors: Shim H,Brown BM,Singh L,Singh V,Fettinger JC,Yarov-Yarovoy V,Wulff H

    更新日期:2019-09-20 00:00:00

  • New Routes in GPCR/β-Arrestin-Driven Signaling in Cancer Progression and Metastasis.

    abstract::Tumor cells acquire invasive and metastatic behavior by sensing changes in the localization and activation of signaling pathways, which in turn determine changes in actin cytoskeleton. The core-scaffold machinery associated to β-arrestin (β-arr) is a key mechanism of G-protein coupled receptors (GPCR) to achieve spati...

    journal_title:Frontiers in pharmacology

    pub_type: 杂志文章,评审


    authors: Bagnato A,Rosanò L

    更新日期:2019-02-19 00:00:00