Neural networks and the anti-inflammatory effect of transcutaneous auricular vagus nerve stimulation in depression.

abstract：BACKGROUND:Plasminogen activation is a ubiquitous source of fibrinolytic and proteolytic activity. Besides its role in prevention of thrombosis, plasminogen is involved in inflammatory reactions in the central nervous system. Plasminogen has been detected in the cerebrospinal fluid (CSF) of patients with inflammatory d...

journal_title：Journal of neuroinflammation

authors： Mezzapesa A,Orset C,Plawinski L,Doeuvre L,Martinez de Lizarrondo S,Chimienti G,Vivien D,Mansour A,Matà S,Pepe G,Anglés-Cano E

更新日期：2014-09-16 00:00:00

abstract：BACKGROUND:Recent evidence has suggested that peripheral inflammatory responses induced by lipopolysaccharides (LPS) play an important role in neuropsychiatric dysfunction in rodents. Interleukin-1β (IL-1β), a pro-inflammatory cytokine, has been proposed to be a key mediator in a variety of behavioral dysfunction induc...

journal_title：Journal of neuroinflammation

authors： Li M,Li C,Yu H,Cai X,Shen X,Sun X,Wang J,Zhang Y,Wang C

更新日期：2017-09-20 00:00:00

abstract：BACKGROUND:Brain inflammation including increases in inflammatory cytokines such as IL-1β is widely believed to contribute to the pathophysiology of Alzheimer's disease. Although IL-1β-induced impairments in long-term potentiation (LTP) in acute hippocampal slices and memory functions in vivo have been well documented,...

journal_title：Journal of neuroinflammation

authors： Tong L,Prieto GA,Cotman CW

更新日期：2018-04-30 00:00:00

abstract：BACKGROUND:Kainic acid (KA)-induced status epilepticus (SE) was involved with release of free radicals. Sesamin is a well-known antioxidant from sesame seeds and it scavenges free radicals in several brain injury models. However the neuroprotective mechanism of sesamin to KA-induced seizure has not been studied. METHO...

journal_title：Journal of neuroinflammation

authors： Hsieh PF,Hou CW,Yao PW,Wu SP,Peng YF,Shen ML,Lin CH,Chao YY,Chang MH,Jeng KC

更新日期：2011-05-24 00:00:00

abstract：BACKGROUND:The effectiveness of ginseng in preventing and treating various central nervous system (CNS) diseases has been widely confirmed. However, ginsenosides, the principal components of ginseng, are characterized by poor accessibility to the brain, and this pharmacokinetic-pharmacological paradox remains poorly ex...

journal_title：Journal of neuroinflammation

authors： Kang A,Hao H,Zheng X,Liang Y,Xie Y,Xie T,Dai C,Zhao Q,Wu X,Xie L,Wang G

更新日期：2011-08-16 00:00:00

abstract：BACKGROUND:Noradrenaline (NA) is known to limit neuroinflammation. However, the previously described induction by NA of a chemokine involved in the progression of immune/inflammatory processes, such as chemokine (C-C motif) ligand 2 (CCL2)/monocyte chemotactic protein-1 (MCP-1), apparently contradicts NA anti-inflammat...

journal_title：Journal of neuroinflammation

authors： Hinojosa AE,Caso JR,García-Bueno B,Leza JC,Madrigal JL

更新日期：2013-07-09 00:00:00

abstract：:BACKGROUND: Twitcher mouse (twi/twi) is an authentic murine model of Krabbe's disease. Accumulation of psychosine, resulting in apoptosis of oligodendrocytes and subsequent demyelination, is a cardinal event to the pathogenesis of this disease. Moreover, recruitment of inflammatory cells plays a significant role in th...

journal_title：Journal of neuroinflammation

authors： Kagitani-Shimono K,Mohri I,Fujitani Y,Suzuki K,Ozono K,Urade Y,Taniike M

更新日期：2005-04-06 00:00:00

abstract：BACKGROUND:Ischemic stroke is a main cause of mortality. Blood-brain barrier (BBB) breakdown appears to play a critical role in inflammation in patients with ischemic stroke and acceleration of brain injury. The BBB has a protective function and is composed of endothelial cells, pericytes, and astrocytes. In ischemic s...

journal_title：Journal of neuroinflammation

authors： Kim Y,Lee S,Zhang H,Lee S,Kim H,Kim Y,Won MH,Kim YM,Kwon YG

更新日期：2020-02-04 00:00:00

abstract：BACKGROUND:Interleukin-17A (IL-17A) is the founding member of a novel family of inflammatory cytokines that plays a critical role in the pathogenesis of many autoimmune diseases, including multiple sclerosis (MS) and its animal model, experimental autoimmune encephalomyelitis (EAE). IL-17A signals through its receptor,...

journal_title：Journal of neuroinflammation

authors： Das Sarma J,Ciric B,Marek R,Sadhukhan S,Caruso ML,Shafagh J,Fitzgerald DC,Shindler KS,Rostami A

更新日期：2009-04-28 00:00:00

abstract：BACKGROUND:Microglia and astrocytes respond to homeostatic disturbances with profound changes of gene expression. This response, known as glial activation or neuroinflammation, can be detrimental to the surrounding tissue. The transcription factor CCAAT/enhancer binding protein β (C/EBPβ) is an important regulator of g...

journal_title：Journal of neuroinflammation

authors： Straccia M,Gresa-Arribas N,Dentesano G,Ejarque-Ortiz A,Tusell JM,Serratosa J,Solà C,Saura J

更新日期：2011-11-10 00:00:00

abstract：BACKGROUND:CD8+ T lymphocytes are critical mediators of neuroinflammatory diseases. Understanding the mechanisms that govern the function of this T cell population is crucial to better understanding central nervous system autoimmune disease pathology. We recently identified a novel population of highly cytotoxic c-Met-...

journal_title：Journal of neuroinflammation

authors： Benkhoucha M,Senoner I,Lalive PH

更新日期：2020-02-19 00:00:00

abstract：BACKGROUND:Increasing evidence supports a key role for inflammation in the neurodegenerative process of familial amyloidotic polyneuropathy (FAP). While there seems to be an overactivation of the neuronal interleukin-1 signaling pathway, the immune response is apparently compromised in FAP. Accordingly, little immune c...

journal_title：Journal of neuroinflammation

authors： Gonçalves NP,Moreira J,Martins D,Vieira P,Obici L,Merlini G,Saraiva M,Saraiva MJ

更新日期：2017-06-06 00:00:00

abstract：BACKGROUND:Mural cells synthesize and deposit laminin to the basement membrane. To investigate the function of mural cell-derived laminin, we generated a mutant mouse line lacking mural cell-derived laminin (termed PKO). In a previous study, we showed that the PKO mice were grossly normal under homeostatic condition, b...

journal_title：Journal of neuroinflammation

authors： Gautam J,Xu L,Nirwane A,Nguyen B,Yao Y

更新日期：2020-04-06 00:00:00

abstract：BACKGROUND:Traumatic brain injury (TBI) is a major cause of death and disability in the USA and the world; it constitutes 30% of injury-related deaths (Taylor et al., MMWR Surveill Summ 66:1-16, 2017). Contact sports athletes often experience repetitive TBI (rTBI), which exerts a cumulative effect later in life. Visual...

journal_title：Journal of neuroinflammation

authors： Das M,Tang X,Han JY,Mayilsamy K,Foran E,Biswal MR,Tzekov R,Mohapatra SS,Mohapatra S

更新日期：2019-05-31 00:00:00

abstract：BACKGROUND:Glycine is the smallest nonessential amino acid and has previously unrecognized neurotherapeutic effects. In this study, we examined the mechanism underlying the neuroprotective effect of glycine (Gly) against neuroapoptosis, neuroinflammation, synaptic dysfunction, and memory impairment resulting from D-gal...

journal_title：Journal of neuroinflammation

authors： Ullah R,Jo MH,Riaz M,Alam SI,Saeed K,Ali W,Rehman IU,Ikram M,Kim MO

更新日期：2020-10-15 00:00:00

abstract：BACKGROUND:Streptococcus pneumoniae meningitis is a serious inflammatory disease of the central nervous system (CNS) and is associated with high morbidity and mortality rates. The inflammatory processes initiated by recognition of bacterial components contribute to apoptosis in the hippocampal dentate gyrus. Brain-deri...

journal_title：Journal of neuroinflammation

authors： Xu D,Lian D,Wu J,Liu Y,Zhu M,Sun J,He D,Li L

更新日期：2017-08-04 00:00:00

abstract：BACKGROUND:Mer tyrosine kinase (MerTK) activity necessary for amyloid-stimulated phagocytosis strongly implicates that MerTK dysregulation might contribute to chronic inflammation implicated in Alzheimer's disease (AD) pathology. However, the precise mechanism involved in the regulation of MerTK expression by amyloid-β...

journal_title：Journal of neuroinflammation

authors： Jhang KA,Park JS,Kim HS,Chong YH

更新日期：2018-03-12 00:00:00

abstract：:Multiple sclerosis (MS) is thought to be a CD4+ T cell mediated autoimmune demyelinating disease of the central nervous system (CNS) that is rarely diagnosed during infancy. Cellular and molecular mechanisms that confer disease resistance in this age group are unknown. We tested the hypothesis that a differential comp...

journal_title：Journal of neuroinflammation

authors： Cravens PD,Kieseier BC,Hussain R,Herndon E,Arellano B,Ben LH,Timmons BC,Castro-Rojas C,Hartung HP,Hemmer B,Weber MS,Zamvil SS,Stüve O

更新日期：2013-05-24 00:00:00

abstract：BACKGROUND:Multiple sclerosis (MS) is an immune-mediated demyelinated disease of the central nervous system. Activation of microglia is involved in the pathogenesis of myelin loss. OBJECTIVE:This study is focused on the role of Hv1 in regulating demyelination and microglial activation through reactive oxygen species (...

journal_title：Journal of neuroinflammation

authors： Chen M,Yang LL,Hu ZW,Qin C,Zhou LQ,Duan YL,Bosco DB,Wu LJ,Zhan KB,Xu SB,Tian DS

更新日期：2020-11-06 00:00:00

abstract：BACKGROUND:Brain circulation disorders such as chronic cerebral hypoperfusion have been associated with a decline in cognitive function during the development of dementia. Astrocytes together with microglia participate in the immune response in the CNS and make them potential sentinels in the brain parenchyma. In addit...

journal_title：Journal of neuroinflammation

authors： Leardini-Tristão M,Andrade G,Garcia C,Reis PA,Lourenço M,Moreira ETS,Lima FRS,Castro-Faria-Neto HC,Tibirica E,Estato V

更新日期：2020-04-16 00:00:00

abstract：BACKGROUND:HIV-associated neuroinflammation is believed to be a major contributing factor in the development of HIV-associated neurocognitive disorders (HAND). In this study, we used micropositron emission tomography (PET) imaging to quantify neuroinflammation in HIV-1 transgenic rat (Tg), a small animal model of HIV, ...

journal_title：Journal of neuroinflammation

authors： Lee DE,Yue X,Ibrahim WG,Lentz MR,Peterson KL,Jagoda EM,Kassiou M,Maric D,Reid WC,Hammoud DA

更新日期：2015-09-17 00:00:00

abstract：AIM:Pre-clinical studies in models of multiple sclerosis and other inflammatory disorders suggest that high-salt diet may induce activation of the immune system and potentiate inflammation. However, high-salt diet constitutes a common non-pharmacological intervention to treat autonomic problems in synucleinopathies suc...

journal_title：Journal of neuroinflammation

authors： Heras-Garvin A,Refolo V,Reindl M,Wenning GK,Stefanova N

更新日期：2020-01-24 00:00:00

abstract：BACKGROUND:Administration of exogenous interferon-γ (IFNγ) aggravates the symptoms of multiple sclerosis (MS), whereas interferon-β (IFNβ) is used for treatment of MS patients. We previously demonstrated that IFNγ induces apoptosis of oligodendroglial progenitor cells (OPCs), suggesting that IFNγ is more toxic to OPCs ...

journal_title：Journal of neuroinflammation

authors： Horiuchi M,Itoh A,Pleasure D,Ozato K,Itoh T

更新日期：2011-01-24 00:00:00

abstract：BACKGROUND:Diabetic neuropathy (DN) is a frequent and debilitating manifestation of diabetes mellitus, to which there are no effective therapeutic approaches. Mesenchymal stem/stromal cells (MSC) have a great potential for the treatment of this syndrome, possibly through regenerative actions on peripheral nerves. Here,...

journal_title：Journal of neuroinflammation

authors： Evangelista AF,Vannier-Santos MA,de Assis Silva GS,Silva DN,Juiz PJL,Nonaka CKV,Dos Santos RR,Soares MBP,Villarreal CF

更新日期：2018-06-22 00:00:00

abstract：BACKGROUND:Previous studies have suggested that peroxisome proliferator activated receptor-gamma (PPAR-gamma)-mediated neuroprotection involves inhibition of microglial activation and decreased expression and activity of inducible nitric oxide synthase (iNOS); however, the underlying molecular mechanisms have not yet b...

journal_title：Journal of neuroinflammation

authors： Xing B,Xin T,Hunter RL,Bing G

更新日期：2008-01-18 00:00:00

abstract：OBJECTIVES:The neurological basis for autism is still not fully understood, and the role of the interaction between neuro-inflammation and neurotransmission impairment needs to be clearer. This study aims to test the possible association between impaired levels of gamma aminobutyric acid (GABA), serotonin, dopamine, ox...

journal_title：Journal of neuroinflammation

authors： Alabdali A,Al-Ayadhi L,El-Ansary A

更新日期：2014-01-08 00:00:00

abstract：BACKGROUND:Demyelination and remyelination are common pathological processes in many neurological disorders, including multiple sclerosis (MS). Clinical evidence suggests extensive involvement of the thalamocortical (TC) system in patients suffering from MS. METHODS:Using murine brain slices of the primary auditory co...

journal_title：Journal of neuroinflammation

authors： Ghaffarian N,Mesgari M,Cerina M,Göbel K,Budde T,Speckmann EJ,Meuth SG,Gorji A

更新日期：2016-06-22 00:00:00

abstract：BACKGROUND:Components of the innate immune complement system have been implicated in the pathogenesis of amyotrophic lateral sclerosis (ALS) specifically using hSOD1 transgenic animals; however, a comprehensive examination of complement expression in other transgenic ALS models has not been performed. This study theref...

journal_title：Journal of neuroinflammation

authors： Lee JD,Levin SC,Willis EF,Li R,Woodruff TM,Noakes PG

更新日期：2018-06-01 00:00:00

abstract：BACKGROUND:S100A9 protein (myeloid-related protein MRP14, also referred to as calgranulin B) is a reliable marker of inflammation, an important proinflammatory factor of innate immunity and acts as an additional antimicrobial peptide in the innate immune system. Evidence indicates that S100A9 contributes to Alzheimer's...

journal_title：Journal of neuroinflammation

authors： Lee EO,Yang JH,Chang KA,Suh YH,Chong YH

更新日期：2013-05-30 00:00:00

abstract：BACKGROUND:Leukocytes are believed to be involved in delayed cell death following traumatic brain injury (TBI). However, data demonstrating that blood-borne inflammatory cells are present in the injured brain prior to the onset of secondary brain damage have been inconclusive. We therefore investigated both the interac...

journal_title：Journal of neuroinflammation

authors： Schwarzmaier SM,Zimmermann R,McGarry NB,Trabold R,Kim SW,Plesnila N

更新日期：2013-02-28 00:00:00