Brain Structural and Functional Imaging Findings in Medication-Overuse Headache.

Abstract:

:This chapter overviews research neuroimaging findings of patients with medication-overuse headache (MOH). Results indicate; (i) correlations between neuropathology and medication-overuse; (ii) changes in brain morphology and cortical function; and (iii) brain recovery subsequent to withdrawal of medication that was overused. Results of this narrative review indicate exacerbated brain structural and functional changes in regions of the pain-matrix and in regions of the mesocortical-limbic circuit in patients with MOH compared to patients with migraine or compared to healthy controls. Modification of brain morphology as well as an association between brain recovery and medication withdrawal suggest that the MOH disease process involves state (brain modification) and trait-like (brain adaptation and recovery) neuromechanisms.

journal_name

Front Neurol

journal_title

Frontiers in neurology

authors

Chong CD

doi

10.3389/fneur.2019.01336

subject

Has Abstract

pub_date

2020-01-28 00:00:00

pages

1336

issn

1664-2295

journal_volume

10

pub_type

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