Role of Tumor-Mediated Dendritic Cell Tolerization in Immune Evasion.

abstract：:The efficacy of allogeneic hematopoietic stem cell transplantation (HSCT) is challenged by acute and chronic graft-versus-host disease (aGVHD and cGVHD) and viral infections due to long-lasting immunodeficiency. Interleukin-7 (IL-7) is a cytokine essential for de novo T cell generation in thymus and peripheral T cell ...

journal_title：Frontiers in immunology

authors： Kielsen K,Enevold C,Heilmann C,Sengeløv H,Pedersen AE,Ryder LP,Müller K

更新日期：2018-02-02 00:00:00

abstract：:Increasing studies have highlighted the effects of the tumor immune micro-environment (TIM) on colon cancer (CC) tumorigenesis, prognosis, and metastasis. However, there is no reliable molecular marker that can effectively estimate the immune infiltration and predict the CC relapse risk. Here, we leveraged the gene ex...

journal_title：Frontiers in immunology

authors： Li X,Wen D,Li X,Yao C,Chong W,Chen H

更新日期：2020-09-03 00:00:00

abstract：:Recognition of cancer antigens drives the clonal expansion of cancer-reactive T cells, which is thought to contribute to restricted T-cell receptor (TCR) repertoires in tumor-infiltrating lymphocytes (TILs). To understand how tumors escape anti-tumor immunity, we investigated tumor-associated T-cell repertoires of pat...

journal_title：Frontiers in immunology

authors： Arakawa A,Vollmer S,Tietze J,Galinski A,Heppt MV,Bürdek M,Berking C,Prinz JC

更新日期：2019-06-18 00:00:00

abstract：:Many current vaccines are less immunogenic and less effective in elderly compared to younger adults due to age-related changes of the immune system. Most vaccines utilized in the elderly contain antigens, which the target population has had previous contact with due to previous vaccination or infection. Therefore, mos...

journal_title：Frontiers in immunology

authors： Weinberger B,Haks MC,de Paus RA,Ottenhoff THM,Bauer T,Grubeck-Loebenstein B

更新日期：2018-05-15 00:00:00

abstract：:A process is a function of time; in immunometabolism, this is reflected by the stepwise adaptation of metabolism to sustain the bio-energetic demand of an immune-response in its various states and shades. This perspective article starts by presenting an early attempt to investigate the physiology of inflammation, in o...

journal_title：Frontiers in immunology

authors： Nagy C,Haschemi A

更新日期：2015-04-08 00:00:00

abstract：:Eosinophils are an enigmatic white blood cell, whose immune functions are still under intense investigation. Classically, the eosinophil was considered to fulfill a protective role against parasitic infections, primarily large multicellular helminths. Although eosinophils are predominantly associated with parasite inf...

journal_title：Frontiers in immunology

authors： Mukherjee M,Lacy P,Ueki S

更新日期：2018-11-26 00:00:00

abstract：:Cysteine cathepsins are key regulators of the innate and adaptive arms of the immune system. Their expression, activity, and subcellular localization are associated with the distinct development and differentiation stages of immune cells. They promote the activation of innate myeloid immune cells since they contribute...

journal_title：Frontiers in immunology

authors： Jakoš T,Pišlar A,Jewett A,Kos J

更新日期：2019-08-28 00:00:00

abstract：:The immunopathological functions associated with human C1q are still growing in terms of novelty, diversity, and pathologic relevance. It is, therefore, not surprising that C1q is being recognized as an important molecular bridge between innate and adaptive immunity. The secret of this functional diversity, in turn, r...

journal_title：Frontiers in immunology

authors： Ghebrehiwet B,Kandov E,Kishore U,Peerschke EIB

更新日期：2018-02-05 00:00:00

abstract：:[This corrects the article DOI: 10.3389/fimmu.2019.00684.]. ...

journal_title：Frontiers in immunology

authors： Kaufmann SHE

更新日期：2019-06-06 00:00:00

abstract：:Tissue macrophages play a crucial role in the maintenance of tissue homeostasis and also contribute to inflammatory and reparatory responses during pathogenic infection and tissue injury. The high heterogeneity of these macrophages is consistent with their adaptation to distinct tissue environments and specialization ...

journal_title：Frontiers in immunology

authors： Cassado Ados A,D'Império Lima MR,Bortoluci KR

更新日期：2015-05-19 00:00:00

abstract：:People are constantly exposed to airborne fungal spores, including Aspergillus fumigatus conidia that can cause life-threatening conditions in immunocompromised patients or acute exacerbations in allergics. However, immunocompetent hosts do not exhibit mycoses or systemic inflammation, due to the sufficient but not ex...

journal_title：Frontiers in immunology

authors： Bogorodskiy AO,Bolkhovitina EL,Gensch T,Troyanova NI,Mishin AV,Okhrimenko IS,Braun A,Spies E,Gordeliy VI,Sapozhnikov AM,Borshchevskiy VI,Shevchenko MA

更新日期：2020-02-25 00:00:00

abstract：:Nephritic factors comprise a heterogeneous group of autoantibodies against neoepitopes generated in the C3 and C5 convertases of the complement system, causing its dysregulation. Classification of these autoantibodies can be clustered according to their stabilization of different convertases either from the classical ...

journal_title：Frontiers in immunology

authors： Corvillo F,Okrój M,Nozal P,Melgosa M,Sánchez-Corral P,López-Trascasa M

更新日期：2019-04-24 00:00:00

abstract：:Our immune system bears the tremendous task of mounting effective anti-microbial responses whilst maintaining immunoregulatory functions to avoid autoimmunity. In order to quickly respond to pathogens, Dendritic cells (DC) are armed with pattern recognition receptors (PRRs), allowing them to recognize highly conserved...

journal_title：Frontiers in immunology

authors： Ng D,Gommerman JL

更新日期：2013-04-22 00:00:00

abstract：:Elimination of potential self-reactive T cells in the thymus is crucial for preventing the onset of autoimmune diseases. Epithelial cell subsets localized in thymic medulla [medullary thymic epithelial cells (mTECs)] contribute to this process by supplying a wide range of self-antigens that are otherwise expressed in ...

journal_title：Frontiers in immunology

authors： Akiyama T,Shinzawa M,Qin J,Akiyama N

更新日期：2013-08-26 00:00:00

abstract：:Allogeneic hematopoietic stem cell transplantation (allo-HSCT) is an important treatment for many types of hematological malignancies. Matching of donor and recipient for the major histocompatibility complex (MHC) improves the HSCT reconstitution, but donor-derived T cells reactive to non-MHC encoded minor histocompat...

journal_title：Frontiers in immunology

authors： Choi EY,Choi K,Nam G,Kim W,Chung M

更新日期：2020-06-10 00:00:00

abstract：:Inflammation is a common characteristic of chronic liver disease (CLD). Inflammasomes are multiprotein complexes that can sense and recognize various exogenous and endogenous danger signals, eventually activating interleukin (IL)-1β and IL-18. The sensor component of the inflammasome system is a nucleotide-binding oli...

journal_title：Frontiers in immunology

authors： Wu X,Dong L,Lin X,Li J

更新日期：2017-12-12 00:00:00

abstract：:Transcriptome profiling approaches have been widely used to investigate the mechanisms underlying psoriasis pathogenesis. Most researchers have measured changes in transcript abundance in skin biopsies; relatively few have examined transcriptome changes in the blood. Although less relevant to the study of psoriasis pa...

journal_title：Frontiers in immunology

authors： Rawat A,Rinchai D,Toufiq M,Marr AK,Kino T,Garand M,Tatari-Calderone Z,Kabeer BSA,Krishnamoorthy N,Bedognetti D,Karim MY,Sastry KS,Chaussabel D

更新日期：2020-11-24 00:00:00

abstract：:Galectins, a family of animal lectins, play central roles in immune system regulation, shaping both innate and adaptive responses in physiological and pathological processes. These include rheumatoid arthritis (RA), a chronic multifactorial autoimmune disease characterized by inflammatory responses that affects both a...

journal_title：Frontiers in immunology

authors： Mendez-Huergo SP,Hockl PF,Stupirski JC,Maller SM,Morosi LG,Pinto NA,Berón AM,Musuruana JL,Nasswetter GG,Cavallasca JA,Rabinovich GA

更新日期：2019-01-09 00:00:00

abstract：:Moraxella catarrhalis is a human-specific commensal of the respiratory tract and an opportunistic pathogen. It is one of the leading cause of otitis media in children and of acute exacerbations in patients with chronic obstructive pulmonary disease, resulting in significant morbidity and economic burden. Vaccines and ...

journal_title：Frontiers in immunology

authors： Laabei M,Colineau L,Bettoni S,Maziarz K,Ermert D,Riesbeck K,Ram S,Blom AM

更新日期：2020-09-02 00:00:00

abstract：:Gamma-delta (γδ) T cells are a subset of T cells that promote the inflammatory responses of lymphoid and myeloid lineages, and are especially vital to the initial inflammatory and immune responses. Given the capability to connect crux inflammations of adaptive and innate immunity, γδ T cells are responsive to multiple...

journal_title：Frontiers in immunology

authors： Wo J,Zhang F,Li Z,Sun C,Zhang W,Sun G

更新日期：2020-10-23 00:00:00

abstract：:Cytosolic DNA fragments are recognized as pathogen- and danger-associated molecular patterns that induce a cascade of innate immune responses. Moreover, excessive cytosolic DNA can enhance chronic inflammation, predominantly by activating inflammasomes, and thereby contributing to the pathogenesis of chronic diseases,...

journal_title：Frontiers in immunology

authors： Danis J,Göblös A,Bata-Csörgő Z,Kemény L,Széll M

更新日期：2017-08-29 00:00:00

abstract：:IgA nephropathy (IgAN) is the dominant type of primary glomerulonephritis worldwide. However, IgAN rarely affects African Blacks and is uncommon in African Americans. Polymeric IgA1 with galactose-deficient hinge-region glycans is recognized as auto-antigen by glycan-specific antibodies, leading to formation of circul...

journal_title：Frontiers in immunology

authors： Zachova K,Kosztyu P,Zadrazil J,Matousovic K,Vondrak K,Hubacek P,Julian BA,Moldoveanu Z,Novak Z,Kostovcikova K,Raska M,Mestecky J

更新日期：2020-02-28 00:00:00

abstract：:Gestational age-dependent immune intolerance at the maternal-fetal interface might be a contributing factor to placental pathology and adverse pregnancy outcomes. Although the intrauterine setting is highly choreographed and considered to be a protective environment for the fetus, unscheduled inflammation might overwh...

journal_title：Frontiers in immunology

authors： Kamity R,Sharma S,Hanna N

更新日期：2019-04-05 00:00:00

abstract：:The lymphatic vasculature plays a crucial role in regulating the inflammatory response by influencing drainage of extravasated fluid, inflammatory mediators, and leukocytes. Lymphatic vessels undergo pronounced enlargement in inflamed tissue and display increased leakiness, indicating reduced functionality. Interferin...

journal_title：Frontiers in immunology

authors： Schwager S,Detmar M

更新日期：2019-02-26 00:00:00

abstract：:In vertebrate animals, the sterol metabolic network is emerging as a central player in immunity and inflammation. Upon infection, flux in the network is acutely moderated by the interferon (IFN) response through direct molecular and bi-directional communications. How sterol metabolism became linked to IFN control and ...

journal_title：Frontiers in immunology

authors： Newmark H,Dantoft W,Ghazal P

更新日期：2017-02-09 00:00:00

abstract：:In early human immunodeficiency virus (HIV) infection, the virus population escapes from multiple CD8(+) cell responses. The later an escape mutation emerges, the slower it outgrows its competition, i.e., the escape rate is lower. This pattern could indicate that the strength of the CD8(+) cell responses is waning, or...

journal_title：Frontiers in immunology

authors： Garcia V,Regoes RR

更新日期：2015-01-13 00:00:00

abstract：:Currently, liver transplantation is the most effective treatment for end-stage liver disease. Immunosuppressive agents are required to be taken after the operations, which have significantly reduced rejection rates and improved the short-term (<1 year) survival rates. However, post-transplant complications related to ...

journal_title：Frontiers in immunology

authors： Huang H,Lu Y,Zhou T,Gu G,Xia Q

更新日期：2018-11-09 00:00:00

abstract：:Phloretin (PT), isolated from the apple tree, was previously demonstrated to have antioxidative and anti-inflammatory effects in macrophages and anti-adiposity effects in adipocytes. Inflammatory immune cells generate high levels of reactive oxygen species (ROS) for stimulated severe airway hyperresponsiveness (AHR) a...

journal_title：Frontiers in immunology

authors： Huang WC,Fang LW,Liou CJ

更新日期：2017-02-13 00:00:00

abstract：:The 5-year survival rate of primary anorectal malignant melanoma is less than 20%. Optimal treatment of this condition remains controversial regarding locally disease, and whether any preferential survival benefit arises from either abdominoperineal resection or wide local excision remains unknown. The majority of pat...

journal_title：Frontiers in immunology

authors： Faure M,Rochigneux P,Olive D,Taix S,Brenot-Rossi I,Gilabert M

更新日期：2018-04-19 00:00:00

abstract：:In human brucellosis, the liver is frequently affected. Brucella abortus triggers a profibrotic response on hepatic stellate cells (HSCs) characterized by inhibition of MMP-9 with concomitant collagen deposition and TGF-β1 secretion through type 4 secretion system (T4SS). Taking into account that it has been reported ...

journal_title：Frontiers in immunology

authors： Arriola Benitez PC,Pesce Viglietti AI,Gomes MTR,Oliveira SC,Quarleri JF,Giambartolomei GH,Delpino MV

更新日期：2020-01-21 00:00:00