Decreases in Circulating Concentrations of Long-Chain Acylcarnitines and Free Fatty Acids During the Glucose Tolerance Test Represent Tissue-Specific Insulin Sensitivity.

abstract：:Obesity is associated with inflammation and type 2 diabetes. Innate immune system comprised of cellular and molecular components plays an important role in the inflammatory reactions. Immune cells like macrophages and their cell surface pattern-recognition receptors (PRRs) are representative for innate immunity promot...

journal_title：Frontiers in endocrinology

authors： Yamamoto Y,Yamamoto H

更新日期：2013-08-21 00:00:00

abstract：:Failure of uterine vascular transformation is associated with pregnancy complications including Intra Uterine Growth Restriction (IUGR). The decidua and its immune cell populations play a key role in the earliest stages of this process. Here we investigate the hypothesis that abnormal decidualization and failure of ma...

journal_title：Frontiers in endocrinology

authors： Dunk C,Kwan M,Hazan A,Walker S,Wright JK,Harris LK,Jones RL,Keating S,Kingdom JCP,Whittle W,Maxwell C,Lye SJ

更新日期：2019-03-20 00:00:00

abstract：:The pathophysiological function of the G-protein coupled melatonin MT1 and MT2 receptors has not yet been well-clarified. Recent advancements using selective MT1/ MT2 receptor ligands and MT1/MT2 receptor knockout mice have suggested that the activation of the MT1 receptors are mainly implicated in the regulation of r...

journal_title：Frontiers in endocrinology

authors： Gobbi G,Comai S

更新日期：2019-03-01 00:00:00

abstract：:Aging represents one of the most complicated and highly integrated somatic processes. Healthy aging is suggested to rely upon the coherent regulation of hormonal and neuronal communication between the central nervous system and peripheral tissues. The hypothalamus is one of the main structures in the body responsible ...

journal_title：Frontiers in endocrinology

authors： Martin B,Chadwick W,Janssens J,Premont RT,Schmalzigaug R,Becker KG,Lehrmann E,Wood WH,Zhang Y,Siddiqui S,Park SS,Cong WN,Daimon CM,Maudsley S

更新日期：2016-01-18 00:00:00

abstract：:Stiff-person syndrome (SPS) is highly associated with anti-glutamic acid decarboxylase (GAD) antibody. However, GAD antibodies alone appear to be insufficient to cause SPS, and they possibly are involved in only part of its pathophysiology. It is suspected that the symptoms of SPS get precipitated by external stimuli....

journal_title：Frontiers in endocrinology

authors： Lee YY,Lin CW,Chen IW

更新日期：2020-09-02 00:00:00

abstract：:Reproductive status is tightly coupled to metabolic state in females, and ovarian cycling in mammals is halted when energy output exceeds energy input, a metabolic condition known as negative energy balance. This inhibition of reproductive function during negative energy balance occurs due to suppression of gonadotrop...

journal_title：Frontiers in endocrinology

authors： True C,Grove KL,Smith MS

更新日期：2011-10-17 00:00:00

abstract：:Thyroid hormones are crucial in normal brain development. Transient and mild thyroid hormone insufficiency in pregnancy is also associated with impaired neurodevelopment in the offspring (e.g., 3-4 IQ score loss in association with maternal free thyroxine in the lowest fifth percentile). While inadequate iodine intake...

journal_title：Frontiers in endocrinology

authors： Ghassabian A,Trasande L

更新日期：2018-04-30 00:00:00

abstract：:Pheochromocytomas and paragangliomas (PHEO/PGL) are rare but occasionally life-threatening neoplasms, and are potentially malignant according to WHO classification in 2017. However, it is also well known that histopathological risk stratification to predict clinical outcome has not yet been established. The first hist...

journal_title：Frontiers in endocrinology

authors： Yamazaki Y,Gao X,Pecori A,Nakamura Y,Tezuka Y,Omata K,Ono Y,Morimoto R,Satoh F,Sasano H

更新日期：2020-10-27 00:00:00

abstract：Background:Many studies suggest that the small ubiquitin-like modifier 4 (SUMO4) M55V gene polymorphism (rs237025) may be associated with an increased risk of type 2 diabetes mellitus (T2DM). However, due to other conflicting results, a clear consensus is lacking in the matter. Objective and methods:A meta-analysis co...

journal_title：Frontiers in endocrinology

authors： Li YY,Wang H,Yang XX,Geng HY,Gong G,Kim HJ,Zhou YH,Wu JJ

更新日期：2017-11-02 00:00:00

abstract：:The mammalian genome contains four genes encoding GABA transporters (GAT1, slc6a1; GAT2, slc6a13; GAT3, slc6a11; BGT1, slc6a12) and five glutamate transporter genes (EAAT1, slc1a3; EAAT2, slc1a2; EAAT3, slc1a1; EAAT4, slc1a6; EAAT5, slc1a7). These transporters keep the extracellular levels of GABA and excitatory amino...

journal_title：Frontiers in endocrinology

authors： Zhou Y,Danbolt NC

更新日期：2013-11-11 00:00:00

abstract：:Women with impaired ovarian reserve or poor ovarian response (POR) to exogenous gonadotropin stimulation present a challenge for reproductive specialists. The primary reasons relate to the still limited knowledge about the POR pathophysiology and the lack of practical solutions for the management of these conditions. ...

journal_title：Frontiers in endocrinology

authors： Esteves SC,Roque M,Bedoschi GM,Conforti A,Humaidan P,Alviggi C

更新日期：2018-08-17 00:00:00

abstract：:[This corrects the article DOI: 10.3389/fendo.2018.00031.]. ...

journal_title：Frontiers in endocrinology

authors： Beattie J,Al-Khafaji H,Noer PR,Alkharobi HE,Alhodhodi A,Meade J,El-Gendy R,Oxvig C

更新日期：2018-09-04 00:00:00

abstract：:Testicular cancer represents the more frequent solid tumor affecting males aged 15-35 years. In the last decades, its incidence showed a progressive increased probably due to genetic and environmental factors. Despite exposure to some viruses such as HIV, HCV, EBV, and HPV is frequently related to cancer development, ...

journal_title：Frontiers in endocrinology

authors： Garolla A,Pizzol D,Bertoldo A,Ghezzi M,Carraro U,Ferlin A,Foresta C

更新日期：2012-12-21 00:00:00

abstract：:After decades of primarily morphological study, positional cloning of the NPHS1 gene was the landmark event that established aberrant podocyte genetics as a pivotal cause of malfunction of the glomerular filter. This ended any uncertainty whether genetic mutation plays a significant role in hereditary nephrotic syndro...

journal_title：Frontiers in endocrinology

authors： Bierzynska A,Soderquest K,Koziell A

更新日期：2015-01-23 00:00:00

abstract：:Background: Oxidative stress plays an important role in the pathogenesis of polycystic ovary syndrome (PCOS). Glutathione peroxidase 1 (GPx1) and catalase (CAT) are the major intracellular antioxidant enzymes that can detoxify hydrogen peroxide into water, preventing cellular injury from reactive oxygen species. The a...

journal_title：Frontiers in endocrinology

authors： Sun Y,Li S,Liu H,Gong Y,Bai H,Huang W,Liu Q,Guan L,Fan P

更新日期：2019-11-08 00:00:00

abstract：:Thyroid hormone concentrations only become sufficient to maintain a euthyroid state through appropriate stimulation by pituitary thyroid-stimulating hormone (TSH). In such a dynamic system under constant high pressure, guarding against overstimulation becomes vital. Therefore, several defensive mechanisms protect agai...

journal_title：Frontiers in endocrinology

authors： Hoermann R,Midgley JE,Larisch R,Dietrich JW

更新日期：2016-11-07 00:00:00

abstract：:Clear evidence indicates that cytokines, for instance, adipokines, hepatokines, inflammatory cytokines, myokines, and osteokines, contribute substantially to the development of abnormal glucose and lipid metabolism. Some cytokines play a positive role in metabolism action, while others have a negative metabolic role l...

journal_title：Frontiers in endocrinology

authors： Shi J,Fan J,Su Q,Yang Z

更新日期：2019-10-30 00:00:00

abstract：:Aim: Exercise training elicits diverse effects on brown (BAT) and white adipose tissue (WAT) physiology in rodents housed below their thermoneutral zone (i.e., 28-32°C). In these conditions, BAT is chronically hyperactive and, unlike human residence, closer to thermoneutrality. Therefore, we set out to determine the e...

journal_title：Frontiers in endocrinology

authors： Aldiss P,Lewis JE,Lupini I,Bloor I,Chavoshinejad R,Boocock DJ,Miles AK,Ebling FJP,Budge H,Symonds ME

更新日期：2020-03-20 00:00:00

abstract：:Objective: Prolactin and progesterone are implicated in glucose homeostasis in and outside of pregnancy. However, their associations with gestational diabetes (GDM) risk were not well-understood. This study investigates this question in a prospective and longitudinal cohort. Methods: This is a nested case-control stud...

journal_title：Frontiers in endocrinology

authors： Li M,Song Y,Rawal S,Hinkle SN,Zhu Y,Tekola-Ayele F,Ferrara A,Tsai MY,Zhang C

更新日期：2020-02-27 00:00:00

abstract：:In neuroendocrine cells, prohormones move from the endoplasmic reticulum to the Golgi complex (GC), where they are sorted and packed into secretory granules. The GC is considered the central station of the secretory pathway of proteins and lipids en route to their final destination. In most mammalian cells, it is form...

journal_title：Frontiers in endocrinology

authors： Martínez-Alonso E,Tomás M,Martínez-Menárguez JA

更新日期：2013-03-28 00:00:00

abstract：:Introduction: The aim of this study was to analyze psychological factors of patients with acromegaly and assessment of their relationship with the quality of life (QoL) in the context of the control of the disease. Materials and methods: A total sample of 50 patients (62% of females; mean age = 51.66 ± 14.5) with acro...

journal_title：Frontiers in endocrinology

authors： Jawiarczyk-Przybyłowska A,Szcześniak D,Ciułkowicz M,Bolanowski M,Rymaszewska J

更新日期：2020-01-14 00:00:00

abstract：:Giant pandas represent one of the most endangered species worldwide, and their reproductive capacity is extremely low. They have a relatively long gestational period, mainly because embryo implantation is delayed. Giant panda cubs comprise only a small proportion of the mother's body weight, making it difficult to det...

journal_title：Frontiers in endocrinology

authors： Cao M,Li C,Liu Y,Cai K,Chen L,Yuan C,Zhao Z,Zhang B,Hou R,Zhou X

更新日期：2020-04-16 00:00:00

abstract：:The insulin-like growth factor (IGF) family plays key roles in growth and development. In the cornea, IGF family members have been implicated in proliferation, differentiation, and migration, critical events that maintain a smooth refracting surface that is essential for vision. The IGF family is composed of multiple ...

journal_title：Frontiers in endocrinology

authors： Stuard WL,Titone R,Robertson DM

更新日期：2020-03-03 00:00:00

abstract：:Over the past decade, the increasing prevalence of obesity and its associated metabolic disorders constitutes one of the most concerning healthcare issues for countries worldwide. In an effort to curb the increased mortality and morbidity derived from the obesity epidemic, various therapeutic strategies have been deve...

journal_title：Frontiers in endocrinology

authors： Ong BX,Brunmeir R,Zhang Q,Peng X,Idris M,Liu C,Xu F

更新日期：2020-02-27 00:00:00

abstract：:Background: Bologna criteria poor ovarian responders have a very low prognosis. Although, it has been proposed that LH supplementation could be beneficial in women with previous hypo-response to FSH. There are no studies comparing the cumulative live birth rates (LBRs) between corifollitropin alfa (CFA) and highly pur...

journal_title：Frontiers in endocrinology

authors： Errázuriz J,Romito A,Drakopoulos P,Frederix B,Racca A,De Munck N,Tournaye H,De Vos M,Blockeel C

更新日期：2019-03-22 00:00:00

abstract：:Osteoporosis is a metabolic skeletal disorder in which bone mass is depleted and bone structure is destroyed to the degree that bone becomes fragile and prone to fractures. Emerging evidence suggests that N6-methyladenosine (m6A) modification, a novel epitranscriptomic marker, has a significant role in bone developmen...

journal_title：Frontiers in endocrinology

authors： Chen X,Hua W,Huang X,Chen Y,Zhang J,Li G

更新日期：2020-01-10 00:00:00

abstract：:Apart from the well-established role of kisspeptin (Kp) in the regulation of reproductive functions, recent data described its action in the control of metabolism. Of particular interest for the review is the population of Kp neurons localized in the arcuate nucleus (ARC) of the hypothalamus, the site of the brain whe...

journal_title：Frontiers in endocrinology

authors： Dudek M,Ziarniak K,Sliwowska JH

更新日期：2018-04-16 00:00:00

abstract：:Successful discontinuation of cabergoline (CAB) treatment has been reported in 31-75% of prolactinomas patients treated for at least 2 years. In contrast, it is not well established whether CAB therapy can be successfully withdrawn after a failed first attempt. This prospective open trial was designed to address this ...

journal_title：Frontiers in endocrinology

authors： Vilar L,Albuquerque JL,Gadelha PS,Rangel Filho F,Siqueira AM,da Fonseca MM,Viana KF,Gomes BS,Lyra R

更新日期：2015-02-04 00:00:00

abstract：:Follicle-stimulating hormone (FSH), a major regulator of spermatogenesis, has a crucial function in the development and function of the testis and it is extensively given as a fertility treatment to stimulate spermatogenesis. We analyzed the effects of different FSH preparations (α-follitropin, β-follitropin, and urof...

journal_title：Frontiers in endocrinology

authors： Arato I,Grande G,Barrachina F,Bellucci C,Lilli C,Jodar M,Aglietti MC,Mancini F,Vincenzoni F,Pontecorvi A,Calafiore R,Oliva R,Luca G,Mancuso F,Milardi D

更新日期：2020-06-18 00:00:00

abstract：:Spontaneous and oxytocin induced contractile activity was quantified in the bicornuate uteri of pregnant rabbits maintained in situ, using data from two- and uni- dimensional video spatiotemporal maps (VSTM) of linear and area strain rate and compared statistically. Spontaneous contractions occurred over a range of fr...

journal_title：Frontiers in endocrinology

authors： Hulls CM,Lentle RG,Chua WH,Suisted P,King QM,Chagas JAB,Chambers JP,Stewart L

更新日期：2019-11-21 00:00:00