Comparative effectiveness of torasemide versus furosemide in symptomatic therapy in heart failure patients: Preliminary results from the randomized TORNADO trial.

Abstract:

BACKGROUND:Recent reports suggest that torasemide might be more beneficial than furosemide in patients with symptomatic heart failure (HF). The aim was to compare the effects of torasemide and furosemide on clinical outcomes in HF patients. METHODS:This study pilot consisted of data from the ongoing multicenter, randomized, unblinded endpoint phase IV TORNADO (NCT01942109) study. HF patients in New York Heart Association (NYHA) II-IV class with a stable dose of furosemide were randomized to treatment with equipotential dose of torasemide (4:1) or continuation of unchanged dose of furosemide. On enrollment and control visit (3 months after enrollment) clinical examination, 6-minute walk test (6MWT) and assessment of fluid retention by ZOE Fluid Status Monitor were performed. The primary endpoint was a composite of improvement of NYHA class, improvement of at least 50 m during 6MWT and decrease in fluid retention of at least 0.5 W after 3-months follow-up. RESULTS:The study group included 40 patients (median age 66 years; 77.5% male). During follow-up 7 patients were hospitalized for HF worsening (3 in torasemide and 4 in furosemide-treated patients). The primary endpoint reached 15 (94%) and 14 (58%) patients on torasemide and furosemide, respectively (p = 0.03). CONCLUSIONS:In HF patients treated with torasemide fluid overload and symptoms improved more than in the furosemide group. This positive effect occurred already within 3-month observation.

journal_name

Cardiol J

journal_title

Cardiology journal

authors

Balsam P,Ozierański K,Marchel M,Gawałko M,Niedziela Ł,Tymińska A,Sieradzki B,Sieradzki M,Fojt A,Bakuła E,Główczyńska R,Peller M,Markulis M,Bednarski J,Kowalik R,Cacko A,Niewiński G,Filipiak KJ,Opolski G,Grabowski M

doi

10.5603/CJ.a2019.0114

subject

Has Abstract

pub_date

2019-01-01 00:00:00

pages

661-668

issue

6

issn

1897-5593

pii

VM/OJS/J/65083

journal_volume

26

pub_type

杂志文章,多中心研究,随机对照试验
  • The relationship between oxidative stress and coronary artery ectasia.

    abstract:BACKGROUND:Whereas coronary artery ectasia (CAE) is a rare abnormality of the coronary arteries, co-existent coronary artery disease (CAD) is commonly seen in CAE patients. Since a causative relationship has been shown to exist between oxidative stress and CAD, we sought to determine whether any relationship exists bet...

    journal_title:Cardiology journal

    pub_type: 杂志文章

    doi:

    authors: Sezen Y,Bas M,Polat M,Yildiz A,Buyukhatipoglu H,Kucukdurmaz Z,Kaya Z,Demirbag R

    更新日期:2010-01-01 00:00:00

  • The use of anticoagulants in morbidly obese patients.

    abstract::Due to its constantly growing incidence, obesity is an increasingly serious social and medical problem. Available data on the use of novel oral anticoagulants in morbidly obese and obese patients are very limited. However, we tried to summarize the available knowledge on the use of anticoagulants in this subpopulation...

    journal_title:Cardiology journal

    pub_type: 杂志文章,评审

    doi:10.5603/CJ.a2015.0054

    authors: Domienik-Karłowicz J,Pruszczyk P

    更新日期:2016-01-01 00:00:00

  • Risk factor paradox: No prognostic impact of arterial hypertension and smoking in patients with ventricular tachyarrhythmias.

    abstract:BACKGROUND:Data regarding the outcome of patients with ventricular tachyarrhythmias related to arterial hypertension (AHT) and smoking is limited. The study sought to assess the prognostic impact of AHT and smoking on survival in patients presenting with ventricular tachyarrhythmias. METHODS:All consecutive patients s...

    journal_title:Cardiology journal

    pub_type: 杂志文章

    doi:10.5603/CJ.a2018.0158

    authors: Weidner K,Behnes M,Rusnak J,Taton G,Schupp T,Reiser L,Bollow A,Reichelt T,Ellguth D,Engelke N,Kuche P,Hoppner J,El-Battrawy I,Lang S,Nienaber CA,Mashayekhi K,Ferdinand D,Weiß C,Borggrefe M,Akin I

    更新日期:2020-01-01 00:00:00

  • Effect of ASA dose doubling versus switching to clopidogrel on plasma inflammatory markers concentration in patients with type 2 diabetes and high platelet reactivity: the AVOCADO study.

    abstract:BACKGROUND:The aim of the study was to compare the effects of 2 strategies of antiplatelet treatment (i.e., 150 mg ASA vs. 75 mg clpoidogrel) on plasma level of inflammatory markers in type 2 diabetes mellitus (T2DM) patients with high platelet reactivity (HPR). METHODS:Study cohort consisted of 304 T2DM patients on c...

    journal_title:Cardiology journal

    pub_type: 杂志文章,多中心研究,随机对照试验

    doi:10.5603/CJ.2013.0045

    authors: Rosiak M,Postula M,Kaplon-Cieslicka A,Kondracka A,Trzepla E,Czlonkowski A,Janicki PK,Filipiak KJ,Opolski G

    更新日期:2013-01-01 00:00:00

  • Echocardiographic evaluation of the systemic ventricle after atrial switch procedure. The usefulness of subcostal imaging.

    abstract:BACKGROUND:Subcostal planes allow demonstration of the entire right ventricular cavity and are frequently used in patients with congenital heart disease; however, their clinical utility in the evaluation of systemic right ventricular function after atrial switch procedure for complete transposition has never been verif...

    journal_title:Cardiology journal

    pub_type: 杂志文章

    doi:

    authors: Hoffman P,Szymański P,Lubiszewska B,Rózański J

    更新日期:2008-01-01 00:00:00

  • Percutaneous coronary angioplasty in elderly patients: Assessment of in-hospital outcomes.

    abstract:BACKGROUND:We aimed to assess in-hospital outcomes of percutaneous transluminal coronary angioplasty (PTCA) in elderly subjects. METHODS:A total of 1000 consecutive patients, who had all been admitted for interventional treatment of symptomatic coronary artery disease, were retrospectively analysed. RESULTS:Elderly p...

    journal_title:Cardiology journal

    pub_type: 杂志文章

    doi:

    authors: Sukiennik A,Król A,Jachalska A,Koziński M,Fabiszak T,Kubica A,Radomski M,Demidowicz K,Bogdan M,Raczak G,Sukiennik T,Zabielska E,Dobosiewicz R,Rychter M,Jabłoński M,Białoszyński T,Chojnicki M,Grześk G,Kubica J

    更新日期:2007-01-01 00:00:00

  • Risk factors of atrial fibrillation recurrence despite successful radiofrequency ablation of accessory pathway: At 11 years of follow-up.

    abstract:BACKGROUND:Previous reports on patients with radiofrequency catheter ablation (RFCA) of accessory pathway (AP) and atrial fibrillation (AF) include only short follow-up periods. The aim of this study was to analyze predictors of recurrence of AF in patients after successful RFCA of APs over long term follow-up periods....

    journal_title:Cardiology journal

    pub_type: 杂志文章

    doi:10.5603/CJ.a2017.0055

    authors: Orczykowski M,Urbanek P,Bodalski R,Derejko P,Warmiński G,Łodyga M,Łasocha D,Mazurkiewicz Ł,Dąbrowski M,Tyczyński P,Zakrzewska-Koperska J,Baranowski R,Oręziak A,Sterliński M,Bilińska M,Szumowski Ł

    更新日期:2017-01-01 00:00:00

  • Ischemic and non-ischemic patterns of late gadolinium enhancement in heart failure with reduced ejection fraction.

    abstract:BACKGROUND:Late gadolinium enhancement (LGE) by cardiac magnetic resonance (CMR) may reveal myocardial fibrosis which is associated with adverse clinical outcomes in patients undergoing implantable cardioverter-defibrillator (ICD) placement. At the same time, transmural LGE in the posterolateral wall is related to nonr...

    journal_title:Cardiology journal

    pub_type: 杂志文章

    doi:10.5603/CJ.a2020.0009

    authors: Matusik PS,Bryll A,Matusik PT,Popiela TJ

    更新日期:2020-02-10 00:00:00

  • The atrial fibrillation in Turkey: Epidemiologic Registry (AFTER).

    abstract:BACKGROUND:AFTER (Atrial Fibrillation in Turkey: Epidemiologic Registry) is a prospective, multicenter study designed with the aim of describing the prevalence and epidemiology of AF practice in Turkey. This study aims to evaluate stroke risk in non-valvular atrial fibrillation (AF) and anticoagulant drug utilization w...

    journal_title:Cardiology journal

    pub_type: 杂志文章,多中心研究

    doi:10.5603/CJ.a2013.0055

    authors: Ertas F,Eren NK,Kaya H,Aribas A,Acar G,Kanadasi M,Gedik S,Oylumlu M,Yuksel M,Ulgen MS,AFTER Investigators.

    更新日期:2013-01-01 00:00:00

  • Myocardial strain characteristics and outcomes after transcatheter aortic valve replacement.

    abstract:BACKGROUND:Objective of this study was to make an assessment of standard functional and defor-mation parameters (strain) in patients after transcatheter aortic valve replacement (TAVR) by cardiac magnetic resonance imaging (CMR) and the evaluation of their prognostic impact. METHODS:Patients undergoing TAVR received C...

    journal_title:Cardiology journal

    pub_type: 杂志文章

    doi:10.5603/CJ.a2017.0121

    authors: Buckert D,Tibi R,Cieslik M,Radermacher M,Qu YY,Rasche V,Bernhardt P,Hombach V,Rottbauer W,Wöhrle J

    更新日期:2018-01-01 00:00:00

  • Diagnostic value of flow mediated dilatation measurement for coronary artery lesions in men under 45 years of age.

    abstract:BACKGROUND:In those without symptoms of coronary artery disease (CAD), the incidence of coronary events is still high. The aim of this study was to evaluate whether flow mediated dilatation (FMD) is a useful tool in identifying those with CAD in who are under 45 years of age. METHODS AND RESULTS:Seventy five men below...

    journal_title:Cardiology journal

    pub_type: 杂志文章

    doi:

    authors: Kaźmierski M,Michalewska-Włudarczyk A,Krzych LJ,Tendera M

    更新日期:2010-01-01 00:00:00

  • Pantoprazole may enhance antiplatelet effect of enteric-coated aspirin in patients with acute coronary syndrome.

    abstract:BACKGROUND:Antiplatelet therapy has proven beneficial in the treatment of cardiovascular disease. Proton pump inhibitors (PPIs) are commonly used for gastroprotection in patients receiving antiplatelet therapy. Several trials have been carried out to establish interactions between PPIs, clopidogrel and soluble formulat...

    journal_title:Cardiology journal

    pub_type: 杂志文章,随机对照试验

    doi:

    authors: Kasprzak M,Koziński M,Bielis L,Boinska J,Plazuk W,Marciniak A,Budzyński J,Siller-Matula J,Rość D,Kubica J

    更新日期:2009-01-01 00:00:00

  • The ventricular assist device: a bridge to ventricular recovery, a bridge to heart transplantation or destination therapy?

    abstract::Despite advances in pharmacological treatments aimed at a neurohormonal blockade for heart failure, there is still a growing number of patients with advanced symptoms who suffer significant morbidity and mortality. At present the most effective cure for end-stage congestive heart failure is cardiac transplantation. Th...

    journal_title:Cardiology journal

    pub_type: 杂志文章

    doi:

    authors: Bielecka A,Wierzbicka M,Goch J

    更新日期:2007-01-01 00:00:00

  • The impact of transferring patients with ST-segment elevation myocardial infarction to percutaneous coronary intervention-capable hospitals on clinical outcomes.

    abstract:BACKGROUND:Primary percutaneous coronary intervention (PCI) is recommended for ST-segment elevation myocardial infarction (STEMI) patients even when the patient must be transported to a PCI-capable hospital. This study aimed to evaluate the long-term clinical outcomes of STEMI patients who were transferred for primary ...

    journal_title:Cardiology journal

    pub_type: 杂志文章,多中心研究

    doi:10.5603/CJ.a2016.0003

    authors: Kim BW,Cha KS,Park MJ,Choi JH,Yun EY,Park JS,Lee HW,Oh JH,Kim JS,Choi JH,Park YH,Lee HC,Kim JH,Chun KJ,Hong TJ,Ahn Y,Jeong MH

    更新日期:2016-01-01 00:00:00

  • The early variation of left ventricular twisting function in patients with lymphoma received anthracycline therapy assessed by three-dimensional speckle tracking echocardiography.

    abstract:BACKGROUND:Anthracycline-induced cardiotoxicity remains a significant and unresolved issue in patients receiving chemotherapy. The aim of this study was to evaluate left ventricular (LV) twisting function by three-dimensional speckle tracking echocardiography (3D-STE) in patients with lymphoma after anthracycline thera...

    journal_title:Cardiology journal

    pub_type: 杂志文章

    doi:10.5603/CJ.a2017.0035

    authors: Song F,Kang Y,Zhang C,Xu Y,Shi J,Guo Y,Zhang Q,Shu X,Cheng L

    更新日期:2017-01-01 00:00:00

  • Does non-pharmacological treatment affect outcomes in dysautonomic syndromes?

    abstract::Dysautonomic syndromes are very common clinical conditions with different presentations and a wide spectrum of mechanisms. Many non-pharmacological and pharmacological interventions have been recommended to treat dysautonomic patients along these years, but the majority of them were not supported by multicenter contro...

    journal_title:Cardiology journal

    pub_type: 杂志文章,评审

    doi:10.5603/CJ.2014.0093

    authors: Hachul D

    更新日期:2014-01-01 00:00:00

  • Variant rs2200733 and rs10033464 on chromosome 4q25 are associated with increased risk of atrial fibrillation after catheter ablation: Evidence from a meta-analysis.

    abstract:BACKGROUND:Common genetic polymorphisms at chromosome 4q25 were associated with increased susceptibility to atrial fibrillation (AF). However, it remained controversial whether these variants could be used as risk predictors for AF recurrence after catheter ablation. We therefore performed a metaanalysis to quantify th...

    journal_title:Cardiology journal

    pub_type: 杂志文章,meta分析,评审

    doi:10.5603/CJ.a2017.0143

    authors: He J,Zhu W,Yu Y,Hu J,Hong K

    更新日期:2018-01-01 00:00:00

  • Prevalence of United States adults with triglycerides ≥ 135 mg/dL: NHANES 2007-2014.

    abstract::n/a - brief communication. ...

    journal_title:Cardiology journal

    pub_type: 杂志文章

    doi:10.5603/CJ.2019.0099

    authors: Fan W,Philip S,Toth PP,Granowitz C,Wong ND

    更新日期:2019-01-01 00:00:00

  • Sick euthyroid syndrome is associated with poor prognosis in patients with ST segment elevation myocardial infarction undergoing primary percutaneous intervention.

    abstract:BACKGROUND:Concomitant thyroid and heart disease are frequently encountered in clinical practice. There are many studies evaluating thyroid function in acute and critical conditions. Information on thyroid dysfunction in ST-segment elevation myocardial infarction (STEMI) is limited; its correlation with short and long-...

    journal_title:Cardiology journal

    pub_type: 杂志文章

    doi:10.5603/CJ.a2013.0108

    authors: Özcan KS,Osmonov D,Toprak E,Güngör B,Tatlısu A,Ekmekçi A,Kaya A,Tayyareci G,Erdinler İ

    更新日期:2014-01-01 00:00:00

  • Comparison of inhaled nitric oxide and aerosolized iloprost in pulmonary hypertension in children with congenital heart surgery.

    abstract:BACKGROUND:Pulmonary arterial hypertension is of importance in congenital cardiac surgery as being a significant cause of morbidity and mortality. Although therapy options are limited, inhaled nitric oxide (NO) is used as a standard therapy. The present study aimed to compare inhaled NO and aerosolized iloprost in chil...

    journal_title:Cardiology journal

    pub_type: 杂志文章,随机对照试验

    doi:10.5603/cj.2012.0070

    authors: Kirbas A,Yalcin Y,Tanrikulu N,Gürer O,Isik O

    更新日期:2012-01-01 00:00:00

  • Effect of milrinone on short-term outcome of patients with myocardial dysfunction undergoing coronary artery bypass graft: A randomized controlled trial.

    abstract:BACKGROUND:Myocardial dysfunction needing inotropic support is a typical complication after on-pump cardiac surgery. In this study, we evaluate the effect of milrinone on patients with ventricular dysfunction undergoing coronary artery bypass graft (CABG). METHODS:Seventy patients with impaired left ventricular functi...

    journal_title:Cardiology journal

    pub_type: 杂志文章,随机对照试验

    doi:

    authors: Jebeli M,Ghazinoor M,Mandegar MH,Rasouli MR,Eghtesadi-Araghi P,Goodarzynejad H,Mohammadzadeh R,Darehzereshki A,Dianat S

    更新日期:2010-01-01 00:00:00

  • Acute and mid-term outcomes of transvenous implant of a new left ventricular quadripolar lead versus bipolar leads for cardiac resynchronization therapy: results from a single-center prospective database.

    abstract:BACKGROUND:The purpose of this study was to evaluate the feasibility of the use of a quadripolar left ventricular (LV) lead for cardiac resynchronization therapy and to compare its acute and mid-term outcomes with those obtained with bipolar leads. Cardiac resynchronization exhibits a high incidence of problems involvi...

    journal_title:Cardiology journal

    pub_type: 杂志文章

    doi:10.5603/cj.2012.0087

    authors: Arias MA,Pachón M,Puchol A,Jiménez-López J,Rodríguez-Padial L

    更新日期:2012-01-01 00:00:00

  • Decrease in QRS amplitude in juvenile female competitive athletes during the initial twenty-one months of intensive training.

    abstract:BACKGROUND:The aim of this project was to study changes in QRS amplitude in junior female athletes during the initial twenty-one months of competitive training programme in aerobic gymnastics. METHODS:Somatometric parameters, heart rate (HR), blood pressure (BP) and 12-lead ECGs were recorded in 12 female athletes, ag...

    journal_title:Cardiology journal

    pub_type: 杂志文章

    doi:

    authors: Bacharova L,Tibenska M,Kucerova D,Kyselovicova O,Medekova H,Kyselovic J

    更新日期:2007-01-01 00:00:00

  • The treatment of acute myocardial infarction due to the occlusion of the left main coronary disease.

    abstract::Acute myocardial infarction (AMI) due to the occlusion of the left main coronary artery (LMCA) is a rare but serious condition in the era of percutaneus coronary intervention (PCI). Even more rare is AMI involved with both LMCA and its branches like trifurcartion or bifurcation: this is challenging for interventional ...

    journal_title:Cardiology journal

    pub_type: 杂志文章

    doi:

    authors: Can MM,Tanboga H,Karabay CY,Güler A,Akgun T,Turkyilmaz E,Ozveren O,Mutlu B

    更新日期:2011-01-01 00:00:00

  • Cardiac resynchronization therapy and atrial fibrillation.

    abstract::Cardiac resynchronization therapy (CRT) is an important advance for the treatment of end-stage heart failure (HF). About 15-50% of HF is complicated by atrial fibrillation (AF), associated with worsened outcomes. The presence of AF may interfere with optimal delivery of CRT due to competition with biventricular (BiV) ...

    journal_title:Cardiology journal

    pub_type: 杂志文章,评审

    doi:

    authors: Kamath GS,Steinberg JS

    更新日期:2009-01-01 00:00:00

  • Paravalvular leak after transcatheter aortic valve implantation (TAVI): Short-term results. Data from Polish national POL-TAVI registry.

    abstract:BACKGROUND:The authors analyzed data from Polish national POL-TAVI registry in terms of paravalvular leak (PVL) occurrence after transcatheter aortic valve implantation (TAVI) and its impact on clinical outcomes. METHODS:A total of 331 patients with severe aortic stenosis underwent TAVI (Edwards Sapien, n = 141; CoreV...

    journal_title:Cardiology journal

    pub_type: 杂志文章

    doi:10.5603/CJ.a2015.0071

    authors: Kleczyński P,Zasada W,Bagieński M,Rzeszutko Ł,Sorysz D,Sobczyński R,Trębacz J,Kapelak B,Zembala M,Dudek D

    更新日期:2016-01-01 00:00:00

  • Usefulness of transesophageal echocardiography before cardioversion in atrial arrhythmias.

    abstract:BACKGROUND:Although many thromboembolism risk factors are well defined, formation of thrombus or dense spontaneous contrast (sludge) in the left atrium remains enigmatic and confounding. Exclusion of the thrombus is extremely important with respect to planned reversal of sinus rhythm. Data regarding the routine transes...

    journal_title:Cardiology journal

    pub_type: 杂志文章

    doi:10.5603/CJ.a2019.0056

    authors: Kosmalska K,Rzyman M,Miękus P,Gilis-Malinowska N,Nowak R,Fijałkowski M

    更新日期:2019-06-21 00:00:00

  • Pulmonary arterial hypertension in the elderly: Clinical perspectives.

    abstract::Pulmonary hypertension (PH) is a rare and devastating disease characterized by progressive increases in pulmonary arterial pressure and pulmonary vascular resistance, which eventually leads to right ventric-ular failure and death. Pulmonary arterial hypertension (PAH) (World Health Organization Group I), a subset of P...

    journal_title:Cardiology journal

    pub_type: 杂志文章

    doi:10.5603/CJ.a2018.0096

    authors: Rothbard N,Agrawal A,Fischer C,Talwar A,Sahni S

    更新日期:2020-01-01 00:00:00

  • Predicted and observed in-hospital mortality after left main coronary artery stenting in 204 patients.

    abstract:BACKGROUND:The purpose of this study was to compare risk predicted using available risk scores and actual outcomes in patients with left main coronary artery disease undergoing percutaneous coronary intervention with stent implantation (PCI LM). METHODS:We studied 204 patients treated with elective or emergent coronar...

    journal_title:Cardiology journal

    pub_type: 杂志文章

    doi:

    authors: Sukiennik A,Ostrowska-Nowak J,Wiśniewska-Szmyt J,Radomski M,Rychter M,Jabłoński M,Białoszyński T,Koziński M,Fabiszak T,Dobosiewicz R,Zabielska E,Sukiennik T,Kubica A,Król A,Demidowicz K,Chojnicki M,Grabczewska Z,Swiatki

    更新日期:2008-01-01 00:00:00

  • Aspirin desensitization in patients undergoing percutaneous coronary intervention: a survey of current practice.

    abstract:BACKGROUND:Aspirin remains the mainstay of anti-platelet therapy in cardiac patients. However, if a patient is allergic to aspirin and dual anti-platelet therapy is indicated - such as with percutaneous coronary intervention (PCI), then there is no clear guidance. One possibility is aspirin desensitization. A variety o...

    journal_title:Cardiology journal

    pub_type: 杂志文章

    doi:10.5603/CJ.2013.0025

    authors: Chapman AR,Rushworth GF,Leslie SJ

    更新日期:2013-01-01 00:00:00