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Targeting CNS Related Protist Pathogens: Calcium Ion Dependency in the Brain-Eating Amoebae.

Abstract：

:Of the free-living amoebae (FLA) Naegleria fowleri, Balamuthia mandrillaris, and Acanthamoeba spp. are known to cause encephalitis. Coined with the term "brain-eating amoebae" (BEA), infection of the central nervous system with FLA has a high mortality rate. A combination of diagnostic delay, lack of new drug development, and incomplete understanding of the dependencies of FLA have resulted in the failure of introducing safer and effective drugs. We inferred that being a shape-changing entity the FLA should have a dependency on calcium (Ca2+) ions that could be targeted to cripple the pathogenicity of the FLA. We used genomic, transcriptomic, and proteomic information available on FLA in online databases to evidence the presence of various Ca2+ion influx regulating channels, reviewing adapter proteins at first and then targeting human-like voltage-gated Ca2+ channels with nifedipine and verapamil that are used clinically for noninfectious diseases to see their effect in trophozoites of Acanthamoeba spp. in particular.

journal_name

ACS Chem Neurosci

journal_title

ACS chemical neuroscience

authors

Baig AM,Khaleeq A,Nazim F

doi

10.1021/acschemneuro.9b00635

subject

Has Abstract

pub_date

2020-08-19 00:00:00

pages

2385-2387

issue

16

issn

1948-7193

journal_volume

11

pub_type

社论

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