Accelerated Physical Emulation of Bayesian Inference in Spiking Neural Networks.

abstract：:Over the past decade there has been a renaissance in our understanding of spinal cord circuits; new technologies are beginning to provide key insights into descending circuits which project onto spinal cord central pattern generators. By integrating work from both the locomotor and animal behavioral fields, we can now...

journal_title：Frontiers in neuroscience

authors： Kim LH,Sharma S,Sharples SA,Mayr KA,Kwok CHT,Whelan PJ

更新日期：2017-10-18 00:00:00

abstract：:Introduction: Ventricular arrhythmia is a major cause of sudden cardiac death in patients with chronic heart failure (CHF). Our recent study demonstrates that N-type Ca2+ currents in intracardiac ganglionic neurons are reduced in the late stage of CHF rats. Rat intracardiac ganglia are divided into the atrioventricula...

journal_title：Frontiers in neuroscience

authors： Zhang D,Tu H,Wang C,Cao L,Muelleman RL,Wadman MC,Li YL

更新日期：2017-05-08 00:00:00

abstract：:Homeostasis in the nervous system requires intricate regulation and is largely accomplished by the blood-brain barrier (BBB). The major gate keeper of the vertebrate BBB is vascular endothelial cells, which form tight junctions (TJs). To gain insight into the development of the BBB, we studied the carpet glia, a subpe...

journal_title：Frontiers in neuroscience

authors： Ho TY,Wu WH,Hung SJ,Liu T,Lee YM,Liu YH

更新日期：2019-03-29 00:00:00

abstract：:Neurofibrillary pathology comprised of pathological tau protein is closely tied to a range of neurodegenerative disorders, the most common of which is Alzheimer's disease. While they are individually rarer, a range of other disorders, the tauopathies (including Pick's disease, progressive supranuclear palsy, corticoba...

journal_title：Frontiers in neuroscience

authors： Novak P,Kontsekova E,Zilka N,Novak M

更新日期：2018-11-02 00:00:00

abstract：:Donepezil is a potent acetylcholinesterase inhibitor, largely used worldwide to alleviate cognitive symptoms in Alzheimer's disease (AD). Beyond the widely described neuronal impact of donepezil, it was recently shown that targeting connexins, the proteins involved in astrocyte network organization, potentiates donepe...

journal_title：Frontiers in neuroscience

authors： Vidal B,Droguerre M,Valdebenito M,Zimmer L,Hamon M,Mouthon F,Charvériat M

更新日期：2020-08-12 00:00:00

abstract：:Lactate is a versatile metabolite with important roles in modulation of brain glucose utilization rate (CMRglc), diagnosis of brain-injured patients, redox- and receptor-mediated signaling, memory, and alteration of gene transcription. Neurons and astrocytes release and accumulate lactate using equilibrative monocarbo...

journal_title：Frontiers in neuroscience

authors： Hertz L,Gibbs ME,Dienel GA

更新日期：2014-09-09 00:00:00

abstract：:Some studies identified hypo-connectivity, while others showed hyper-connectivity of the insula in the autism spectrum disorders (ASD). These contradictory findings leave open the question of whether and to what extent functional connectivity of the insula is altered and how functional connectivity of the insula is as...

journal_title：Frontiers in neuroscience

authors： Xu J,Wang H,Zhang L,Xu Z,Li T,Zhou Z,Zhou Z,Gan Y,Hu Q

更新日期：2018-04-11 00:00:00

abstract：:D-norpseudoephedrine (NPE), also known as cathine, is found naturally in the shrub Catha edulis "Khat." NPE has been widely used as an appetite suppressant for the treatment of obesity. Although it is known that NPE acts on α1-adrenergic receptors, there is little information about the role of dopamine receptors on NP...

journal_title：Frontiers in neuroscience

authors： Kalyanasundar B,Perez CI,Arroyo B,Moreno MG,Gutierrez R

更新日期：2020-10-16 00:00:00

abstract：:Emerging evidence suggest an impaired endocannabinoid activity in the pathophysiology of binge eating disorder (BED). Herein, we investigated whether endocannabinoid tone could be modified as a consequence of dietary-induced binge eating in female rats. For this purpose, brain levels of the endocannabinoids anandamide...

journal_title：Frontiers in neuroscience

authors： Satta V,Scherma M,Piscitelli F,Usai P,Castelli MP,Bisogno T,Fratta W,Fadda P

更新日期：2018-02-02 00:00:00

abstract：:The neuronal cascade related to the perception of either purely olfactory or trigeminal airborne chemicals has been investigated using electroencephalography (EEG) microstate analyses and source localization. However, most airborne chemicals are bimodal in nature, encompassing both properties. Moreover, there is an on...

journal_title：Frontiers in neuroscience

authors： Hucke CI,Heinen RM,Pacharra M,Wascher E,van Thriel C

更新日期：2021-01-13 00:00:00

abstract：:A large body of experimental and clinical evidence has strongly suggested that monoamines play an important role in regulating epileptogenesis, seizure susceptibility, convulsions, and comorbid psychiatric disorders commonly seen in people with epilepsy (PWE). However, neither the relative significance of individual m...

journal_title：Frontiers in neuroscience

authors： Svob Strac D,Pivac N,Smolders IJ,Fogel WA,De Deurwaerdere P,Di Giovanni G

更新日期：2016-11-10 00:00:00

abstract：:Cognitive control of emotions depends on intermodular long-distance communications. However, negative connections between connector hubs are removed by traditional hard-thresholding approach in graph-theoretical research. Using soft-thresholding approach to reserve negative links, we explore time-varying features of c...

journal_title：Frontiers in neuroscience

authors： Zhang W,Chen J,Ren G,Tang F,Liu Q,Li H

更新日期：2019-10-25 00:00:00

abstract：:In the present review, we deliver an overview of the involvement of metabotropic glutamate receptor 5 (mGluR5) activity and density in pathological anxiety, mood disorders and addiction. Specifically, we will describe mGluR5 studies in humans that employed Positron Emission Tomography (PET) and combined the findings w...

journal_title：Frontiers in neuroscience

authors： Terbeck S,Akkus F,Chesterman LP,Hasler G

更新日期：2015-03-18 00:00:00

abstract：:Many complex brain disorders, such as autism spectrum disorders, exhibit a wide range of symptoms and disability. To understand how brain communication is impaired in such conditions, functional connectivity studies seek to understand individual differences in brain network structure in terms of covariates that measur...

journal_title：Frontiers in neuroscience

authors： Narayan M,Allen GI

更新日期：2016-04-12 00:00:00

abstract：:Pain and stress are both phenomena that challenge an individual's homeostasis and have significant overlap in conceptual and physiological processes. Allostasis is the ability to adapt to pain and stress and maintain homeostasis; however, if either process becomes chronic, it may result in negative long-term outcomes....

journal_title：Frontiers in neuroscience

authors： Lunde CE,Sieberg CB

更新日期：2020-03-26 00:00:00

abstract：:The prevalence of depressive disorders is growing worldwide, notably due to stagnation in the development of drugs with greater antidepressant efficacy, the continuous large proportion of patients who do not respond to conventional antidepressants, and the increasing rate of chronic medical conditions associated with ...

journal_title：Frontiers in neuroscience

authors： Vancassel S,Capuron L,Castanon N

更新日期：2018-07-24 00:00:00

abstract：:Heterogeneity between late-onset Parkinson's disease (LOPD) and early-onset Parkinson's disease (EOPD) is mainly reflected in the following aspects including genetics, disease progression, drug response, clinical manifestation, and neuropathological change. Although many studies have investigated these differences in ...

journal_title：Frontiers in neuroscience

authors： Yue Y,Jiang Y,Shen T,Pu J,Lai HY,Zhang B

更新日期：2020-02-25 00:00:00

abstract：Background:Cranial irradiation is a common therapy for the treatment of brain tumors, but unfortunately patients suffer from side effects, particularly cognitive impairment, caused by neurodegenerative and neuroinflammatory mechanisms. Finding a therapeutic agent protecting hippocampal neurons would be beneficial. Fing...

journal_title：Frontiers in neuroscience

authors： Metzdorf J,Hobloss Z,Schlevogt S,Ayzenberg I,Stahlke S,Pedreiturria X,Haupeltshofer S,Gold R,Tönges L,Kleiter I

更新日期：2019-07-09 00:00:00

abstract：:Recent neuroimaging studies in primates aim to define the functional properties of auditory cortical areas, especially areas beyond A1, in order to further our understanding of the auditory cortical organization. Precise mapping of functional magnetic resonance imaging (fMRI) results and interpretation of their locali...

journal_title：Frontiers in neuroscience

authors： Joly O,Baumann S,Balezeau F,Thiele A,Griffiths TD

更新日期：2014-07-21 00:00:00

abstract：:Experiments often challenge the null hypothesis that an intervention, for instance application of non-invasive brain stimulation (NIBS), has no effect on an outcome measure. In conventional statistics, a positive result rejects that hypothesis, but a null result is meaningless. Informally, however, researchers often d...

journal_title：Frontiers in neuroscience

authors： de Graaf TA,Sack AT

更新日期：2018-12-11 00:00:00

abstract：:A growing body of work underlines striking similarities between biological neural networks and recurrent, binary neural networks. A relatively smaller body of work, however, addresses the similarities between learning dynamics employed in deep artificial neural networks and synaptic plasticity in spiking neural networ...

journal_title：Frontiers in neuroscience

authors： Kaiser J,Mostafa H,Neftci E

更新日期：2020-05-12 00:00:00

abstract：:Neuromorphic systems are gaining increasing importance in an era where CMOS digital computing techniques are reaching physical limits. These silicon systems mimic extremely energy efficient neural computing structures, potentially both for solving engineering applications as well as understanding neural computation. T...

journal_title：Frontiers in neuroscience

authors： Hasler J,Marr B

更新日期：2013-09-10 00:00:00

abstract：:Alzheimer's disease (AD) and Parkinson's disease (PD) are the two most common neurodegenerative disorders worldwide, with age being their major risk factor. The increasing worldwide life expectancy, together with the scarcity of available treatment choices, makes it thus pressing to find the molecular basis of AD and ...

journal_title：Frontiers in neuroscience

authors： Bordone MC,Barbosa-Morais NL

更新日期：2020-12-09 00:00:00

abstract：:The dentate gyrus (DG) is a region in the mammalian brain critical for memory encoding with a neuronal architecture and function that deviates considerably from other cortical areas. One of the major differences of the DG compared to other brain regions is the finding that the dentate gyrus generates new principal neu...

journal_title：Frontiers in neuroscience

authors： Piatti VC,Ewell LA,Leutgeb JK

更新日期：2013-04-04 00:00:00

abstract：Background:Early exposure to nociceptive events may cause brain structural alterations in preterm neonates, with long-lasting consequences on neurodevelopmental outcome. Little is known on the extent to which early pain may affect brain connectivity. We aim to evaluate brain functional connectivity changes in preterm n...

journal_title：Frontiers in neuroscience

authors： Tortora D,Severino M,Di Biase C,Malova M,Parodi A,Minghetti D,Traggiai C,Uccella S,Boeri L,Morana G,Rossi A,Ramenghi LA

更新日期：2019-08-23 00:00:00

abstract：:There has been evidence that during brain development, emerging thalamocortical (TC) and corticothalamic (CT) pathways converge in some brain regions and follow each other's trajectories to their final destinations. Corpus callosal (CC) pathways also emerge at a similar developmental stage, and are known to converge w...

journal_title：Frontiers in neuroscience

authors： Wang R,Wilkinson M,Kane T,Takahashi E

更新日期：2017-11-01 00:00:00

abstract：:This paper developed a cognitive task-load (CTL) classification algorithm and allocation strategy to sustain the optimal operator CTL levels over time in safety-critical human-machine integrated systems. An adaptive human-machine system is designed based on a non-linear dynamic CTL classifier, which maps a set of elec...

journal_title：Frontiers in neuroscience

authors： Zhang J,Yin Z,Wang R

更新日期：2017-03-17 00:00:00

abstract：:Alcohol and drug dependence are serious public health problems worldwide. The prevalence of alcohol and drug dependence in the United States and other parts of the world is significant. Given the limitations in the efficacy of current pharmacotherapies to treat these disorders, research in developing alternative pharm...

journal_title：Frontiers in neuroscience

authors： Rahman S,Engleman EA,Bell RL

更新日期：2015-01-15 00:00:00

abstract：:A coordinate transformation framework for understanding how neurons compute sensorimotor behaviors has generated significant advances toward our understanding of basic brain function. This influential scaffold focuses on neuronal encoding of spatial information represented in different coordinate systems (e.g., eye-ce...

journal_title：Frontiers in neuroscience

authors： Chang SW

更新日期：2013-08-21 00:00:00

abstract：Background:Cochlear implants (CIs), which have been designed primarily to support spoken communication of persons with severe to profound hearing loss, are highly effective in supporting speech perception in quiet listening conditions. CI users as a group achieve significantly poorer perception and appraisal of music, ...

journal_title：Frontiers in neuroscience

authors： Gfeller K,Driscoll V,Schwalje A

更新日期：2019-11-21 00:00:00